Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM372970 (3-chloro-4-fluoro-5-[2- | US10246432, Example 11 |...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 6.92 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2ZS2ZVS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM372970 (3-chloro-4-fluoro-5-[2- | US10246432, Example 11 |...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 6.92 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &... | Citation and Details BindingDB Entry DOI: 10.7270/Q2G73JNN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM372970 (3-chloro-4-fluoro-5-[2- | US10246432, Example 11 |...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 6.92 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | Assay Description Membrane PreparationcDNA encoding the human mGlu5 receptor was transfected into HEK293 cells using the transfection reagent Genejuice (Novagen). Fort... | US Patent US10584111 (2020) BindingDB Entry DOI: 10.7270/Q2BR8VK9 | |||||||||||
More data for this Ligand-Target Pair |