Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N6-adenosine-methyltransferase catalytic subunit (Homo sapiens) | BDBM50572910 (CHEMBL4861007) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of METTL3 (unknown origin) using 3' biotinylated RNA (UCUGGACUAAA) and 3H-SAM as a substrate preincubated for 5 mins followed by substrate... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00280 BindingDB Entry DOI: 10.7270/Q2GQ72JV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
N6-adenosine-methyltransferase catalytic subunit (Homo sapiens) | BDBM50572910 (CHEMBL4861007) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of METTL3-mediated m6A methylation in human MOLM-3 cells assessed as reduction in mRNA level measured after 24 hrs by LC-MS/MS analysis | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00280 BindingDB Entry DOI: 10.7270/Q2GQ72JV | |||||||||||
More data for this Ligand-Target Pair |