Found 1488 hits of ic50 for UniProtKB: P27815 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50415001
(CHEMBL570015 | GSK-256066 | GSK-256066 (3))Show SMILES COc1cccc(Nc2c(cnc3c(C)cc(cc23)S(=O)(=O)c2cccc(c2)C(=O)N(C)C)C(N)=O)c1 Show InChI InChI=1S/C27H26N4O5S/c1-16-11-21(37(34,35)20-10-5-7-17(12-20)27(33)31(2)3)14-22-24(16)29-15-23(26(28)32)25(22)30-18-8-6-9-19(13-18)36-4/h5-15H,1-4H3,(H2,28,32)(H,29,30) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 0.00300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113877 BindingDB Entry DOI: 10.7270/Q2PK0M78 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50415001
(CHEMBL570015 | GSK-256066 | GSK-256066 (3))Show SMILES COc1cccc(Nc2c(cnc3c(C)cc(cc23)S(=O)(=O)c2cccc(c2)C(=O)N(C)C)C(N)=O)c1 Show InChI InChI=1S/C27H26N4O5S/c1-16-11-21(37(34,35)20-10-5-7-17(12-20)27(33)31(2)3)14-22-24(16)29-15-23(26(28)32)25(22)30-18-8-6-9-19(13-18)36-4/h5-15H,1-4H3,(H2,28,32)(H,29,30) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 0.00300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human PDE4 expressed in Saccharomyces cerevisiae preincubated for 30 mins followed by cAMP substrate addition |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.9b02170 BindingDB Entry DOI: 10.7270/Q2W95DVV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495704
(Chf-6001 | Chf6001 | J3.309.618F)Show SMILES CS(=O)(=O)Nc1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C30H30Cl2F2N2O8S/c1-45(39,40)35-24-8-6-20(11-27(24)41-15-17-2-3-17)29(37)43-26(12-21-22(31)13-36(38)14-23(21)32)19-7-9-25(44-30(33)34)28(10-19)42-16-18-4-5-18/h6-11,13-14,17-18,26,30,35H,2-5,12,15-16H2,1H3/t26-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0260 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of PDE4 in human U937 cell lysate using cAMP as substrate by LANCE assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.9b02170 BindingDB Entry DOI: 10.7270/Q2W95DVV |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495709
(CHEMBL3113966)Show SMILES Cc1ccc(cc1NS(C)(=O)=O)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C27H26Cl2F2N2O7S/c1-15-3-6-18(9-22(15)32-41(2,36)37)26(34)39-24(11-19-20(28)12-33(35)13-21(19)29)17-7-8-23(40-27(30)31)25(10-17)38-14-16-4-5-16/h3,6-10,12-13,16,24,27,32H,4-5,11,14H2,1-2H3/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495735
(CHEMBL3113954)Show SMILES CS(=O)(=O)Nc1ccc(cc1CO)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C27H26Cl2F2N2O8S/c1-42(37,38)32-22-6-4-17(8-18(22)13-34)26(35)40-24(10-19-20(28)11-33(36)12-21(19)29)16-5-7-23(41-27(30)31)25(9-16)39-14-15-2-3-15/h4-9,11-12,15,24,27,32,34H,2-3,10,13-14H2,1H3/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50199701
(CHEMBL3968147)Show SMILES CCn1nc(cc(NC(=O)Nc2c(Cl)cncc2Cl)c1=O)-c1cccc(c1)-c1cccc(c1)C(=O)NCCCCCCCN(C)CCO Show InChI InChI=1S/C35H41Cl2N7O4/c1-3-44-34(47)31(40-35(48)41-32-28(36)22-38-23-29(32)37)21-30(42-44)26-13-9-11-24(19-26)25-12-10-14-27(20-25)33(46)39-15-7-5-4-6-8-16-43(2)17-18-45/h9-14,19-23,45H,3-8,15-18H2,1-2H3,(H,39,46)(H2,38,40,41,48) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of PDE4 (unknown origin) expressed in Saccharomyces cerevisiae using [3H] cAMP as substrate incubated for 1 hr by scintillation proximity ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.9b02170 BindingDB Entry DOI: 10.7270/Q2W95DVV |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495750
(CHEMBL3113949)Show SMILES COc1ccc(cc1S(=O)(=O)N(C)C)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C28H28Cl2F2N2O8S/c1-33(2)43(37,38)26-11-18(7-9-23(26)39-3)27(35)41-24(12-19-20(29)13-34(36)14-21(19)30)17-6-8-22(42-28(31)32)25(10-17)40-15-16-4-5-16/h6-11,13-14,16,24,28H,4-5,12,15H2,1-3H3/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495736
(CHEMBL3113948)Show SMILES CNS(=O)(=O)c1cc(ccc1OC)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C27H26Cl2F2N2O8S/c1-32-42(36,37)25-10-17(6-8-22(25)38-2)26(34)40-23(11-18-19(28)12-33(35)13-20(18)29)16-5-7-21(41-27(30)31)24(9-16)39-14-15-3-4-15/h5-10,12-13,15,23,27,32H,3-4,11,14H2,1-2H3/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495733
(CHEMBL3113962)Show SMILES Oc1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C29H27Cl2F2NO7/c30-21-12-34(37)13-22(31)20(21)11-25(18-6-8-24(41-29(32)33)27(9-18)39-15-17-3-4-17)40-28(36)19-5-7-23(35)26(10-19)38-14-16-1-2-16/h5-10,12-13,16-17,25,29,35H,1-4,11,14-15H2/t25-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495747
(CHEMBL3113968)Show SMILES COc1ccc(NS(C)(=O)=O)cc1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C27H26Cl2F2N2O8S/c1-38-22-8-6-17(32-42(2,36)37)10-19(22)26(34)40-24(11-18-20(28)12-33(35)13-21(18)29)16-5-7-23(41-27(30)31)25(9-16)39-14-15-3-4-15/h5-10,12-13,15,24,27,32H,3-4,11,14H2,1-2H3/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495710
(CHEMBL3113976)Show SMILES COc1ccc(cc1NS(C)(=O)=O)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C27H26Cl2F2N2O8S/c1-38-22-7-6-17(9-21(22)32-42(2,36)37)26(34)40-24(11-18-19(28)12-33(35)13-20(18)29)16-5-8-23(41-27(30)31)25(10-16)39-14-15-3-4-15/h5-10,12-13,15,24,27,32H,3-4,11,14H2,1-2H3/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495704
(Chf-6001 | Chf6001 | J3.309.618F)Show SMILES CS(=O)(=O)Nc1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C30H30Cl2F2N2O8S/c1-45(39,40)35-24-8-6-20(11-27(24)41-15-17-2-3-17)29(37)43-26(12-21-22(31)13-36(38)14-23(21)32)19-7-9-25(44-30(33)34)28(10-19)42-16-18-4-5-18/h6-11,13-14,17-18,26,30,35H,2-5,12,15-16H2,1H3/t26-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495703
(CHEMBL3113943)Show SMILES COc1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C30H29Cl2F2NO7/c1-38-24-8-7-20(11-27(24)39-15-17-2-3-17)29(36)41-26(12-21-22(31)13-35(37)14-23(21)32)19-6-9-25(42-30(33)34)28(10-19)40-16-18-4-5-18/h6-11,13-14,17-18,26,30H,2-5,12,15-16H2,1H3/t26-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISA |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495724
(CHEMBL3113950)Show SMILES CS(=O)(=O)Nc1ccc(cc1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C26H24Cl2F2N2O7S/c1-40(35,36)31-18-7-4-16(5-8-18)25(33)38-23(11-19-20(27)12-32(34)13-21(19)28)17-6-9-22(39-26(29)30)24(10-17)37-14-15-2-3-15/h4-10,12-13,15,23,26,31H,2-3,11,14H2,1H3/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495703
(CHEMBL3113943)Show SMILES COc1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C30H29Cl2F2NO7/c1-38-24-8-7-20(11-27(24)39-15-17-2-3-17)29(36)41-26(12-21-22(31)13-35(37)14-23(21)32)19-6-9-25(42-30(33)34)28(10-19)40-16-18-4-5-18/h6-11,13-14,17-18,26,30H,2-5,12,15-16H2,1H3/t26-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495725
(CHEMBL3113946)Show SMILES COc1ccc(cc1OC(C)=O)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C28H25Cl2F2NO8/c1-15(34)39-26-10-18(6-7-22(26)37-2)27(35)40-24(11-19-20(29)12-33(36)13-21(19)30)17-5-8-23(41-28(31)32)25(9-17)38-14-16-3-4-16/h5-10,12-13,16,24,28H,3-4,11,14H2,1-2H3/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495705
(CHEMBL3113964)Show SMILES OC(=O)c1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C30H27Cl2F2NO8/c31-22-12-35(39)13-23(32)21(22)11-25(18-6-8-24(43-30(33)34)27(9-18)41-15-17-3-4-17)42-29(38)19-5-7-20(28(36)37)26(10-19)40-14-16-1-2-16/h5-10,12-13,16-17,25,30H,1-4,11,14-15H2,(H,36,37)/t25-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50559711
(CHEMBL4800045)Show SMILES CCNC(=O)c1cc(cc(c1)-c1cc(NC(=O)Nc2c(Cl)cncc2Cl)c(=O)n(CC)n1)C(=O)NCCCN(C)C | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of PDE4 (unknown origin) expressed in Saccharomyces cerevisiae using [3H] cAMP as substrate incubated for 1 hr by scintillation proximity ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.9b02170 BindingDB Entry DOI: 10.7270/Q2W95DVV |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495746
(CHEMBL3113953)Show SMILES Cc1cc(ccc1NS(C)(=O)=O)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C27H26Cl2F2N2O7S/c1-15-9-18(5-7-22(15)32-41(2,36)37)26(34)39-24(11-19-20(28)12-33(35)13-21(19)29)17-6-8-23(40-27(30)31)25(10-17)38-14-16-3-4-16/h5-10,12-13,16,24,27,32H,3-4,11,14H2,1-2H3/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50223276
(CHEMBL65426)Show SMILES ONC(=O)CN1CCC(CC1)(C#N)c1ccc(OC(F)F)c(OC2CCCC2)c1 Show InChI InChI=1S/C20H25F2N3O4/c21-19(22)29-16-6-5-14(11-17(16)28-15-3-1-2-4-15)20(13-23)7-9-25(10-8-20)12-18(26)24-27/h5-6,11,15,19,27H,1-4,7-10,12H2,(H,24,26) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.0510 | n/a | n/a | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase 4 (PDE4) prepared from human U937 cells |
Bioorg Med Chem Lett 14: 207-10 (2004)
BindingDB Entry DOI: 10.7270/Q21G0PFV |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495718
(CHEMBL3113967)Show SMILES CS(=O)(=O)Nc1cc(OCC2CC2)cc(c1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C30H30Cl2F2N2O8S/c1-45(39,40)35-21-8-20(9-22(11-21)41-15-17-2-3-17)29(37)43-27(12-23-24(31)13-36(38)14-25(23)32)19-6-7-26(44-30(33)34)28(10-19)42-16-18-4-5-18/h6-11,13-14,17-18,27,30,35H,2-5,12,15-16H2,1H3/t27-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495723
(CHEMBL3113951)Show SMILES COc1cc(ccc1NS(C)(=O)=O)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C27H26Cl2F2N2O8S/c1-38-24-10-17(5-7-21(24)32-42(2,36)37)26(34)40-23(11-18-19(28)12-33(35)13-20(18)29)16-6-8-22(41-27(30)31)25(9-16)39-14-15-3-4-15/h5-10,12-13,15,23,27,32H,3-4,11,14H2,1-2H3/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495710
(CHEMBL3113976)Show SMILES COc1ccc(cc1NS(C)(=O)=O)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C27H26Cl2F2N2O8S/c1-38-22-7-6-17(9-21(22)32-42(2,36)37)26(34)40-24(11-18-19(28)12-33(35)13-20(18)29)16-5-8-23(41-27(30)31)25(10-16)39-14-15-3-4-15/h5-10,12-13,15,24,27,32H,3-4,11,14H2,1-2H3/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISA |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495704
(Chf-6001 | Chf6001 | J3.309.618F)Show SMILES CS(=O)(=O)Nc1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C30H30Cl2F2N2O8S/c1-45(39,40)35-24-8-6-20(11-27(24)41-15-17-2-3-17)29(37)43-26(12-21-22(31)13-36(38)14-23(21)32)19-7-9-25(44-30(33)34)28(10-19)42-16-18-4-5-18/h6-11,13-14,17-18,26,30,35H,2-5,12,15-16H2,1H3/t26-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISA |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495722
(CHEMBL3113955)Show SMILES COc1cc(NS(C)(=O)=O)ccc1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C27H26Cl2F2N2O8S/c1-38-24-10-17(32-42(2,36)37)6-7-18(24)26(34)40-23(11-19-20(28)12-33(35)13-21(19)29)16-5-8-22(41-27(30)31)25(9-16)39-14-15-3-4-15/h5-10,12-13,15,23,27,32H,3-4,11,14H2,1-2H3/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495731
(CHEMBL3113978)Show SMILES COc1ccc(cc1OC)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C27H25Cl2F2NO7/c1-35-21-7-6-17(10-24(21)36-2)26(33)38-23(11-18-19(28)12-32(34)13-20(18)29)16-5-8-22(39-27(30)31)25(9-16)37-14-15-3-4-15/h5-10,12-13,15,23,27H,3-4,11,14H2,1-2H3/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495729
(CHEMBL3113937)Show SMILES [O-][n+]1cc(Cl)c(C[C@H](OC(=O)c2ccccc2)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1 |r| Show InChI InChI=1S/C25H21Cl2F2NO5/c26-19-12-30(32)13-20(27)18(19)11-22(34-24(31)16-4-2-1-3-5-16)17-8-9-21(35-25(28)29)23(10-17)33-14-15-6-7-15/h1-5,8-10,12-13,15,22,25H,6-7,11,14H2/t22-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0720 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495719
(CHEMBL3113963)Show SMILES OCc1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C30H29Cl2F2NO7/c31-23-12-35(38)13-24(32)22(23)11-27(19-7-8-25(42-30(33)34)28(9-19)40-16-18-3-4-18)41-29(37)20-5-6-21(14-36)26(10-20)39-15-17-1-2-17/h5-10,12-13,17-18,27,30,36H,1-4,11,14-16H2/t27-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495701
(CHEMBL3113947)Show SMILES COc1ccc(cc1NC(C)=O)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C28H26Cl2F2N2O7/c1-15(35)33-22-9-18(6-7-23(22)38-2)27(36)40-25(11-19-20(29)12-34(37)13-21(19)30)17-5-8-24(41-28(31)32)26(10-17)39-14-16-3-4-16/h5-10,12-13,16,25,28H,3-4,11,14H2,1-2H3,(H,33,35)/t25-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50223272
(CHEMBL67668)Show SMILES COc1ccc(cc1OC1CCCC1)C1(CCN(CC(=O)NO)CC1)C#N Show InChI InChI=1S/C20H27N3O4/c1-26-17-7-6-15(12-18(17)27-16-4-2-3-5-16)20(14-21)8-10-23(11-9-20)13-19(24)22-25/h6-7,12,16,25H,2-5,8-11,13H2,1H3,(H,22,24) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase 4 (PDE4) prepared from human U937 cells |
Bioorg Med Chem Lett 14: 207-10 (2004)
BindingDB Entry DOI: 10.7270/Q21G0PFV |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495726
(CHEMBL3113945)Show SMILES COc1ccc(cc1O)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C26H23Cl2F2NO7/c1-35-21-6-5-16(8-20(21)32)25(33)37-23(10-17-18(27)11-31(34)12-19(17)28)15-4-7-22(38-26(29)30)24(9-15)36-13-14-2-3-14/h4-9,11-12,14,23,26,32H,2-3,10,13H2,1H3/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495734
(CHEMBL3113958)Show SMILES Nc1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C29H28Cl2F2N2O6/c30-21-12-35(37)13-22(31)20(21)11-25(18-6-8-24(41-29(32)33)27(9-18)39-15-17-3-4-17)40-28(36)19-5-7-23(34)26(10-19)38-14-16-1-2-16/h5-10,12-13,16-17,25,29H,1-4,11,14-15,34H2/t25-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495738
(CHEMBL3113939)Show SMILES Cc1ccc(cc1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C26H23Cl2F2NO5/c1-15-2-6-17(7-3-15)25(32)35-23(11-19-20(27)12-31(33)13-21(19)28)18-8-9-22(36-26(29)30)24(10-18)34-14-16-4-5-16/h2-3,6-10,12-13,16,23,26H,4-5,11,14H2,1H3/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495734
(CHEMBL3113958)Show SMILES Nc1ccc(cc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C29H28Cl2F2N2O6/c30-21-12-35(37)13-22(31)20(21)11-25(18-6-8-24(41-29(32)33)27(9-18)39-15-17-3-4-17)40-28(36)19-5-7-23(34)26(10-19)38-14-16-1-2-16/h5-10,12-13,16-17,25,29H,1-4,11,14-15,34H2/t25-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISA |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495708
(CHEMBL3113975)Show SMILES CS(=O)(=O)Nc1cc(ccc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C30H30Cl2F2N2O8S/c1-45(39,40)35-24-10-20(7-8-25(24)41-15-17-2-3-17)29(37)43-27(12-21-22(31)13-36(38)14-23(21)32)19-6-9-26(44-30(33)34)28(11-19)42-16-18-4-5-18/h6-11,13-14,17-18,27,30,35H,2-5,12,15-16H2,1H3/t27-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISA |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495731
(CHEMBL3113978)Show SMILES COc1ccc(cc1OC)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C27H25Cl2F2NO7/c1-35-21-7-6-17(10-24(21)36-2)26(33)38-23(11-18-19(28)12-32(34)13-20(18)29)16-5-8-22(39-27(30)31)25(9-16)37-14-15-3-4-15/h5-10,12-13,15,23,27H,3-4,11,14H2,1-2H3/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISA |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495724
(CHEMBL3113950)Show SMILES CS(=O)(=O)Nc1ccc(cc1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C26H24Cl2F2N2O7S/c1-40(35,36)31-18-7-4-16(5-8-18)25(33)38-23(11-19-20(27)12-32(34)13-21(19)28)17-6-9-22(39-26(29)30)24(10-17)37-14-15-2-3-15/h4-10,12-13,15,23,26,31H,2-3,11,14H2,1H3/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISA |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495702
(CHEMBL3113977)Show SMILES COc1cc(NS(C)(=O)=O)cc(c1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C27H26Cl2F2N2O8S/c1-38-19-8-17(7-18(10-19)32-42(2,36)37)26(34)40-24(11-20-21(28)12-33(35)13-22(20)29)16-5-6-23(41-27(30)31)25(9-16)39-14-15-3-4-15/h5-10,12-13,15,24,27,32H,3-4,11,14H2,1-2H3/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release after 18 hrs by ELISA |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50074893
(2-[4-(6,7-Diethoxy-2,3-bis-hydroxymethyl-naphthale...)Show SMILES CCOc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OCC Show InChI InChI=1S/C34H30N4O5/c1-3-42-29-15-23-14-24(19-39)28(20-40)32(27(23)17-30(29)43-4-2)21-11-13-36-31(16-21)38-34(41)26-10-6-5-9-25(26)33(37-38)22-8-7-12-35-18-22/h5-18,39-40H,3-4,19-20H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of guinea pig lung Phosphodiesterase 4 |
J Med Chem 42: 1088-99 (1999)
Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495708
(CHEMBL3113975)Show SMILES CS(=O)(=O)Nc1cc(ccc1OCC1CC1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C30H30Cl2F2N2O8S/c1-45(39,40)35-24-10-20(7-8-25(24)41-15-17-2-3-17)29(37)43-27(12-21-22(31)13-36(38)14-23(21)32)19-6-9-26(44-30(33)34)28(11-19)42-16-18-4-5-18/h6-11,13-14,17-18,27,30,35H,2-5,12,15-16H2,1H3/t27-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495737
(CHEMBL3113942)Show SMILES COc1ccc(cc1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C26H23Cl2F2NO6/c1-34-18-7-4-16(5-8-18)25(32)36-23(11-19-20(27)12-31(33)13-21(19)28)17-6-9-22(37-26(29)30)24(10-17)35-14-15-2-3-15/h4-10,12-13,15,23,26H,2-3,11,14H2,1H3/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495711
(CHEMBL3113961)Show SMILES [O-][n+]1cc(Cl)c(C[C@H](OC(=O)c2ccc(NS(=O)(=O)C3CC3)c(OCC3CC3)c2)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1 |r| Show InChI InChI=1S/C32H32Cl2F2N2O8S/c33-24-14-38(40)15-25(34)23(24)13-28(20-6-10-27(46-32(35)36)30(11-20)44-17-19-3-4-19)45-31(39)21-5-9-26(37-47(41,42)22-7-8-22)29(12-21)43-16-18-1-2-18/h5-6,9-12,14-15,18-19,22,28,32,37H,1-4,7-8,13,16-17H2/t28-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50074897
(2-[4-(7-Ethoxy-2,3-bis-hydroxymethyl-6-methoxy-nap...)Show SMILES CCOc1cc2c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c(CO)c(CO)cc2cc1OC Show InChI InChI=1S/C33H28N4O5/c1-3-42-29-16-26-22(14-28(29)41-2)13-23(18-38)27(19-39)31(26)20-10-12-35-30(15-20)37-33(40)25-9-5-4-8-24(25)32(36-37)21-7-6-11-34-17-21/h4-17,38-39H,3,18-19H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Company, Ltd.
Curated by ChEMBL
| Assay Description In vitro inhibition of Phosphodiesterase 4 from guinea pig lung |
J Med Chem 42: 1088-99 (1999)
Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495728
(CHEMBL3113938)Show SMILES [O-][n+]1cc(Cl)c(C[C@H](OC(=O)c2ccc(Cl)cc2)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1 |r| Show InChI InChI=1S/C25H20Cl3F2NO5/c26-17-6-3-15(4-7-17)24(32)35-22(10-18-19(27)11-31(33)12-20(18)28)16-5-8-21(36-25(29)30)23(9-16)34-13-14-1-2-14/h3-9,11-12,14,22,25H,1-2,10,13H2/t22-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495702
(CHEMBL3113977)Show SMILES COc1cc(NS(C)(=O)=O)cc(c1)C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C27H26Cl2F2N2O8S/c1-38-19-8-17(7-18(10-19)32-42(2,36)37)26(34)40-24(11-20-21(28)12-33(35)13-22(20)29)16-5-6-23(41-27(30)31)25(9-16)39-14-15-3-4-15/h5-10,12-13,15,24,27,32H,3-4,11,14H2,1-2H3/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50047247
(1,3-Dibutyl-7-(2-oxo-propyl)-3,7-dihydro-purine-2,...)Show InChI InChI=1S/C16H24N4O3/c1-4-6-8-19-14-13(18(11-17-14)10-12(3)21)15(22)20(16(19)23)9-7-5-2/h11H,4-10H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Concentration at which 50% of the activity of the Phosphodiesterase 4 from Human U937 cells is inhibited |
J Med Chem 43: 1223-33 (2000)
Article DOI: 10.1021/jm990558l BindingDB Entry DOI: 10.7270/Q2NK3HRK |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50223263
(CHEMBL291889)Show InChI InChI=1S/C19H25N3O4/c1-25-16-6-5-14(11-17(16)26-15-3-2-4-15)19(13-20)7-9-22(10-8-19)12-18(23)21-24/h5-6,11,15,24H,2-4,7-10,12H2,1H3,(H,21,23) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase 4 (PDE4) prepared from human U937 cells |
Bioorg Med Chem Lett 14: 207-10 (2004)
BindingDB Entry DOI: 10.7270/Q21G0PFV |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495716
(CHEMBL3113970)Show SMILES CS(=O)(=O)Nc1cccc(C(=O)O[C@@H](Cc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(OC(F)F)c(OCC3CC3)c2)c1OCC1CC1 |r| Show InChI InChI=1S/C30H30Cl2F2N2O8S/c1-45(39,40)35-24-4-2-3-20(28(24)42-16-18-7-8-18)29(37)43-26(12-21-22(31)13-36(38)14-23(21)32)19-9-10-25(44-30(33)34)27(11-19)41-15-17-5-6-17/h2-4,9-11,13-14,17-18,26,30,35H,5-8,12,15-16H2,1H3/t26-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50473381
(CHEMBL314936)Show SMILES COc1ccc(cc1OCCCCOc1ccc(cc1)-n1ccnc1)C1=NN(C2CCCCCC2)C(=O)C2CC=CCC12 |c:43,t:28| Show InChI InChI=1S/C35H42N4O4/c1-41-32-19-14-26(34-30-12-6-7-13-31(30)35(40)39(37-34)28-10-4-2-3-5-11-28)24-33(32)43-23-9-8-22-42-29-17-15-27(16-18-29)38-21-20-36-25-38/h6-7,14-21,24-25,28,30-31H,2-5,8-13,22-23H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase 4 (PDE4) in human neutrophils |
J Med Chem 44: 2523-35 (2001)
Article DOI: 10.1021/jm010838c BindingDB Entry DOI: 10.7270/Q23N2644 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50495727
(CHEMBL3113940)Show SMILES [O-][n+]1cc(Cl)c(C[C@H](OC(=O)c2ccc(cc2)C(F)(F)F)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1 |r| Show InChI InChI=1S/C26H20Cl2F5NO5/c27-19-11-34(36)12-20(28)18(19)10-22(38-24(35)15-3-6-17(7-4-15)26(31,32)33)16-5-8-21(39-25(29)30)23(9-16)37-13-14-1-2-14/h3-9,11-12,14,22,25H,1-2,10,13H2/t22-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay |
J Med Chem 57: 793-816 (2014)
Article DOI: 10.1021/jm401549m BindingDB Entry DOI: 10.7270/Q2RF5Z0D |
More data for this Ligand-Target Pair | |