Compile Data Set for Download or QSAR

Found 113 hits Enz. Inhib. hit(s) with all data for entry = 7439   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM195013 (US9206198, 78 | US9206198, 79) Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC(O)c3ccc4C(=O)OCc4c3Cl)CC2)C1=O |t:1| Show InChI InChI=1S/C23H25ClN2O6/c1-13-17(12-32-20(13)28)26-9-6-23(22(26)30)4-7-25(8-5-23)10-18(27)15-3-2-14-16(19(15)24)11-31-21(14)29/h2-3,18,27H,4-12H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	37
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194963 (US9206198, 18) Show SMILES CO[C@@H](CN1CC2CCC(C1)CC1(CCN(C3=CC(=O)OC3)C1=O)C2)c1ccc2C(=O)OCc2c1C |r,t:17,TLB:22:12:7.8:5.10.4,THB:3:4:7.8:11.24.12| Show InChI InChI=1S/C28H34N2O6/c1-17-21(5-6-22-23(17)16-36-26(22)32)24(34-2)14-29-12-18-3-4-19(13-29)11-28(10-18)7-8-30(27(28)33)20-9-25(31)35-15-20/h5-6,9,18-19,24H,3-4,7-8,10-16H2,1-2H3/t18?,19?,24-,28?/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	37
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194951 (US9206198, 5) Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C3=CC(=O)OC3)C2=O)CC1 |r,t:23| Show InChI InChI=1S/C23H26N2O6/c1-14-16(2-3-17-18(14)13-31-21(17)28)19(26)11-24-7-4-23(5-8-24)6-9-25(22(23)29)15-10-20(27)30-12-15/h2-3,10,19,26H,4-9,11-13H2,1H3/t19-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	37
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194967 (US9206198, 22) Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C2=O)C2=C(F)C(=O)OC2)CC1 |r,c:26| Show InChI InChI=1S/C23H25FN2O6/c1-13-14(2-3-15-16(13)11-31-20(15)28)18(27)10-25-7-4-23(5-8-25)6-9-26(22(23)30)17-12-32-21(29)19(17)24/h2-3,18,27H,4-12H2,1H3/t18-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	37
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194968 (US9206198, 23) Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCCN(C3=CC(=O)OC3)C2=O)CC1 |r,t:24| Show InChI InChI=1S/C24H28N2O6/c1-15-17(3-4-18-19(15)14-32-22(18)29)20(27)12-25-9-6-24(7-10-25)5-2-8-26(23(24)30)16-11-21(28)31-13-16/h3-4,11,20,27H,2,5-10,12-14H2,1H3/t20-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	37
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194970 (US9206198, 25) Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C2=O)C2=C(Cl)C(=O)OC2)CC1 |r,c:26| Show InChI InChI=1S/C23H25ClN2O6/c1-13-14(2-3-15-16(13)11-31-20(15)28)18(27)10-25-7-4-23(5-8-25)6-9-26(22(23)30)17-12-32-21(29)19(17)24/h2-3,18,27H,4-12H2,1H3/t18-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	37
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM195018 (US9206198, 85A | US9206198, 85B) Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC2)C(C)(C)C(O)c2ccc3C(=O)OCc3c2C)C1=O |t:1| Show InChI InChI=1S/C26H32N2O6/c1-15-17(5-6-18-19(15)13-33-23(18)31)21(29)25(3,4)27-10-7-26(8-11-27)9-12-28(24(26)32)20-14-34-22(30)16(20)2/h5-6,21,29H,7-14H2,1-4H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM195013 (US9206198, 78 | US9206198, 79) Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC(O)c3ccc4C(=O)OCc4c3Cl)CC2)C1=O |t:1| Show InChI InChI=1S/C23H25ClN2O6/c1-13-17(12-32-20(13)28)26-9-6-23(22(26)30)4-7-25(8-5-23)10-18(27)15-3-2-14-16(19(15)24)11-31-21(14)29/h2-3,18,27H,4-12H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM195012 (US9206198, 76 | US9206198, 77) Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC(O)c3ccc4C(=O)OCc4c3C3CC3)CC2)C1=O |t:1| Show InChI InChI=1S/C26H30N2O6/c1-15-20(14-34-23(15)30)28-11-8-26(25(28)32)6-9-27(10-7-26)12-21(29)18-5-4-17-19(13-33-24(17)31)22(18)16-2-3-16/h4-5,16,21,29H,2-3,6-14H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194956 (US9206198, 9) Show SMILES CC1=C(COC1=O)N1CCCC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,t:1| Show InChI InChI=1S/C25H30N2O6/c1-15-17(4-5-18-19(15)13-32-23(18)30)21(28)12-26-10-7-25(8-11-26)6-3-9-27(24(25)31)20-14-33-22(29)16(20)2/h4-5,21,28H,3,6-14H2,1-2H3/t21-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM195005 (US9206198, 66) Show SMILES CCC1CC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C(=O)N1C1=CC(=O)OC1 |r,t:31| Show InChI InChI=1S/C25H30N2O6/c1-3-16-11-25(24(31)27(16)17-10-22(29)32-13-17)6-8-26(9-7-25)12-21(28)18-4-5-19-20(15(18)2)14-33-23(19)30/h4-5,10,16,21,28H,3,6-9,11-14H2,1-2H3/t16?,21-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194992 (US9206198, 53C) Show SMILES C[C@H]([C@@H](O)c1ccc2C(=O)OCc2c1C)N1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2)CC1 |r,c:27| Show InChI InChI=1S/C25H30N2O6/c1-14-17(4-5-18-19(14)12-32-23(18)30)21(28)16(3)26-9-6-25(7-10-26)8-11-27(24(25)31)20-13-33-22(29)15(20)2/h4-5,16,21,28H,6-13H2,1-3H3/t16-,21-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	37
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194992 (US9206198, 53C) Show SMILES C[C@H]([C@@H](O)c1ccc2C(=O)OCc2c1C)N1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2)CC1 |r,c:27| Show InChI InChI=1S/C25H30N2O6/c1-14-17(4-5-18-19(14)12-32-23(18)30)21(28)16(3)26-9-6-25(7-10-26)8-11-27(24(25)31)20-13-33-22(29)15(20)2/h4-5,16,21,28H,6-13H2,1-3H3/t16-,21-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM195030 (US9206198, 53A) Show SMILES C[C@@H]([C@H](O)c1ccc2C(=O)OCc2c1C)N1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2)CC1 |r,c:27| Show InChI InChI=1S/C25H30N2O6/c1-14-17(4-5-18-19(14)12-32-23(18)30)21(28)16(3)26-9-6-25(7-10-26)8-11-27(24(25)31)20-13-33-22(29)15(20)2/h4-5,16,21,28H,6-13H2,1-3H3/t16-,21-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM195014 (US9206198, 80 | US9206198, 81) Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC(O)c3ccc4C(=O)OCc4c3F)CC2)C1=O |t:1| Show InChI InChI=1S/C23H25FN2O6/c1-13-17(12-32-20(13)28)26-9-6-23(22(26)30)4-7-25(8-5-23)10-18(27)15-3-2-14-16(19(15)24)11-31-21(14)29/h2-3,18,27H,4-12H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	37
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM195011 (US9206198, 74 | US9206198, 75) Show SMILES CCc1c2COC(=O)c2ccc1C(O)CN1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2)CC1 |c:27| Show InChI InChI=1S/C25H30N2O6/c1-3-16-17(4-5-18-19(16)13-32-23(18)30)21(28)12-26-9-6-25(7-10-26)8-11-27(24(25)31)20-14-33-22(29)15(20)2/h4-5,21,28H,3,6-14H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	37
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194953 (US9206198, 6B) Show SMILES C[C@H]1CC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C(=O)N1C1=CC(=O)OC1 |r,t:30| Show InChI InChI=1S/C24H28N2O6/c1-14-10-24(23(30)26(14)16-9-21(28)31-12-16)5-7-25(8-6-24)11-20(27)17-3-4-18-19(15(17)2)13-32-22(18)29/h3-4,9,14,20,27H,5-8,10-13H2,1-2H3/t14-,20-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM195012 (US9206198, 76 | US9206198, 77) Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC(O)c3ccc4C(=O)OCc4c3C3CC3)CC2)C1=O |t:1| Show InChI InChI=1S/C26H30N2O6/c1-15-20(14-34-23(15)30)28-11-8-26(25(28)32)6-9-27(10-7-26)12-21(29)18-5-4-17-19(13-33-24(17)31)22(18)16-2-3-16/h4-5,16,21,29H,2-3,6-14H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	37
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194970 (US9206198, 25) Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C2=O)C2=C(Cl)C(=O)OC2)CC1 |r,c:26| Show InChI InChI=1S/C23H25ClN2O6/c1-13-14(2-3-15-16(13)11-31-20(15)28)18(27)10-25-7-4-23(5-8-25)6-9-26(22(23)30)17-12-32-21(29)19(17)24/h2-3,18,27H,4-12H2,1H3/t18-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194947 (US9206198, 1) Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CCc3ccc4C(=O)OCc4c3C)CC2)C1=O |t:1| Show InChI InChI=1S/C24H28N2O5/c1-15-17(3-4-18-19(15)13-30-22(18)28)5-9-25-10-6-24(7-11-25)8-12-26(23(24)29)20-14-31-21(27)16(20)2/h3-4H,5-14H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194954 (US9206198, 7) Show SMILES CC1=C(COC1=O)N1CCC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,t:1| Show InChI InChI=1S/C24H28N2O6/c1-14-16(3-4-17-18(14)12-31-22(17)29)20(27)11-25-8-5-24(6-9-25)7-10-26(23(24)30)19-13-32-21(28)15(19)2/h3-4,20,27H,5-13H2,1-2H3/t20-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	37
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194956 (US9206198, 9) Show SMILES CC1=C(COC1=O)N1CCCC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,t:1| Show InChI InChI=1S/C25H30N2O6/c1-15-17(4-5-18-19(15)13-32-23(18)30)21(28)12-26-10-7-25(8-11-26)6-3-9-27(24(25)31)20-14-33-22(29)16(20)2/h4-5,21,28H,3,6-14H2,1-2H3/t21-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	37
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194965 (US9206198, 20) Show SMILES CO[C@@H](CN1C2CCC1CC1(CCN(C1=O)C1=C(C)C(=O)OC1)C2)c1ccc2C(=O)OCc2c1C |r,c:18,THB:11:10:6.7:4| Show InChI InChI=1S/C27H32N2O6/c1-15-19(6-7-20-21(15)13-34-25(20)31)23(33-3)12-29-17-4-5-18(29)11-27(10-17)8-9-28(26(27)32)22-14-35-24(30)16(22)2/h6-7,17-18,23H,4-5,8-14H2,1-3H3/t17?,18?,23-,27?/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194954 (US9206198, 7) Show SMILES CC1=C(COC1=O)N1CCC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,t:1| Show InChI InChI=1S/C24H28N2O6/c1-14-16(3-4-17-18(14)12-31-22(17)29)20(27)11-25-8-5-24(6-9-25)7-10-26(23(24)30)19-13-32-21(28)15(19)2/h3-4,20,27H,5-13H2,1-2H3/t20-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194962 (US9206198, 17) Show SMILES CCC1=C(COC1=O)N1CCC2(CCN(C[C@H](OC)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,t:2| Show InChI InChI=1S/C26H32N2O6/c1-4-17-21(15-34-23(17)29)28-12-9-26(25(28)31)7-10-27(11-8-26)13-22(32-3)18-5-6-19-20(16(18)2)14-33-24(19)30/h5-6,22H,4,7-15H2,1-3H3/t22-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.4	37
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194980 (US9206198, 39 | US9206198, 42) Show SMILES CC1CC2(CC3CCC(C2)N3C[C@H](O)c2ccc3C(=O)OCc3c2C)C(=O)N1C1=CC(=O)OC1 |r,wD:12.14,t:33,TLB:2:3:6.7:10,11:10:6.7:9.4.3,(5.93,1.35,;5.06,.08,;3.52,.03,;3.09,-1.45,;1.39,-1.37,;.23,-.26,;.75,1.19,;1.13,-.04,;.51,-1.74,;1.69,-2.65,;-1.46,-1.13,;-2.79,-.36,;-4.13,-1.13,;-4.13,-2.67,;-5.46,-.36,;-5.46,1.18,;-6.79,1.95,;-8.13,1.18,;-9.59,1.66,;-10.36,2.99,;-10.5,.41,;-9.59,-.83,;-8.13,-.36,;-6.79,-1.13,;-6.79,-2.67,;4.36,-2.32,;3.23,1.13,;5.58,-1.37,;6.79,.09,;7.7,1.34,;9.16,.86,;10.5,1.63,;9.16,-.68,;7.7,-1.16,)| Show InChI InChI=1S/C26H30N2O6/c1-14-8-26(25(32)28(14)18-7-23(30)33-12-18)9-16-3-4-17(10-26)27(16)11-22(29)19-5-6-20-21(15(19)2)13-34-24(20)31/h5-7,14,16-17,22,29H,3-4,8-13H2,1-2H3/t14?,16?,17?,22-,26?/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194979 (US9206198, 38) Show SMILES CC1=C(COC1=O)N1CCC2(CCN(C[C@H](O)c3cc4COC(=O)c4cc3C)CC2)C1=O |r,t:1| Show InChI InChI=1S/C24H28N2O6/c1-14-9-18-16(12-31-22(18)29)10-17(14)20(27)11-25-6-3-24(4-7-25)5-8-26(23(24)30)19-13-32-21(28)15(19)2/h9-10,20,27H,3-8,11-13H2,1-2H3/t20-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM195006 (US9206198, 69) Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CC(C3CC3)N(C3=CC(=O)OC3)C2=O)CC1 |r,t:27| Show InChI InChI=1S/C26H30N2O6/c1-15-18(4-5-19-20(15)14-34-24(19)31)22(29)12-27-8-6-26(7-9-27)11-21(16-2-3-16)28(25(26)32)17-10-23(30)33-13-17/h4-5,10,16,21-22,29H,2-3,6-9,11-14H2,1H3/t21?,22-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM195022 (US9206198, 6A) Show SMILES C[C@@H]1CC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C(=O)N1C1=CC(=O)OC1 |r,t:30| Show InChI InChI=1S/C24H28N2O6/c1-14-10-24(23(30)26(14)16-9-21(28)31-12-16)5-7-25(8-6-24)11-20(27)17-3-4-18-19(15(17)2)13-32-22(18)29/h3-4,9,14,20,27H,5-8,10-13H2,1-2H3/t14-,20+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM195033 (US9206198, 67) Show SMILES CCC1CC2(CCN(C[C@@H](O)c3ccc4C(=O)OCc4c3C)CC2)C(=O)N1C1=CC(=O)OC1 |r,t:31| Show InChI InChI=1S/C25H30N2O6/c1-3-16-11-25(24(31)27(16)17-10-22(29)32-13-17)6-8-26(9-7-25)12-21(28)18-4-5-19-20(15(18)2)14-33-23(19)30/h4-5,10,16,21,28H,3,6-9,11-14H2,1-2H3/t16?,21-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM195026 (US9206198, 30) Show SMILES CC1CC2(CCN(C[C@@H](O)c3ccc4C(=O)OCc4c3C)CC2)C(=O)N1C1=C(C)C(=O)OC1 |r,c:30| Show InChI InChI=1S/C25H30N2O6/c1-14-10-25(24(31)27(14)20-13-33-22(29)16(20)3)6-8-26(9-7-25)11-21(28)17-4-5-18-19(15(17)2)12-32-23(18)30/h4-5,14,21,28H,6-13H2,1-3H3/t14?,21-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194963 (US9206198, 18) Show SMILES CO[C@@H](CN1CC2CCC(C1)CC1(CCN(C3=CC(=O)OC3)C1=O)C2)c1ccc2C(=O)OCc2c1C |r,t:17,TLB:22:12:7.8:5.10.4,THB:3:4:7.8:11.24.12| Show InChI InChI=1S/C28H34N2O6/c1-17-21(5-6-22-23(17)16-36-26(22)32)24(34-2)14-29-12-18-3-4-19(13-29)11-28(10-18)7-8-30(27(28)33)20-9-25(31)35-15-20/h5-6,9,18-19,24H,3-4,7-8,10-16H2,1-2H3/t18?,19?,24-,28?/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194968 (US9206198, 23) Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCCN(C3=CC(=O)OC3)C2=O)CC1 |r,t:24| Show InChI InChI=1S/C24H28N2O6/c1-15-17(3-4-18-19(15)14-32-22(18)29)20(27)12-25-9-6-24(7-10-25)5-2-8-26(23(24)30)16-11-21(28)31-13-16/h3-4,11,20,27H,2,5-10,12-14H2,1H3/t20-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM195005 (US9206198, 66) Show SMILES CCC1CC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C(=O)N1C1=CC(=O)OC1 |r,t:31| Show InChI InChI=1S/C25H30N2O6/c1-3-16-11-25(24(31)27(16)17-10-22(29)32-13-17)6-8-26(9-7-25)12-21(28)18-4-5-19-20(15(18)2)14-33-23(19)30/h4-5,10,16,21,28H,3,6-9,11-14H2,1-2H3/t16?,21-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.4	37
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194987 (US9206198, 48) Show SMILES CC1=C(COC1=O)N1CCC2(CCN(C[C@@H](F)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,t:1| Show InChI InChI=1S/C24H27FN2O5/c1-14-16(3-4-17-18(14)12-31-22(17)29)19(25)11-26-8-5-24(6-9-26)7-10-27(23(24)30)20-13-32-21(28)15(20)2/h3-4,19H,5-13H2,1-2H3/t19-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM195033 (US9206198, 67) Show SMILES CCC1CC2(CCN(C[C@@H](O)c3ccc4C(=O)OCc4c3C)CC2)C(=O)N1C1=CC(=O)OC1 |r,t:31| Show InChI InChI=1S/C25H30N2O6/c1-3-16-11-25(24(31)27(16)17-10-22(29)32-13-17)6-8-26(9-7-25)12-21(28)18-4-5-19-20(15(18)2)14-33-23(19)30/h4-5,10,16,21,28H,3,6-9,11-14H2,1-2H3/t16?,21-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.4	37
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM195026 (US9206198, 30) Show SMILES CC1CC2(CCN(C[C@@H](O)c3ccc4C(=O)OCc4c3C)CC2)C(=O)N1C1=C(C)C(=O)OC1 |r,c:30| Show InChI InChI=1S/C25H30N2O6/c1-14-10-25(24(31)27(14)20-13-33-22(29)16(20)3)6-8-26(9-7-25)11-21(28)17-4-5-18-19(15(17)2)12-32-23(18)30/h4-5,14,21,28H,6-13H2,1-3H3/t14?,21-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.4	37
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194958 (US9206198, 11) Show SMILES CO[C@@H](CN1CCC2(CCN(C2=O)C2=CC(=O)OC2C)CC1)c1ccc2C(=O)OCc2c1C |r,t:14| Show InChI InChI=1S/C25H30N2O6/c1-15-17(4-5-18-19(15)14-32-23(18)29)21(31-3)13-26-9-6-25(7-10-26)8-11-27(24(25)30)20-12-22(28)33-16(20)2/h4-5,12,16,21H,6-11,13-14H2,1-3H3/t16?,21-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.4	37
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194990 (US9206198, 51) Show SMILES CO[C@@H](CN1CCC2(CCN(C3=CC(=O)OC3)C2=O)CC1)c1ccc2C(=O)OCc2c1C |r,t:11| Show InChI InChI=1S/C24H28N2O6/c1-15-17(3-4-18-19(15)14-32-22(18)28)20(30-2)12-25-8-5-24(6-9-25)7-10-26(23(24)29)16-11-21(27)31-13-16/h3-4,11,20H,5-10,12-14H2,1-2H3/t20-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.4	37
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194981 (US9206198, 40 | US9206198, 41) Show SMILES CC1CC2(CC3CCC(C2)N3C[C@@H](O)c2ccc3C(=O)OCc3c2C)C(=O)N1C1=CC(=O)OC1 |r,wU:12.14,t:33,TLB:2:3:6.7:10,11:10:6.7:9.4.3,(5.93,1.35,;5.06,.08,;3.52,.03,;3.09,-1.45,;1.39,-1.37,;.23,-.26,;.75,1.19,;1.13,-.04,;.51,-1.74,;1.69,-2.65,;-1.46,-1.13,;-2.79,-.36,;-4.13,-1.13,;-4.13,-2.67,;-5.46,-.36,;-5.46,1.18,;-6.79,1.95,;-8.13,1.18,;-9.59,1.66,;-10.36,2.99,;-10.5,.41,;-9.59,-.83,;-8.13,-.36,;-6.79,-1.13,;-6.79,-2.67,;4.36,-2.32,;3.23,1.13,;5.58,-1.37,;6.79,.09,;7.7,1.34,;9.16,.86,;10.5,1.63,;9.16,-.68,;7.7,-1.16,)| Show InChI InChI=1S/C26H30N2O6/c1-14-8-26(25(32)28(14)18-7-23(30)33-12-18)9-16-3-4-17(10-26)27(16)11-22(29)19-5-6-20-21(15(19)2)13-34-24(20)31/h5-7,14,16-17,22,29H,3-4,8-13H2,1-2H3/t14?,16?,17?,22-,26?/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM195023 (US9206198, 12) Show SMILES CO[C@H](CN1CCC2(CCN(C2=O)C2=CC(=O)OC2C)CC1)c1ccc2C(=O)OCc2c1C |r,t:14| Show InChI InChI=1S/C25H30N2O6/c1-15-17(4-5-18-19(15)14-32-23(18)29)21(31-3)13-26-9-6-25(7-10-26)8-11-27(24(25)30)20-12-22(28)33-16(20)2/h4-5,12,16,21H,6-11,13-14H2,1-3H3/t16?,21-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.4	37
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194957 (US9206198, 10) Show SMILES CO[C@@H](CN1CCC2(CCN(C2)C2=CC(=O)OC2)CC1)c1ccc2C(=O)OCc2c1C |r,t:13| Show InChI InChI=1S/C24H30N2O5/c1-16-18(3-4-19-20(16)14-31-23(19)28)21(29-2)12-25-8-5-24(6-9-25)7-10-26(15-24)17-11-22(27)30-13-17/h3-4,11,21H,5-10,12-15H2,1-2H3/t21-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.4	37
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM195011 (US9206198, 74 | US9206198, 75) Show SMILES CCc1c2COC(=O)c2ccc1C(O)CN1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2)CC1 |c:27| Show InChI InChI=1S/C25H30N2O6/c1-3-16-17(4-5-18-19(16)13-32-23(18)30)21(28)12-26-9-6-25(7-10-26)8-11-27(24(25)31)20-14-33-22(29)15(20)2/h4-5,21,28H,3,6-14H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM195009 (US9206198, 72) Show SMILES CC1=CC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C(=O)N1C1=CC(=O)OC1 |r,t:1,30| Show InChI InChI=1S/C24H26N2O6/c1-14-10-24(23(30)26(14)16-9-21(28)31-12-16)5-7-25(8-6-24)11-20(27)17-3-4-18-19(15(17)2)13-32-22(18)29/h3-4,9-10,20,27H,5-8,11-13H2,1-2H3/t20-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194989 (US9206198, 50) Show SMILES CCO[C@@H](CN1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2)CC1)c1ccc2C(=O)OCc2c1C |r,c:15| Show InChI InChI=1S/C26H32N2O6/c1-4-32-22(18-5-6-19-20(16(18)2)14-33-24(19)30)13-27-10-7-26(8-11-27)9-12-28(25(26)31)21-15-34-23(29)17(21)3/h5-6,22H,4,7-15H2,1-3H3/t22-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194982 (US9206198, 43) Show SMILES CC1=C(COC1=O)N1C=CC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,c:9,t:1| Show InChI InChI=1S/C24H26N2O6/c1-14-16(3-4-17-18(14)12-31-22(17)29)20(27)11-25-8-5-24(6-9-25)7-10-26(23(24)30)19-13-32-21(28)15(19)2/h3-4,7,10,20,27H,5-6,8-9,11-13H2,1-2H3/t20-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194978 (US9206198, 37) Show SMILES CC1=C(COC1=O)N1CCC2(CCN(C[C@@H](O)c3cc4COC(=O)c4cc3C)CC2)C1=O |r,t:1| Show InChI InChI=1S/C24H28N2O6/c1-14-9-18-16(12-31-22(18)29)10-17(14)20(27)11-25-6-3-24(4-7-25)5-8-26(23(24)30)19-13-32-21(28)15(19)2/h9-10,20,27H,3-8,11-13H2,1-2H3/t20-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194977 (US9206198, 36) Show SMILES CC1=C(COC1=O)N1CC(=O)C2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,t:1| Show InChI InChI=1S/C24H26N2O7/c1-13-15(3-4-16-17(13)11-32-22(16)30)19(27)9-25-7-5-24(6-8-25)20(28)10-26(23(24)31)18-12-33-21(29)14(18)2/h3-4,19,27H,5-12H2,1-2H3/t19-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194967 (US9206198, 22) Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C2=O)C2=C(F)C(=O)OC2)CC1 |r,c:26| Show InChI InChI=1S/C23H25FN2O6/c1-13-14(2-3-15-16(13)11-31-20(15)28)18(27)10-25-7-4-23(5-8-25)6-9-26(22(23)30)17-12-32-21(29)19(17)24/h2-3,18,27H,4-12H2,1H3/t18-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194955 (US9206198, 8) Show SMILES CC1=C(COC1=O)N1CCC2(CCN(C[C@@H](O)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,t:1| Show InChI InChI=1S/C24H28N2O6/c1-14-16(3-4-17-18(14)12-31-22(17)29)20(27)11-25-8-5-24(6-9-25)7-10-26(23(24)30)19-13-32-21(28)15(19)2/h3-4,20,27H,5-13H2,1-2H3/t20-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 113 total )  |  Next  |  Last  >>

Jump to: