Found 76 hits of ki for UniProtKB: P12392 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50100715
(2-(6-Bromo-pyridin-3-yl)-7-aza-bicyclo[2.2.1]hepta...)Show InChI InChI=1S/C11H13BrN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.0550 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute
Curated by ChEMBL
| Assay Description Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in Xenopus oocytes using [3H]-epibatidine as radioligand |
Bioorg Med Chem Lett 14: 1889-96 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.007 BindingDB Entry DOI: 10.7270/Q2S75FR9 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50049757
(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 0.0870 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute
Curated by ChEMBL
| Assay Description Inhibition of [3H]-epibatidine binding to Nicotinic acetylcholine receptor alpha4-beta2 from rat membranes |
Bioorg Med Chem Lett 14: 1889-96 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.007 BindingDB Entry DOI: 10.7270/Q2S75FR9 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50049757
(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago
Curated by ChEMBL
| Assay Description Displacement of [3H]epibatidine from rat alpha-2-beta-4 nACHR expressed in human HEK293 cells |
J Med Chem 49: 2673-6 (2006)
Article DOI: 10.1021/jm051196m BindingDB Entry DOI: 10.7270/Q2GX4F96 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50049757
(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 0.0950 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago
Curated by ChEMBL
| Assay Description Binding affinity towards Nicotinic acetylcholine receptor alpha2-beta4 using [3H]epibatidine |
Bioorg Med Chem Lett 14: 1855-8 (2004)
Article DOI: 10.1016/j.bmcl.2003.10.071 BindingDB Entry DOI: 10.7270/Q269753N |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50049757
(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 0.0950 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center
Curated by ChEMBL
| Assay Description Tested for binding affinity against Nicotinic acetylcholine receptor alpha2-beta4 |
J Med Chem 46: 921-4 (2003)
Article DOI: 10.1021/jm025613w BindingDB Entry DOI: 10.7270/Q2P271VS |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50049757
(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 0.0950 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
| Assay Description In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta4 using 0.5 nM [3H]epibatidine |
Bioorg Med Chem Lett 15: 4385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.039 BindingDB Entry DOI: 10.7270/Q2H41V62 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50475407
(CHEMBL198228)Show SMILES CN1C2CCC1C(C2)c1cnc(Cl)c(c1)-c1ccccc1 |TLB:0:1:6.7:4.3,THB:8:6:1:4.3| Show InChI InChI=1S/C18H19ClN2/c1-21-14-7-8-17(21)15(10-14)13-9-16(18(19)20-11-13)12-5-3-2-4-6-12/h2-6,9,11,14-15,17H,7-8,10H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
| Assay Description In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta4 using 0.5 nM [3H]epibatidine |
Bioorg Med Chem Lett 15: 4385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.039 BindingDB Entry DOI: 10.7270/Q2H41V62 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50106490
(2-(6-Chloro-5-phenyl-pyridin-3-yl)-7-aza-bicyclo[2...)Show SMILES Clc1ncc(cc1-c1ccccc1)C1CC2CCC1N2 |THB:4:13:19:17.16| Show InChI InChI=1S/C17H17ClN2/c18-17-15(11-4-2-1-3-5-11)8-12(10-19-17)14-9-13-6-7-16(14)20-13/h1-5,8,10,13-14,16,20H,6-7,9H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.470 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
| Assay Description In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta4 using 0.5 nM [3H]epibatidine |
Bioorg Med Chem Lett 15: 4385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.039 BindingDB Entry DOI: 10.7270/Q2H41V62 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50475411
(CHEMBL197830)Show SMILES Cc1ccc(cc1)-c1cc(cnc1F)C1CC2CCC1N2 |TLB:9:14:20:18.17| Show InChI InChI=1S/C18H19FN2/c1-11-2-4-12(5-3-11)16-8-13(10-20-18(16)19)15-9-14-6-7-17(15)21-14/h2-5,8,10,14-15,17,21H,6-7,9H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.541 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
| Assay Description In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta4 using 0.5 nM [3H]epibatidine |
Bioorg Med Chem Lett 15: 4385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.039 BindingDB Entry DOI: 10.7270/Q2H41V62 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50475410
(CHEMBL372133)Show SMILES COc1ccc(cc1)-c1cc(cnc1Cl)C1CC2CCC1N2 |TLB:10:15:21:19.18| Show InChI InChI=1S/C18H19ClN2O/c1-22-14-5-2-11(3-6-14)16-8-12(10-20-18(16)19)15-9-13-4-7-17(15)21-13/h2-3,5-6,8,10,13,15,17,21H,4,7,9H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.862 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
| Assay Description In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta4 using 0.5 nM [3H]epibatidine |
Bioorg Med Chem Lett 15: 4385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.039 BindingDB Entry DOI: 10.7270/Q2H41V62 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50100707
((R)-2-(6-Fluoro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]...)Show InChI InChI=1S/C11H13FN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute
Curated by ChEMBL
| Assay Description Binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta4 expressed in Xenopus oocytes using [3H]epibatidine as radioligand |
Bioorg Med Chem Lett 14: 1889-96 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.007 BindingDB Entry DOI: 10.7270/Q2S75FR9 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50100717
(2-(pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane | 2-P...)Show InChI InChI=1S/C11H14N2/c1-2-8(7-12-5-1)10-6-9-3-4-11(10)13-9/h1-2,5,7,9-11,13H,3-4,6H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute
Curated by ChEMBL
| Assay Description Binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta4 expressed in Xenopus oocytes using [3H]-epibatidine as radioligand |
Bioorg Med Chem Lett 14: 1889-96 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.007 BindingDB Entry DOI: 10.7270/Q2S75FR9 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50100713
(5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-pyridin-2-ylamin...)Show InChI InChI=1S/C11H15N3/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2,(H2,12,13) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute
Curated by ChEMBL
| Assay Description Inhibition of [3H]-nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 from rat membranes |
Bioorg Med Chem Lett 14: 1889-96 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.007 BindingDB Entry DOI: 10.7270/Q2S75FR9 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50171007
(4-[5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-2-fluoro-pyri...)Show SMILES Fc1ncc(cc1-c1ccc(cc1)C#N)C1CC2CCC1N2 |TLB:4:15:21:19.18| Show InChI InChI=1S/C18H16FN3/c19-18-16(12-3-1-11(9-20)2-4-12)7-13(10-21-18)15-8-14-5-6-17(15)22-14/h1-4,7,10,14-15,17,22H,5-6,8H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
| Assay Description In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta4 using 0.5 nM [3H]epibatidine |
Bioorg Med Chem Lett 15: 4385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.039 BindingDB Entry DOI: 10.7270/Q2H41V62 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM86816
(CAS_45263769 | NSC_45263769 | rac-2-(5-(4-chloroph...)Show SMILES Fc1ncc(cc1-c1ccc(Cl)cc1)C1CC2CCC1N2 |TLB:4:14:17.18:20| Show InChI InChI=1S/C17H16ClFN2/c18-12-3-1-10(2-4-12)15-7-11(9-20-17(15)19)14-8-13-5-6-16(14)21-13/h1-4,7,9,13-14,16,21H,5-6,8H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 4.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
| Assay Description In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta4 using 0.5 nM [3H]epibatidine |
Bioorg Med Chem Lett 15: 4385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.039 BindingDB Entry DOI: 10.7270/Q2H41V62 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50475409
(CHEMBL197526)Show SMILES Cc1ccc(cc1)-c1cc(cnc1Cl)C1CC2CCC1N2 |TLB:9:14:20:18.17| Show InChI InChI=1S/C18H19ClN2/c1-11-2-4-12(5-3-11)16-8-13(10-20-18(16)19)15-9-14-6-7-17(15)21-14/h2-5,8,10,14-15,17,21H,6-7,9H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 5.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
| Assay Description In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta4 using 0.5 nM [3H]epibatidine |
Bioorg Med Chem Lett 15: 4385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.039 BindingDB Entry DOI: 10.7270/Q2H41V62 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50143282
((-)-cytisine | (1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-m...)Show InChI InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8?,9-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 5.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago
Curated by ChEMBL
| Assay Description Displacement of [3H]epibatidine from rat alpha-2-beta-4 nACHR expressed in human HEK293 cells |
J Med Chem 49: 2673-6 (2006)
Article DOI: 10.1021/jm051196m BindingDB Entry DOI: 10.7270/Q2GX4F96 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM86815
(CAS_45266019 | NSC_45266019 | rac-2-(6-fluoro-5-(4...)Show SMILES Fc1ccc(cc1)-c1cc(cnc1F)C1CC2CCC1N2 |TLB:9:14:17.18:20| Show InChI InChI=1S/C17H16F2N2/c18-12-3-1-10(2-4-12)15-7-11(9-20-17(15)19)14-8-13-5-6-16(14)21-13/h1-4,7,9,13-14,16,21H,5-6,8H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 6.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
| Assay Description In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta4 using 0.5 nM [3H]epibatidine |
Bioorg Med Chem Lett 15: 4385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.039 BindingDB Entry DOI: 10.7270/Q2H41V62 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50475406
(CHEMBL372326)Show SMILES Fc1ncc(cc1-c1ccc(Cl)c(Cl)c1)C1CC2CCC1N2 |TLB:4:15:21:19.18| Show InChI InChI=1S/C17H15Cl2FN2/c18-14-3-1-9(6-15(14)19)13-5-10(8-21-17(13)20)12-7-11-2-4-16(12)22-11/h1,3,5-6,8,11-12,16,22H,2,4,7H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
| Assay Description In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta4 using 0.5 nM [3H]epibatidine |
Bioorg Med Chem Lett 15: 4385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.039 BindingDB Entry DOI: 10.7270/Q2H41V62 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50475816
(CHEMBL205644)Show InChI InChI=1S/C13H16N2O/c1-2-10-3-4-12-11-5-9(6-14-7-11)8-15(12)13(10)16/h2-4,9,11,14H,1,5-8H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago
Curated by ChEMBL
| Assay Description Displacement of [3H]epibatidine from rat alpha-2-beta-4 nACHR expressed in human HEK293 cells |
J Med Chem 49: 2673-6 (2006)
Article DOI: 10.1021/jm051196m BindingDB Entry DOI: 10.7270/Q2GX4F96 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50216347
((1R,4R)-2-(3-pyridinyl)-2,5-diazabicyclo[2.2.1]hep...)Show InChI InChI=1S/C10H13N3/c1-2-9(5-11-3-1)13-7-8-4-10(13)6-12-8/h1-3,5,8,10,12H,4,6-7H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago
Curated by ChEMBL
| Assay Description Displacement of [3H]epibatidine from rat alpha2beta4 nAChR by liquid scintillation counting |
Eur J Med Chem 124: 689-697 (2016)
Article DOI: 10.1016/j.ejmech.2016.09.016 BindingDB Entry DOI: 10.7270/Q2H41TDB |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50106488
(2-(6-Fluoro-5-phenyl-pyridin-3-yl)-7-aza-bicyclo[2...)Show SMILES Fc1ncc(cc1-c1ccccc1)C1CC2CCC1N2 |THB:4:13:19:17.16| Show InChI InChI=1S/C17H17FN2/c18-17-15(11-4-2-1-3-5-11)8-12(10-19-17)14-9-13-6-7-16(14)20-13/h1-5,8,10,13-14,16,20H,6-7,9H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
| Assay Description In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta4 using 0.5 nM [3H]epibatidine |
Bioorg Med Chem Lett 15: 4385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.039 BindingDB Entry DOI: 10.7270/Q2H41V62 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50452056
(CHEMBL417586)Show SMILES Clc1ccc(cn1)C1CC2CCC1N2CCN1C2CCC1C(C2)c1ccc(Cl)nc1 |TLB:23:21:16:19.18,14:13:7.8:11.10,THB:4:7:13:11.10,15:16:21.22:19.18| Show InChI InChI=1S/C24H28Cl2N4/c25-23-7-1-15(13-27-23)19-11-17-3-5-21(19)29(17)9-10-30-18-4-6-22(30)20(12-18)16-2-8-24(26)28-14-16/h1-2,7-8,13-14,17-22H,3-6,9-12H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago
Curated by ChEMBL
| Assay Description Binding affinity towards Nicotinic acetylcholine receptor alpha3-beta2 using [3H]epibatidine |
Bioorg Med Chem Lett 14: 1855-8 (2004)
Article DOI: 10.1016/j.bmcl.2003.10.071 BindingDB Entry DOI: 10.7270/Q269753N |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50475408
(CHEMBL382533)Show SMILES Cc1cccc(c1)-c1cc(cnc1F)C1CC2CCC1N2 |TLB:9:14:20:18.17| Show InChI InChI=1S/C18H19FN2/c1-11-3-2-4-12(7-11)16-8-13(10-20-18(16)19)15-9-14-5-6-17(15)21-14/h2-4,7-8,10,14-15,17,21H,5-6,9H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
| Assay Description In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta4 using 0.5 nM [3H]epibatidine |
Bioorg Med Chem Lett 15: 4385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.039 BindingDB Entry DOI: 10.7270/Q2H41V62 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50474544
(CHEMBL170873)Show SMILES Clc1ccc2C3C4CCC(N4)C3CCc2n1 |TLB:12:11:10:7.8,THB:4:5:10:7.8| Show InChI InChI=1S/C13H15ClN2/c14-12-6-2-8-10(16-12)3-1-7-9-4-5-11(15-9)13(7)8/h2,6-7,9,11,13,15H,1,3-5H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center
Curated by ChEMBL
| Assay Description Tested for binding affinity against Nicotinic acetylcholine receptor alpha2-beta4 |
J Med Chem 46: 921-4 (2003)
Article DOI: 10.1021/jm025613w BindingDB Entry DOI: 10.7270/Q2P271VS |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50452054
(CHEMBL53620)Show SMILES Clc1ccc(cn1)C1CC2CCC1N2CCCCCCN1C2CCC1C(C2)c1ccc(Cl)nc1 |TLB:14:13:7.8:11.10,27:25:20:23.22,THB:19:20:25.26:23.22,4:7:13:11.10| Show InChI InChI=1S/C28H36Cl2N4/c29-27-11-5-19(17-31-27)23-15-21-7-9-25(23)33(21)13-3-1-2-4-14-34-22-8-10-26(34)24(16-22)20-6-12-28(30)32-18-20/h5-6,11-12,17-18,21-26H,1-4,7-10,13-16H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 48 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago
Curated by ChEMBL
| Assay Description Binding affinity towards Nicotinic acetylcholine receptor alpha3-beta2 using [3H]epibatidine |
Bioorg Med Chem Lett 14: 1855-8 (2004)
Article DOI: 10.1016/j.bmcl.2003.10.071 BindingDB Entry DOI: 10.7270/Q269753N |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50452053
(CHEMBL55732)Show SMILES Clc1ccc(cn1)C1CC2CCC1N2CCCN1C2CCC1C(C2)c1ccc(Cl)nc1 |TLB:14:13:7.8:11.10,24:22:17:20.19,THB:4:7:13:11.10| Show InChI InChI=1S/C25H30Cl2N4/c26-24-8-2-16(14-28-24)20-12-18-4-6-22(20)30(18)10-1-11-31-19-5-7-23(31)21(13-19)17-3-9-25(27)29-15-17/h2-3,8-9,14-15,18-23H,1,4-7,10-13H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 57 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago
Curated by ChEMBL
| Assay Description Binding affinity towards Nicotinic acetylcholine receptor alpha3-beta4 using [3H]epibatidine |
Bioorg Med Chem Lett 14: 1855-8 (2004)
Article DOI: 10.1016/j.bmcl.2003.10.071 BindingDB Entry DOI: 10.7270/Q269753N |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50475405
(CHEMBL197725)Show SMILES Cc1cc(ccc1F)-c1cc(cnc1F)C1CC2CCC1N2 |TLB:10:15:21:19.18| Show InChI InChI=1S/C18H18F2N2/c1-10-6-11(2-4-16(10)19)15-7-12(9-21-18(15)20)14-8-13-3-5-17(14)22-13/h2,4,6-7,9,13-14,17,22H,3,5,8H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
| Assay Description In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta4 using 0.5 nM [3H]epibatidine |
Bioorg Med Chem Lett 15: 4385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.039 BindingDB Entry DOI: 10.7270/Q2H41V62 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50088438
(1-(pyridin-3-yl)-1,4-diazepane | 1-Pyridin-3-yl-[1...)Show InChI InChI=1S/C10H15N3/c1-3-10(9-12-4-1)13-7-2-5-11-6-8-13/h1,3-4,9,11H,2,5-8H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 62 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago
Curated by ChEMBL
| Assay Description Displacement of [3H]epibatidine from rat alpha2beta4 nAChR by liquid scintillation counting |
Eur J Med Chem 124: 689-697 (2016)
Article DOI: 10.1016/j.ejmech.2016.09.016 BindingDB Entry DOI: 10.7270/Q2H41TDB |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50452055
(CHEMBL56045)Show SMILES Clc1ccc(cn1)C1CC2CCC1N2CCCCCCCCCCN1C2CCC1C(C2)c1ccc(Cl)nc1 |TLB:14:13:7.8:11.10,31:29:24:27.26,THB:23:24:29.30:27.26,4:7:13:11.10| Show InChI InChI=1S/C32H44Cl2N4/c33-31-15-9-23(21-35-31)27-19-25-11-13-29(27)37(25)17-7-5-3-1-2-4-6-8-18-38-26-12-14-30(38)28(20-26)24-10-16-32(34)36-22-24/h9-10,15-16,21-22,25-30H,1-8,11-14,17-20H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 72 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago
Curated by ChEMBL
| Assay Description Binding affinity towards Nicotinic acetylcholine receptor alpha3-beta2 using [3H]epibatidine |
Bioorg Med Chem Lett 14: 1855-8 (2004)
Article DOI: 10.1016/j.bmcl.2003.10.071 BindingDB Entry DOI: 10.7270/Q269753N |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM221048
(US9284322, varenicline | US9303017, Varenicline)Show InChI InChI=1S/C13H13N3/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1/h1-2,4-5,8-9,14H,3,6-7H2/t8-,9+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
DrugBank MCE PC cid PC sid PDB UniChem
| US Patent
| 94 | -8.90 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Georgetown University; Duke University
US Patent
| Assay Description Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.... |
US Patent US9303017 (2016)
BindingDB Entry DOI: 10.7270/Q25X27SF |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50166908
(5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca...)Show InChI InChI=1S/C13H13N3/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1/h1-2,4-5,8-9,14H,3,6-7H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| US Patent
| 94 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
BioCryst Pharmaceuticals
| |
Bioorg Med Chem 17: 3934-58 (2009)
BindingDB Entry DOI: 10.7270/Q24T6MQ8 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM82070
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
KEGG PC cid PC sid PDB UniChem
Similars
| US Patent
| 110 | -8.82 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Georgetown University; Duke University
US Patent
| Assay Description Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.... |
US Patent US9303017 (2016)
BindingDB Entry DOI: 10.7270/Q25X27SF |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50004108
((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem
Patents
Similars
| US Patent
| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
BioCryst Pharmaceuticals
| |
Bioorg Med Chem 17: 3934-58 (2009)
BindingDB Entry DOI: 10.7270/Q24T6MQ8 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM82070
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
KEGG PC cid PC sid PDB UniChem
Similars
| Article PubMed
| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
| Assay Description In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta4 using 0.5 nM [3H]epibatidine |
Bioorg Med Chem Lett 15: 4385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.039 BindingDB Entry DOI: 10.7270/Q2H41V62 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM82070
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
KEGG PC cid PC sid PDB UniChem
Similars
| Article PubMed
| 112 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago
Curated by ChEMBL
| Assay Description Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 using [3H]epibatidine |
Bioorg Med Chem Lett 14: 1855-8 (2004)
Article DOI: 10.1016/j.bmcl.2003.10.071 BindingDB Entry DOI: 10.7270/Q269753N |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM82070
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
KEGG PC cid PC sid PDB UniChem
Similars
| Article PubMed
| 112 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center
Curated by ChEMBL
| Assay Description Tested for binding affinity against Nicotinic acetylcholine receptor alpha2-beta4 |
J Med Chem 46: 921-4 (2003)
Article DOI: 10.1021/jm025613w BindingDB Entry DOI: 10.7270/Q2P271VS |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50475815
(CHEMBL379303)Show InChI InChI=1S/C12H16N2O/c1-8-2-11-10-4-9(5-13-6-10)7-14(11)12(15)3-8/h2-3,9-10,13H,4-7H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago
Curated by ChEMBL
| Assay Description Displacement of [3H]epibatidine from rat alpha-2-beta-4 nACHR expressed in human HEK293 cells |
J Med Chem 49: 2673-6 (2006)
Article DOI: 10.1021/jm051196m BindingDB Entry DOI: 10.7270/Q2GX4F96 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50382474
(CHEMBL2024096 | US9303017, Sazetidine-A)Show InChI InChI=1S/C15H20N2O2/c18-8-4-2-1-3-5-13-9-15(11-16-10-13)19-12-14-6-7-17-14/h9-11,14,17-18H,1-2,4,6-8,12H2/t14-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| 210 | -8.46 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Georgetown University; Duke University
US Patent
| Assay Description Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.... |
US Patent US9303017 (2016)
BindingDB Entry DOI: 10.7270/Q25X27SF |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM397477
(US9993465, Sazetidine-A)Show InChI InChI=1S/C15H20N2O2/c1-12-15(19-11-14-6-7-16-14)9-13(10-17-12)5-3-2-4-8-18/h9-10,14,16,18H,2,4,6-8,11H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
BioCryst Pharmaceuticals
| |
Bioorg Med Chem 17: 3934-58 (2009)
BindingDB Entry DOI: 10.7270/Q24T6MQ8 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50210335
(CHEMBL3898434)Show SMILES [H][C@@]1(CCOC)C[C@@]1([H])c1cncc(c1)N1CCCNCC1 |r| Show InChI InChI=1S/C16H25N3O/c1-20-8-3-13-10-16(13)14-9-15(12-18-11-14)19-6-2-4-17-5-7-19/h9,11-13,16-17H,2-8,10H2,1H3/t13-,16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 256 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago
Curated by ChEMBL
| Assay Description Displacement of [3H]epibatidine from rat alpha2beta4 nAChR by liquid scintillation counting |
Eur J Med Chem 124: 689-697 (2016)
Article DOI: 10.1016/j.ejmech.2016.09.016 BindingDB Entry DOI: 10.7270/Q2H41TDB |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50475814
(CHEMBL208438)Show InChI InChI=1S/C12H16N2O2/c15-7-8-2-11-10-1-9(4-13-5-10)6-14(11)12(16)3-8/h2-3,9-10,13,15H,1,4-7H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago
Curated by ChEMBL
| Assay Description Displacement of [3H]epibatidine from rat alpha-2-beta-4 nACHR expressed in human HEK293 cells |
J Med Chem 49: 2673-6 (2006)
Article DOI: 10.1021/jm051196m BindingDB Entry DOI: 10.7270/Q2GX4F96 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50210337
(CHEMBL3970672)Show InChI InChI=1S/C15H20N4O2/c20-7-2-13-9-15(21-18-13)12-8-14(11-17-10-12)19-5-1-3-16-4-6-19/h8-11,16,20H,1-7H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 331 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago
Curated by ChEMBL
| Assay Description Displacement of [3H]epibatidine from rat alpha2beta4 nAChR by liquid scintillation counting |
Eur J Med Chem 124: 689-697 (2016)
Article DOI: 10.1016/j.ejmech.2016.09.016 BindingDB Entry DOI: 10.7270/Q2H41TDB |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50210334
(CHEMBL3948977)Show SMILES [H][C@]1(CCOC)C[C@]1([H])c1cncc(c1)N1CCCNCC1 |r| Show InChI InChI=1S/C16H25N3O/c1-20-8-3-13-10-16(13)14-9-15(12-18-11-14)19-6-2-4-17-5-7-19/h9,11-13,16-17H,2-8,10H2,1H3/t13-,16-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 460 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago
Curated by ChEMBL
| Assay Description Displacement of [3H]epibatidine from rat alpha2beta4 nAChR by liquid scintillation counting |
Eur J Med Chem 124: 689-697 (2016)
Article DOI: 10.1016/j.ejmech.2016.09.016 BindingDB Entry DOI: 10.7270/Q2H41TDB |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50474542
(CHEMBL425135)Show SMILES Clc1cc2CCC3C4CCC(N4)C3c2cn1 |TLB:5:6:11:9.8,THB:13:12:11:9.8| Show InChI InChI=1S/C13H15ClN2/c14-12-5-7-1-2-8-10-3-4-11(16-10)13(8)9(7)6-15-12/h5-6,8,10-11,13,16H,1-4H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 717 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center
Curated by ChEMBL
| Assay Description Tested for binding affinity against Nicotinic acetylcholine receptor alpha2-beta4 |
J Med Chem 46: 921-4 (2003)
Article DOI: 10.1021/jm025613w BindingDB Entry DOI: 10.7270/Q2P271VS |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50168255
((+/-)6-(2-Phenylethyl)nicotine | 5-(1-Methyl-pyrro...)Show InChI InChI=1S/C18H22N2/c1-20-13-5-8-18(20)16-10-12-17(19-14-16)11-9-15-6-3-2-4-7-15/h2-4,6-7,10,12,14,18H,5,8-9,11,13H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University
Curated by ChEMBL
| Assay Description Binding affinity for rat Nicotinic acetylcholine receptor alpha2-beta4 |
Bioorg Med Chem Lett 15: 3237-40 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.072 BindingDB Entry DOI: 10.7270/Q2DF6TZK |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50475822
(CHEMBL208066)Show InChI InChI=1S/C16H18N2OS/c1-10-2-5-15(20-10)13-3-4-14-12-6-11(7-17-8-12)9-18(14)16(13)19/h2-5,11-12,17H,6-9H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago
Curated by ChEMBL
| Assay Description Displacement of [3H]epibatidine from rat alpha-2-beta-4 nACHR expressed in human HEK293 cells |
J Med Chem 49: 2673-6 (2006)
Article DOI: 10.1021/jm051196m BindingDB Entry DOI: 10.7270/Q2GX4F96 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50210338
(CHEMBL3926480)Show SMILES [H][C@]1(CCOC)C[C@]1([H])c1cncc(c1)N1C[C@]2([H])C[C@@]1([H])CN2 |r| Show InChI InChI=1S/C16H23N3O/c1-20-3-2-11-5-16(11)12-4-14(8-17-7-12)19-10-13-6-15(19)9-18-13/h4,7-8,11,13,15-16,18H,2-3,5-6,9-10H2,1H3/t11-,13-,15-,16-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 4.81E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago
Curated by ChEMBL
| Assay Description Displacement of [3H]epibatidine from rat alpha2beta4 nAChR by liquid scintillation counting |
Eur J Med Chem 124: 689-697 (2016)
Article DOI: 10.1016/j.ejmech.2016.09.016 BindingDB Entry DOI: 10.7270/Q2H41TDB |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50474543
(CHEMBL367641)Show SMILES Clc1ccc2c(CCC22CC3CCC2N3)n1 |THB:7:8:14:12.11| Show InChI InChI=1S/C13H15ClN2/c14-12-4-2-9-10(16-12)5-6-13(9)7-8-1-3-11(13)15-8/h2,4,8,11,15H,1,3,5-7H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 7.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center
Curated by ChEMBL
| Assay Description Tested for binding affinity against Nicotinic acetylcholine receptor alpha2-beta4 |
J Med Chem 46: 921-4 (2003)
Article DOI: 10.1021/jm025613w BindingDB Entry DOI: 10.7270/Q2P271VS |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-2/beta-4
(Rattus norvegicus (Rat)) | BDBM50475811
(CHEMBL382845)Show InChI InChI=1S/C17H17FN2O/c18-14-3-1-12(2-4-14)15-5-6-16-13-7-11(8-19-9-13)10-20(16)17(15)21/h1-6,11,13,19H,7-10H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 8.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago
Curated by ChEMBL
| Assay Description Displacement of [3H]epibatidine from rat alpha-2-beta-4 nACHR expressed in human HEK293 cells |
J Med Chem 49: 2673-6 (2006)
Article DOI: 10.1021/jm051196m BindingDB Entry DOI: 10.7270/Q2GX4F96 |
More data for this Ligand-Target Pair | |