Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM173271![]() (US10323032, Example 107 | US9096596, 107 | US90965...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | 9.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Displacement of [3H]A-804598 from human recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells after 1 hr by radioligand binding assay | ACS Med Chem Lett 7: 348-50 (2016) Article DOI: 10.1021/acsmedchemlett.6b00083 BindingDB Entry DOI: 10.7270/Q2CZ392F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Rattus norvegicus (Rat)) | BDBM173255![]() (US10323032, Example 7 | US9096596, 7 | US9604982, ...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Displacement of [3H]A-804598 from rat recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells after 1 hr by radioligand binding assay | ACS Med Chem Lett 7: 348-50 (2016) Article DOI: 10.1021/acsmedchemlett.6b00083 BindingDB Entry DOI: 10.7270/Q2CZ392F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM173255![]() (US10323032, Example 7 | US9096596, 7 | US9604982, ...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Displacement of [3H]A-804598 from human recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells after 1 hr by radioligand binding assay | ACS Med Chem Lett 7: 348-50 (2016) Article DOI: 10.1021/acsmedchemlett.6b00083 BindingDB Entry DOI: 10.7270/Q2CZ392F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Rattus norvegicus (Rat)) | BDBM173271![]() (US10323032, Example 107 | US9096596, 107 | US90965...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Displacement of [3H]A-804598 from rat recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells after 1 hr by radioligand binding assay | ACS Med Chem Lett 7: 348-50 (2016) Article DOI: 10.1021/acsmedchemlett.6b00083 BindingDB Entry DOI: 10.7270/Q2CZ392F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM173348![]() (US10323032, Example 66 | US9096596, 66 | US9604982...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Displacement of [3H]A-804598 from human recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells after 1 hr by radioligand binding assay | ACS Med Chem Lett 7: 348-50 (2016) Article DOI: 10.1021/acsmedchemlett.6b00083 BindingDB Entry DOI: 10.7270/Q2CZ392F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Rattus norvegicus (Rat)) | BDBM173260![]() (US10323032, Example 12 | US9096596, 12 | US9604982...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | 58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Displacement of [3H]A-804598 from rat recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells after 1 hr by radioligand binding assay | ACS Med Chem Lett 7: 348-50 (2016) Article DOI: 10.1021/acsmedchemlett.6b00083 BindingDB Entry DOI: 10.7270/Q2CZ392F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM173260![]() (US10323032, Example 12 | US9096596, 12 | US9604982...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | 59 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Displacement of [3H]A-804598 from human recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells after 1 hr by radioligand binding assay | ACS Med Chem Lett 7: 348-50 (2016) Article DOI: 10.1021/acsmedchemlett.6b00083 BindingDB Entry DOI: 10.7270/Q2CZ392F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM173271![]() (US10323032, Example 107 | US9096596, 107 | US90965...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Antagonist activity against human recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells assessed as reduction in BzATP -induced Ca2+ fl... | ACS Med Chem Lett 7: 348-50 (2016) Article DOI: 10.1021/acsmedchemlett.6b00083 BindingDB Entry DOI: 10.7270/Q2CZ392F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM173348![]() (US10323032, Example 66 | US9096596, 66 | US9604982...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Antagonist activity against human recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells assessed as reduction in BzATP -induced Ca2+ fl... | ACS Med Chem Lett 7: 348-50 (2016) Article DOI: 10.1021/acsmedchemlett.6b00083 BindingDB Entry DOI: 10.7270/Q2CZ392F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Rattus norvegicus (Rat)) | BDBM173348![]() (US10323032, Example 66 | US9096596, 66 | US9604982...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Antagonist activity against rat recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells assessed as reduction in BzATP -induced Ca2+ flux... | ACS Med Chem Lett 7: 348-50 (2016) Article DOI: 10.1021/acsmedchemlett.6b00083 BindingDB Entry DOI: 10.7270/Q2CZ392F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM173255![]() (US10323032, Example 7 | US9096596, 7 | US9604982, ...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Antagonist activity against human recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells assessed as reduction in BzATP -induced Ca2+ fl... | ACS Med Chem Lett 7: 348-50 (2016) Article DOI: 10.1021/acsmedchemlett.6b00083 BindingDB Entry DOI: 10.7270/Q2CZ392F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM173260![]() (US10323032, Example 12 | US9096596, 12 | US9604982...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Antagonist activity against human recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells assessed as reduction in BzATP -induced Ca2+ fl... | ACS Med Chem Lett 7: 348-50 (2016) Article DOI: 10.1021/acsmedchemlett.6b00083 BindingDB Entry DOI: 10.7270/Q2CZ392F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Rattus norvegicus (Rat)) | BDBM173255![]() (US10323032, Example 7 | US9096596, 7 | US9604982, ...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 489 | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Antagonist activity against rat recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells assessed as reduction in BzATP -induced Ca2+ flux... | ACS Med Chem Lett 7: 348-50 (2016) Article DOI: 10.1021/acsmedchemlett.6b00083 BindingDB Entry DOI: 10.7270/Q2CZ392F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM173255![]() (US10323032, Example 7 | US9096596, 7 | US9604982, ...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 562 | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Antagonist activity against ATP-gated P2X7 receptor in LPS-stimulated human whole blood assessed as reduction in P2X7 agonist 2'(3')-O-(4-benzoylbenz... | ACS Med Chem Lett 7: 348-50 (2016) Article DOI: 10.1021/acsmedchemlett.6b00083 BindingDB Entry DOI: 10.7270/Q2CZ392F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM173271![]() (US10323032, Example 107 | US9096596, 107 | US90965...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Antagonist activity against ATP-gated P2X7 receptor in LPS-stimulated human whole blood assessed as reduction in P2X7 agonist 2'(3')-O-(4-benzoylbenz... | ACS Med Chem Lett 7: 348-50 (2016) Article DOI: 10.1021/acsmedchemlett.6b00083 BindingDB Entry DOI: 10.7270/Q2CZ392F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM50173582![]() (CHEMBL3810255) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Antagonist activity against human recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells assessed as reduction in BzATP -induced Ca2+ fl... | ACS Med Chem Lett 7: 348-50 (2016) Article DOI: 10.1021/acsmedchemlett.6b00083 BindingDB Entry DOI: 10.7270/Q2CZ392F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Rattus norvegicus (Rat)) | BDBM50173582![]() (CHEMBL3810255) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Antagonist activity against rat recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells assessed as reduction in BzATP -induced Ca2+ flux... | ACS Med Chem Lett 7: 348-50 (2016) Article DOI: 10.1021/acsmedchemlett.6b00083 BindingDB Entry DOI: 10.7270/Q2CZ392F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM173260![]() (US10323032, Example 12 | US9096596, 12 | US9604982...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Antagonist activity against ATP-gated P2X7 receptor in LPS-stimulated human whole blood assessed as reduction in P2X7 agonist 2'(3')-O-(4-benzoylbenz... | ACS Med Chem Lett 7: 348-50 (2016) Article DOI: 10.1021/acsmedchemlett.6b00083 BindingDB Entry DOI: 10.7270/Q2CZ392F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Rattus norvegicus (Rat)) | BDBM173271![]() (US10323032, Example 107 | US9096596, 107 | US90965...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Antagonist activity against rat recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells assessed as reduction in BzATP -induced Ca2+ flux... | ACS Med Chem Lett 7: 348-50 (2016) Article DOI: 10.1021/acsmedchemlett.6b00083 BindingDB Entry DOI: 10.7270/Q2CZ392F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Rattus norvegicus (Rat)) | BDBM173260![]() (US10323032, Example 12 | US9096596, 12 | US9604982...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.97E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Antagonist activity against rat recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells assessed as reduction in BzATP -induced Ca2+ flux... | ACS Med Chem Lett 7: 348-50 (2016) Article DOI: 10.1021/acsmedchemlett.6b00083 BindingDB Entry DOI: 10.7270/Q2CZ392F | |||||||||||
More data for this Ligand-Target Pair |