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Compile Data Set for Download or QSAR

Found 93 hits Enz. Inhib. hit(s) with all data for assayid = 3 entry = 50032099   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324404
PNG
((E)-4-(2-(3-Nitrostyryl)-4-oxo-6-phenylquinazolin-...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(cc2c1=O)-c1ccccc1
Show InChI InChI=1S/C29H19N3O5/c33-28-25-18-22(20-6-2-1-3-7-20)12-15-26(25)30-27(16-9-19-5-4-8-24(17-19)32(36)37)31(28)23-13-10-21(11-14-23)29(34)35/h1-18H,(H,34,35)/b16-9+
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n/an/a 3.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324405
PNG
((E)-4-(2-(3-Nitrostyryl)-4-oxobenzo[g]quinazolin-3...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2cc3ccccc3cc2c1=O
Show InChI InChI=1S/C27H17N3O5/c31-26-23-15-19-5-1-2-6-20(19)16-24(23)28-25(13-8-17-4-3-7-22(14-17)30(34)35)29(26)21-11-9-18(10-12-21)27(32)33/h1-16H,(H,32,33)/b13-8+
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n/an/a 5.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324399
PNG
((E)-4-(6-iodo-2-(3-nitrostyryl)-4-oxoquinazolin-3(...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(I)cc2c1=O
Show InChI InChI=1S/C23H14IN3O5/c24-16-7-10-20-19(13-16)22(28)26(17-8-5-15(6-9-17)23(29)30)21(25-20)11-4-14-2-1-3-18(12-14)27(31)32/h1-13H,(H,29,30)/b11-4+
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n/an/a 6.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324473
PNG
((E)-3-(2-methoxyphenyl)-2-(2-nitrostyryl)quinazoli...)
Show SMILES COc1ccccc1-n1c(\C=C\c2ccccc2[N+]([O-])=O)nc2ccccc2c1=O |(33.08,.19,;31.74,.96,;31.74,2.5,;33.07,3.27,;33.06,4.81,;31.73,5.58,;30.4,4.8,;30.4,3.27,;29.07,2.5,;29.08,.94,;30.41,.19,;30.42,-1.37,;31.76,-2.13,;33.07,-1.35,;34.41,-2.12,;34.42,-3.66,;33.09,-4.43,;31.75,-3.67,;30.42,-4.44,;29.08,-3.67,;30.42,-5.98,;27.74,.16,;26.4,.93,;25.05,.16,;23.72,.93,;23.72,2.47,;25.05,3.25,;26.39,2.48,;27.72,3.27,;27.71,4.81,)|
Show InChI InChI=1S/C23H17N3O4/c1-30-21-13-7-6-12-20(21)25-22(24-18-10-4-3-9-17(18)23(25)27)15-14-16-8-2-5-11-19(16)26(28)29/h2-15H,1H3/b15-14+
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n/an/a 7.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324428
PNG
((E)-3-(6-Iodo-2-(3-nitrostyryl)-4-oxoquinazolin-3(...)
Show SMILES OC(=O)c1cccc(c1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(I)cc2c1=O
Show InChI InChI=1S/C23H14IN3O5/c24-16-8-9-20-19(13-16)22(28)26(17-5-2-4-15(12-17)23(29)30)21(25-20)10-7-14-3-1-6-18(11-14)27(31)32/h1-13H,(H,29,30)/b10-7+
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n/an/a 1.10E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324398
PNG
((E)-4-(6-Bromo-2-(3-nitrostyryl)-4-oxoquinazolin-3...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(Br)cc2c1=O
Show InChI InChI=1S/C23H14BrN3O5/c24-16-7-10-20-19(13-16)22(28)26(17-8-5-15(6-9-17)23(29)30)21(25-20)11-4-14-2-1-3-18(12-14)27(31)32/h1-13H,(H,29,30)/b11-4+
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n/an/a 1.30E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324392
PNG
((E)-4-(6-Chloro-2-(3-nitrostyryl)-4-oxoquinazolin-...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(Cl)cc2c1=O
Show InChI InChI=1S/C23H14ClN3O5/c24-16-7-10-20-19(13-16)22(28)26(17-8-5-15(6-9-17)23(29)30)21(25-20)11-4-14-2-1-3-18(12-14)27(31)32/h1-13H,(H,29,30)/b11-4+
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n/an/a 1.30E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324400
PNG
((E)-4-(6-Methyl-2-(3-nitrostyryl)-4-oxoquinazolin-...)
Show SMILES Cc1ccc2nc(\C=C\c3cccc(c3)[N+]([O-])=O)n(-c3ccc(cc3)C(O)=O)c(=O)c2c1
Show InChI InChI=1S/C24H17N3O5/c1-15-5-11-21-20(13-15)23(28)26(18-9-7-17(8-10-18)24(29)30)22(25-21)12-6-16-3-2-4-19(14-16)27(31)32/h2-14H,1H3,(H,29,30)/b12-6+
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n/an/a 1.50E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324461
PNG
((E)-4-(2-(2-nitrostyryl)-4-oxoquinazolin-3(4H)-yl)...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2ccccc2[N+]([O-])=O)nc2ccccc2c1=O
Show InChI InChI=1S/C23H15N3O5/c27-22-18-6-2-3-7-19(18)24-21(14-11-15-5-1-4-8-20(15)26(30)31)25(22)17-12-9-16(10-13-17)23(28)29/h1-14H,(H,28,29)/b14-11+
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n/an/a 1.70E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324387
PNG
((E)-4-(2-(2-hydroxystyryl)-4-oxoquinazolin-3(4H)-y...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2ccccc2O)nc2ccccc2c1=O
Show InChI InChI=1S/C23H16N2O4/c26-20-8-4-1-5-15(20)11-14-21-24-19-7-3-2-6-18(19)22(27)25(21)17-12-9-16(10-13-17)23(28)29/h1-14,26H,(H,28,29)/b14-11+
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n/an/a 1.80E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324409
PNG
((E)-4-(2-(3-Nitrostyryl)-4-oxo-6-propylquinazolin-...)
Show SMILES CCCc1ccc2nc(\C=C\c3cccc(c3)[N+]([O-])=O)n(-c3ccc(cc3)C(O)=O)c(=O)c2c1
Show InChI InChI=1S/C26H21N3O5/c1-2-4-17-7-13-23-22(16-17)25(30)28(20-11-9-19(10-12-20)26(31)32)24(27-23)14-8-18-5-3-6-21(15-18)29(33)34/h3,5-16H,2,4H2,1H3,(H,31,32)/b14-8+
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n/an/a 1.80E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324463
PNG
((E)-3-(2-(2-nitrostyryl)-4-oxoquinazolin-3(4H)-yl)...)
Show SMILES OC(=O)c1cccc(c1)-n1c(\C=C\c2ccccc2[N+]([O-])=O)nc2ccccc2c1=O
Show InChI InChI=1S/C23H15N3O5/c27-22-18-9-2-3-10-19(18)24-21(13-12-15-6-1-4-11-20(15)26(30)31)25(22)17-8-5-7-16(14-17)23(28)29/h1-14H,(H,28,29)/b13-12+
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n/an/a 2.00E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324434
PNG
((E)-4-(6-methyl-4-oxo-2-styrylquinazolin-3(4H)-yl)...)
Show SMILES Cc1ccc2nc(\C=C\c3ccccc3)n(-c3ccc(cc3)C(O)=O)c(=O)c2c1
Show InChI InChI=1S/C24H18N2O3/c1-16-7-13-21-20(15-16)23(27)26(19-11-9-18(10-12-19)24(28)29)22(25-21)14-8-17-5-3-2-4-6-17/h2-15H,1H3,(H,28,29)/b14-8+
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n/an/a 2.50E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324383
PNG
((E)-4-(4-oxo-2-(3-(trifluoromethyl)styryl)quinazol...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)C(F)(F)F)nc2ccccc2c1=O
Show InChI InChI=1S/C24H15F3N2O3/c25-24(26,27)17-5-3-4-15(14-17)8-13-21-28-20-7-2-1-6-19(20)22(30)29(21)18-11-9-16(10-12-18)23(31)32/h1-14H,(H,31,32)/b13-8+
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n/an/a 2.60E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324459
PNG
((E)-4-(2-(3-Nitrostyryl)-4-oxoquinazolin-3(4H)-yl)...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccccc2c1=O
Show InChI InChI=1S/C23H15N3O5/c27-22-19-6-1-2-7-20(19)24-21(13-8-15-4-3-5-18(14-15)26(30)31)25(22)17-11-9-16(10-12-17)23(28)29/h1-14H,(H,28,29)/b13-8+
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n/an/a 3.00E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324445
PNG
((E)-6-iodo-3-(2-methoxyphenyl)-2-(2-(pyridin-3-yl)...)
Show SMILES COc1ccccc1-n1c(\C=C\c2cccnc2)nc2ccc(I)cc2c1=O |(9.99,5.86,;9.99,4.32,;11.33,3.56,;12.66,4.34,;14.01,3.58,;14.01,2.04,;12.68,1.26,;11.34,2.03,;10.01,1.26,;10.02,-.29,;11.36,-1.06,;11.36,-2.6,;12.69,-3.36,;14.01,-2.58,;15.35,-3.34,;15.35,-4.89,;14.02,-5.66,;12.69,-4.9,;8.68,-1.07,;7.35,-.3,;6,-1.07,;4.67,-.3,;4.67,1.24,;3.34,2.01,;6,2.01,;7.34,1.24,;8.67,2.03,;8.66,3.57,)|
Show InChI InChI=1S/C22H16IN3O2/c1-28-20-7-3-2-6-19(20)26-21(11-8-15-5-4-12-24-14-15)25-18-10-9-16(23)13-17(18)22(26)27/h2-14H,1H3/b11-8+
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n/an/a 3.00E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324411
PNG
(4-(2-(3-Nitrostyryl)-4-oxo-6-styrylquinazolin-3(4H...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(\C=C\c3ccccc3)cc2c1=O
Show InChI InChI=1S/C31H21N3O5/c35-30-27-20-23(10-9-21-5-2-1-3-6-21)11-17-28(27)32-29(18-12-22-7-4-8-26(19-22)34(38)39)33(30)25-15-13-24(14-16-25)31(36)37/h1-20H,(H,36,37)/b10-9+,18-12+
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n/an/a 3.00E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324386
PNG
((E)-4-(2-(3-hydroxystyryl)-4-oxoquinazolin-3(4H)-y...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(O)c2)nc2ccccc2c1=O
Show InChI InChI=1S/C23H16N2O4/c26-18-5-3-4-15(14-18)8-13-21-24-20-7-2-1-6-19(20)22(27)25(21)17-11-9-16(10-12-17)23(28)29/h1-14,26H,(H,28,29)/b13-8+
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n/an/a 3.00E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324436
PNG
((E)-4-(2-(2-(naphthalen-2-yl)vinyl)-4-oxoquinazoli...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2ccc3ccccc3c2)nc2ccccc2c1=O
Show InChI InChI=1S/C27H18N2O3/c30-26-23-7-3-4-8-24(23)28-25(29(26)22-14-12-20(13-15-22)27(31)32)16-10-18-9-11-19-5-1-2-6-21(19)17-18/h1-17H,(H,31,32)/b16-10+
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n/an/a 3.10E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324452
PNG
((E)-4-(6-Iodo-4-oxo-2-(2-(pyridin-3-yl)vinyl)quina...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccnc2)nc2ccc(I)cc2c1=O
Show InChI InChI=1S/C22H14IN3O3/c23-16-6-9-19-18(12-16)21(27)26(17-7-4-15(5-8-17)22(28)29)20(25-19)10-3-14-2-1-11-24-13-14/h1-13H,(H,28,29)/b10-3+
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n/an/a 3.10E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324397
PNG
((E)-4-(6-Fluoro-2-(3-nitrostyryl)-4-oxoquinazolin-...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(F)cc2c1=O
Show InChI InChI=1S/C23H14FN3O5/c24-16-7-10-20-19(13-16)22(28)26(17-8-5-15(6-9-17)23(29)30)21(25-20)11-4-14-2-1-3-18(12-14)27(31)32/h1-13H,(H,29,30)/b11-4+
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n/an/a 3.30E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324389
PNG
((E)-4-(2-(3-methylstyryl)-4-oxoquinazolin-3(4H)-yl...)
Show SMILES Cc1cccc(\C=C\c2nc3ccccc3c(=O)n2-c2ccc(cc2)C(O)=O)c1
Show InChI InChI=1S/C24H18N2O3/c1-16-5-4-6-17(15-16)9-14-22-25-21-8-3-2-7-20(21)23(27)26(22)19-12-10-18(11-13-19)24(28)29/h2-15H,1H3,(H,28,29)/b14-9+
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n/an/a 3.40E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324385
PNG
((E)-4-(2-(4-hydroxystyryl)-4-oxoquinazolin-3(4H)-y...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2ccc(O)cc2)nc2ccccc2c1=O
Show InChI InChI=1S/C23H16N2O4/c26-18-12-5-15(6-13-18)7-14-21-24-20-4-2-1-3-19(20)22(27)25(21)17-10-8-16(9-11-17)23(28)29/h1-14,26H,(H,28,29)/b14-7+
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n/an/a 3.50E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324380
PNG
((E)-4-(2-(3-methoxystyryl)-4-oxoquinazolin-3(4H)-y...)
Show SMILES COc1cccc(\C=C\c2nc3ccccc3c(=O)n2-c2ccc(cc2)C(O)=O)c1
Show InChI InChI=1S/C24H18N2O4/c1-30-19-6-4-5-16(15-19)9-14-22-25-21-8-3-2-7-20(21)23(27)26(22)18-12-10-17(11-13-18)24(28)29/h2-15H,1H3,(H,28,29)/b14-9+
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n/an/a 3.60E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324437
PNG
((E)-4-(2-(2-(6-methoxynaphthalen-2-yl)vinyl)-4-oxo...)
Show SMILES COc1ccc2cc(\C=C\c3nc4ccccc4c(=O)n3-c3ccc(cc3)C(O)=O)ccc2c1
Show InChI InChI=1S/C28H20N2O4/c1-34-23-14-11-20-16-18(6-8-21(20)17-23)7-15-26-29-25-5-3-2-4-24(25)27(31)30(26)22-12-9-19(10-13-22)28(32)33/h2-17H,1H3,(H,32,33)/b15-7+
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n/an/a 3.60E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324417
PNG
((E)-4-(6,7-Dimethoxy-2-(3-nitrostyryl)-4-oxoquinaz...)
Show SMILES COC(=O)c1cccc(\C=C\c2nc3ccc(OC)cc3c(=O)n2-c2ccc(cc2)C(O)=O)c1
Show InChI InChI=1S/C26H20N2O6/c1-33-20-11-12-22-21(15-20)24(29)28(19-9-7-17(8-10-19)25(30)31)23(27-22)13-6-16-4-3-5-18(14-16)26(32)34-2/h3-15H,1-2H3,(H,30,31)/b13-6+
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n/an/a 3.90E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324414
PNG
((E)-Methyl 4-(6-Methoxy-2-(3-nitrostyryl)-4-oxoqui...)
Show SMILES COC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(OC)cc2c1=O
Show InChI InChI=1S/C25H19N3O6/c1-33-20-11-12-22-21(15-20)24(29)27(18-9-7-17(8-10-18)25(30)34-2)23(26-22)13-6-16-4-3-5-19(14-16)28(31)32/h3-15H,1-2H3/b13-6+
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n/an/a 4.60E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324453
PNG
((E)-3-(6-Iodo-4-oxo-2-(2-(pyridin-3-yl)vinyl)quina...)
Show SMILES OC(=O)c1cccc(c1)-n1c(\C=C\c2cccnc2)nc2ccc(I)cc2c1=O
Show InChI InChI=1S/C22H14IN3O3/c23-16-7-8-19-18(12-16)21(27)26(17-5-1-4-15(11-17)22(28)29)20(25-19)9-6-14-3-2-10-24-13-14/h1-13H,(H,28,29)/b9-6+
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n/an/a 4.90E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324441
PNG
((E)-3-phenyl-2-(2-(pyridin-3-yl)vinyl)quinazolin-4...)
Show SMILES O=c1n(-c2ccccc2)c(\C=C\c2cccnc2)nc2ccccc12
Show InChI InChI=1S/C21H15N3O/c25-21-18-10-4-5-11-19(18)23-20(13-12-16-7-6-14-22-15-16)24(21)17-8-2-1-3-9-17/h1-15H/b13-12+
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n/an/a 5.10E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324381
PNG
((E)-4-(2-(2-methoxystyryl)-4-oxoquinazolin-3(4H)-y...)
Show SMILES COc1ccccc1\C=C\c1nc2ccccc2c(=O)n1-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18N2O4/c1-30-21-9-5-2-6-16(21)12-15-22-25-20-8-4-3-7-19(20)23(27)26(22)18-13-10-17(11-14-18)24(28)29/h2-15H,1H3,(H,28,29)/b15-12+
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n/an/a 5.10E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324393
PNG
((E)-4-(7-Chloro-2-(3-nitrostyryl)-4-oxoquinazolin-...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2cc(Cl)ccc2c1=O
Show InChI InChI=1S/C23H14ClN3O5/c24-16-7-10-19-20(13-16)25-21(11-4-14-2-1-3-18(12-14)27(31)32)26(22(19)28)17-8-5-15(6-9-17)23(29)30/h1-13H,(H,29,30)/b11-4+
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n/an/a 5.20E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324382
PNG
((E)-4-(4-oxo-2-(4-(trifluoromethyl)styryl)quinazol...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2ccc(cc2)C(F)(F)F)nc2ccccc2c1=O
Show InChI InChI=1S/C24H15F3N2O3/c25-24(26,27)17-10-5-15(6-11-17)7-14-21-28-20-4-2-1-3-19(20)22(30)29(21)18-12-8-16(9-13-18)23(31)32/h1-14H,(H,31,32)/b14-7+
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n/an/a 5.50E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324433
PNG
((E)-4-(6-Iodo-4-oxo-2-styrylquinazolin-3(4H)-yl)be...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2ccccc2)nc2ccc(I)cc2c1=O
Show InChI InChI=1S/C23H15IN2O3/c24-17-9-12-20-19(14-17)22(27)26(18-10-7-16(8-11-18)23(28)29)21(25-20)13-6-15-4-2-1-3-5-15/h1-14H,(H,28,29)/b13-6+
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n/an/a 6.60E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324438
PNG
((E)-4-(2-(2-(naphthalen-1-yl)vinyl)-4-oxoquinazoli...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc3ccccc23)nc2ccccc2c1=O
Show InChI InChI=1S/C27H18N2O3/c30-26-23-10-3-4-11-24(23)28-25(29(26)21-15-12-20(13-16-21)27(31)32)17-14-19-8-5-7-18-6-1-2-9-22(18)19/h1-17H,(H,31,32)/b17-14+
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n/an/a 6.80E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324458
PNG
((E)-3-(2-(3-nitrostyryl)-4-oxoquinazolin-3(4H)-yl)...)
Show SMILES OC(=O)c1cccc(c1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccccc2c1=O
Show InChI InChI=1S/C23H15N3O5/c27-22-19-9-1-2-10-20(19)24-21(12-11-15-5-3-8-18(13-15)26(30)31)25(22)17-7-4-6-16(14-17)23(28)29/h1-14H,(H,28,29)/b12-11+
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n/an/a 6.90E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324435
PNG
(4-(6-Methyl-4-oxo-2-phenethylquinazolin-3(4H)-yl)b...)
Show SMILES Cc1ccc2nc(CCc3ccccc3)n(-c3ccc(cc3)C(O)=O)c(=O)c2c1
Show InChI InChI=1S/C24H20N2O3/c1-16-7-13-21-20(15-16)23(27)26(19-11-9-18(10-12-19)24(28)29)22(25-21)14-8-17-5-3-2-4-6-17/h2-7,9-13,15H,8,14H2,1H3,(H,28,29)
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n/an/a 7.80E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324419
PNG
((E)-4-(2-(4-(methylthio)styryl)-4-oxoquinazolin-3(...)
Show SMILES CSc1ccc(\C=C\c2nc3ccccc3c(=O)n2-c2ccc(cc2)C(O)=O)cc1
Show InChI InChI=1S/C24H18N2O3S/c1-30-19-13-6-16(7-14-19)8-15-22-25-21-5-3-2-4-20(21)23(27)26(22)18-11-9-17(10-12-18)24(28)29/h2-15H,1H3,(H,28,29)/b15-8+
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n/an/a 7.90E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324413
PNG
((E)-4-(6-Methoxy-2-(3-nitrostyryl)-4-oxoquinazolin...)
Show SMILES COc1ccc2nc(\C=C\c3cccc(c3)[N+]([O-])=O)n(-c3ccc(cc3)C(N)=O)c(=O)c2c1
Show InChI InChI=1S/C24H18N4O5/c1-33-19-10-11-21-20(14-19)24(30)27(17-8-6-16(7-9-17)23(25)29)22(26-21)12-5-15-3-2-4-18(13-15)28(31)32/h2-14H,1H3,(H2,25,29)/b12-5+
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n/an/a 8.20E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324471
PNG
((E)-4-(4-oxo-2-styrylquinazolin-3(4H)-yl)benzoic a...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2ccccc2)nc2ccccc2c1=O
Show InChI InChI=1S/C23H16N2O3/c26-22-19-8-4-5-9-20(19)24-21(15-10-16-6-2-1-3-7-16)25(22)18-13-11-17(12-14-18)23(27)28/h1-15H,(H,27,28)/b15-10+
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n/an/a 8.50E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324422
PNG
((E)-4-(2-(4-(difluoromethoxy)styryl)-4-oxoquinazol...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2ccc(OC(F)F)cc2)nc2ccccc2c1=O
Show InChI InChI=1S/C24H16F2N2O4/c25-24(26)32-18-12-5-15(6-13-18)7-14-21-27-20-4-2-1-3-19(20)22(29)28(21)17-10-8-16(9-11-17)23(30)31/h1-14,24H,(H,30,31)/b14-7+
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n/an/a 8.90E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324455
PNG
((E)-4-(2-(4-nitrostyryl)-4-oxoquinazolin-3(4H)-yl)...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2ccc(cc2)[N+]([O-])=O)nc2ccccc2c1=O
Show InChI InChI=1S/C23H15N3O5/c27-22-19-3-1-2-4-20(19)24-21(14-7-15-5-10-18(11-6-15)26(30)31)25(22)17-12-8-16(9-13-17)23(28)29/h1-14H,(H,28,29)/b14-7+
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n/an/a 9.30E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324390
PNG
((E)-4-(2-(2-methylstyryl)-4-oxoquinazolin-3(4H)-yl...)
Show SMILES Cc1ccccc1\C=C\c1nc2ccccc2c(=O)n1-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18N2O3/c1-16-6-2-3-7-17(16)12-15-22-25-21-9-5-4-8-20(21)23(27)26(22)19-13-10-18(11-14-19)24(28)29/h2-15H,1H3,(H,28,29)/b15-12+
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n/an/a 9.30E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324472
PNG
((E)-4-(2-(4-methoxystyryl)-4-oxoquinazolin-3(4H)-y...)
Show SMILES COc1ccc(\C=C\c2nc3ccccc3c(=O)n2-c2ccc(cc2)C(O)=O)cc1
Show InChI InChI=1S/C24H18N2O4/c1-30-19-13-6-16(7-14-19)8-15-22-25-21-5-3-2-4-20(21)23(27)26(22)18-11-9-17(10-12-18)24(28)29/h2-15H,1H3,(H,28,29)/b15-8+
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n/an/a 9.80E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324462
PNG
((E)-3-(4-methoxyphenyl)-2-(4-nitrostyryl)quinazoli...)
Show SMILES COc1ccc(cc1)-n1c(\C=C\c2ccc(cc2)[N+]([O-])=O)nc2ccccc2c1=O
Show InChI InChI=1S/C23H17N3O4/c1-30-19-13-11-17(12-14-19)25-22(24-21-5-3-2-4-20(21)23(25)27)15-8-16-6-9-18(10-7-16)26(28)29/h2-15H,1H3/b15-8+
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n/an/a 9.80E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324408
PNG
((E)-4-(6-Isopropyl-2-(3-nitrostyryl)-4-oxoquinazol...)
Show SMILES CC(C)c1ccc2nc(\C=C\c3cccc(c3)[N+]([O-])=O)n(-c3ccc(cc3)C(O)=O)c(=O)c2c1
Show InChI InChI=1S/C26H21N3O5/c1-16(2)19-9-12-23-22(15-19)25(30)28(20-10-7-18(8-11-20)26(31)32)24(27-23)13-6-17-4-3-5-21(14-17)29(33)34/h3-16H,1-2H3,(H,31,32)/b13-6+
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n/an/a 9.80E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324451
PNG
((E)-6-iodo-3-(2-nitrophenyl)-2-(2-(pyridin-3-yl)vi...)
Show SMILES [O-][N+](=O)c1ccccc1-n1c(\C=C\c2cccnc2)nc2ccc(I)cc2c1=O |(18.58,-22.91,;17.82,-24.26,;16.27,-24.27,;18.6,-25.6,;19.93,-24.82,;21.27,-25.58,;21.27,-27.12,;19.94,-27.9,;18.61,-27.13,;17.28,-27.9,;17.29,-29.45,;18.62,-30.22,;18.62,-31.76,;19.96,-32.52,;21.28,-31.74,;22.61,-32.5,;22.62,-34.05,;21.29,-34.82,;19.95,-34.06,;15.95,-30.22,;14.62,-29.45,;13.27,-30.23,;11.94,-29.46,;11.94,-27.92,;10.61,-27.15,;13.27,-27.14,;14.61,-27.91,;15.94,-27.13,;15.92,-25.59,)|
Show InChI InChI=1S/C21H13IN4O3/c22-15-8-9-17-16(12-15)21(27)25(18-5-1-2-6-19(18)26(28)29)20(24-17)10-7-14-4-3-11-23-13-14/h1-13H/b10-7+
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n/an/a 1.05E+5n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324420
PNG
((E)-4-(2-(4-cyanostyryl)-4-oxoquinazolin-3(4H)-yl)...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2ccc(cc2)C#N)nc2ccccc2c1=O
Show InChI InChI=1S/C24H15N3O3/c25-15-17-7-5-16(6-8-17)9-14-22-26-21-4-2-1-3-20(21)23(28)27(22)19-12-10-18(11-13-19)24(29)30/h1-14H,(H,29,30)/b14-9+
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n/an/a 1.06E+5n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324415
PNG
((E)-4-(6-Methoxy-2-(3-methoxystyryl)-4-oxoquinazol...)
Show SMILES COc1cccc(\C=C\c2nc3ccc(OC)cc3c(=O)n2-c2ccc(cc2)C(O)=O)c1
Show InChI InChI=1S/C25H20N2O5/c1-31-19-5-3-4-16(14-19)6-13-23-26-22-12-11-20(32-2)15-21(22)24(28)27(23)18-9-7-17(8-10-18)25(29)30/h3-15H,1-2H3,(H,29,30)/b13-6+
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n/an/a 1.09E+5n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324395
PNG
((E)-4-(6,8-Dichloro-2-(3-nitrostyryl)-4-oxoquinazo...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2c(Cl)cc(Cl)cc2c1=O
Show InChI InChI=1S/C23H13Cl2N3O5/c24-15-11-18-21(19(25)12-15)26-20(9-4-13-2-1-3-17(10-13)28(32)33)27(22(18)29)16-7-5-14(6-8-16)23(30)31/h1-12H,(H,30,31)/b9-4+
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n/an/a 1.09E+5n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324391
PNG
((E)-4-(5-Chloro-2-(3-nitrostyryl)-4-oxoquinazolin-...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2cccc(Cl)c2c1=O
Show InChI InChI=1S/C23H14ClN3O5/c24-18-5-2-6-19-21(18)22(28)26(16-10-8-15(9-11-16)23(29)30)20(25-19)12-7-14-3-1-4-17(13-14)27(31)32/h1-13H,(H,29,30)/b12-7+
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n/an/a 1.10E+5n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
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