Compile Data Set for Download or QSAR

Found 177 hits of ic50 for UniProtKB: P0C1U9   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50494811 (CHEMBL3094350) Show SMILES CCNC(=O)Nc1nc2cc(cc(-c3ccccn3)c2s1)-c1cnc(nc1)N1CCC(C)(CC1)C(O)=O Show InChI InChI=1S/C26H27N7O3S/c1-3-27-24(36)32-25-31-20-13-16(12-18(21(20)37-25)19-6-4-5-9-28-19)17-14-29-23(30-15-17)33-10-7-26(2,8-11-33)22(34)35/h4-6,9,12-15H,3,7-8,10-11H2,1-2H3,(H,34,35)(H2,27,31,32,36)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	15.5	n/a	n/a	n/a	n/a	n/a	n/a
Biota Holdings Ltd Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus DNA topoisomerase 4 subunit ParC2/ParE2 after 60 mins by malachite green staining assay				Bioorg Med Chem Lett 23: 6598-603 (2013) Article DOI: 10.1016/j.bmcl.2013.10.058 BindingDB Entry DOI: 10.7270/Q2HD7ZMQ
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50494806 (CHEMBL3094349) Show SMILES CCNC(=O)Nc1nc2cc(cc(-c3ccccn3)c2s1)-c1cnc(nc1)N1CCC(CC1)C(O)=O Show InChI InChI=1S/C25H25N7O3S/c1-2-26-24(35)31-25-30-20-12-16(11-18(21(20)36-25)19-5-3-4-8-27-19)17-13-28-23(29-14-17)32-9-6-15(7-10-32)22(33)34/h3-5,8,11-15H,2,6-7,9-10H2,1H3,(H,33,34)(H2,26,30,31,35)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	23.8	n/a	n/a	n/a	n/a	n/a	n/a
Biota Holdings Ltd Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus DNA topoisomerase 4 subunit ParC2/ParE2 after 60 mins by malachite green staining assay				Bioorg Med Chem Lett 23: 6598-603 (2013) Article DOI: 10.1016/j.bmcl.2013.10.058 BindingDB Entry DOI: 10.7270/Q2HD7ZMQ
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50572198 (CHEMBL4873479) Show SMILES COc1ccc2nccc(CCN3CCC(CC3)NCc3cc(F)c(Br)c(F)c3)c2n1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using supercoiled pNO1 plasmid DNA as substrate incubated f...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00345 BindingDB Entry DOI: 10.7270/Q28D012J
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50572196 (CHEMBL4879265) Show SMILES COc1ccc2nccc(CCN3CCC(CC3)NCc3ccc(I)c(F)c3)c2n1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using supercoiled pNO1 plasmid DNA as substrate incubated f...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00345 BindingDB Entry DOI: 10.7270/Q28D012J
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50440321 (CHEMBL2424893) Show SMILES COc1ccc2nccc(NC(=O)[C@H]3CC[C@@H](CC3)NCc3ccc4SCC(=O)Nc4n3)c2n1 |r,wU:13.12,wD:16.19,(6.06,-13.06,;7.4,-13.83,;7.4,-15.37,;6.08,-16.14,;6.09,-17.67,;7.41,-18.43,;7.41,-19.97,;8.74,-20.74,;10.08,-19.97,;10.07,-18.42,;11.4,-17.64,;12.74,-18.41,;12.75,-19.95,;14.07,-17.63,;14.06,-16.09,;15.39,-15.32,;16.73,-16.09,;16.73,-17.63,;15.4,-18.4,;18.06,-15.32,;19.4,-16.08,;20.73,-15.31,;20.72,-13.78,;22.05,-13.01,;23.39,-13.77,;24.72,-13,;26.05,-13.78,;26.05,-15.32,;27.38,-16.09,;24.72,-16.08,;23.39,-15.32,;22.06,-16.09,;8.74,-17.66,;8.73,-16.13,)| Show InChI InChI=1S/C24H26N6O3S/c1-33-21-9-7-17-22(30-21)18(10-11-25-17)28-24(32)14-2-4-15(5-3-14)26-12-16-6-8-19-23(27-16)29-20(31)13-34-19/h6-11,14-15,26H,2-5,12-13H2,1H3,(H,25,28,32)(H,27,29,31)/t14-,15-	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	125	n/a	n/a	n/a	n/a	n/a	n/a
Actelion Pharmaceuticals Ltd Curated by ChEMBL					Assay Description Inhibition of wild type Staphylococcus aureus ATCC 29213 topoisomerase-4 subunit 2GrlA/2GrlB assessed as pBR322 relaxation after 1 hr				J Med Chem 56: 7396-415 (2013) Article DOI: 10.1021/jm400963y BindingDB Entry DOI: 10.7270/Q2HT2QRV
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50561963 (CHEMBL4787821) Show SMILES COc1ccc2nccc(CC[C@H]3OC[C@@H](CO3)NC(=O)c3ccc4OCC(=O)Nc4n3)c2c1 |r,wU:12.11,wD:15.18,(61.61,-32.73,;61.62,-34.26,;62.95,-35.03,;62.95,-36.57,;64.28,-37.34,;65.61,-36.57,;66.95,-37.35,;68.28,-36.57,;68.28,-35.02,;66.94,-34.26,;66.94,-32.72,;68.27,-31.94,;69.61,-32.71,;70.93,-31.92,;72.27,-32.7,;72.27,-34.24,;70.94,-35.01,;69.6,-34.25,;73.6,-35.01,;74.94,-34.24,;74.94,-32.7,;76.27,-35,;76.27,-36.54,;77.6,-37.31,;78.93,-36.54,;80.27,-37.3,;81.61,-36.53,;81.6,-34.98,;82.93,-34.21,;80.26,-34.2,;78.93,-34.99,;77.59,-34.23,;65.61,-35.03,;64.28,-34.26,)| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase-4 assessed as reduction in decatenation of kinetoplast DNA agarose gel electrophoresis method				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00428 BindingDB Entry DOI: 10.7270/Q2Z89H4G
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50572197 (CHEMBL4879088) Show SMILES COc1ccc2nccc(CCN3CCC(CC3)NCc3cc(F)c(Cl)c(F)c3)c2n1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	215	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using supercoiled pNO1 plasmid DNA as substrate incubated f...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00345 BindingDB Entry DOI: 10.7270/Q28D012J
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50582949 (CHEMBL5090088) Show SMILES OC(=O)c1cn(C2CC2)c2cc(N3CCN(CCC(=O)Nc4ccc(cc4)S(=O)(=O)Nc4cnc5ccccc5n4)CC3)c(F)cc2c1=O Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using kDNA as substrate incubated for 30 mins by fluorimetr...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.114021 BindingDB Entry DOI: 10.7270/Q2DZ0D6N
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50572195 (CHEMBL4868908) Show SMILES COc1ccc2nccc(CCN3CCC(CC3)NCc3ccc(Br)c(F)c3)c2n1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	241	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using supercoiled pNO1 plasmid DNA as substrate incubated f...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00345 BindingDB Entry DOI: 10.7270/Q28D012J
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50547867 (CHEMBL4793192) Show SMILES Cl.Cc1[nH]c(C(=O)Nc2nc3ccc(NC(=O)CCN)cc3s2)c(Cl)c1Cl Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus DNA topoisomerase 4 using supercoiled pNO1 plasmid DNA as substrate incubated for 30 mins by fluorescence assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00416 BindingDB Entry DOI: 10.7270/Q2JW8JGG
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50547859 (CHEMBL4752708) Show SMILES Cc1[nH]c(C(=O)Nc2nc3ccc(NC(=O)C(O)=O)cc3s2)c(Cl)c1Cl Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus DNA topoisomerase 4 using supercoiled pNO1 plasmid DNA as substrate incubated for 30 mins by fluorescence assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00416 BindingDB Entry DOI: 10.7270/Q2JW8JGG
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50393503 (CHEMBL2158050) Show SMILES COc1ccc2ncc(F)c([C@@H](O)CC[C@@H]3CCN(CCSc4cccs4)C[C@@H]3C(O)=O)c2c1 |r| Show InChI InChI=1S/C25H29FN2O4S2/c1-32-17-5-6-21-18(13-17)24(20(26)14-27-21)22(29)7-4-16-8-9-28(15-19(16)25(30)31)10-12-34-23-3-2-11-33-23/h2-3,5-6,11,13-14,16,19,22,29H,4,7-10,12,15H2,1H3,(H,30,31)/t16-,19+,22+/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Chemistry Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus RN4220 DNA topoisomerase 4 expressed in Escherichia coli BL21(DE3) cells using supercoiled pBR322 DNA as substrat...				J Med Chem 63: 5664-5674 (2020) Article DOI: 10.1021/acs.jmedchem.9b01738 BindingDB Entry DOI: 10.7270/Q2HD8064
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50561965 (CHEMBL4787145) Show SMILES COc1ccc2nccc(CC[C@H]3OC[C@@H](CO3)NC(=O)c3ccc4SCC(=O)Nc4n3)c2c1 |r,wU:12.11,wD:15.18,(32.16,-49.84,;32.16,-51.37,;33.5,-52.14,;33.5,-53.68,;34.82,-54.45,;36.15,-53.68,;37.49,-54.46,;38.83,-53.68,;38.82,-52.13,;37.49,-51.37,;37.48,-49.83,;38.81,-49.05,;40.15,-49.82,;41.47,-49.03,;42.81,-49.81,;42.82,-51.35,;41.48,-52.12,;40.15,-51.35,;44.15,-52.12,;45.48,-51.35,;45.48,-49.81,;46.82,-52.11,;46.81,-53.65,;48.15,-54.42,;49.48,-53.65,;50.81,-54.41,;52.15,-53.63,;52.15,-52.09,;53.47,-51.32,;50.8,-51.31,;49.47,-52.1,;48.14,-51.34,;36.16,-52.14,;34.83,-51.37,)| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase-4 assessed as reduction in decatenation of kinetoplast DNA agarose gel electrophoresis method				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00428 BindingDB Entry DOI: 10.7270/Q2Z89H4G
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50577588 (CHEMBL4875924) Show SMILES [H][C@@]1(OC[C@@H](CO1)NCc1cc2NC(=O)CSc2cn1)[C@@H](O)Cc1c(F)cnc2ccc(OC)nc12 |r,wU:20.23,wD:4.7,1.0,(30.53,-53.76,;29.2,-53,;27.86,-52.24,;27.86,-50.7,;29.19,-49.93,;30.53,-50.7,;30.53,-52.23,;29.19,-48.39,;30.52,-47.61,;31.86,-48.38,;33.18,-47.61,;34.51,-48.37,;35.84,-47.59,;37.18,-48.36,;38.51,-47.59,;37.18,-49.91,;35.85,-50.67,;34.51,-49.91,;33.19,-50.69,;31.86,-49.92,;29.2,-54.54,;30.55,-55.3,;27.89,-55.31,;27.89,-56.85,;29.22,-57.61,;30.55,-56.83,;29.22,-59.16,;27.9,-59.94,;26.56,-59.17,;25.23,-59.95,;23.9,-59.18,;23.9,-57.63,;22.56,-56.86,;22.56,-55.32,;25.23,-56.86,;26.56,-57.63,)| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase IV decatenation activity using kDNA as substrate by ethidium bromide/bromophenol blue staining base...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01250 BindingDB Entry DOI: 10.7270/Q2CN77R0
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50577587 (CHEMBL4869929) Show SMILES [H][C@@]1(OC[C@@H](CO1)NCc1cc2NC(=O)COc2cn1)[C@@H](O)Cc1c(F)cnc2ccc(OC)nc12 |r,wU:20.23,wD:4.7,1.0,(11.74,-54.25,;10.42,-53.49,;9.08,-52.74,;9.08,-51.19,;10.41,-50.42,;11.75,-51.19,;11.75,-52.72,;10.41,-48.88,;11.74,-48.1,;13.07,-48.87,;14.4,-48.1,;15.73,-48.86,;17.06,-48.08,;18.4,-48.85,;19.73,-48.08,;18.4,-50.4,;17.06,-51.16,;15.73,-50.4,;14.4,-51.18,;13.07,-50.41,;10.42,-55.03,;11.76,-55.79,;9.11,-55.8,;9.11,-57.34,;10.44,-58.1,;11.77,-57.33,;10.44,-59.65,;9.12,-60.43,;7.78,-59.66,;6.45,-60.44,;5.12,-59.67,;5.12,-58.12,;3.78,-57.35,;3.78,-55.81,;6.44,-57.35,;7.78,-58.12,)| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase IV decatenation activity using kDNA as substrate by ethidium bromide/bromophenol blue staining base...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01250 BindingDB Entry DOI: 10.7270/Q2CN77R0
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50582944 (CHEMBL5086095) Show SMILES OC(=O)c1cn(C2CC2)c2cc(N3CCN(CC(=O)Nc4ccc(cc4)S(=O)(=O)Nc4cnc5ccccc5n4)CC3)c(F)cc2c1=O Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using kDNA as substrate incubated for 30 mins by fluorimetr...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.114021 BindingDB Entry DOI: 10.7270/Q2DZ0D6N
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50577579 (CHEMBL4867964) Show SMILES [H][C@@]1(OC[C@@H](CO1)NCc1ccc2OCCOc2c1)[C@@H](O)Cc1c(F)cnc2ccc(OC)nc12 |r,wU:19.22,wD:4.7,1.0,(12.1,-14.99,;10.78,-14.23,;9.44,-13.47,;9.44,-11.93,;10.77,-11.15,;12.11,-11.93,;12.11,-13.46,;10.77,-9.61,;12.1,-8.84,;13.43,-9.61,;13.43,-11.15,;14.76,-11.92,;16.09,-11.14,;17.42,-11.9,;18.76,-11.13,;18.76,-9.59,;17.42,-8.82,;16.09,-9.6,;14.76,-8.84,;10.78,-15.77,;12.12,-16.53,;9.46,-16.54,;9.46,-18.08,;10.8,-18.84,;12.13,-18.07,;10.8,-20.39,;9.47,-21.17,;8.14,-20.4,;6.81,-21.18,;5.47,-20.41,;5.47,-18.86,;4.14,-18.09,;4.14,-16.55,;6.8,-18.09,;8.14,-18.86,)| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase IV decatenation activity using kDNA as substrate by ethidium bromide/bromophenol blue staining base...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01250 BindingDB Entry DOI: 10.7270/Q2CN77R0
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50582952 (CHEMBL5087299) Show SMILES CC(N1CCN(CC1)c1cc2n(cc(C(O)=O)c(=O)c2cc1F)C1CC1)C(=O)Nc1ccc(cc1)S(=O)(=O)Nc1cc(C)on1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using kDNA as substrate incubated for 30 mins by fluorimetr...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.114021 BindingDB Entry DOI: 10.7270/Q2DZ0D6N
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50597278 (CHEMBL5196889) Show SMILES [H][C@@]1(OC[C@@H](CO1)NC(=O)c1ccc2SCC(=O)Nc2n1)[C@@H](O)Cc1c(F)cnc2ccc(OC)nc12 |r,wD:21.24,4.7,1.0,(-1.88,-1.31,;-1.49,.18,;-.73,1.51,;.81,1.5,;1.57,.17,;.8,-1.15,;-.72,-1.14,;3.11,.17,;3.88,1.5,;3.11,2.83,;5.42,1.5,;6.18,.16,;7.72,.15,;8.49,1.48,;10.02,1.47,;10.8,2.8,;10.04,4.14,;10.81,5.48,;8.49,4.15,;7.72,2.82,;6.18,2.82,;-3.01,.18,;-3.34,1.68,;-4.16,-.85,;-4.15,-2.39,;-2.82,-3.15,;-1.5,-2.37,;-2.81,-4.7,;-4.14,-5.47,;-5.47,-4.7,;-6.81,-5.48,;-8.14,-4.71,;-8.14,-3.16,;-9.48,-2.4,;-10.81,-3.17,;-6.81,-2.4,;-5.47,-3.16,)| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00111 BindingDB Entry DOI: 10.7270/Q2TT4W0M
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50577585 (CHEMBL4856026) Show SMILES [H][C@@]1(OC[C@@H](CO1)NCc1cc2SCOc2cn1)[C@@H](O)Cc1c(F)cnc2ccc(OC)nc12 |r,wU:18.21,wD:4.7,1.0,(46.47,-34.25,;45.15,-33.49,;43.8,-32.74,;43.8,-31.19,;45.14,-30.42,;46.48,-31.19,;46.48,-32.72,;45.14,-28.88,;46.47,-28.11,;47.8,-28.87,;49.12,-28.1,;50.46,-28.85,;51.94,-28.38,;52.85,-29.63,;51.93,-30.88,;50.46,-30.4,;49.13,-31.18,;47.8,-30.41,;45.15,-35.03,;46.49,-35.79,;43.83,-35.81,;43.83,-37.35,;45.17,-38.11,;46.5,-37.33,;45.17,-39.66,;43.84,-40.43,;42.51,-39.66,;41.17,-40.44,;39.84,-39.67,;39.84,-38.13,;38.51,-37.36,;38.51,-35.82,;41.17,-37.36,;42.51,-38.12,)| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase IV decatenation activity using kDNA as substrate by ethidium bromide/bromophenol blue staining base...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01250 BindingDB Entry DOI: 10.7270/Q2CN77R0
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50582950 (CHEMBL5075535) Show SMILES OC(=O)c1cn(C2CC2)c2cc(N3CCN(CCC(=O)Nc4ccc(cc4)S(=O)(=O)Nc4cncc(Cl)n4)CC3)c(F)cc2c1=O Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using kDNA as substrate incubated for 30 mins by fluorimetr...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.114021 BindingDB Entry DOI: 10.7270/Q2DZ0D6N
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50440323 (CHEMBL2424833) Show SMILES COc1ccc2ncc(F)c([C@@H](O)[C@H](O)[C@@H]3CC[C@H](CO3)NCc3ccc4SCC(=O)Nc4n3)c2n1 |r| Show InChI InChI=1S/C24H26FN5O5S/c1-34-19-7-4-15-21(30-19)20(14(25)9-27-15)23(33)22(32)16-5-2-13(10-35-16)26-8-12-3-6-17-24(28-12)29-18(31)11-36-17/h3-4,6-7,9,13,16,22-23,26,32-33H,2,5,8,10-11H2,1H3,(H,28,29,31)/t13-,16+,22-,23-/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Actelion Pharmaceuticals Ltd Curated by ChEMBL					Assay Description Inhibition of wild type Staphylococcus aureus ATCC 29213 topoisomerase-4 subunit 2GrlA/2GrlB assessed as pBR322 relaxation after 1 hr				J Med Chem 56: 7396-415 (2013) Article DOI: 10.1021/jm400963y BindingDB Entry DOI: 10.7270/Q2HT2QRV
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50440312 (CHEMBL2424891) Show SMILES COc1cnc2cccc([C@@H](O)[C@H](O)[C@@H]3CC[C@H](CO3)NCc3ccc4SCC(=O)Nc4n3)c2c1 |r| Show InChI InChI=1S/C25H28N4O5S/c1-33-16-9-18-17(3-2-4-19(18)27-11-16)23(31)24(32)20-7-5-15(12-34-20)26-10-14-6-8-21-25(28-14)29-22(30)13-35-21/h2-4,6,8-9,11,15,20,23-24,26,31-32H,5,7,10,12-13H2,1H3,(H,28,29,30)/t15-,20+,23-,24-/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Actelion Pharmaceuticals Ltd Curated by ChEMBL					Assay Description Inhibition of wild type Staphylococcus aureus ATCC 29213 topoisomerase-4 subunit 2GrlA/2GrlB assessed as pBR322 relaxation after 1 hr				J Med Chem 56: 7396-415 (2013) Article DOI: 10.1021/jm400963y BindingDB Entry DOI: 10.7270/Q2HT2QRV
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50440327 (CHEMBL2424883) Show SMILES COc1ccc2nccc(CC[C@@H]3CC[C@H](CO3)NCc3ccc4SCC(=O)Nc4n3)c2n1 |r| Show InChI InChI=1S/C24H27N5O3S/c1-31-22-9-7-19-23(29-22)15(10-11-25-19)2-5-18-6-3-17(13-32-18)26-12-16-4-8-20-24(27-16)28-21(30)14-33-20/h4,7-11,17-18,26H,2-3,5-6,12-14H2,1H3,(H,27,28,30)/t17-,18-/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Actelion Pharmaceuticals Ltd Curated by ChEMBL					Assay Description Inhibition of wild type Staphylococcus aureus ATCC 29213 topoisomerase-4 subunit 2GrlA/2GrlB assessed as pBR322 relaxation after 1 hr				J Med Chem 56: 7396-415 (2013) Article DOI: 10.1021/jm400963y BindingDB Entry DOI: 10.7270/Q2HT2QRV
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50440332 (CHEMBL2424885) Show SMILES COc1ccc2nccc([C@@H](O)[C@H](O)[C@@H]3CC[C@H](CO3)NCc3ccc4SCC(=O)Nc4n3)c2n1 |r| Show InChI InChI=1S/C24H27N5O5S/c1-33-20-7-4-16-21(29-20)15(8-9-25-16)22(31)23(32)17-5-2-14(11-34-17)26-10-13-3-6-18-24(27-13)28-19(30)12-35-18/h3-4,6-9,14,17,22-23,26,31-32H,2,5,10-12H2,1H3,(H,27,28,30)/t14-,17+,22-,23-/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Actelion Pharmaceuticals Ltd Curated by ChEMBL					Assay Description Inhibition of wild type Staphylococcus aureus ATCC 29213 topoisomerase-4 subunit 2GrlA/2GrlB assessed as pBR322 relaxation after 1 hr				J Med Chem 56: 7396-415 (2013) Article DOI: 10.1021/jm400963y BindingDB Entry DOI: 10.7270/Q2HT2QRV
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50440325 (CHEMBL2424890) Show SMILES COc1ccc2cccc([C@@H](O)[C@H](O)[C@@H]3CC[C@H](CO3)NCc3ccc4SCC(=O)Nc4n3)c2n1 |r| Show InChI InChI=1S/C25H28N4O5S/c1-33-21-10-5-14-3-2-4-17(22(14)29-21)23(31)24(32)18-8-6-16(12-34-18)26-11-15-7-9-19-25(27-15)28-20(30)13-35-19/h2-5,7,9-10,16,18,23-24,26,31-32H,6,8,11-13H2,1H3,(H,27,28,30)/t16-,18+,23-,24-/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Actelion Pharmaceuticals Ltd Curated by ChEMBL					Assay Description Inhibition of wild type Staphylococcus aureus ATCC 29213 topoisomerase-4 subunit 2GrlA/2GrlB assessed as pBR322 relaxation after 1 hr				J Med Chem 56: 7396-415 (2013) Article DOI: 10.1021/jm400963y BindingDB Entry DOI: 10.7270/Q2HT2QRV
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50597266 (CHEMBL5200272) Show SMILES Fc1cnc2ccc(=O)n3CC(C[C@H]4OC[C@@H](CO4)NCc4ccc5OCCOc5c4)c1c23 |r,wU:13.12,wD:16.19,(-1.7,-1.84,;-3.03,-2.61,;-3.03,-4.15,;-4.37,-4.92,;-5.7,-4.15,;-7.03,-4.92,;-8.37,-4.15,;-8.37,-2.61,;-9.7,-1.84,;-7.03,-1.84,;-6.47,-.41,;-4.93,-.41,;-4.16,.92,;-2.62,.92,;-1.85,2.26,;-.31,2.26,;.46,.92,;-.31,-.41,;-1.85,-.41,;2,.92,;2.77,2.26,;4.31,2.26,;5.08,.92,;6.62,.92,;7.39,2.26,;8.93,2.26,;9.7,3.59,;8.93,4.92,;7.39,4.92,;6.62,3.59,;5.08,3.59,;-4.37,-1.84,;-5.7,-2.61,)| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00111 BindingDB Entry DOI: 10.7270/Q2TT4W0M
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM21690 (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...) Show SMILES OC(=O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using kDNA as substrate incubated for 30 mins by fluorimetr...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.114021 BindingDB Entry DOI: 10.7270/Q2DZ0D6N
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50050549 (GSK2140944 | Gepotidacin) Show SMILES O=c1ccc2ncc(=O)n3[C@H](CN4CCC(CC4)NCc4cc5CCCOc5cn4)Cn1c23 |r| Show InChI InChI=1S/C24H28N6O3/c31-22-4-3-20-24-29(22)15-19(30(24)23(32)13-27-20)14-28-7-5-17(6-8-28)25-11-18-10-16-2-1-9-33-21(16)12-26-18/h3-4,10,12-13,17,19,25H,1-2,5-9,11,14-15H2/t19-/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus DNA topoisomerase 4				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50577565 (CHEMBL4850745) Show SMILES COc1ccc2ncc(F)c(C(O)C[C@H]3OC[C@@H](CO3)NCc3ccc(Cl)c(Cl)c3)c2n1 |r,wU:14.13,wD:17.20,(20.71,-30.05,;20.71,-31.59,;22.04,-32.36,;22.04,-33.9,;23.37,-34.67,;24.7,-33.89,;26.04,-34.66,;27.37,-33.88,;27.37,-32.34,;28.69,-31.56,;26.03,-31.58,;26.03,-30.04,;24.68,-29.27,;27.34,-29.26,;27.34,-27.72,;26.01,-26.96,;26.01,-25.42,;27.34,-24.64,;28.68,-25.41,;28.68,-26.95,;27.34,-23.1,;28.67,-22.33,;30.01,-23.1,;30.01,-24.63,;31.34,-25.4,;32.66,-24.63,;34,-25.4,;32.66,-23.08,;33.99,-22.31,;31.33,-22.32,;24.7,-32.35,;23.37,-31.58,)| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase IV decatenation activity using kDNA as substrate by ethidium bromide/bromophenol blue staining base...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01250 BindingDB Entry DOI: 10.7270/Q2CN77R0
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50582946 (CHEMBL5092701) Show SMILES NS(=O)(=O)c1ccc(NC(=O)CCN2CCN(CC2)c2cc3n(cc(C(O)=O)c(=O)c3cc2F)C2CC2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using kDNA as substrate incubated for 30 mins by fluorimetr...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.114021 BindingDB Entry DOI: 10.7270/Q2DZ0D6N
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50597267 (CHEMBL5201666) Show SMILES Fc1ccc2ccc(=O)n3CC(C[C@H]4OC[C@@H](CO4)NCc4ccc5OCCOc5c4)c1c23 |r,wU:13.12,wD:16.19,(-1.7,-1.84,;-3.03,-2.61,;-3.03,-4.15,;-4.37,-4.92,;-5.7,-4.15,;-7.03,-4.92,;-8.37,-4.15,;-8.37,-2.61,;-9.7,-1.84,;-7.03,-1.84,;-6.47,-.41,;-4.93,-.41,;-4.16,.92,;-2.62,.92,;-1.85,2.26,;-.31,2.26,;.46,.92,;-.31,-.41,;-1.85,-.41,;2,.92,;2.77,2.26,;4.31,2.26,;5.08,.92,;6.62,.92,;7.39,2.26,;8.93,2.26,;9.7,3.59,;8.93,4.92,;7.39,4.92,;6.62,3.59,;5.08,3.59,;-4.37,-1.84,;-5.7,-2.61,)| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00111 BindingDB Entry DOI: 10.7270/Q2TT4W0M
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50582940 (CHEMBL5084320) Show SMILES [#7]\[#6](-[#7])=[#7]\S(=O)(=O)c1ccc(cc1)\[#7]=[#7]\[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]1)-c1cc2n(cc(-[#6](-[#8])=O)c(=O)c2cc1F)-[#6]-1-[#6]-[#6]-1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using kDNA as substrate incubated for 30 mins by fluorimetr...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.114021 BindingDB Entry DOI: 10.7270/Q2DZ0D6N
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50249796 (CHEMBL4752072) Show SMILES Cl.C[C@H](NC(=O)c1ccc(NC(=O)c2[nH]c(C)c(Cl)c2Cl)c(OC2CCNCC2)c1)C(O)=O |r| Show InChI InChI=1S/C21H21N3O4S/c1-4-15-11-16-12-17(7-8-18(16)24(5-2)21(15)25)23-29(26,27)20-9-6-14(13-22)10-19(20)28-3/h6-12,23H,4-5H2,1-3H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	690	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of BRD4 bromodomain 1 (unknown origin) incubated in dark for 30 mins by TR-FRET assay				Citation and Details Article DOI: 10.1016/j.ejmech.2019.02.004 BindingDB Entry DOI: 10.7270/Q23J3HK1
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50561966 (CHEMBL4759626) Show SMILES COc1ccc2nccc(CC[C@H]3OC[C@@H](CO3)NC(=O)c3ccc4SCC(=O)Nc4c3)c2c1 |r,wU:12.11,wD:15.18,(61.72,-49.58,;61.72,-51.11,;63.06,-51.88,;63.06,-53.43,;64.38,-54.2,;65.71,-53.42,;67.05,-54.2,;68.39,-53.42,;68.38,-51.87,;67.05,-51.11,;67.04,-49.57,;68.37,-48.79,;69.71,-49.56,;71.03,-48.77,;72.37,-49.55,;72.38,-51.09,;71.04,-51.86,;69.71,-51.1,;73.71,-51.86,;75.04,-51.09,;75.04,-49.55,;76.38,-51.86,;76.37,-53.4,;77.71,-54.16,;79.04,-53.39,;80.37,-54.15,;81.71,-53.38,;81.71,-51.83,;83.03,-51.06,;80.36,-51.06,;79.03,-51.84,;77.7,-51.08,;65.72,-51.88,;64.39,-51.11,)| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase-4 assessed as reduction in decatenation of kinetoplast DNA agarose gel electrophoresis method				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00428 BindingDB Entry DOI: 10.7270/Q2Z89H4G
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50572201 (CHEMBL4864750) Show SMILES COc1ccc2nccc(CCN3CCC(CC3)NCc3ccc(I)c(F)c3F)c2n1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	725	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using supercoiled pNO1 plasmid DNA as substrate incubated f...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00345 BindingDB Entry DOI: 10.7270/Q28D012J
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50249794 (CHEMBL4785583) Show SMILES C[C@H](NC(=O)c1ccc(NC(=O)c2[nH]c(C)c(Cl)c2Cl)c(OC2CCN(CC2)C(=O)OC(C)(C)C)c1)C(O)=O |r| Show InChI InChI=1S/C20H19N3O4S/c1-13-9-15-11-16(6-7-17(15)22(2)20(13)24)23(3)28(25,26)19-8-5-14(12-21)10-18(19)27-4/h5-11H,1-4H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of BRD4 bromodomain 1 (unknown origin) incubated in dark for 30 mins by TR-FRET assay				Citation and Details Article DOI: 10.1016/j.ejmech.2019.02.004 BindingDB Entry DOI: 10.7270/Q23J3HK1
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50577575 (CHEMBL4851183) Show SMILES [H][C@@]1(OC[C@@H](CO1)NCc1cc2OCCOc2cn1)[C@@H](O)Cc1c(F)ccc2ccc(OC)nc12 |r,wU:19.22,wD:4.7,1.0,(11.25,-30.96,;9.92,-30.19,;8.58,-29.44,;8.58,-27.9,;9.91,-27.12,;11.25,-27.89,;11.25,-29.43,;9.91,-25.58,;11.24,-24.81,;12.58,-25.58,;13.9,-24.8,;15.23,-25.56,;16.56,-24.79,;17.9,-25.56,;17.9,-27.1,;16.57,-27.87,;15.23,-27.11,;13.91,-27.88,;12.58,-27.12,;9.92,-31.73,;11.27,-32.5,;8.61,-32.51,;8.61,-34.05,;9.94,-34.81,;11.27,-34.03,;9.94,-36.36,;8.62,-37.13,;7.28,-36.37,;5.95,-37.15,;4.62,-36.37,;4.62,-34.83,;3.28,-34.06,;3.28,-32.52,;5.95,-34.06,;7.28,-34.82,)| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase IV decatenation activity using kDNA as substrate by ethidium bromide/bromophenol blue staining base...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01250 BindingDB Entry DOI: 10.7270/Q2CN77R0
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50561964 (CHEMBL4755744) Show SMILES COc1ccc2nccc(CC[C@H]3OC[C@@H](CO3)NC(=O)c3ccc4OCC(=O)Nc4c3)c2c1 |r,wU:12.11,wD:15.18,(4.07,-48.98,;4.08,-50.52,;5.41,-51.28,;5.42,-52.83,;6.74,-53.6,;8.07,-52.83,;9.41,-53.6,;10.75,-52.83,;10.74,-51.28,;9.41,-50.52,;9.4,-48.98,;10.73,-48.19,;12.07,-48.96,;13.39,-48.18,;14.73,-48.95,;14.74,-50.5,;13.4,-51.26,;12.07,-50.5,;16.06,-51.26,;17.4,-50.5,;17.4,-48.96,;18.74,-51.26,;18.73,-52.8,;20.07,-53.57,;21.4,-52.79,;22.73,-53.56,;24.07,-52.78,;24.07,-51.24,;25.39,-50.46,;22.72,-50.46,;21.39,-51.25,;20.06,-50.49,;8.08,-51.29,;6.74,-50.52,)| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase-4 assessed as reduction in decatenation of kinetoplast DNA agarose gel electrophoresis method				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00428 BindingDB Entry DOI: 10.7270/Q2Z89H4G
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50547857 (CHEMBL4792173) Show SMILES Cc1[nH]c(C(=O)Nc2ccc3nc(NC(=O)C(O)=O)sc3c2)c(Cl)c1Cl Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	910	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus DNA topoisomerase 4 using supercoiled pNO1 plasmid DNA as substrate incubated for 30 mins by fluorescence assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00416 BindingDB Entry DOI: 10.7270/Q2JW8JGG
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50249798 (CHEMBL4795890) Show SMILES Cl.C[C@@H](NC(=O)c1ccc(NC(=O)c2[nH]c(C)c(Cl)c2Cl)c(OC2CCNCC2)c1)C(O)=O |r| Show InChI InChI=1S/C19H17N3O4S/c1-12-8-14-9-16(18(26-3)10-17(14)22(2)19(12)23)21-27(24,25)15-6-4-13(11-20)5-7-15/h4-10,21H,1-3H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	960	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of BRD4 bromodomain 1 (unknown origin) incubated in dark for 30 mins by TR-FRET assay				Citation and Details Article DOI: 10.1016/j.ejmech.2019.02.004 BindingDB Entry DOI: 10.7270/Q23J3HK1
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50577577 (CHEMBL4848487) Show SMILES [H][C@@]1(OC[C@@H](CO1)NCc1ccc2OCC(=O)Nc2n1)[C@@H](O)Cc1c(F)ccc2ccc(OC)nc12 |r,wU:20.23,wD:4.7,1.0,(44.26,-30.26,;42.93,-29.49,;41.59,-28.74,;41.59,-27.2,;42.92,-26.42,;44.26,-27.19,;44.26,-28.72,;42.92,-24.88,;44.25,-24.11,;45.58,-24.88,;45.58,-26.41,;46.92,-27.18,;48.24,-26.4,;49.57,-27.17,;50.91,-26.4,;50.91,-24.86,;52.24,-24.09,;49.57,-24.09,;48.24,-24.86,;46.91,-24.1,;42.93,-31.03,;44.28,-31.79,;41.62,-31.81,;41.62,-33.35,;42.95,-34.11,;44.28,-33.33,;42.95,-35.66,;41.63,-36.43,;40.29,-35.67,;38.96,-36.44,;37.63,-35.67,;37.63,-34.13,;36.29,-33.36,;36.29,-31.82,;38.95,-33.36,;40.29,-34.12,)| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	990	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase IV decatenation activity using kDNA as substrate by ethidium bromide/bromophenol blue staining base...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01250 BindingDB Entry DOI: 10.7270/Q2CN77R0
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50572194 (CHEMBL4862136) Show SMILES COc1ccc2nccc(CCN3CCC(CC3)NCc3ccc(Cl)c(F)c3)c2n1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.02E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using supercoiled pNO1 plasmid DNA as substrate incubated f...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00345 BindingDB Entry DOI: 10.7270/Q28D012J
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50597276 (CHEMBL5177294) Show SMILES [H][C@@]1(OC[C@@H](CO1)NC(=O)c1ccc2OCC(=O)Nc2n1)[C@@H](O)Cc1c(F)cnc2ccc(OC)nc12 |r,wD:21.24,4.7,1.0,(-1.88,-1.31,;-1.49,.18,;-.73,1.51,;.81,1.5,;1.57,.17,;.8,-1.15,;-.72,-1.14,;3.11,.17,;3.88,1.5,;3.11,2.83,;5.42,1.5,;6.18,.16,;7.71,.15,;8.49,1.48,;10.02,1.47,;10.8,2.8,;10.04,4.14,;10.81,5.48,;8.49,4.15,;7.71,2.82,;6.18,2.82,;-3.01,.18,;-3.34,1.68,;-4.16,-.85,;-4.15,-2.39,;-2.82,-3.15,;-1.5,-2.37,;-2.81,-4.7,;-4.14,-5.47,;-5.47,-4.7,;-6.81,-5.48,;-8.14,-4.71,;-8.14,-3.16,;-9.48,-2.4,;-10.81,-3.17,;-6.81,-2.4,;-5.47,-3.16,)| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00111 BindingDB Entry DOI: 10.7270/Q2TT4W0M
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50577589 (CHEMBL4869986) Show SMILES [H][C@@]1(OC[C@@H](CO1)NCc1ccc(Cl)c(Cl)c1)[C@@H](O)Cc1c(F)cnc2ccc(OC)nc12 |r,wU:17.19,wD:4.7,1.0,(50.13,-53.68,;48.8,-52.92,;47.46,-52.17,;47.46,-50.62,;48.79,-49.85,;50.13,-50.62,;50.13,-52.15,;48.79,-48.31,;50.12,-47.54,;51.46,-48.3,;51.46,-49.84,;52.79,-50.61,;54.12,-49.84,;55.46,-50.6,;54.12,-48.29,;55.44,-47.51,;52.78,-47.53,;48.8,-54.46,;50.15,-55.22,;47.49,-55.23,;47.49,-56.77,;48.82,-57.54,;50.15,-56.76,;48.82,-59.08,;47.5,-59.86,;46.16,-59.09,;44.83,-59.87,;43.5,-59.1,;43.5,-57.55,;42.16,-56.79,;42.16,-55.25,;44.83,-56.78,;46.16,-57.55,)| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase IV decatenation activity using kDNA as substrate by ethidium bromide/bromophenol blue staining base...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01250 BindingDB Entry DOI: 10.7270/Q2CN77R0
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50582953 (CHEMBL5087899) Show SMILES CC(N1CCN(CC1)c1cc2n(cc(C(O)=O)c(=O)c2cc1F)C1CC1)C(=O)Nc1ccc(cc1)S(=O)(=O)Nc1cnc2ccccc2n1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.21E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using kDNA as substrate incubated for 30 mins by fluorimetr...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.114021 BindingDB Entry DOI: 10.7270/Q2DZ0D6N
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50572200 (CHEMBL4862951) Show SMILES COc1ccc2nccc(CCN3CCC(CC3)NCc3ccc(Br)c(F)c3F)c2n1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using supercoiled pNO1 plasmid DNA as substrate incubated f...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00345 BindingDB Entry DOI: 10.7270/Q28D012J
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50577573 (CHEMBL4875838) Show SMILES [H][C@@]1(OC[C@@H](CO1)NCc1ccc(Cl)c(Cl)c1)[C@@H](O)Cc1c(F)cnc2ccc(OC)cc12 |r,wU:17.19,wD:4.7,1.0,(46.92,-12.03,;45.6,-11.27,;44.25,-10.52,;44.25,-8.97,;45.59,-8.2,;46.93,-8.97,;46.93,-10.5,;45.59,-6.65,;46.92,-5.88,;48.25,-6.65,;48.25,-8.19,;49.59,-8.96,;50.91,-8.18,;52.25,-8.94,;50.91,-6.64,;52.25,-5.86,;49.58,-5.88,;45.6,-12.81,;46.94,-13.57,;44.28,-13.59,;44.28,-15.13,;45.62,-15.89,;46.95,-15.11,;45.62,-17.44,;44.29,-18.21,;42.96,-17.45,;41.62,-18.22,;40.29,-17.45,;40.29,-15.91,;38.96,-15.14,;38.96,-13.6,;41.62,-15.14,;42.96,-15.9,)| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase IV decatenation activity using kDNA as substrate by ethidium bromide/bromophenol blue staining base...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01250 BindingDB Entry DOI: 10.7270/Q2CN77R0
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50577580 (CHEMBL4865826) Show SMILES [H][C@@]1(OC[C@@H](CO1)NCc1cc2OCCOc2cn1)[C@@H](O)Cc1c(F)cnc2ccc(OC)nc12 |r,wU:19.22,wD:4.7,1.0,(29.25,-15.08,;27.93,-14.32,;26.58,-13.57,;26.58,-12.02,;27.92,-11.25,;29.26,-12.02,;29.26,-13.55,;27.92,-9.71,;29.25,-8.93,;30.58,-9.7,;31.91,-8.93,;33.24,-9.69,;34.57,-8.91,;35.91,-9.69,;35.91,-11.23,;34.57,-12,;33.24,-11.23,;31.91,-12.01,;30.58,-11.24,;27.93,-15.86,;29.27,-16.62,;26.61,-16.63,;26.61,-18.17,;27.95,-18.93,;29.28,-18.16,;27.95,-20.48,;26.62,-21.26,;25.29,-20.49,;23.95,-21.27,;22.62,-20.5,;22.62,-18.95,;21.29,-18.18,;21.29,-16.64,;23.95,-18.18,;25.29,-18.95,)| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase IV decatenation activity using kDNA as substrate by ethidium bromide/bromophenol blue staining base...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01250 BindingDB Entry DOI: 10.7270/Q2CN77R0
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A/B (Staphylococcus aureus)	BDBM50577581 (CHEMBL4874489) Show SMILES [H][C@@]1(OC[C@@H](CO1)NCc1cc2CCCOc2cn1)[C@@H](O)Cc1c(F)cnc2ccc(OC)nc12 |r,wU:19.22,wD:4.7,1.0,(46.4,-15.49,;45.08,-14.72,;43.73,-13.97,;43.73,-12.43,;45.07,-11.65,;46.41,-12.42,;46.41,-13.95,;45.07,-10.11,;46.4,-9.34,;47.73,-10.11,;49.05,-9.33,;50.39,-10.09,;51.72,-9.32,;53.06,-10.09,;53.06,-11.63,;51.72,-12.4,;50.39,-11.63,;49.06,-12.41,;47.73,-11.65,;45.08,-16.26,;46.42,-17.02,;43.76,-17.04,;43.76,-18.58,;45.1,-19.34,;46.43,-18.56,;45.1,-20.89,;43.77,-21.66,;42.44,-20.9,;41.1,-21.67,;39.77,-20.9,;39.77,-19.36,;38.44,-18.59,;38.44,-17.05,;41.1,-18.59,;42.44,-19.35,)| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Staphylococcus aureus topoisomerase IV decatenation activity using kDNA as substrate by ethidium bromide/bromophenol blue staining base...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01250 BindingDB Entry DOI: 10.7270/Q2CN77R0
					More data for this Ligand-Target Pair

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