Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Maternal embryonic leucine zipper kinase (Homo sapiens (Human)) | BDBM60438![]() (US9067937, 28) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | 7.4 | 25 |
OncoTherapy Science, Inc. US Patent | Assay Description MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ... | US Patent US9067937 (2015) BindingDB Entry DOI: 10.7270/Q2BR8QX4 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Maternal embryonic leucine zipper kinase (Homo sapiens (Human)) | BDBM60438![]() (US9067937, 28) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a |
Stanford University Curated by ChEMBL | Assay Description Binding affinity to wild-type human full length MELK (M1 to V651 residues) expressed in bacterial expression system by Kinomescan method | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115193 BindingDB Entry DOI: 10.7270/Q2ZC86FF | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |