Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cannabinoid receptor 2 (Homo sapiens (Human)) | BDBM227552 (US9339486, CP55,940) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB US Patent | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
The Cleveland Clinic Foundation US Patent | Assay Description Cell membrane homogenates (15 μg protein) were incubated for 120 min at 37° C. with 0.8 nM [3H]WIN 55212-2 (the reference standard [Munro, 1993 ... | US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM227552 (US9339486, CP55,940) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB US Patent | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
The Cleveland Clinic Foundation US Patent | Assay Description Cell membrane homogenates (25 μg protein) were incubated for 120 min at 37° C. with 0.5 nM [3H]CP 55940 (the reference standard [Rinaldi-Carmona... | US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cannabinoid receptor 2 (Homo sapiens (Human)) | BDBM50335938 ((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | US Patent | 422 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
The Cleveland Clinic Foundation US Patent | Assay Description Cell membrane homogenates (15 μg protein) were incubated for 120 min at 37° C. with 0.8 nM [3H]WIN 55212-2 (the reference standard [Munro, 1993 ... | US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50335938 ((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | US Patent | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
The Cleveland Clinic Foundation US Patent | Assay Description Cell membrane homogenates (25 μg protein) were incubated for 120 min at 37° C. with 0.5 nM [3H]CP 55940 (the reference standard [Rinaldi-Carmona... | US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM227552 (US9339486, CP55,940) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | n/a | n/a | 9 | n/a | n/a | n/a | n/a |
The Cleveland Clinic Foundation US Patent | Assay Description Functional activity was evaluated using GTPγ[35S] assay in CHO membrane extracts expressing recombinant hCB1 (human CB1) receptors or hCB2 (huma... | US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cannabinoid receptor 2 (Homo sapiens (Human)) | BDBM50335938 ((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | US Patent | n/a | n/a | n/a | n/a | 128 | n/a | n/a | n/a | n/a |
The Cleveland Clinic Foundation US Patent | Assay Description Functional activity was evaluated using GTPγ[35S] assay in CHO membrane extracts expressing recombinant hCB1 (human CB1) receptors or hCB2 (huma... | US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 2 (Homo sapiens (Human)) | BDBM227552 (US9339486, CP55,940) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | n/a | n/a | 6.5 | n/a | n/a | n/a | n/a |
The Cleveland Clinic Foundation US Patent | Assay Description Functional activity was evaluated using GTPγ[35S] assay in CHO membrane extracts expressing recombinant hCB1 (human CB1) receptors or hCB2 (huma... | US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cannabinoid receptor 1 (Rattus norvegicus (rat)) | BDBM50335938 ((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | US Patent | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
The Cleveland Clinic Foundation US Patent | Assay Description The compound of Example 3 was tested for agonist activity at the rat CB1 (rCB1) and rCB2 receptors, at eight concentrations, in duplicate: 10, 3, 1, ... | US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Rattus norvegicus (rat)) | BDBM227552 (US9339486, CP55,940) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | n/a | n/a | 0.140 | n/a | n/a | n/a | n/a |
The Cleveland Clinic Foundation US Patent | Assay Description The compound of Example 3 was tested for agonist activity at the rat CB1 (rCB1) and rCB2 receptors, at eight concentrations, in duplicate: 10, 3, 1, ... | US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cannabinoid receptor 2 (Rattus norvegicus (Rat)) | BDBM50335938 ((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | US Patent | n/a | n/a | n/a | n/a | 21.7 | n/a | n/a | n/a | n/a |
The Cleveland Clinic Foundation US Patent | Assay Description The compound of Example 3 was tested for agonist activity at the rat CB1 (rCB1) and rCB2 receptors, at eight concentrations, in duplicate: 10, 3, 1, ... | US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50335938 ((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | US Patent | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
The Cleveland Clinic Foundation US Patent | Assay Description Functional activity was evaluated using GTPγ[35S] assay in CHO membrane extracts expressing recombinant hCB1 (human CB1) receptors or hCB2 (huma... | US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 2 (Homo sapiens (Human)) | BDBM227551 (US9339486, 5) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 409 | n/a | n/a | n/a | n/a |
The Cleveland Clinic Foundation US Patent | Assay Description Functional activity was evaluated using GTPγ[35S] assay in CHO membrane extracts expressing recombinant hCB1 (human CB1) receptors or hCB2 (huma... | US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 2 (Rattus norvegicus (Rat)) | BDBM227552 (US9339486, CP55,940) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | US Patent | n/a | n/a | n/a | n/a | 1.13 | n/a | n/a | n/a | n/a |
The Cleveland Clinic Foundation US Patent | Assay Description The compound of Example 3 was tested for agonist activity at the rat CB1 (rCB1) and rCB2 receptors, at eight concentrations, in duplicate: 10, 3, 1, ... | US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 2 (Homo sapiens (Human)) | BDBM227550 (US9339486, 2) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 479 | n/a | n/a | n/a | n/a |
The Cleveland Clinic Foundation US Patent | Assay Description Functional activity was evaluated using GTPγ[35S] assay in CHO membrane extracts expressing recombinant hCB1 (human CB1) receptors or hCB2 (huma... | US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 2 (Homo sapiens (Human)) | BDBM50335938 ((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | US Patent | n/a | n/a | n/a | n/a | 160 | n/a | n/a | n/a | n/a |
The Cleveland Clinic Foundation US Patent | Assay Description Functional activity was evaluated using GTPγ[35S] assay in CHO membrane extracts expressing recombinant hCB1 (human CB1) receptors or hCB2 (huma... | US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9 | |||||||||||
More data for this Ligand-Target Pair |