BindingDB PrimarySearch

Found 8 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily M member 8' and Ligand = 'BDBM50318482'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50318482 ((-)-menthol \| CHEMBL470670 \| MENTHOL \| US11406649,...) Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O \|r\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	9.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
KU Leuven Curated by ChEMBL					Assay Description Displacement of [3H]menthol from human TRPM8 expressed in HEK293 cell membranes by scintillation counting				Nat Chem Biol 3: 174-82 (2007) Article DOI: 10.1038/nchembio862 BindingDB Entry DOI: 10.7270/Q2057G4K
KU Leuven Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50318482 ((-)-menthol \| CHEMBL470670 \| MENTHOL \| US11406649,...) Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O \|r\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay				Bioorg Med Chem Lett 23: 6118-22 (2013) Article DOI: 10.1016/j.bmcl.2013.09.016 BindingDB Entry DOI: 10.7270/Q2125V4N
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50318482 ((-)-menthol \| CHEMBL470670 \| MENTHOL \| US11406649,...) Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O \|r\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	DrugBank	n/a	n/a	n/a	n/a	6.00E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50318482 ((-)-menthol \| CHEMBL470670 \| MENTHOL \| US11406649,...) Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O \|r\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a
KU Leuven Curated by ChEMBL					Assay Description Activity at human TRPM8 expressed in HEK293 cells assessed as compound concentration causing leftward shift of voltage for half maximal activation				Nat Chem Biol 3: 174-82 (2007) Article DOI: 10.1038/nchembio862 BindingDB Entry DOI: 10.7270/Q2057G4K
KU Leuven Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50318482 ((-)-menthol \| CHEMBL470670 \| MENTHOL \| US11406649,...) Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O \|r\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	1.01E+4	n/a	n/a	n/a	n/a
Kansei Science Research and Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-Machi, Haga-Gun, Tochigi 321-3497, Japan. Curated by ChEMBL					Assay Description Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for ...				ACS Med Chem Lett 8: 715-719 (2017) Article DOI: 10.1021/acsmedchemlett.7b00104 BindingDB Entry DOI: 10.7270/Q2CZ39N2
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50318482 ((-)-menthol \| CHEMBL470670 \| MENTHOL \| US11406649,...) Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O \|r\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	DrugBank US Patent	n/a	n/a	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a
TBA					Assay Description In the first set of data, the potency and in vitro effects of test compounds were evaluated on cloned hTRPM8 channel (encoded by the human TRPM8 gene...				Citation and Details BindingDB Entry DOI: 10.7270/Q24B34J8
TBA					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Rattus norvegicus (Rat))	BDBM50318482 ((-)-menthol \| CHEMBL470670 \| MENTHOL \| US11406649,...) Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	7.50E+4	n/a	n/a	n/a	n/a
University of Salerno Curated by ChEMBL					Assay Description Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as increase in current amplitude at +80 mV holding potential by whole cell patch-cla...				J Med Chem 59: 2179-91 (2016) Article DOI: 10.1021/acs.jmedchem.5b01914 BindingDB Entry DOI: 10.7270/Q2B85B1Z
University of Salerno Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50318482 ((-)-menthol \| CHEMBL470670 \| MENTHOL \| US11406649,...) Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O \|r\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	1.44E+4	n/a	n/a	n/a	n/a	n/a
KU Leuven Curated by ChEMBL					Assay Description Binding affinity to human TRPM8 expressed in HEK293 cell membranes				Nat Chem Biol 3: 174-82 (2007) Article DOI: 10.1038/nchembio862 BindingDB Entry DOI: 10.7270/Q2057G4K
KU Leuven Curated by ChEMBL					More data for this Ligand-Target Pair