Found 8 hits Enz. Inhib. hit(s) with Target = 'Leukotriene B4 receptor 1/2' and Ligand = 'BDBM50215737' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Leukotriene B4 receptor 1/2
(Homo sapiens (Human)) | BDBM50215737
![PNG](/data/jpeg/tenK5021/BindingDB_50215737.png) (CHEMBL50425)Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(Cl)ccc1C(O)=O Show InChI InChI=1S/C29H23ClO4/c30-23-11-13-24(29(32)33)26(16-23)21-10-12-25-27(15-21)34-17-22(28(25)31)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,31H,14,17H2,(H,32,33)/t22-,28+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils. |
Bioorg Med Chem Lett 8: 1781-6 (1998)
BindingDB Entry DOI: 10.7270/Q2RR21F1 |
More data for this Ligand-Target Pair | |
Leukotriene B4 receptor 1/2
(Homo sapiens (Human)) | BDBM50215737
![PNG](/data/jpeg/tenK5021/BindingDB_50215737.png) (CHEMBL50425)Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(Cl)ccc1C(O)=O Show InChI InChI=1S/C29H23ClO4/c30-23-11-13-24(29(32)33)26(16-23)21-10-12-25-27(15-21)34-17-22(28(25)31)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,31H,14,17H2,(H,32,33)/t22-,28+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils. |
Bioorg Med Chem Lett 8: 1781-6 (1998)
BindingDB Entry DOI: 10.7270/Q2RR21F1 |
More data for this Ligand-Target Pair | |
Leukotriene B4 receptor 1/2
(Homo sapiens (Human)) | BDBM50215737
![PNG](/data/jpeg/tenK5021/BindingDB_50215737.png) (CHEMBL50425)Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(Cl)ccc1C(O)=O Show InChI InChI=1S/C29H23ClO4/c30-23-11-13-24(29(32)33)26(16-23)21-10-12-25-27(15-21)34-17-22(28(25)31)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,31H,14,17H2,(H,32,33)/t22-,28+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils. |
Bioorg Med Chem Lett 8: 1781-6 (1998)
BindingDB Entry DOI: 10.7270/Q2RR21F1 |
More data for this Ligand-Target Pair | |
Leukotriene B4 receptor 1/2
(Homo sapiens (Human)) | BDBM50215737
![PNG](/data/jpeg/tenK5021/BindingDB_50215737.png) (CHEMBL50425)Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(Cl)ccc1C(O)=O Show InChI InChI=1S/C29H23ClO4/c30-23-11-13-24(29(32)33)26(16-23)21-10-12-25-27(15-21)34-17-22(28(25)31)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,31H,14,17H2,(H,32,33)/t22-,28+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils. |
Bioorg Med Chem Lett 8: 1781-6 (1998)
BindingDB Entry DOI: 10.7270/Q2RR21F1 |
More data for this Ligand-Target Pair | |
Leukotriene B4 receptor 1/2
(Homo sapiens (Human)) | BDBM50215737
![PNG](/data/jpeg/tenK5021/BindingDB_50215737.png) (CHEMBL50425)Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(Cl)ccc1C(O)=O Show InChI InChI=1S/C29H23ClO4/c30-23-11-13-24(29(32)33)26(16-23)21-10-12-25-27(15-21)34-17-22(28(25)31)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,31H,14,17H2,(H,32,33)/t22-,28+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 590 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Ability to inhibit LTB4-induced CD11b up-regulation on isolated human neutrophils |
Bioorg Med Chem Lett 8: 1781-6 (1998)
BindingDB Entry DOI: 10.7270/Q2RR21F1 |
More data for this Ligand-Target Pair | |
Leukotriene B4 receptor 1/2
(Homo sapiens (Human)) | BDBM50215737
![PNG](/data/jpeg/tenK5021/BindingDB_50215737.png) (CHEMBL50425)Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(Cl)ccc1C(O)=O Show InChI InChI=1S/C29H23ClO4/c30-23-11-13-24(29(32)33)26(16-23)21-10-12-25-27(15-21)34-17-22(28(25)31)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,31H,14,17H2,(H,32,33)/t22-,28+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 590 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Ability to inhibit LTB4-induced CD11b up-regulation on isolated human neutrophils |
Bioorg Med Chem Lett 8: 1781-6 (1998)
BindingDB Entry DOI: 10.7270/Q2RR21F1 |
More data for this Ligand-Target Pair | |
Leukotriene B4 receptor 1/2
(Homo sapiens (Human)) | BDBM50215737
![PNG](/data/jpeg/tenK5021/BindingDB_50215737.png) (CHEMBL50425)Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(Cl)ccc1C(O)=O Show InChI InChI=1S/C29H23ClO4/c30-23-11-13-24(29(32)33)26(16-23)21-10-12-25-27(15-21)34-17-22(28(25)31)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,31H,14,17H2,(H,32,33)/t22-,28+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Ability to inhibit LTB4-induced CD11b up-regulation on isolated human neutrophils in whole blood |
Bioorg Med Chem Lett 8: 1781-6 (1998)
BindingDB Entry DOI: 10.7270/Q2RR21F1 |
More data for this Ligand-Target Pair | |
Leukotriene B4 receptor 1/2
(Homo sapiens (Human)) | BDBM50215737
![PNG](/data/jpeg/tenK5021/BindingDB_50215737.png) (CHEMBL50425)Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(Cl)ccc1C(O)=O Show InChI InChI=1S/C29H23ClO4/c30-23-11-13-24(29(32)33)26(16-23)21-10-12-25-27(15-21)34-17-22(28(25)31)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,31H,14,17H2,(H,32,33)/t22-,28+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Ability to inhibit LTB4-induced CD11b up-regulation on isolated human neutrophils in whole blood |
Bioorg Med Chem Lett 8: 1781-6 (1998)
BindingDB Entry DOI: 10.7270/Q2RR21F1 |
More data for this Ligand-Target Pair | |