Found 33 hits Enz. Inhib. hit(s) with all data for entry = 50046860 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50134434
(CHEMBL3746046)Show SMILES Cc1c(nn2c(Nc3cc(Cl)cc(Cl)c3)c3C(=O)NCCc3nc12)S(C)(=O)=O Show InChI InChI=1S/C17H15Cl2N5O3S/c1-8-14-22-12-3-4-20-16(25)13(12)15(24(14)23-17(8)28(2,26)27)21-11-6-9(18)5-10(19)7-11/h5-7,21H,3-4H2,1-2H3,(H,20,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50134433
(CHEMBL3745968)Show SMILES COc1cccc(Nc2c3C(=O)NCCc3nc3c(C)c(nn23)S(C)(=O)=O)c1 Show InChI InChI=1S/C18H19N5O4S/c1-10-15-21-13-7-8-19-17(24)14(13)16(23(15)22-18(10)28(3,25)26)20-11-5-4-6-12(9-11)27-2/h4-6,9,20H,7-8H2,1-3H3,(H,19,24) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50134432
(CHEMBL3747036)Show SMILES CSc1nn2c(Nc3cc(Cl)cc(Cl)c3)c3C(=O)NCCc3nc2c1C Show InChI InChI=1S/C17H15Cl2N5OS/c1-8-14-22-12-3-4-20-16(25)13(12)15(24(14)23-17(8)26-2)21-11-6-9(18)5-10(19)7-11/h5-7,21H,3-4H2,1-2H3,(H,20,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50134429
(CHEMBL3746964)Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)c1nn2c(Nc3cc(Cl)cc(Cl)c3)c(cnc2c1C)C(N)=O Show InChI InChI=1S/C23H20Cl2N6O4S/c1-12-20-27-11-18(19(26)32)21(28-16-9-14(24)8-15(25)10-16)31(20)29-22(12)36(34,35)17-6-4-5-13(7-17)23(33)30(2)3/h4-11,28H,1-3H3,(H2,26,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50134428
(CHEMBL3746007)Show SMILES COc1cccc(Nc2c(cnc3c(C)c(nn23)S(=O)(=O)c2cccc(c2)C(=O)N(C)C)C(N)=O)c1 Show InChI InChI=1S/C24H24N6O5S/c1-14-21-26-13-19(20(25)31)22(27-16-8-6-9-17(12-16)35-4)30(21)28-23(14)36(33,34)18-10-5-7-15(11-18)24(32)29(2)3/h5-13,27H,1-4H3,(H2,25,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50134393
(CHEMBL3746464)Show SMILES COc1cccc(Nc2c(cnc3c(C)c(nn23)S(=O)(=O)c2ccccc2)C(N)=O)c1 Show InChI InChI=1S/C21H19N5O4S/c1-13-19-23-12-17(18(22)27)20(24-14-7-6-8-15(11-14)30-2)26(19)25-21(13)31(28,29)16-9-4-3-5-10-16/h3-12,24H,1-2H3,(H2,22,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50134434
(CHEMBL3746046)Show SMILES Cc1c(nn2c(Nc3cc(Cl)cc(Cl)c3)c3C(=O)NCCc3nc12)S(C)(=O)=O Show InChI InChI=1S/C17H15Cl2N5O3S/c1-8-14-22-12-3-4-20-16(25)13(12)15(24(14)23-17(8)28(2,26)27)21-11-6-9(18)5-10(19)7-11/h5-7,21H,3-4H2,1-2H3,(H,20,25) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis by HTRF assay in presence of dye d2 labelled cAMP |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50134430
(CHEMBL3747248)Show SMILES COc1cccc(Nc2c(cnc3c(C(C)C)c(nn23)S(C)(=O)=O)C(N)=O)c1 Show InChI InChI=1S/C18H21N5O4S/c1-10(2)14-17-20-9-13(15(19)24)16(23(17)22-18(14)28(4,25)26)21-11-6-5-7-12(8-11)27-3/h5-10,21H,1-4H3,(H2,19,24) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50134431
(CHEMBL3747181)Show SMILES CC(C)c1c(nn2c(Nc3cc(Cl)cc(Cl)c3)c(cnc12)C(N)=O)S(C)(=O)=O Show InChI InChI=1S/C17H17Cl2N5O3S/c1-8(2)13-16-21-7-12(14(20)25)15(24(16)23-17(13)28(3,26)27)22-11-5-9(18)4-10(19)6-11/h4-8,22H,1-3H3,(H2,20,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50134394
(CHEMBL3747325)Show SMILES Cc1c(nn2c(Nc3cc(Cl)cc(Cl)c3)c(cnc12)C(N)=O)S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C20H15Cl2N5O3S/c1-11-18-24-10-16(17(23)28)19(25-14-8-12(21)7-13(22)9-14)27(18)26-20(11)31(29,30)15-5-3-2-4-6-15/h2-10,25H,1H3,(H2,23,28) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50134391
(CHEMBL3747090)Show SMILES Cc1c(nn2c(Nc3cc(Cl)cc(Cl)c3)c(cnc12)C(N)=O)S(C)(=O)=O Show InChI InChI=1S/C15H13Cl2N5O3S/c1-7-13-19-6-11(12(18)23)14(22(13)21-15(7)26(2,24)25)20-10-4-8(16)3-9(17)5-10/h3-6,20H,1-2H3,(H2,18,23) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50134433
(CHEMBL3745968)Show SMILES COc1cccc(Nc2c3C(=O)NCCc3nc3c(C)c(nn23)S(C)(=O)=O)c1 Show InChI InChI=1S/C18H19N5O4S/c1-10-15-21-13-7-8-19-17(24)14(13)16(23(15)22-18(10)28(3,25)26)20-11-5-4-6-12(9-11)27-2/h4-6,9,20H,7-8H2,1-3H3,(H,19,24) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis by HTRF assay in presence of dye d2 labelled cAMP |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50134389
(CHEMBL3747338)Show InChI InChI=1S/C14H11Cl2N5O/c1-7-5-19-21-13(7)18-6-11(12(17)22)14(21)20-10-3-8(15)2-9(16)4-10/h2-6,20H,1H3,(H2,17,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50134390
(CHEMBL3747602)Show SMILES COc1cccc(Nc2c(cnc3c(C)c(nn23)S(C)(=O)=O)C(N)=O)c1 Show InChI InChI=1S/C16H17N5O4S/c1-9-14-18-8-12(13(17)22)15(21(14)20-16(9)26(3,23)24)19-10-5-4-6-11(7-10)25-2/h4-8,19H,1-3H3,(H2,17,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50134392
(CHEMBL3747423)Show InChI InChI=1S/C16H17N5O2/c1-3-10-8-19-21-15(10)18-9-13(14(17)22)16(21)20-11-5-4-6-12(7-11)23-2/h4-9,20H,3H2,1-2H3,(H2,17,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50134429
(CHEMBL3746964)Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)c1nn2c(Nc3cc(Cl)cc(Cl)c3)c(cnc2c1C)C(N)=O Show InChI InChI=1S/C23H20Cl2N6O4S/c1-12-20-27-11-18(19(26)32)21(28-16-9-14(24)8-15(25)10-16)31(20)29-22(12)36(34,35)17-6-4-5-13(7-17)23(33)30(2)3/h4-11,28H,1-3H3,(H2,26,32) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis by HTRF assay in presence of dye d2 labelled cAMP |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50134386
(CHEMBL3747655)Show InChI InChI=1S/C15H15N5O2/c1-9-7-18-20-14(9)17-8-12(13(16)21)15(20)19-10-4-3-5-11(6-10)22-2/h3-8,19H,1-2H3,(H2,16,21) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 165 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50134393
(CHEMBL3746464)Show SMILES COc1cccc(Nc2c(cnc3c(C)c(nn23)S(=O)(=O)c2ccccc2)C(N)=O)c1 Show InChI InChI=1S/C21H19N5O4S/c1-13-19-23-12-17(18(22)27)20(24-14-7-6-8-15(11-14)30-2)26(19)25-21(13)31(28,29)16-9-4-3-5-10-16/h3-12,24H,1-2H3,(H2,22,27) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 243 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis by HTRF assay in presence of dye d2 labelled cAMP |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50134430
(CHEMBL3747248)Show SMILES COc1cccc(Nc2c(cnc3c(C(C)C)c(nn23)S(C)(=O)=O)C(N)=O)c1 Show InChI InChI=1S/C18H21N5O4S/c1-10(2)14-17-20-9-13(15(19)24)16(23(17)22-18(14)28(4,25)26)21-11-6-5-7-12(8-11)27-3/h5-10,21H,1-4H3,(H2,19,24) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis by HTRF assay in presence of dye d2 labelled cAMP |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50134432
(CHEMBL3747036)Show SMILES CSc1nn2c(Nc3cc(Cl)cc(Cl)c3)c3C(=O)NCCc3nc2c1C Show InChI InChI=1S/C17H15Cl2N5OS/c1-8-14-22-12-3-4-20-16(25)13(12)15(24(14)23-17(8)26-2)21-11-6-9(18)5-10(19)7-11/h5-7,21H,3-4H2,1-2H3,(H,20,25) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis by HTRF assay in presence of dye d2 labelled cAMP |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50134431
(CHEMBL3747181)Show SMILES CC(C)c1c(nn2c(Nc3cc(Cl)cc(Cl)c3)c(cnc12)C(N)=O)S(C)(=O)=O Show InChI InChI=1S/C17H17Cl2N5O3S/c1-8(2)13-16-21-7-12(14(20)25)15(24(16)23-17(13)28(3,26)27)22-11-5-9(18)4-10(19)6-11/h4-8,22H,1-3H3,(H2,20,25) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 507 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis by HTRF assay in presence of dye d2 labelled cAMP |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50134428
(CHEMBL3746007)Show SMILES COc1cccc(Nc2c(cnc3c(C)c(nn23)S(=O)(=O)c2cccc(c2)C(=O)N(C)C)C(N)=O)c1 Show InChI InChI=1S/C24H24N6O5S/c1-14-21-26-13-19(20(25)31)22(27-16-8-6-9-17(12-16)35-4)30(21)28-23(14)36(33,34)18-10-5-7-15(11-18)24(32)29(2)3/h5-13,27H,1-4H3,(H2,25,31) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 629 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis by HTRF assay in presence of dye d2 labelled cAMP |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50134391
(CHEMBL3747090)Show SMILES Cc1c(nn2c(Nc3cc(Cl)cc(Cl)c3)c(cnc12)C(N)=O)S(C)(=O)=O Show InChI InChI=1S/C15H13Cl2N5O3S/c1-7-13-19-6-11(12(18)23)14(22(13)21-15(7)26(2,24)25)20-10-4-8(16)3-9(17)5-10/h3-6,20H,1-2H3,(H2,18,23) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis by HTRF assay in presence of dye d2 labelled cAMP |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50134390
(CHEMBL3747602)Show SMILES COc1cccc(Nc2c(cnc3c(C)c(nn23)S(C)(=O)=O)C(N)=O)c1 Show InChI InChI=1S/C16H17N5O4S/c1-9-14-18-8-12(13(17)22)15(21(14)20-16(9)26(3,23)24)19-10-5-4-6-11(7-10)25-2/h4-8,19H,1-3H3,(H2,17,22) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis by HTRF assay in presence of dye d2 labelled cAMP |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50134387
(CHEMBL3747623)Show InChI InChI=1S/C14H13N5O/c1-9-7-17-19-13(9)16-8-11(12(15)20)14(19)18-10-5-3-2-4-6-10/h2-8,18H,1H3,(H2,15,20) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50134392
(CHEMBL3747423)Show InChI InChI=1S/C16H17N5O2/c1-3-10-8-19-21-15(10)18-9-13(14(17)22)16(21)20-11-5-4-6-12(7-11)23-2/h4-9,20H,3H2,1-2H3,(H2,17,22) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis by HTRF assay in presence of dye d2 labelled cAMP |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50134394
(CHEMBL3747325)Show SMILES Cc1c(nn2c(Nc3cc(Cl)cc(Cl)c3)c(cnc12)C(N)=O)S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C20H15Cl2N5O3S/c1-11-18-24-10-16(17(23)28)19(25-14-8-12(21)7-13(22)9-14)27(18)26-20(11)31(29,30)15-5-3-2-4-6-15/h2-10,25H,1H3,(H2,23,28) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis by HTRF assay in presence of dye d2 labelled cAMP |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50134389
(CHEMBL3747338)Show InChI InChI=1S/C14H11Cl2N5O/c1-7-5-19-21-13(7)18-6-11(12(17)22)14(21)20-10-3-8(15)2-9(16)4-10/h2-6,20H,1H3,(H2,17,22) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis by HTRF assay in presence of dye d2 labelled cAMP |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50134388
(CHEMBL3747039)Show InChI InChI=1S/C16H17N5O2/c1-10-8-19-21-14(10)18-9-13(16(22)17-2)15(21)20-11-5-4-6-12(7-11)23-3/h4-9,20H,1-3H3,(H,17,22) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis by HTRF assay in presence of dye d2 labelled cAMP |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50134387
(CHEMBL3747623)Show InChI InChI=1S/C14H13N5O/c1-9-7-17-19-13(9)16-8-11(12(15)20)14(19)18-10-5-3-2-4-6-10/h2-8,18H,1H3,(H2,15,20) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis by HTRF assay in presence of dye d2 labelled cAMP |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50134386
(CHEMBL3747655)Show InChI InChI=1S/C15H15N5O2/c1-9-7-18-20-14(9)17-8-12(13(16)21)15(20)19-10-4-3-5-11(6-10)22-2/h3-8,19H,1-2H3,(H2,16,21) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis by HTRF assay in presence of dye d2 labelled cAMP |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50134388
(CHEMBL3747039)Show InChI InChI=1S/C16H17N5O2/c1-10-8-19-21-14(10)18-9-13(16(22)17-2)15(21)20-11-5-4-6-12(7-11)23-3/h4-9,20H,1-3H3,(H,17,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50134386
(CHEMBL3747655)Show InChI InChI=1S/C15H15N5O2/c1-9-7-18-20-14(9)17-8-12(13(16)21)15(20)19-10-4-3-5-11(6-10)22-2/h3-8,19H,1-2H3,(H2,16,21) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE3 by fluorescence capillary-electrophoresis assay |
Bioorg Med Chem Lett 26: 454-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M |
More data for this Ligand-Target Pair | |