Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM100351 (US10533001, Example Table 9a.4 | US11414410, Table...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen | Assay Description SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.).... | J Med Chem 50: 3528-39 (2007) BindingDB Entry DOI: 10.7270/Q28K7CDJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM100351 (US10533001, Example Table 9a.4 | US11414410, Table...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
PORTOLA PHARMACEUTICALS, INC. US Patent | Assay Description Syk and JAK: The activity of a specified compound as an inhibitor of a JAK kinase may be assessed in vitro or in vivo. In some embodiments, the activ... | US Patent US10533001 (2020) BindingDB Entry DOI: 10.7270/Q2Z03BJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM100351 (US10533001, Example Table 9a.4 | US11414410, Table...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | n/a |
PORTOLA PHARMACEUTICALS, INC. US Patent | Assay Description Syk and JAK: The activity of a specified compound as an inhibitor of a JAK kinase may be assessed in vitro or in vivo. In some embodiments, the activ... | US Patent US10533001 (2020) BindingDB Entry DOI: 10.7270/Q2Z03BJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM100351 (US10533001, Example Table 9a.4 | US11414410, Table...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc. US Patent | Assay Description This assay is an ATP-site dependent competition binding assay in which human kinases of interest are fused to a proprietary tag (T7 bacteriophage). T... | US Patent US8937070 (2015) BindingDB Entry DOI: 10.7270/Q2GB22RV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM100351 (US10533001, Example Table 9a.4 | US11414410, Table...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc. US Patent | Assay Description ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit. | US Patent US8501944 (2013) BindingDB Entry DOI: 10.7270/Q20Z71W0 | |||||||||||
More data for this Ligand-Target Pair |