Found 1010 hits of ic50 for UniProtKB: Q6ZN18 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287072
(CHEMBL4159112 | US10759787, Example 12 | US1105981...)Show SMILES CCN(C1CCOCC1)c1cc2oc(CN3CCN(C)CC3)cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1CC Show InChI InChI=1S/C32H45N5O5/c1-6-24-27(37(7-2)22-8-14-41-15-9-22)18-29-25(17-23(42-29)20-36-12-10-35(4)11-13-36)30(24)32(39)33-19-26-28(40-5)16-21(3)34-31(26)38/h16-18,22H,6-15,19-20H2,1-5H3,(H,33,39)(H,34,38) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287050
(CHEMBL4161265)Show SMILES CCN(C1CCOCC1)c1cc2oc(Cl)cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C25H30ClN3O5/c1-5-29(16-6-8-33-9-7-16)19-12-21-17(11-22(26)34-21)23(15(19)3)25(31)27-13-18-20(32-4)10-14(2)28-24(18)30/h10-12,16H,5-9,13H2,1-4H3,(H,27,31)(H,28,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287052
(CHEMBL4165937)Show SMILES CCN(C1CCOCC1)c1cc2oc(cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C)C1CC1 Show InChI InChI=1S/C28H35N3O5/c1-5-31(19-8-10-35-11-9-19)22-14-25-20(13-23(36-25)18-6-7-18)26(17(22)3)28(33)29-15-21-24(34-4)12-16(2)30-27(21)32/h12-14,18-19H,5-11,15H2,1-4H3,(H,29,33)(H,30,32) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287284
(CHEMBL4160111)Show SMILES CCN(C1CCOCC1)c1cc2occc2c(C(=O)NCc2c(CC)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C26H33N3O4/c1-5-18-13-16(3)28-25(30)21(18)15-27-26(31)24-17(4)22(14-23-20(24)9-12-33-23)29(6-2)19-7-10-32-11-8-19/h9,12-14,19H,5-8,10-11,15H2,1-4H3,(H,27,31)(H,28,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287068
(CHEMBL4172576 | US10759787, Example 30 | US1105981...)Show SMILES CCN(C1CCOCC1)c1cc2oc(cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C)C#N Show InChI InChI=1S/C26H30N4O5/c1-5-30(17-6-8-34-9-7-17)21-12-23-19(11-18(13-27)35-23)24(16(21)3)26(32)28-14-20-22(33-4)10-15(2)29-25(20)31/h10-12,17H,5-9,14H2,1-4H3,(H,28,32)(H,29,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287071
(CHEMBL4164687 | US10759787, Example 29 | US1105981...)Show SMILES CCN(C1CCOCC1)c1cc2oc(cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C)C(F)(F)F Show InChI InChI=1S/C26H30F3N3O5/c1-5-32(16-6-8-36-9-7-16)19-12-21-17(11-22(37-21)26(27,28)29)23(15(19)3)25(34)30-13-18-20(35-4)10-14(2)31-24(18)33/h10-12,16H,5-9,13H2,1-4H3,(H,30,34)(H,31,33) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287125
(CHEMBL4170327 | US10759787, Example 19 | US1105981...)Show SMILES CCN(C1CCOCC1)c1cc2oc(C)cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C26H33N3O5/c1-6-29(18-7-9-33-10-8-18)21-13-23-19(12-16(3)34-23)24(17(21)4)26(31)27-14-20-22(32-5)11-15(2)28-25(20)30/h11-13,18H,6-10,14H2,1-5H3,(H,27,31)(H,28,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287049
(CHEMBL4162316)Show SMILES CCN(C1CCOCC1)c1cc2occc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1CC Show InChI InChI=1S/C26H33N3O5/c1-5-18-21(29(6-2)17-7-10-33-11-8-17)14-23-19(9-12-34-23)24(18)26(31)27-15-20-22(32-4)13-16(3)28-25(20)30/h9,12-14,17H,5-8,10-11,15H2,1-4H3,(H,27,31)(H,28,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287283
(CHEMBL4177454)Show SMILES CCN(C1CCOCC1)c1cc2oc(C)cc2c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C26H33N3O4/c1-6-29(19-7-9-32-10-8-19)22-13-23-20(12-17(4)33-23)24(18(22)5)26(31)27-14-21-15(2)11-16(3)28-25(21)30/h11-13,19H,6-10,14H2,1-5H3,(H,27,31)(H,28,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287054
(CHEMBL4174176)Show SMILES CCN(C1CCOCC1)c1cc2occc2c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C25H31N3O4/c1-5-28(18-6-9-31-10-7-18)21-13-22-19(8-11-32-22)23(17(21)4)25(30)26-14-20-15(2)12-16(3)27-24(20)29/h8,11-13,18H,5-7,9-10,14H2,1-4H3,(H,26,30)(H,27,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287048
(CHEMBL4162499 | US10759787, Example 9 | US11059811...)Show SMILES CCN(C1CCOCC1)c1cc2oc(cc2c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1CC)C1CCN(CC1)C(C)C Show InChI InChI=1S/C34H48N4O4/c1-7-26-29(38(8-2)25-11-15-41-16-12-25)19-31-27(18-30(42-31)24-9-13-37(14-10-24)21(3)4)32(26)34(40)35-20-28-22(5)17-23(6)36-33(28)39/h17-19,21,24-25H,7-16,20H2,1-6H3,(H,35,40)(H,36,39) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287277
(CHEMBL4170753 | US10759787, Example 18 | US1105981...)Show SMILES CCN(C1CCOCC1)c1cc2occc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C25H31N3O5/c1-5-28(17-6-9-32-10-7-17)20-13-22-18(8-11-33-22)23(16(20)3)25(30)26-14-19-21(31-4)12-15(2)27-24(19)29/h8,11-13,17H,5-7,9-10,14H2,1-4H3,(H,26,30)(H,27,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM172038
(US10155002, Compound 44 | US10647700, Compound EPZ...)Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9,18-20,29H,5,10-17,21-22H2,1-4H3,(H,35,39)(H,36,40) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287058
(CHEMBL4169191)Show SMILES CCN(C1CCOCC1)c1cc2oc(F)cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C25H30FN3O5/c1-5-29(16-6-8-33-9-7-16)19-12-21-17(11-22(26)34-21)23(15(19)3)25(31)27-13-18-20(32-4)10-14(2)28-24(18)30/h10-12,16H,5-9,13H2,1-4H3,(H,27,31)(H,28,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287276
(CHEMBL4162406)Show SMILES CCN(C1CCOCC1)c1cc2occc2c(C(=O)NCc2c(cc(C)[nH]c2=O)C(F)(F)F)c1C Show InChI InChI=1S/C25H28F3N3O4/c1-4-31(16-5-8-34-9-6-16)20-12-21-17(7-10-35-21)22(15(20)3)24(33)29-13-18-19(25(26,27)28)11-14(2)30-23(18)32/h7,10-12,16H,4-6,8-9,13H2,1-3H3,(H,29,33)(H,30,32) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287051
(CHEMBL4169368)Show SMILES CCN(C1CCOCC1)c1cc2oc(CN3CCOCC3)cc2c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1CC Show InChI InChI=1S/C31H42N4O5/c1-5-24-27(35(6-2)22-7-11-38-12-8-22)17-28-25(16-23(40-28)19-34-9-13-39-14-10-34)29(24)31(37)32-18-26-20(3)15-21(4)33-30(26)36/h15-17,22H,5-14,18-19H2,1-4H3,(H,32,37)(H,33,36) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287056
(CHEMBL4169598 | US10759787, Example 20 | US1105981...)Show SMILES CCN(C1CCOCC1)c1cc2occ(C)c2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C26H33N3O5/c1-6-29(18-7-9-33-10-8-18)20-12-22-23(15(2)14-34-22)24(17(20)4)26(31)27-13-19-21(32-5)11-16(3)28-25(19)30/h11-12,14,18H,6-10,13H2,1-5H3,(H,27,31)(H,28,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287306
(CHEMBL4167587)Show SMILES CCN(C1CCOCC1)c1cc2sccc2c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C25H31N3O3S/c1-5-28(18-6-9-31-10-7-18)21-13-22-19(8-11-32-22)23(17(21)4)25(30)26-14-20-15(2)12-16(3)27-24(20)29/h8,11-13,18H,5-7,9-10,14H2,1-4H3,(H,26,30)(H,27,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287119
(CHEMBL4169762)Show SMILES CCN(C1CCOCC1)c1cc2oc(cc2c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1CC)C1CCN(C)CC1 Show InChI InChI=1S/C32H44N4O4/c1-6-24-27(36(7-2)23-10-14-39-15-11-23)18-29-25(17-28(40-29)22-8-12-35(5)13-9-22)30(24)32(38)33-19-26-20(3)16-21(4)34-31(26)37/h16-18,22-23H,6-15,19H2,1-5H3,(H,33,38)(H,34,37) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287053
(CHEMBL4161444 | US10759787, Example 1 | US11059811...)Show SMILES CCN(C1CCOCC1)c1cc2oc(CN3CCCCC3)cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1CC Show InChI InChI=1S/C32H44N4O5/c1-5-24-27(36(6-2)22-10-14-40-15-11-22)18-29-25(17-23(41-29)20-35-12-8-7-9-13-35)30(24)32(38)33-19-26-28(39-4)16-21(3)34-31(26)37/h16-18,22H,5-15,19-20H2,1-4H3,(H,33,38)(H,34,37) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287047
(CHEMBL4176373)Show SMILES CCN(C1CCOCC1)c1cc2occc2c(C(=O)NCc2ccc(C)[nH]c2=O)c1Cl Show InChI InChI=1S/C23H26ClN3O4/c1-3-27(16-6-9-30-10-7-16)18-12-19-17(8-11-31-19)20(21(18)24)23(29)25-13-15-5-4-14(2)26-22(15)28/h4-5,8,11-12,16H,3,6-7,9-10,13H2,1-2H3,(H,25,29)(H,26,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287307
(CHEMBL4176554 | US10759787, Example 6 | US11059811...)Show SMILES CCN(C1CCOCC1)c1cc2oc(CN3CCOCC3)cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1CC Show InChI InChI=1S/C31H42N4O6/c1-5-23-26(35(6-2)21-7-11-39-12-8-21)17-28-24(16-22(41-28)19-34-9-13-40-14-10-34)29(23)31(37)32-18-25-27(38-4)15-20(3)33-30(25)36/h15-17,21H,5-14,18-19H2,1-4H3,(H,32,37)(H,33,36) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437 BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259371
(US9505745, 48 | US9790212, Example 48)Show SMILES CCC(c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)=C1CCNCC1 |(1.29,-4.65,;.52,-3.32,;-1.02,-3.32,;-1.79,-1.98,;-3.33,-1.98,;-3.81,-.52,;-2.56,.39,;-2.56,1.93,;-3.9,2.7,;-1.23,2.7,;-1.23,4.24,;.1,5.01,;.1,6.55,;-1.23,7.32,;1.44,7.32,;2.77,6.55,;4.1,7.32,;2.77,5.01,;1.44,4.24,;1.44,2.7,;-1.32,-.52,;.02,.25,;-1.79,-4.65,;-3.33,-4.65,;-4.1,-5.98,;-3.33,-7.32,;-1.79,-7.32,;-1.02,-5.98,)| Show InChI InChI=1S/C22H29N3O2S/c1-5-17(16-6-8-23-9-7-16)20-15(4)19(12-28-20)21(26)24-11-18-13(2)10-14(3)25-22(18)27/h10,12,23H,5-9,11H2,1-4H3,(H,24,26)(H,25,27) | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
US Patent
| Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com... |
US Patent US9790212 (2017)
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259367
(US9505745, 44 | US9505745, 45 | US9790212, Example...)Show SMILES CCC([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(2.06,-3.32,;1.29,-1.98,;-.25,-1.98,;-1.02,-3.32,;-2.56,-3.32,;-3.33,-4.65,;-2.56,-5.98,;-1.02,-5.98,;-.25,-4.65,;-3.33,-7.32,;-2.56,-8.65,;-4.87,-7.32,;-1.02,-.65,;-2.56,-.65,;-3.04,.82,;-1.79,1.72,;-1.79,3.26,;-3.13,4.03,;-.46,4.03,;-.46,5.57,;.87,6.34,;.87,7.88,;-.46,8.65,;2.21,8.65,;3.54,7.88,;4.87,8.65,;3.54,6.34,;2.21,5.57,;2.21,4.03,;-.55,.82,;.79,1.59,)| | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
US Patent
| Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com... |
US Patent US9790212 (2017)
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259359
(US9505745, 36 | US9790212, Example 36)Show SMILES C\C=C(/[C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(7.71,-2.37,;6.62,-1.28,;5.14,-1.67,;4.74,-3.16,;3.25,-3.56,;2.85,-5.05,;3.94,-6.14,;5.43,-5.74,;5.83,-4.25,;3.54,-7.62,;4.63,-8.71,;2.05,-8.02,;4.05,-.59,;2.51,-.59,;2.03,.88,;3.28,1.78,;3.28,3.32,;1.94,4.09,;4.61,4.09,;4.61,5.63,;5.94,6.4,;5.94,7.94,;4.61,8.71,;7.28,8.71,;8.61,7.94,;9.94,8.71,;8.61,6.4,;7.28,5.63,;7.28,4.09,;4.52,.88,;5.86,1.65,)| | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
US Patent
| Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com... |
US Patent US9790212 (2017)
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259356
(US9505745, 33 | US9790212, Example 33)Show SMILES C\C=C(/C1CCNCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C22H29N3O2S/c1-5-17(16-6-8-23-9-7-16)20-15(4)19(12-28-20)21(26)24-11-18-13(2)10-14(3)25-22(18)27/h5,10,12,16,23H,6-9,11H2,1-4H3,(H,24,26)(H,25,27)/b17-5+ | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
US Patent
| Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com... |
US Patent US9790212 (2017)
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259355
(US9505745, 32 | US9790212, Example 32)Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)n(C)c2=O)c1C |r,wU:3.2,wD:6.9,(5.55,-2.37,;4.46,-1.28,;2.98,-1.67,;2.58,-3.16,;3.67,-4.25,;3.27,-5.74,;1.78,-6.14,;.69,-5.05,;1.09,-3.56,;1.38,-7.62,;2.47,-8.71,;-.11,-8.02,;1.89,-.59,;.35,-.59,;-.13,.88,;1.12,1.78,;1.12,3.32,;2.45,4.09,;-.22,4.09,;-.22,5.63,;-1.55,6.4,;-1.55,7.94,;-.22,8.71,;-2.88,8.71,;-4.22,7.94,;-5.55,8.71,;-4.22,6.4,;-5.55,5.63,;-2.88,5.63,;-2.88,4.09,;2.36,.88,;3.7,1.65,)| Show InChI InChI=1S/C25H38N4O2S/c1-8-29(20-11-9-19(10-12-20)27(5)6)25-18(4)22(15-32-25)23(30)26-14-21-16(2)13-17(3)28(7)24(21)31/h13,15,19-20H,8-12,14H2,1-7H3,(H,26,30)/t19-,20- | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
US Patent
| Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com... |
US Patent US9790212 (2017)
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259342
(US9505745, 19 | US9790212, Example 19)Show SMILES CCN(C1CCOCC1)c1sc(Br)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H28BrN3O3S/c1-5-25(15-6-8-28-9-7-15)21-14(4)17(18(22)29-21)20(27)23-11-16-12(2)10-13(3)24-19(16)26/h10,15H,5-9,11H2,1-4H3,(H,23,27)(H,24,26) | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
US Patent
| Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com... |
US Patent US9790212 (2017)
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259335
(US9505745, 12 | US9790212, Example 12)Show SMILES CCN(C1CCNCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H30N4O2S/c1-5-25(16-6-8-22-9-7-16)21-15(4)18(12-28-21)19(26)23-11-17-13(2)10-14(3)24-20(17)27/h10,12,16,22H,5-9,11H2,1-4H3,(H,23,26)(H,24,27) | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
US Patent
| Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com... |
US Patent US9790212 (2017)
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259339
(US9505745, 16 | US9790212, Example 16)Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1csc(N(CC)[C@H]2CC[C@@H](CC2)N(C)C)c1C |r,wU:25.29,wD:22.22,(10.2,-4.23,;9.43,-2.9,;7.89,-2.9,;7.12,-1.57,;8.21,-.48,;7.81,1.01,;8.9,2.1,;6.32,1.41,;5.23,.32,;3.75,.72,;5.63,-1.17,;4.54,-2.26,;4.94,-3.74,;3.85,-4.83,;2.37,-4.43,;4.25,-6.32,;3.35,-7.57,;4.25,-8.81,;5.72,-8.34,;7.05,-9.11,;8.38,-8.34,;9.72,-9.11,;7.05,-10.65,;5.72,-11.42,;5.72,-12.96,;7.05,-13.73,;8.38,-12.96,;8.38,-11.42,;7.05,-15.27,;8.38,-16.04,;5.72,-16.04,;5.72,-6.8,;7.05,-6.03,)| | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
US Patent
| Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com... |
US Patent US9790212 (2017)
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259341
(US9505745, 18 | US9790212, Example 18)Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(7.97,-10.65,;6.88,-9.56,;5.4,-9.96,;5,-11.45,;3.51,-11.84,;3.11,-13.33,;4.2,-14.42,;5.69,-14.02,;6.09,-12.53,;3.8,-15.91,;4.89,-17,;2.31,-16.31,;4.31,-8.87,;2.77,-8.87,;2.29,-7.4,;3.54,-6.5,;3.54,-4.96,;2.2,-4.19,;4.87,-4.19,;4.87,-2.65,;6.2,-1.88,;7.54,-2.65,;7.54,-4.19,;8.87,-4.96,;8.87,-1.88,;8.87,-.34,;10.21,.43,;7.54,.43,;6.2,-.34,;4.87,.43,;4.78,-7.4,;6.27,-7.01,)| | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
US Patent
| Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com... |
US Patent US9790212 (2017)
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM347682
(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)Show SMILES CCN(C1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,(4.8,8.93,;4.03,7.6,;2.49,7.6,;1.72,6.27,;.18,6.27,;-.59,4.93,;.18,3.6,;1.72,3.6,;2.49,4.93,;-.59,2.27,;.18,.93,;-2.13,2.27,;1.72,8.93,;.18,8.93,;-.3,10.4,;.95,11.3,;.95,12.84,;2.28,13.61,;-.39,13.61,;-.39,15.15,;-1.72,15.92,;-1.72,17.46,;-.39,18.23,;-3.05,18.23,;-4.39,17.46,;-5.72,18.23,;-4.39,15.92,;-3.05,15.15,;-3.05,13.61,;2.19,10.4,;3.53,11.17,)| | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
US Patent
| Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com... |
US Patent US9790212 (2017)
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM347682
(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)Show SMILES CCN(C1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,(4.8,8.93,;4.03,7.6,;2.49,7.6,;1.72,6.27,;.18,6.27,;-.59,4.93,;.18,3.6,;1.72,3.6,;2.49,4.93,;-.59,2.27,;.18,.93,;-2.13,2.27,;1.72,8.93,;.18,8.93,;-.3,10.4,;.95,11.3,;.95,12.84,;2.28,13.61,;-.39,13.61,;-.39,15.15,;-1.72,15.92,;-1.72,17.46,;-.39,18.23,;-3.05,18.23,;-4.39,17.46,;-5.72,18.23,;-4.39,15.92,;-3.05,15.15,;-3.05,13.61,;2.19,10.4,;3.53,11.17,)| | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
US Patent
| Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com... |
US Patent US9790212 (2017)
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259371
(US9505745, 48 | US9790212, Example 48)Show SMILES CCC(c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)=C1CCNCC1 |(1.29,-4.65,;.52,-3.32,;-1.02,-3.32,;-1.79,-1.98,;-3.33,-1.98,;-3.81,-.52,;-2.56,.39,;-2.56,1.93,;-3.9,2.7,;-1.23,2.7,;-1.23,4.24,;.1,5.01,;.1,6.55,;-1.23,7.32,;1.44,7.32,;2.77,6.55,;4.1,7.32,;2.77,5.01,;1.44,4.24,;1.44,2.7,;-1.32,-.52,;.02,.25,;-1.79,-4.65,;-3.33,-4.65,;-4.1,-5.98,;-3.33,-7.32,;-1.79,-7.32,;-1.02,-5.98,)| Show InChI InChI=1S/C22H29N3O2S/c1-5-17(16-6-8-23-9-7-16)20-15(4)19(12-28-20)21(26)24-11-18-13(2)10-14(3)25-22(18)27/h10,12,23H,5-9,11H2,1-4H3,(H,24,26)(H,25,27) | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259367
(US9505745, 44 | US9505745, 45 | US9790212, Example...)Show SMILES CCC([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(2.06,-3.32,;1.29,-1.98,;-.25,-1.98,;-1.02,-3.32,;-2.56,-3.32,;-3.33,-4.65,;-2.56,-5.98,;-1.02,-5.98,;-.25,-4.65,;-3.33,-7.32,;-2.56,-8.65,;-4.87,-7.32,;-1.02,-.65,;-2.56,-.65,;-3.04,.82,;-1.79,1.72,;-1.79,3.26,;-3.13,4.03,;-.46,4.03,;-.46,5.57,;.87,6.34,;.87,7.88,;-.46,8.65,;2.21,8.65,;3.54,7.88,;4.87,8.65,;3.54,6.34,;2.21,5.57,;2.21,4.03,;-.55,.82,;.79,1.59,)| | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259359
(US9505745, 36 | US9790212, Example 36)Show SMILES C\C=C(/[C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(7.71,-2.37,;6.62,-1.28,;5.14,-1.67,;4.74,-3.16,;3.25,-3.56,;2.85,-5.05,;3.94,-6.14,;5.43,-5.74,;5.83,-4.25,;3.54,-7.62,;4.63,-8.71,;2.05,-8.02,;4.05,-.59,;2.51,-.59,;2.03,.88,;3.28,1.78,;3.28,3.32,;1.94,4.09,;4.61,4.09,;4.61,5.63,;5.94,6.4,;5.94,7.94,;4.61,8.71,;7.28,8.71,;8.61,7.94,;9.94,8.71,;8.61,6.4,;7.28,5.63,;7.28,4.09,;4.52,.88,;5.86,1.65,)| | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259356
(US9505745, 33 | US9790212, Example 33)Show SMILES C\C=C(/C1CCNCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C22H29N3O2S/c1-5-17(16-6-8-23-9-7-16)20-15(4)19(12-28-20)21(26)24-11-18-13(2)10-14(3)25-22(18)27/h5,10,12,16,23H,6-9,11H2,1-4H3,(H,24,26)(H,25,27)/b17-5+ | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259355
(US9505745, 32 | US9790212, Example 32)Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)n(C)c2=O)c1C |r,wU:3.2,wD:6.9,(5.55,-2.37,;4.46,-1.28,;2.98,-1.67,;2.58,-3.16,;3.67,-4.25,;3.27,-5.74,;1.78,-6.14,;.69,-5.05,;1.09,-3.56,;1.38,-7.62,;2.47,-8.71,;-.11,-8.02,;1.89,-.59,;.35,-.59,;-.13,.88,;1.12,1.78,;1.12,3.32,;2.45,4.09,;-.22,4.09,;-.22,5.63,;-1.55,6.4,;-1.55,7.94,;-.22,8.71,;-2.88,8.71,;-4.22,7.94,;-5.55,8.71,;-4.22,6.4,;-5.55,5.63,;-2.88,5.63,;-2.88,4.09,;2.36,.88,;3.7,1.65,)| Show InChI InChI=1S/C25H38N4O2S/c1-8-29(20-11-9-19(10-12-20)27(5)6)25-18(4)22(15-32-25)23(30)26-14-21-16(2)13-17(3)28(7)24(21)31/h13,15,19-20H,8-12,14H2,1-7H3,(H,26,30)/t19-,20- | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259342
(US9505745, 19 | US9790212, Example 19)Show SMILES CCN(C1CCOCC1)c1sc(Br)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H28BrN3O3S/c1-5-25(15-6-8-28-9-7-15)21-14(4)17(18(22)29-21)20(27)23-11-16-12(2)10-13(3)24-19(16)26/h10,15H,5-9,11H2,1-4H3,(H,23,27)(H,24,26) | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259341
(US9505745, 18 | US9790212, Example 18)Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(7.97,-10.65,;6.88,-9.56,;5.4,-9.96,;5,-11.45,;3.51,-11.84,;3.11,-13.33,;4.2,-14.42,;5.69,-14.02,;6.09,-12.53,;3.8,-15.91,;4.89,-17,;2.31,-16.31,;4.31,-8.87,;2.77,-8.87,;2.29,-7.4,;3.54,-6.5,;3.54,-4.96,;2.2,-4.19,;4.87,-4.19,;4.87,-2.65,;6.2,-1.88,;7.54,-2.65,;7.54,-4.19,;8.87,-4.96,;8.87,-1.88,;8.87,-.34,;10.21,.43,;7.54,.43,;6.2,-.34,;4.87,.43,;4.78,-7.4,;6.27,-7.01,)| | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259339
(US9505745, 16 | US9790212, Example 16)Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1csc(N(CC)[C@H]2CC[C@@H](CC2)N(C)C)c1C |r,wU:25.29,wD:22.22,(10.2,-4.23,;9.43,-2.9,;7.89,-2.9,;7.12,-1.57,;8.21,-.48,;7.81,1.01,;8.9,2.1,;6.32,1.41,;5.23,.32,;3.75,.72,;5.63,-1.17,;4.54,-2.26,;4.94,-3.74,;3.85,-4.83,;2.37,-4.43,;4.25,-6.32,;3.35,-7.57,;4.25,-8.81,;5.72,-8.34,;7.05,-9.11,;8.38,-8.34,;9.72,-9.11,;7.05,-10.65,;5.72,-11.42,;5.72,-12.96,;7.05,-13.73,;8.38,-12.96,;8.38,-11.42,;7.05,-15.27,;8.38,-16.04,;5.72,-16.04,;5.72,-6.8,;7.05,-6.03,)| | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259335
(US9505745, 12 | US9790212, Example 12)Show SMILES CCN(C1CCNCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H30N4O2S/c1-5-25(16-6-8-22-9-7-16)21-15(4)18(12-28-21)19(26)23-11-17-13(2)10-14(3)24-20(17)27/h10,12,16,22H,5-9,11H2,1-4H3,(H,23,26)(H,24,27) | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259331
(US9505745, 8)Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(5.26,-.65,;4.49,-1.98,;2.95,-1.98,;2.18,-3.32,;.64,-3.32,;-.13,-4.65,;.64,-5.98,;2.18,-5.98,;2.95,-4.65,;-.13,-7.32,;-1.67,-7.32,;.64,-8.65,;2.18,-.65,;.64,-.65,;.16,.82,;1.41,1.72,;1.41,3.26,;2.74,4.03,;.08,4.03,;.08,5.57,;-1.26,6.34,;-1.26,7.88,;.08,8.65,;-2.59,8.65,;-3.93,7.88,;-5.26,8.65,;-3.93,6.34,;-2.59,5.57,;-2.59,4.03,;2.66,.82,;3.99,1.59,)| | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259330
(US9505745, 7)Show SMILES CCN([C@@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,6.9,(5.26,-.65,;4.49,-1.98,;2.95,-1.98,;2.18,-3.32,;.64,-3.32,;-.13,-4.65,;.64,-5.98,;2.18,-5.98,;2.95,-4.65,;-.13,-7.32,;-1.67,-7.32,;.64,-8.65,;2.18,-.65,;.64,-.65,;.16,.82,;1.41,1.72,;1.41,3.26,;2.74,4.03,;.08,4.03,;.08,5.57,;-1.26,6.34,;-1.26,7.88,;.08,8.65,;-2.59,8.65,;-3.93,7.88,;-5.26,8.65,;-3.93,6.34,;-2.59,5.57,;-2.59,4.03,;2.66,.82,;3.99,1.59,)| | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259341
(US9505745, 18 | US9790212, Example 18)Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(7.97,-10.65,;6.88,-9.56,;5.4,-9.96,;5,-11.45,;3.51,-11.84,;3.11,-13.33,;4.2,-14.42,;5.69,-14.02,;6.09,-12.53,;3.8,-15.91,;4.89,-17,;2.31,-16.31,;4.31,-8.87,;2.77,-8.87,;2.29,-7.4,;3.54,-6.5,;3.54,-4.96,;2.2,-4.19,;4.87,-4.19,;4.87,-2.65,;6.2,-1.88,;7.54,-2.65,;7.54,-4.19,;8.87,-4.96,;8.87,-1.88,;8.87,-.34,;10.21,.43,;7.54,.43,;6.2,-.34,;4.87,.43,;4.78,-7.4,;6.27,-7.01,)| | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
US Patent
| Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com... |
US Patent US9790212 (2017)
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM347682
(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)Show SMILES CCN(C1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,(4.8,8.93,;4.03,7.6,;2.49,7.6,;1.72,6.27,;.18,6.27,;-.59,4.93,;.18,3.6,;1.72,3.6,;2.49,4.93,;-.59,2.27,;.18,.93,;-2.13,2.27,;1.72,8.93,;.18,8.93,;-.3,10.4,;.95,11.3,;.95,12.84,;2.28,13.61,;-.39,13.61,;-.39,15.15,;-1.72,15.92,;-1.72,17.46,;-.39,18.23,;-3.05,18.23,;-4.39,17.46,;-5.72,18.23,;-4.39,15.92,;-3.05,15.15,;-3.05,13.61,;2.19,10.4,;3.53,11.17,)| | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
US Patent
| Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com... |
US Patent US9790212 (2017)
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259369
(US9505745, 46 | US9505745, 47 | US9790212, Example...)Show SMILES CCC([C@H]1CC[C@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,6.9,(2.06,-3.32,;1.29,-1.98,;-.25,-1.98,;-1.02,-3.32,;-.25,-4.65,;-1.02,-5.98,;-2.56,-5.98,;-3.33,-4.65,;-2.56,-3.32,;-3.33,-7.32,;-2.56,-8.65,;-4.87,-7.32,;-1.02,-.65,;-2.56,-.65,;-3.04,.82,;-1.79,1.72,;-1.79,3.26,;-3.13,4.03,;-.46,4.03,;-.46,5.57,;.87,6.34,;.87,7.88,;-.46,8.65,;2.21,8.65,;3.54,7.88,;4.87,8.65,;3.54,6.34,;2.21,5.57,;2.21,4.03,;-.55,.82,;.79,1.59,)| | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
US Patent
| Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com... |
US Patent US9790212 (2017)
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259357
(US9505745, 34 | US9790212, Example 35)Show SMILES C\C=C(/[C@H]1CC[C@@H](CC1)NC(=O)OC(C)(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,wD:6.9,(5.06,-1.28,;3.97,-.19,;2.48,-.59,;2.09,-2.07,;3.17,-3.16,;2.78,-4.65,;1.29,-5.05,;.2,-3.96,;.6,-2.47,;.89,-6.54,;1.98,-7.62,;1.58,-9.11,;3.47,-7.23,;4.56,-8.32,;6.04,-7.92,;4.16,-9.8,;5.64,-9.4,;1.4,.5,;-.14,.5,;-.62,1.97,;.63,2.87,;.63,4.41,;1.96,5.18,;-.71,5.18,;-.71,6.72,;-2.04,7.49,;-2.04,9.03,;-.71,9.8,;-3.38,9.8,;-4.71,9.03,;-6.04,9.8,;-4.71,7.49,;-3.38,6.72,;-3.38,5.18,;1.87,1.97,;3.21,2.74,)| | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
US Patent
| Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com... |
US Patent US9790212 (2017)
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2 |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259369
(US9505745, 46 | US9505745, 47 | US9790212, Example...)Show SMILES CCC([C@H]1CC[C@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,6.9,(2.06,-3.32,;1.29,-1.98,;-.25,-1.98,;-1.02,-3.32,;-.25,-4.65,;-1.02,-5.98,;-2.56,-5.98,;-3.33,-4.65,;-2.56,-3.32,;-3.33,-7.32,;-2.56,-8.65,;-4.87,-7.32,;-1.02,-.65,;-2.56,-.65,;-3.04,.82,;-1.79,1.72,;-1.79,3.26,;-3.13,4.03,;-.46,4.03,;-.46,5.57,;.87,6.34,;.87,7.88,;-.46,8.65,;2.21,8.65,;3.54,7.88,;4.87,8.65,;3.54,6.34,;2.21,5.57,;2.21,4.03,;-.55,.82,;.79,1.59,)| | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259341
(US9505745, 18 | US9790212, Example 18)Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(7.97,-10.65,;6.88,-9.56,;5.4,-9.96,;5,-11.45,;3.51,-11.84,;3.11,-13.33,;4.2,-14.42,;5.69,-14.02,;6.09,-12.53,;3.8,-15.91,;4.89,-17,;2.31,-16.31,;4.31,-8.87,;2.77,-8.87,;2.29,-7.4,;3.54,-6.5,;3.54,-4.96,;2.2,-4.19,;4.87,-4.19,;4.87,-2.65,;6.2,-1.88,;7.54,-2.65,;7.54,-4.19,;8.87,-4.96,;8.87,-1.88,;8.87,-.34,;10.21,.43,;7.54,.43,;6.2,-.34,;4.87,.43,;4.78,-7.4,;6.27,-7.01,)| | PDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this Ligand-Target Pair | |