BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 84 hits of ec50 for UniProtKB: P35439   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50432711
PNG
(CHEMBL2348224)
Show SMILES C[C@@]1(C[C@H]1[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C7H11NO4/c1-7(6(11)12)2-3(7)4(8)5(9)10/h3-4H,2,8H2,1H3,(H,9,10)(H,11,12)/t3-,4-,7-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 45n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant wild type GluN1/GluN2B receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp technique

J Med Chem 56: 4071-81 (2013)


Article DOI: 10.1021/jm400346a
BindingDB Entry DOI: 10.7270/Q20G3MHR
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50220152
PNG
((1S,2R)-2-((S)-Amino-carboxy-methyl)-cyclopropanec...)
Show SMILES N[C@@H]([C@@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C6H9NO4/c7-4(6(10)11)2-1-3(2)5(8)9/h2-4H,1,7H2,(H,8,9)(H,10,11)/t2-,3+,4+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 83n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant wild type GluN1/GluN2B receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp technique

J Med Chem 56: 4071-81 (2013)


Article DOI: 10.1021/jm400346a
BindingDB Entry DOI: 10.7270/Q20G3MHR
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM18133
PNG
(2-aminoacetic acid | CHEMBL773 | Glycine | [14C]Gl...)
Show SMILES NCC(O)=O
Show InChI InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/an/an/a 240n/an/an/an/a


TBA

Assay Description
Agonist activity at rat GluN1/GluN2B NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01810
BindingDB Entry DOI: 10.7270/Q21R6VFZ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238357
PNG
(CHEMBL4100452)
Show SMILES CC(C)Oc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=S)c2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C30H32F3NO3S/c1-19(2)36-25-10-8-24(9-11-25)35-18-28-27-13-12-26(37-20(3)4)17-21(27)14-15-34(28)29(38)22-6-5-7-23(16-22)30(31,32)33/h5-13,16-17,19-20,28H,14-15,18H2,1-4H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 270n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50432710
PNG
(CHEMBL2348221)
Show SMILES CC[C@@]1(C[C@H]1[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C8H13NO4/c1-2-8(7(12)13)3-4(8)5(9)6(10)11/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t4-,5-,8-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 272n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant wild type GluN1/GluN2B receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp technique

J Med Chem 56: 4071-81 (2013)


Article DOI: 10.1021/jm400346a
BindingDB Entry DOI: 10.7270/Q20G3MHR
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238364
PNG
(CHEMBL4064008)
Show SMILES COc1ccc(OC[C@H]2N(CCc3cc(OC(C)C)ccc23)C(=S)c2cccc(Cl)c2)cc1 |r|
Show InChI InChI=1S/C27H28ClNO3S/c1-18(2)32-24-11-12-25-19(16-24)13-14-29(27(33)20-5-4-6-21(28)15-20)26(25)17-31-23-9-7-22(30-3)8-10-23/h4-12,15-16,18,26H,13-14,17H2,1-3H3/t26-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 320n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238352
PNG
(CHEMBL4061206)
Show SMILES CCOc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=S)c2cccc(Br)c2)cc1
Show InChI InChI=1S/C28H30BrNO3S/c1-4-31-23-8-10-24(11-9-23)32-18-27-26-13-12-25(33-19(2)3)17-20(26)14-15-30(27)28(34)21-6-5-7-22(29)16-21/h5-13,16-17,19,27H,4,14-15,18H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 340n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238367
PNG
(CHEMBL4089357)
Show SMILES CCOc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=S)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C28H30ClNO3S/c1-4-31-23-8-10-24(11-9-23)32-18-27-26-13-12-25(33-19(2)3)17-20(26)14-15-30(27)28(34)21-6-5-7-22(29)16-21/h5-13,16-17,19,27H,4,14-15,18H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 400n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238335
PNG
(CHEMBL4083076)
Show SMILES CCOc1ccc(OC[C@H]2N(CCc3cc(OC(C)C)ccc23)C(=S)c2cccc(F)c2)cc1 |r|
Show InChI InChI=1S/C28H30FNO3S/c1-4-31-23-8-10-24(11-9-23)32-18-27-26-13-12-25(33-19(2)3)17-20(26)14-15-30(27)28(34)21-6-5-7-22(29)16-21/h5-13,16-17,19,27H,4,14-15,18H2,1-3H3/t27-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 490n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238350
PNG
(CHEMBL4063861)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=S)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C27H28ClNO3S/c1-18(2)32-24-11-12-25-19(16-24)13-14-29(27(33)20-5-4-6-21(28)15-20)26(25)17-31-23-9-7-22(30-3)8-10-23/h4-12,15-16,18,26H,13-14,17H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 490n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238355
PNG
(CHEMBL4091770)
Show SMILES CC(C)Oc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=S)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C29H32ClNO3S/c1-19(2)33-25-10-8-24(9-11-25)32-18-28-27-13-12-26(34-20(3)4)17-21(27)14-15-31(28)29(35)22-6-5-7-23(30)16-22/h5-13,16-17,19-20,28H,14-15,18H2,1-4H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 550n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238353
PNG
(CHEMBL4081483)
Show SMILES CCOc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=S)c2cccc(F)c2)cc1
Show InChI InChI=1S/C28H30FNO3S/c1-4-31-23-8-10-24(11-9-23)32-18-27-26-13-12-25(33-19(2)3)17-20(26)14-15-30(27)28(34)21-6-5-7-22(29)16-21/h5-13,16-17,19,27H,4,14-15,18H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 550n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM23167
PNG
((2R)-2-amino-3-hydroxypropanoic acid | CHEMBL28512...)
Show SMILES N[C@H](CO)C(O)=O
Show InChI InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
PDB
Article
PubMed
n/an/an/an/a 620n/an/an/an/a


TBA

Assay Description
Agonist activity at rat GluN1/GluN2B NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01810
BindingDB Entry DOI: 10.7270/Q21R6VFZ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238356
PNG
(CHEMBL4062279)
Show SMILES CC(C)Oc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=S)c2cccc(F)c2)cc1
Show InChI InChI=1S/C29H32FNO3S/c1-19(2)33-25-10-8-24(9-11-25)32-18-28-27-13-12-26(34-20(3)4)17-21(27)14-15-31(28)29(35)22-6-5-7-23(30)16-22/h5-13,16-17,19-20,28H,14-15,18H2,1-4H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 670n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238363
PNG
(CHEMBL4099510)
Show SMILES CCOc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=S)c2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C29H30F3NO3S/c1-4-34-23-8-10-24(11-9-23)35-18-27-26-13-12-25(36-19(2)3)17-20(26)14-15-33(27)28(37)21-6-5-7-22(16-21)29(30,31)32/h5-13,16-17,19,27H,4,14-15,18H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 720n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238354
PNG
(CHEMBL4070902)
Show SMILES CCOc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=S)c2ccc(F)c(Cl)c2)cc1
Show InChI InChI=1S/C28H29ClFNO3S/c1-4-32-21-6-8-22(9-7-21)33-17-27-24-11-10-23(34-18(2)3)15-19(24)13-14-31(27)28(35)20-5-12-26(30)25(29)16-20/h5-12,15-16,18,27H,4,13-14,17H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 840n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50237806
PNG
(CHEMBL4099073)
Show SMILES CCOc1ccc(OCC2N(CCc3cc(OCC(C)C)ccc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C29H32ClNO4/c1-4-33-24-8-10-25(11-9-24)35-19-28-27-13-12-26(34-18-20(2)3)17-21(27)14-15-31(28)29(32)22-6-5-7-23(30)16-22/h5-13,16-17,20,28H,4,14-15,18-19H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.00E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238351
PNG
(CHEMBL4091645)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=S)c2cccc(F)c2)cc1
Show InChI InChI=1S/C27H28FNO3S/c1-18(2)32-24-11-12-25-19(16-24)13-14-29(27(33)20-5-4-6-21(28)15-20)26(25)17-31-23-9-7-22(30-3)8-10-23/h4-12,15-16,18,26H,13-14,17H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.40E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238347
PNG
(CHEMBL4064895)
Show SMILES CC(C)Oc1ccc2C(COc3ccc(OC(F)(F)F)cc3)N(CCc2c1)C(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C27H25ClF3NO4/c1-17(2)35-23-10-11-24-18(15-23)12-13-32(26(33)19-4-3-5-20(28)14-19)25(24)16-34-21-6-8-22(9-7-21)36-27(29,30)31/h3-11,14-15,17,25H,12-13,16H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.40E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238372
PNG
(CHEMBL4083995)
Show SMILES CC(C)Oc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=O)c2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C30H32F3NO4/c1-19(2)37-25-10-8-24(9-11-25)36-18-28-27-13-12-26(38-20(3)4)17-21(27)14-15-34(28)29(35)22-6-5-7-23(16-22)30(31,32)33/h5-13,16-17,19-20,28H,14-15,18H2,1-4H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.50E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238338
PNG
(CHEMBL4068612)
Show SMILES COc1ccc(OCC2N(CCc3cc(OCC(C)C)ccc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C28H30ClNO4/c1-19(2)17-33-25-11-12-26-20(16-25)13-14-30(28(31)21-5-4-6-22(29)15-21)27(26)18-34-24-9-7-23(32-3)8-10-24/h4-12,15-16,19,27H,13-14,17-18H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.50E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238341
PNG
(CHEMBL4064435)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=O)c2cccc(I)c2)cc1
Show InChI InChI=1S/C27H28INO4/c1-18(2)33-24-11-12-25-19(16-24)13-14-29(27(30)20-5-4-6-21(28)15-20)26(25)17-32-23-9-7-22(31-3)8-10-23/h4-12,15-16,18,26H,13-14,17H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.70E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238365
PNG
(CHEMBL4069391)
Show SMILES CCC(CC)Oc1ccc2C(COc3ccc(OC)cc3)N(CCc2c1)C(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C29H32ClNO4/c1-4-23(5-2)35-26-13-14-27-20(18-26)15-16-31(29(32)21-7-6-8-22(30)17-21)28(27)19-34-25-11-9-24(33-3)10-12-25/h6-14,17-18,23,28H,4-5,15-16,19H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.80E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50461814
PNG
(CHEMBL4228835)
Show SMILES [H][C@@]12CCC[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@H](CC[C@]12C)OC(=O)CCCCCC(O)=O |r,t:16|
Show InChI InChI=1S/C26H40O4/c1-25-14-6-7-21(25)20-11-10-18-17-19(12-16-26(18,2)22(20)13-15-25)30-24(29)9-5-3-4-8-23(27)28/h10,19-22H,3-9,11-17H2,1-2H3,(H,27,28)/t19-,20-,21-,22-,25-,26-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.80E+3n/an/an/an/a



Institute of Physiology of the Czech Academy of Sciences

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1alpha/GluN2B receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced ...

J Med Chem 61: 4505-4516 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00255
BindingDB Entry DOI: 10.7270/Q2Z03BTB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238332
PNG
(CHEMBL4100185)
Show SMILES CCOc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=O)c2ccc(F)c(Cl)c2)cc1
Show InChI InChI=1S/C28H29ClFNO4/c1-4-33-21-6-8-22(9-7-21)34-17-27-24-11-10-23(35-18(2)3)15-19(24)13-14-31(27)28(32)20-5-12-26(30)25(29)16-20/h5-12,15-16,18,27H,4,13-14,17H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 2.20E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238370
PNG
(CHEMBL4101706)
Show SMILES CCOc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=O)c2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C29H30F3NO4/c1-4-35-23-8-10-24(11-9-23)36-18-27-26-13-12-25(37-19(2)3)17-20(26)14-15-33(27)28(34)21-6-5-7-22(16-21)29(30,31)32/h5-13,16-17,19,27H,4,14-15,18H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 2.40E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238345
PNG
(CHEMBL4072003)
Show SMILES CCOc1ccc(OCC2N(CCc3cc(OCC(C)C)ccc23)C(=O)c2cccc(F)c2)cc1
Show InChI InChI=1S/C29H32FNO4/c1-4-33-24-8-10-25(11-9-24)35-19-28-27-13-12-26(34-18-20(2)3)17-21(27)14-15-31(28)29(32)22-6-5-7-23(30)16-22/h5-13,16-17,20,28H,4,14-15,18-19H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 2.50E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238339
PNG
(CHEMBL4096621)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC4CCCCC4)ccc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C30H32ClNO4/c1-34-24-10-12-25(13-11-24)35-20-29-28-15-14-27(36-26-8-3-2-4-9-26)19-21(28)16-17-32(29)30(33)22-6-5-7-23(31)18-22/h5-7,10-15,18-19,26,29H,2-4,8-9,16-17,20H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 2.70E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50461792
PNG
(CHEMBL4226027)
Show SMILES [H][C@@]12CCC[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@H](CC[C@]12C)OC(=O)CCCCC(O)=O |r,t:16|
Show InChI InChI=1S/C25H38O4/c1-24-13-5-6-20(24)19-10-9-17-16-18(11-15-25(17,2)21(19)12-14-24)29-23(28)8-4-3-7-22(26)27/h9,18-21H,3-8,10-16H2,1-2H3,(H,26,27)/t18-,19-,20-,21-,24-,25-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 2.80E+3n/an/an/an/a



Institute of Physiology of the Czech Academy of Sciences

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1alpha/GluN2B receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced ...

J Med Chem 61: 4505-4516 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00255
BindingDB Entry DOI: 10.7270/Q2Z03BTB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238358
PNG
(CHEMBL4073626)
Show SMILES COc1ccc(OC[C@H]2N(CCc3cc(OC(C)C)ccc23)C(=O)c2cccc(Cl)c2)cc1 |r|
Show InChI InChI=1S/C27H28ClNO4/c1-18(2)33-24-11-12-25-19(16-24)13-14-29(27(30)20-5-4-6-21(28)15-20)26(25)17-32-23-9-7-22(31-3)8-10-23/h4-12,15-16,18,26H,13-14,17H2,1-3H3/t26-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 3.00E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238371
PNG
(CHEMBL4101865)
Show SMILES CC(C)Oc1ccc2C(COc3ccc(OC(F)(F)F)cc3)N(CCc2c1)C(=O)c1cccc(F)c1
Show InChI InChI=1S/C27H25F4NO4/c1-17(2)35-23-10-11-24-18(15-23)12-13-32(26(33)19-4-3-5-20(28)14-19)25(24)16-34-21-6-8-22(9-7-21)36-27(29,30)31/h3-11,14-15,17,25H,12-13,16H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 3.20E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238330
PNG
(CHEMBL4063668)
Show SMILES CCOc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1S/C28H30BrNO4/c1-4-32-23-8-10-24(11-9-23)33-18-27-26-13-12-25(34-19(2)3)17-20(26)14-15-30(27)28(31)21-6-5-7-22(29)16-21/h5-13,16-17,19,27H,4,14-15,18H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 3.40E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238331
PNG
(CHEMBL4061988)
Show SMILES CCOc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=O)c2ccc(F)c(F)c2)cc1
Show InChI InChI=1S/C28H29F2NO4/c1-4-33-21-6-8-22(9-7-21)34-17-27-24-11-10-23(35-18(2)3)15-19(24)13-14-31(27)28(32)20-5-12-25(29)26(30)16-20/h5-12,15-16,18,27H,4,13-14,17H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 3.70E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238348
PNG
(CHEMBL4094134)
Show SMILES CC(C)Oc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C29H32ClNO4/c1-19(2)34-25-10-8-24(9-11-25)33-18-28-27-13-12-26(35-20(3)4)17-21(27)14-15-31(28)29(32)22-6-5-7-23(30)16-22/h5-13,16-17,19-20,28H,14-15,18H2,1-4H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 3.80E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238333
PNG
(CHEMBL4066872)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1S/C27H28BrNO4/c1-18(2)33-24-11-12-25-19(16-24)13-14-29(27(30)20-5-4-6-21(28)15-20)26(25)17-32-23-9-7-22(31-3)8-10-23/h4-12,15-16,18,26H,13-14,17H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 3.90E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50237914
PNG
(CHEMBL4081036)
Show SMILES CCOc1ccc(OCC2N(CCc3cc(OC4CCCC4)ccc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C30H32ClNO4/c1-2-34-24-10-12-25(13-11-24)35-20-29-28-15-14-27(36-26-8-3-4-9-26)19-21(28)16-17-32(29)30(33)22-6-5-7-23(31)18-22/h5-7,10-15,18-19,26,29H,2-4,8-9,16-17,20H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 4.00E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238362
PNG
(CHEMBL4078507)
Show SMILES CCOc1ccc(OCC2N(CCc3cc(OC4CCCC4)ccc23)C(=O)c2cccc(F)c2)cc1
Show InChI InChI=1S/C30H32FNO4/c1-2-34-24-10-12-25(13-11-24)35-20-29-28-15-14-27(36-26-8-3-4-9-26)19-21(28)16-17-32(29)30(33)22-6-5-7-23(31)18-22/h5-7,10-15,18-19,26,29H,2-4,8-9,16-17,20H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 4.40E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238334
PNG
(CHEMBL4083997)
Show SMILES CCOc1ccc(OC[C@H]2N(CCc3cc(OC(C)C)ccc23)C(=O)c2cccc(F)c2)cc1 |r|
Show InChI InChI=1S/C28H30FNO4/c1-4-32-23-8-10-24(11-9-23)33-18-27-26-13-12-25(34-19(2)3)17-20(26)14-15-30(27)28(31)21-6-5-7-22(29)16-21/h5-13,16-17,19,27H,4,14-15,18H2,1-3H3/t27-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 4.70E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50461806
PNG
(CHEMBL4225836)
Show SMILES [H][C@@]12CCC[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@H](CC[C@]12C)OC(=O)CC(O)=O |r,t:16|
Show InChI InChI=1S/C22H32O4/c1-21-9-3-4-17(21)16-6-5-14-12-15(26-20(25)13-19(23)24)7-11-22(14,2)18(16)8-10-21/h5,15-18H,3-4,6-13H2,1-2H3,(H,23,24)/t15-,16-,17-,18-,21-,22-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
KEGG
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 4.70E+3n/an/an/an/a



Institute of Physiology of the Czech Academy of Sciences

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1alpha/GluN2B receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced ...

J Med Chem 61: 4505-4516 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00255
BindingDB Entry DOI: 10.7270/Q2Z03BTB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238280
PNG
(CHEMBL4064718)
Show SMILES COc1ccc(OCC2N(CCc3cc(ccc23)N2CCOCC2)C(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1S/C28H29BrN2O4/c1-33-24-6-8-25(9-7-24)35-19-27-26-10-5-23(30-13-15-34-16-14-30)18-20(26)11-12-31(27)28(32)21-3-2-4-22(29)17-21/h2-10,17-18,27H,11-16,19H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 4.80E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238279
PNG
(CHEMBL4073306)
Show SMILES COc1ccc(OCC2N(CCc3cc(ccc23)N2CCCCC2)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C29H31ClN2O3/c1-34-25-9-11-26(12-10-25)35-20-28-27-13-8-24(31-15-3-2-4-16-31)19-21(27)14-17-32(28)29(33)22-6-5-7-23(30)18-22/h5-13,18-19,28H,2-4,14-17,20H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 4.90E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238337
PNG
(CHEMBL4095932)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C27H28ClNO4/c1-18(2)33-24-11-12-25-19(16-24)13-14-29(27(30)20-5-4-6-21(28)15-20)26(25)17-32-23-9-7-22(31-3)8-10-23/h4-12,15-16,18,26H,13-14,17H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 5.20E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50461801
PNG
(CHEMBL4229097)
Show SMILES [H][C@@]12CCC[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@H](CC[C@]12C)OC(=O)CCCC(O)=O |r,t:16|
Show InChI InChI=1S/C24H36O4/c1-23-12-4-5-19(23)18-9-8-16-15-17(28-22(27)7-3-6-21(25)26)10-14-24(16,2)20(18)11-13-23/h8,17-20H,3-7,9-15H2,1-2H3,(H,25,26)/t17-,18-,19-,20-,23-,24-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 5.20E+3n/an/an/an/a



Institute of Physiology of the Czech Academy of Sciences

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1alpha/GluN2B receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced ...

J Med Chem 61: 4505-4516 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00255
BindingDB Entry DOI: 10.7270/Q2Z03BTB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238361
PNG
(CHEMBL4093717)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=O)c2cccc(c2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C27H28N2O6/c1-18(2)35-24-11-12-25-19(16-24)13-14-28(27(30)20-5-4-6-21(15-20)29(31)32)26(25)17-34-23-9-7-22(33-3)8-10-23/h4-12,15-16,18,26H,13-14,17H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 5.30E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238368
PNG
(CHEMBL4104348)
Show SMILES CCOc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C28H30ClNO4/c1-4-32-23-8-10-24(11-9-23)33-18-27-26-13-12-25(34-19(2)3)17-20(26)14-15-30(27)28(31)21-6-5-7-22(29)16-21/h5-13,16-17,19,27H,4,14-15,18H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 5.30E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238274
PNG
(CHEMBL4103457)
Show SMILES COc1ccc(OCC2N(CCc3cc(ccc23)N(C)C(C)C)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C28H31ClN2O3/c1-19(2)30(3)23-8-13-26-20(17-23)14-15-31(28(32)21-6-5-7-22(29)16-21)27(26)18-34-25-11-9-24(33-4)10-12-25/h5-13,16-17,19,27H,14-15,18H2,1-4H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 5.90E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238343
PNG
(CHEMBL4073018)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=O)c2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C28H28F3NO4/c1-18(2)36-24-11-12-25-19(16-24)13-14-32(26(25)17-35-23-9-7-22(34-3)8-10-23)27(33)20-5-4-6-21(15-20)28(29,30)31/h4-12,15-16,18,26H,13-14,17H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 6.10E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238349
PNG
(CHEMBL4101301)
Show SMILES CC(C)Oc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=O)c2cccc(F)c2)cc1
Show InChI InChI=1S/C29H32FNO4/c1-19(2)34-25-10-8-24(9-11-25)33-18-28-27-13-12-26(35-20(3)4)17-21(27)14-15-31(28)29(32)22-6-5-7-23(30)16-22/h5-13,16-17,19-20,28H,14-15,18H2,1-4H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 7.10E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50238369
PNG
(CHEMBL4100301)
Show SMILES CCOc1ccc(OCC2N(CCc3cc(OC(C)C)ccc23)C(=O)c2cccc(F)c2)cc1
Show InChI InChI=1S/C28H30FNO4/c1-4-32-23-8-10-24(11-9-23)33-18-27-26-13-12-25(34-19(2)3)17-20(26)14-15-30(27)28(31)21-6-5-7-22(29)16-21/h5-13,16-17,19,27H,4,14-15,18H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 7.20E+3n/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and ...

J Med Chem 60: 5556-5585 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00239
BindingDB Entry DOI: 10.7270/Q298898H
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50461800
PNG
(CHEMBL4225347)
Show SMILES [H][C@@]12CCC[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@H](CC[C@]12C)OC(=O)CCC(O)=O |r,t:16|
Show InChI InChI=1S/C23H34O4/c1-22-11-3-4-18(22)17-6-5-15-14-16(27-21(26)8-7-20(24)25)9-13-23(15,2)19(17)10-12-22/h5,16-19H,3-4,6-14H2,1-2H3,(H,24,25)/t16-,17-,18-,19-,22-,23-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 7.40E+3n/an/an/an/a



Institute of Physiology of the Czech Academy of Sciences

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat GluN1alpha/GluN2B receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced ...

J Med Chem 61: 4505-4516 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00255
BindingDB Entry DOI: 10.7270/Q2Z03BTB
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 84 total )  |  Next  |  Last  >>
Jump to: