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Compile Data Set for Download or QSAR

Found 45 hits Enz. Inhib. hit(s) with all data for entry = 50037868   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50198353
PNG
(CHEMBL227753 | CHEMBL534948 | N-(2,6-dimethylpheny...)
Show SMILES CN1CCCC(COc2ccc(cc2)-c2cnc(Nc3c(C)cccc3C)c3cncn23)C1
Show InChI InChI=1S/C27H31N5O/c1-19-6-4-7-20(2)26(19)30-27-25-14-28-18-32(25)24(15-29-27)22-9-11-23(12-10-22)33-17-21-8-5-13-31(3)16-21/h4,6-7,9-12,14-15,18,21H,5,8,13,16-17H2,1-3H3,(H,29,30)
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n/an/a 8n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of Lck

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198360
PNG
(CHEMBL227906 | N-(2,6-dimethylphenyl)-5-(3-methoxy...)
Show SMILES COc1cccc(c1)-c1cnc(Nc2c(C)cccc2C)c2cncn12
Show InChI InChI=1S/C21H20N4O/c1-14-6-4-7-15(2)20(14)24-21-19-11-22-13-25(19)18(12-23-21)16-8-5-9-17(10-16)26-3/h4-13H,1-3H3,(H,23,24)
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n/an/a 11n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198372
PNG
(CHEMBL387641 | N-(2,6-dimethylphenyl)-5-thiophen-2...)
Show SMILES Cc1cccc(C)c1Nc1ncc(-c2cccs2)n2cncc12
Show InChI InChI=1S/C18H16N4S/c1-12-5-3-6-13(2)17(12)21-18-15-9-19-11-22(15)14(10-20-18)16-7-4-8-23-16/h3-11H,1-2H3,(H,20,21)
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n/an/a 12n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198370
PNG
(CHEMBL223873 | N-(2,6-dimethyl-phenyl)-5-phenylimi...)
Show SMILES Cc1cccc(C)c1Nc1ncc(-c2ccccc2)n2cncc12
Show InChI InChI=1S/C20H18N4/c1-14-7-6-8-15(2)19(14)23-20-18-11-21-13-24(18)17(12-22-20)16-9-4-3-5-10-16/h3-13H,1-2H3,(H,22,23)
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n/an/a 13n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198361
PNG
(CHEMBL227699 | N-(2,6-dimethylphenyl)-5-[4-(2-pyrr...)
Show SMILES Cc1cccc(C)c1Nc1ncc(-c2ccc(OCCN3CCCC3)cc2)n2cncc12
Show InChI InChI=1S/C26H29N5O/c1-19-6-5-7-20(2)25(19)29-26-24-16-27-18-31(24)23(17-28-26)21-8-10-22(11-9-21)32-15-14-30-12-3-4-13-30/h5-11,16-18H,3-4,12-15H2,1-2H3,(H,28,29)
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n/an/a 15n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198378
PNG
(CHEMBL389031 | N-(2,6-dimethylphenyl)-5-(4-methoxy...)
Show SMILES COc1ccc(cc1)-c1cnc(Nc2c(C)cccc2C)c2cncn12
Show InChI InChI=1S/C21H20N4O/c1-14-5-4-6-15(2)20(14)24-21-19-11-22-13-25(19)18(12-23-21)16-7-9-17(26-3)10-8-16/h4-13H,1-3H3,(H,23,24)
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n/an/a 15n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198377
PNG
(CHEMBL389422 | N-(2,6-dimethylphenyl)-5-[3-(1-meth...)
Show SMILES CN1CCCC(COc2cccc(c2)-c2cnc(Nc3c(C)cccc3C)c3cncn23)C1
Show InChI InChI=1S/C27H31N5O/c1-19-7-4-8-20(2)26(19)30-27-25-14-28-18-32(25)24(15-29-27)22-10-5-11-23(13-22)33-17-21-9-6-12-31(3)16-21/h4-5,7-8,10-11,13-15,18,21H,6,9,12,16-17H2,1-3H3,(H,29,30)
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n/an/a 19n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198365
PNG
(CHEMBL226613 | N-[5-(4-dimethylaminophenyl)imidazo...)
Show SMILES CN(C)c1ccc(cc1)-c1cnc(Nc2c(C)cccc2C)c2cncn12
Show InChI InChI=1S/C22H23N5/c1-15-6-5-7-16(2)21(15)25-22-20-12-23-14-27(20)19(13-24-22)17-8-10-18(11-9-17)26(3)4/h5-14H,1-4H3,(H,24,25)
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n/an/a 19n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198353
PNG
(CHEMBL227753 | CHEMBL534948 | N-(2,6-dimethylpheny...)
Show SMILES CN1CCCC(COc2ccc(cc2)-c2cnc(Nc3c(C)cccc3C)c3cncn23)C1
Show InChI InChI=1S/C27H31N5O/c1-19-6-4-7-20(2)26(19)30-27-25-14-28-18-32(25)24(15-29-27)22-9-11-23(12-10-22)33-17-21-8-5-13-31(3)16-21/h4,6-7,9-12,14-15,18,21H,5,8,13,16-17H2,1-3H3,(H,29,30)
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n/an/a 20n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198353
PNG
(CHEMBL227753 | CHEMBL534948 | N-(2,6-dimethylpheny...)
Show SMILES CN1CCCC(COc2ccc(cc2)-c2cnc(Nc3c(C)cccc3C)c3cncn23)C1
Show InChI InChI=1S/C27H31N5O/c1-19-6-4-7-20(2)26(19)30-27-25-14-28-18-32(25)24(15-29-27)22-9-11-23(12-10-22)33-17-21-8-5-13-31(3)16-21/h4,6-7,9-12,14-15,18,21H,5,8,13,16-17H2,1-3H3,(H,29,30)
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n/an/a 20n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198354
PNG
(CHEMBL389451 | N-[5-(3,4-dimethoxyphenyl)imidazo[1...)
Show SMILES COc1ccc(cc1OC)-c1cnc(Nc2c(C)cccc2C)c2cncn12
Show InChI InChI=1S/C22H22N4O2/c1-14-6-5-7-15(2)21(14)25-22-18-11-23-13-26(18)17(12-24-22)16-8-9-19(27-3)20(10-16)28-4/h5-13H,1-4H3,(H,24,25)
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n/an/a 23n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198379
PNG
(CHEMBL227836 | N-(2,6-dimethylphenyl)-5-[4-(2-morp...)
Show SMILES Cc1cccc(C)c1Nc1ncc(-c2ccc(OCCN3CCOCC3)cc2)n2cncc12
Show InChI InChI=1S/C26H29N5O2/c1-19-4-3-5-20(2)25(19)29-26-24-16-27-18-31(24)23(17-28-26)21-6-8-22(9-7-21)33-15-12-30-10-13-32-14-11-30/h3-9,16-18H,10-15H2,1-2H3,(H,28,29)
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n/an/a 37n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198369
PNG
(CHEMBL388859 | N-(5-phenylimidazo[1,5-a]pyrazin-8-...)
Show SMILES Cc1cc(C)c(Nc2ncc(-c3ccccc3)n3cncc23)c(C)c1
Show InChI InChI=1S/C21H20N4/c1-14-9-15(2)20(16(3)10-14)24-21-19-11-22-13-25(19)18(12-23-21)17-7-5-4-6-8-17/h4-13H,1-3H3,(H,23,24)
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n/an/a 38n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198366
PNG
(CHEMBL223912 | N-(2,6-dichlorophenyl)-5-phenylimid...)
Show SMILES Clc1cccc(Cl)c1Nc1ncc(-c2ccccc2)n2cncc12
Show InChI InChI=1S/C18H12Cl2N4/c19-13-7-4-8-14(20)17(13)23-18-16-9-21-11-24(16)15(10-22-18)12-5-2-1-3-6-12/h1-11H,(H,22,23)
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n/an/a 42n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198357
PNG
(CHEMBL228091 | N-(2,6-dimethylphenyl)-5-(4-fluorop...)
Show SMILES Cc1cccc(C)c1Nc1ncc(-c2ccc(F)cc2)n2cncc12
Show InChI InChI=1S/C20H17FN4/c1-13-4-3-5-14(2)19(13)24-20-18-10-22-12-25(18)17(11-23-20)15-6-8-16(21)9-7-15/h3-12H,1-2H3,(H,23,24)
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n/an/a 42n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198374
PNG
(4-[8-(2,6-dimethylphenylamino)imidazo[1,5-a]-pyraz...)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1cnc(Nc2c(C)cccc2C)c2cncn12
Show InChI InChI=1S/C23H23N5O/c1-15-6-5-7-16(2)21(15)26-22-20-12-24-14-28(20)19(13-25-22)17-8-10-18(11-9-17)23(29)27(3)4/h5-14H,1-4H3,(H,25,26)
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n/an/a 52n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198358
PNG
(CHEMBL227652 | N-(2,6-dimethylphenyl)-5-[5-(4-meth...)
Show SMILES Cc1cccc(C)c1Nc1ncc(C2=CCC(CN3CCCC3)=[S+]2)n2cncc12 |c:24,t:14|
Show InChI InChI=1S/C23H26N5S/c1-16-6-5-7-17(2)22(16)26-23-20-12-24-15-28(20)19(13-25-23)21-9-8-18(29-21)14-27-10-3-4-11-27/h5-7,9,12-13,15H,3-4,8,10-11,14H2,1-2H3,(H,25,26)/q+1
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n/an/a 52n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198376
PNG
(CHEMBL534947 | N-(2,6-dimethylphenyl)-5-[3-(2-pyrr...)
Show SMILES Cc1cccc(C)c1Nc1ncc(-c2cccc(OCCN3CCCC3)c2)n2cncc12
Show InChI InChI=1S/C26H29N5O/c1-19-7-5-8-20(2)25(19)29-26-24-16-27-18-31(24)23(17-28-26)21-9-6-10-22(15-21)32-14-13-30-11-3-4-12-30/h5-10,15-18H,3-4,11-14H2,1-2H3,(H,28,29)
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n/an/a 55n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198380
PNG
(CHEMBL226773 | N-(2-chloro-6-methylphenyl)-6-(3-me...)
Show SMILES COc1cccc(c1)-c1cnc(Nc2c(C)cccc2Cl)c2cncn12
Show InChI InChI=1S/C20H17ClN4O/c1-13-5-3-8-16(21)19(13)24-20-18-10-22-12-25(18)17(11-23-20)14-6-4-7-15(9-14)26-2/h3-12H,1-2H3,(H,23,24)
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n/an/a 59n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50151366
PNG
((2-Chloro-6-methyl-phenyl)-[8-((S)-3-methyl-pipera...)
Show SMILES C[C@H]1CN(CCN1)c1ccc2nc(Nc3c(C)cccc3Cl)c3cncn3c2n1
Show InChI InChI=1S/C21H22ClN7/c1-13-4-3-5-15(22)19(13)27-20-17-10-23-12-29(17)21-16(25-20)6-7-18(26-21)28-9-8-24-14(2)11-28/h3-7,10,12,14,24H,8-9,11H2,1-2H3,(H,25,27)/t14-/m0/s1
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n/an/a 96n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198355
PNG
(CHEMBL376555 | N-(2,6-dimethylphenyl)-5-pyridin-4-...)
Show SMILES Cc1cccc(C)c1Nc1ncc(-c2ccncc2)n2cncc12
Show InChI InChI=1S/C19H17N5/c1-13-4-3-5-14(2)18(13)23-19-17-10-21-12-24(17)16(11-22-19)15-6-8-20-9-7-15/h3-12H,1-2H3,(H,22,23)
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n/an/a 108n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198363
PNG
(CHEMBL224691 | N-(2-chloro-6-methylphenyl)-6-(4-fl...)
Show SMILES Cc1cccc(Cl)c1Nc1ncc(-c2ccc(F)cc2)n2cncc12
Show InChI InChI=1S/C19H14ClFN4/c1-12-3-2-4-15(20)18(12)24-19-17-9-22-11-25(17)16(10-23-19)13-5-7-14(21)8-6-13/h2-11H,1H3,(H,23,24)
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n/an/a 145n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198381
PNG
(CHEMBL388820 | N-(2,6-dimethylphenyl)-5-(4-trifluo...)
Show SMILES Cc1cccc(C)c1Nc1ncc(-c2ccc(cc2)C(F)(F)F)n2cncc12
Show InChI InChI=1S/C21H17F3N4/c1-13-4-3-5-14(2)19(13)27-20-18-10-25-12-28(18)17(11-26-20)15-6-8-16(9-7-15)21(22,23)24/h3-12H,1-2H3,(H,26,27)
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n/an/a 235n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198375
PNG
(4-[8-(2,6-dimethylphenylamino)imidazo[1,5-a]pyrazi...)
Show SMILES Cc1cccc(C)c1Nc1ncc(-c2ccc(cc2)C#N)n2cncc12
Show InChI InChI=1S/C21H17N5/c1-14-4-3-5-15(2)20(14)25-21-19-11-23-13-26(19)18(12-24-21)17-8-6-16(10-22)7-9-17/h3-9,11-13H,1-2H3,(H,24,25)
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n/an/a 235n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198356
PNG
(4-[8-(2,6-dimethylphenylamino)imidazo[1,5-a]-pyraz...)
Show SMILES Cc1cccc(C)c1Nc1ncc(-c2ccc(cc2)C(O)=O)n2cncc12
Show InChI InChI=1S/C21H18N4O2/c1-13-4-3-5-14(2)19(13)24-20-18-10-22-12-25(18)17(11-23-20)15-6-8-16(9-7-15)21(26)27/h3-12H,1-2H3,(H,23,24)(H,26,27)
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n/an/a 235n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198367
PNG
(CHEMBL227859 | N-[5-(4-methoxyphenyl)imidazo[1,5-a...)
Show SMILES COc1ccc(cc1)-c1cnc(Nc2ccccc2C)c2cncn12
Show InChI InChI=1S/C20H18N4O/c1-14-5-3-4-6-17(14)23-20-19-11-21-13-24(19)18(12-22-20)15-7-9-16(25-2)10-8-15/h3-13H,1-2H3,(H,22,23)
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n/an/a 260n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50370960
PNG
(CHEMBL541412)
Show SMILES CN1CCN(CC2=[S+]C(=CC2)c2cnc(Nc3c(C)cccc3C)c3cncn23)CC1 |c:8,t:6|
Show InChI InChI=1S/C24H29N6S/c1-17-5-4-6-18(2)23(17)27-24-21-13-25-16-30(21)20(14-26-24)22-8-7-19(31-22)15-29-11-9-28(3)10-12-29/h4-6,8,13-14,16H,7,9-12,15H2,1-3H3,(H,26,27)/q+1
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n/an/a 305n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198362
PNG
(CHEMBL388136 | N-(2,6-difluorophenyl)-5-phenylimid...)
Show SMILES Fc1cccc(F)c1Nc1ncc(-c2ccccc2)n2cncc12
Show InChI InChI=1S/C18H12F2N4/c19-13-7-4-8-14(20)17(13)23-18-16-9-21-11-24(16)15(10-22-18)12-5-2-1-3-6-12/h1-11H,(H,22,23)
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n/an/a 490n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198353
PNG
(CHEMBL227753 | CHEMBL534948 | N-(2,6-dimethylpheny...)
Show SMILES CN1CCCC(COc2ccc(cc2)-c2cnc(Nc3c(C)cccc3C)c3cncn23)C1
Show InChI InChI=1S/C27H31N5O/c1-19-6-4-7-20(2)26(19)30-27-25-14-28-18-32(25)24(15-29-27)22-9-11-23(12-10-22)33-17-21-8-5-13-31(3)16-21/h4,6-7,9-12,14-15,18,21H,5,8,13,16-17H2,1-3H3,(H,29,30)
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n/an/a 530n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc in COS7 cells by ELISA

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198364
PNG
(CHEMBL390367 | N-(2-methoxy-6-methylphenyl)-5-phen...)
Show SMILES COc1cccc(C)c1Nc1ncc(-c2ccccc2)n2cncc12
Show InChI InChI=1S/C20H18N4O/c1-14-7-6-10-18(25-2)19(14)23-20-17-11-21-13-24(17)16(12-22-20)15-8-4-3-5-9-15/h3-13H,1-2H3,(H,22,23)
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n/an/a 693n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198379
PNG
(CHEMBL227836 | N-(2,6-dimethylphenyl)-5-[4-(2-morp...)
Show SMILES Cc1cccc(C)c1Nc1ncc(-c2ccc(OCCN3CCOCC3)cc2)n2cncc12
Show InChI InChI=1S/C26H29N5O2/c1-19-4-3-5-20(2)25(19)29-26-24-16-27-18-31(24)23(17-28-26)21-6-8-22(9-7-21)33-15-12-30-10-13-32-14-11-30/h3-9,16-18H,10-15H2,1-2H3,(H,28,29)
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n/an/a 700n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc in COS7 cells by ELISA

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198377
PNG
(CHEMBL389422 | N-(2,6-dimethylphenyl)-5-[3-(1-meth...)
Show SMILES CN1CCCC(COc2cccc(c2)-c2cnc(Nc3c(C)cccc3C)c3cncn23)C1
Show InChI InChI=1S/C27H31N5O/c1-19-7-4-8-20(2)26(19)30-27-25-14-28-18-32(25)24(15-29-27)22-10-5-11-23(13-22)33-17-21-9-6-12-31(3)16-21/h4-5,7-8,10-11,13-15,18,21H,6,9,12,16-17H2,1-3H3,(H,29,30)
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n/an/a 740n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc in COS7 cells by ELISA

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198358
PNG
(CHEMBL227652 | N-(2,6-dimethylphenyl)-5-[5-(4-meth...)
Show SMILES Cc1cccc(C)c1Nc1ncc(C2=CCC(CN3CCCC3)=[S+]2)n2cncc12 |c:24,t:14|
Show InChI InChI=1S/C23H26N5S/c1-16-6-5-7-17(2)22(16)26-23-20-12-24-15-28(20)19(13-25-23)21-9-8-18(29-21)14-27-10-3-4-11-27/h5-7,9,12-13,15H,3-4,8,10-11,14H2,1-2H3,(H,25,26)/q+1
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n/an/a 820n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc in COS7 cells by ELISA

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198361
PNG
(CHEMBL227699 | N-(2,6-dimethylphenyl)-5-[4-(2-pyrr...)
Show SMILES Cc1cccc(C)c1Nc1ncc(-c2ccc(OCCN3CCCC3)cc2)n2cncc12
Show InChI InChI=1S/C26H29N5O/c1-19-6-5-7-20(2)25(19)29-26-24-16-27-18-31(24)23(17-28-26)21-8-10-22(11-9-21)32-15-14-30-12-3-4-13-30/h5-11,16-18H,3-4,12-15H2,1-2H3,(H,28,29)
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n/an/a 950n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc in COS7 cells by ELISA

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198376
PNG
(CHEMBL534947 | N-(2,6-dimethylphenyl)-5-[3-(2-pyrr...)
Show SMILES Cc1cccc(C)c1Nc1ncc(-c2cccc(OCCN3CCCC3)c2)n2cncc12
Show InChI InChI=1S/C26H29N5O/c1-19-7-5-8-20(2)25(19)29-26-24-16-27-18-31(24)23(17-28-26)21-9-6-10-22(15-21)32-14-13-30-11-3-4-12-30/h5-10,15-18H,3-4,11-14H2,1-2H3,(H,28,29)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc in COS7 cells by ELISA

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50370960
PNG
(CHEMBL541412)
Show SMILES CN1CCN(CC2=[S+]C(=CC2)c2cnc(Nc3c(C)cccc3C)c3cncn23)CC1 |c:8,t:6|
Show InChI InChI=1S/C24H29N6S/c1-17-5-4-6-18(2)23(17)27-24-21-13-25-16-30(21)20(14-26-24)22-8-7-19(31-22)15-29-11-9-28(3)10-12-29/h4-6,8,13-14,16H,7,9-12,15H2,1-3H3,(H,26,27)/q+1
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n/an/a 2.30E+3n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc in COS7 cells by ELISA

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50198353
PNG
(CHEMBL227753 | CHEMBL534948 | N-(2,6-dimethylpheny...)
Show SMILES CN1CCCC(COc2ccc(cc2)-c2cnc(Nc3c(C)cccc3C)c3cncn23)C1
Show InChI InChI=1S/C27H31N5O/c1-19-6-4-7-20(2)26(19)30-27-25-14-28-18-32(25)24(15-29-27)22-9-11-23(12-10-22)33-17-21-8-5-13-31(3)16-21/h4,6-7,9-12,14-15,18,21H,5,8,13,16-17H2,1-3H3,(H,29,30)
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n/an/a 2.73E+3n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of EGFR

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198382
PNG
(CHEMBL227376 | N-(2,6-dimethylphenyl)imidazo[1,5-a...)
Show SMILES Cc1cccc(C)c1Nc1nccn2cncc12
Show InChI InChI=1S/C14H14N4/c1-10-4-3-5-11(2)13(10)17-14-12-8-15-9-18(12)7-6-16-14/h3-9H,1-2H3,(H,16,17)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198384
PNG
(CHEMBL390957 | N-[5-(4-methoxyphenyl)imidazo[1,5-a...)
Show SMILES COc1ccc(cc1)-c1cnc(Nc2ccccc2)c2cncn12
Show InChI InChI=1S/C19H16N4O/c1-24-16-9-7-14(8-10-16)17-12-21-19(18-11-20-13-23(17)18)22-15-5-3-2-4-6-15/h2-13H,1H3,(H,21,22)
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n/an/a 3.70E+3n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198371
PNG
(CHEMBL426903 | N-Phenyl-5-phenylimidazo[1,5-a]pyra...)
Show SMILES N(c1ccccc1)c1ncc(-c2ccccc2)n2cncc12
Show InChI InChI=1S/C18H14N4/c1-3-7-14(8-4-1)16-12-20-18(17-11-19-13-22(16)17)21-15-9-5-2-6-10-15/h1-13H,(H,20,21)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))		BDBM50198353
PNG
(CHEMBL227753 | CHEMBL534948 | N-(2,6-dimethylpheny...)
Show SMILES CN1CCCC(COc2ccc(cc2)-c2cnc(Nc3c(C)cccc3C)c3cncn23)C1
Show InChI InChI=1S/C27H31N5O/c1-19-6-4-7-20(2)26(19)30-27-25-14-28-18-32(25)24(15-29-27)22-9-11-23(12-10-22)33-17-21-8-5-13-31(3)16-21/h4,6-7,9-12,14-15,18,21H,5,8,13,16-17H2,1-3H3,(H,29,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta2

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50198353
PNG
(CHEMBL227753 | CHEMBL534948 | N-(2,6-dimethylpheny...)
Show SMILES CN1CCCC(COc2ccc(cc2)-c2cnc(Nc3c(C)cccc3C)c3cncn23)C1
Show InChI InChI=1S/C27H31N5O/c1-19-6-4-7-20(2)26(19)30-27-25-14-28-18-32(25)24(15-29-27)22-9-11-23(12-10-22)33-17-21-8-5-13-31(3)16-21/h4,6-7,9-12,14-15,18,21H,5,8,13,16-17H2,1-3H3,(H,29,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of KDR

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (Human))		BDBM50198353
PNG
(CHEMBL227753 | CHEMBL534948 | N-(2,6-dimethylpheny...)
Show SMILES CN1CCCC(COc2ccc(cc2)-c2cnc(Nc3c(C)cccc3C)c3cncn23)C1
Show InChI InChI=1S/C27H31N5O/c1-19-6-4-7-20(2)26(19)30-27-25-14-28-18-32(25)24(15-29-27)22-9-11-23(12-10-22)33-17-21-8-5-13-31(3)16-21/h4,6-7,9-12,14-15,18,21H,5,8,13,16-17H2,1-3H3,(H,29,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of Zap70

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM50198353
PNG
(CHEMBL227753 | CHEMBL534948 | N-(2,6-dimethylpheny...)
Show SMILES CN1CCCC(COc2ccc(cc2)-c2cnc(Nc3c(C)cccc3C)c3cncn23)C1
Show InChI InChI=1S/C27H31N5O/c1-19-6-4-7-20(2)26(19)30-27-25-14-28-18-32(25)24(15-29-27)22-9-11-23(12-10-22)33-17-21-8-5-13-31(3)16-21/h4,6-7,9-12,14-15,18,21H,5,8,13,16-17H2,1-3H3,(H,29,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of Syk

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50198359
PNG
(CHEMBL388807 | N-methyl-N-phenyl-5-phenylimidazo[1...)
Show SMILES CN(c1ccccc1)c1ncc(-c2ccccc2)n2cncc12
Show InChI InChI=1S/C19H16N4/c1-22(16-10-6-3-7-11-16)19-18-12-20-14-23(18)17(13-21-19)15-8-4-2-5-9-15/h2-14H,1H3
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n/an/a 1.00E+6n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay

Bioorg Med Chem 15: 868-85 (2006)


Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H
More data for this
Ligand-Target Pair