Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'RAF proto-oncogene serine/threonine-protein kinase' and Ligand = 'BDBM26015'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM26015 (N-methyl-4-[(2-{[3-(trifluoromethyl)phenyl]amino}-...) Show SMILES CNC(=O)c1cc(Oc2ccc3nc(Nc4cccc(c4)C(F)(F)F)[nH]c3c2)ccn1 Show InChI InChI=1S/C21H16F3N5O2/c1-25-19(30)18-11-15(7-8-26-18)31-14-5-6-16-17(10-14)29-20(28-16)27-13-4-2-3-12(9-13)21(22,23)24/h2-11H,1H3,(H,25,30)(H2,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	7.8	22
Novartis					Assay Description To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...				J Med Chem 51: 7049-52 (2008) Article DOI: 10.1021/jm801050k BindingDB Entry DOI: 10.7270/Q2B56H1C
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