Found 102 hits of ic50 for UniProtKB: P07949 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB
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| Article
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| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of KIF5B-RET fusion protein (unknown origin) by radiometric assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112755
BindingDB Entry DOI: 10.7270/Q2J96B20 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50538514
(CHEMBL4644274)Show SMILES COc1ccc(cc1OC)-c1cnn2c(N)c(c(NC3CC(C)(C)N(C)C(C)(C)C3)nc12)-c1ccccc1 Show InChI InChI=1S/C30H38N6O2/c1-29(2)16-21(17-30(3,4)35(29)5)33-27-25(19-11-9-8-10-12-19)26(31)36-28(34-27)22(18-32-36)20-13-14-23(37-6)24(15-20)38-7/h8-15,18,21H,16-17,31H2,1-7H3,(H,33,34) | PDB
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| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l... |
ACS Med Chem Lett 11: 558-565 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00015
BindingDB Entry DOI: 10.7270/Q29S1VJ7 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50538516
(CHEMBL4643578)Show SMILES COC(=O)N1CCN(CC1)C(=O)c1ccc(cc1)-c1cnn2c(N)c(c(NC3CC(C)(C)N(C)C(C)(C)C3)nc12)-c1ccccc1 Show InChI InChI=1S/C35H44N8O3/c1-34(2)20-26(21-35(3,4)40(34)5)38-30-28(24-10-8-7-9-11-24)29(36)43-31(39-30)27(22-37-43)23-12-14-25(15-13-23)32(44)41-16-18-42(19-17-41)33(45)46-6/h7-15,22,26H,16-21,36H2,1-6H3,(H,38,39) | PDB
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| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l... |
ACS Med Chem Lett 11: 558-565 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00015
BindingDB Entry DOI: 10.7270/Q29S1VJ7 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50601766
(CHEMBL5171764)Show SMILES COC1(CCC(CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@@H](C)c1ccc(nc1)-n1cc(F)cn1 |r| | PDB
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TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02167
BindingDB Entry DOI: 10.7270/Q22R3WQ4 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50538515
(CHEMBL4636056)Show SMILES [H][C@]12CN(C(=O)c3ccc(cc3)-c3cnn4c(N)c(c(NC5CC(C)(C)N(C)C(C)(C)C5)nc34)-c3ccccc3)[C@]([H])(CO1)C2 |r| Show InChI InChI=1S/C34H41N7O2/c1-33(2)16-24(17-34(3,4)39(33)5)37-30-28(22-9-7-6-8-10-22)29(35)41-31(38-30)27(18-36-41)21-11-13-23(14-12-21)32(42)40-19-26-15-25(40)20-43-26/h6-14,18,24-26H,15-17,19-20,35H2,1-5H3,(H,37,38)/t25-,26-/m0/s1 | PDB
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| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l... |
ACS Med Chem Lett 11: 558-565 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00015
BindingDB Entry DOI: 10.7270/Q29S1VJ7 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50538508
(CHEMBL4634073)Show SMILES COC(=O)Nc1ccc(cc1)-c1c(OC2CCN(C)CC2)nc2c(cnn2c1N)-c1ccc(OC)c(OC)c1 Show InChI InChI=1S/C28H32N6O5/c1-33-13-11-20(12-14-33)39-27-24(17-5-8-19(9-6-17)31-28(35)38-4)25(29)34-26(32-27)21(16-30-34)18-7-10-22(36-2)23(15-18)37-3/h5-10,15-16,20H,11-14,29H2,1-4H3,(H,31,35) | PDB
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The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l... |
ACS Med Chem Lett 11: 558-565 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00015
BindingDB Entry DOI: 10.7270/Q29S1VJ7 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50538517
(CHEMBL4639022)Show SMILES CN1C(C)(C)CC(CC1(C)C)Nc1nc2c(cnn2c(N)c1-c1ccccc1)-c1ccc(cc1)C(=O)N1CCN(CC1)S(C)(=O)=O Show InChI InChI=1S/C34H44N8O3S/c1-33(2)20-26(21-34(3,4)39(33)5)37-30-28(24-10-8-7-9-11-24)29(35)42-31(38-30)27(22-36-42)23-12-14-25(15-13-23)32(43)40-16-18-41(19-17-40)46(6,44)45/h7-15,22,26H,16-21,35H2,1-6H3,(H,37,38) | PDB
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The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l... |
ACS Med Chem Lett 11: 558-565 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00015
BindingDB Entry DOI: 10.7270/Q29S1VJ7 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50097956
(3-(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidi...)Show InChI InChI=1S/C17H18N4O/c18-16-15-14(11-4-3-7-13(22)8-11)9-21(12-5-1-2-6-12)17(15)20-10-19-16/h3-4,7-10,12,22H,1-2,5-6H2,(H2,18,19,20) | PDB
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| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of KIF5B-RET fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hr... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00450
BindingDB Entry DOI: 10.7270/Q23R0XP8 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50556136
(CHEMBL4790634)Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(Oc4nc(nc5[nH]ncc45)-c4cccnc4)c3)cc2C(F)(F)F)CC1 | PDB
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| n/a | n/a | 8.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of KIF5B-RET fusion protein (unknown origin) by radiometric assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112755
BindingDB Entry DOI: 10.7270/Q2J96B20 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50575343
(CHEMBL4858720)Show SMILES Nc1ncnc2n(cc(-c3cccc(O)c3)c12)[C@@H]1C[C@H](CO)C1 |r,wU:17.19,19.22,(11.65,-9.07,;11.66,-10.61,;12.99,-11.37,;13,-12.92,;11.66,-13.69,;10.32,-12.92,;8.86,-13.4,;7.95,-12.16,;8.85,-10.91,;8.37,-9.46,;6.87,-9.15,;6.38,-7.69,;7.41,-6.53,;8.92,-6.85,;9.95,-5.7,;9.4,-8.31,;10.32,-11.38,;8.4,-14.88,;7.03,-15.58,;7.73,-16.95,;7.26,-18.42,;8.3,-19.56,;9.1,-16.25,)| | PDB
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TBA
| Assay Description
Inhibition of KIF5B-RET fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hr... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00450
BindingDB Entry DOI: 10.7270/Q23R0XP8 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50575351
(CHEMBL4874648)Show SMILES COC(=O)N[C@H]1CC[C@H](CC1)n1cc(-c2ccc(Cl)c(N)c2)c2c(N)ncnc12 |r,wU:8.11,5.4,(7.07,-20.4,;8.57,-20.08,;9.05,-18.61,;10.56,-18.29,;8.02,-17.47,;8.49,-16,;7.46,-14.86,;7.94,-13.4,;9.44,-13.07,;10.48,-14.21,;10,-15.68,;9.91,-11.61,;9,-10.37,;9.9,-9.12,;9.42,-7.66,;7.91,-7.35,;7.43,-5.89,;8.45,-4.74,;7.97,-3.27,;9.96,-5.05,;10.99,-3.9,;10.44,-6.51,;11.36,-9.59,;12.7,-8.81,;12.69,-7.27,;14.03,-9.58,;14.04,-11.13,;12.7,-11.9,;11.37,-11.13,)| | PDB
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TBA
| Assay Description
Inhibition of KIF5B-RET fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hr... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00450
BindingDB Entry DOI: 10.7270/Q23R0XP8 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50538508
(CHEMBL4634073)Show SMILES COC(=O)Nc1ccc(cc1)-c1c(OC2CCN(C)CC2)nc2c(cnn2c1N)-c1ccc(OC)c(OC)c1 Show InChI InChI=1S/C28H32N6O5/c1-33-13-11-20(12-14-33)39-27-24(17-5-8-19(9-6-17)31-28(35)38-4)25(29)34-26(32-27)21(16-30-34)18-7-10-22(36-2)23(15-18)37-3/h5-10,15-16,20H,11-14,29H2,1-4H3,(H,31,35) | PDB
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The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B-RET V804M mutant (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs b... |
ACS Med Chem Lett 11: 558-565 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00015
BindingDB Entry DOI: 10.7270/Q29S1VJ7 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50575352
(CHEMBL4857808)Show SMILES COC(=O)NC12CCC(CC1)(CC2)n1cc(-c2ccc(Cl)c(N)c2)c2c(N)ncnc12 | PDB
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TBA
| Assay Description
Inhibition of KIF5B-RET fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hr... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00450
BindingDB Entry DOI: 10.7270/Q23R0XP8 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50575353
(CHEMBL4859681)Show SMILES COC(=O)NC12CCC(CC1)(CC2)n1cc(-c2cc(N)c(Cl)cc2F)c2c(N)ncnc12 | PDB
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TBA
| Assay Description
Inhibition of KIF5B-RET fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hr... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00450
BindingDB Entry DOI: 10.7270/Q23R0XP8 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50538512
(CHEMBL4638840)Show SMILES COc1ccc(cc1OC)-c1cnn2c(N)c(c(NC3CCN(C)CC3)nc12)-c1ccccc1 Show InChI InChI=1S/C26H30N6O2/c1-31-13-11-19(12-14-31)29-25-23(17-7-5-4-6-8-17)24(27)32-26(30-25)20(16-28-32)18-9-10-21(33-2)22(15-18)34-3/h4-10,15-16,19H,11-14,27H2,1-3H3,(H,29,30) | PDB
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The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l... |
ACS Med Chem Lett 11: 558-565 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00015
BindingDB Entry DOI: 10.7270/Q29S1VJ7 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50538507
(CHEMBL4640601)Show SMILES COc1ccc(cc1OC)-c1cnn2c(N)c(-c3ccccc3)c(OC3CCN(C)CC3)nc12 Show InChI InChI=1S/C26H29N5O3/c1-30-13-11-19(12-14-30)34-26-23(17-7-5-4-6-8-17)24(27)31-25(29-26)20(16-28-31)18-9-10-21(32-2)22(15-18)33-3/h4-10,15-16,19H,11-14,27H2,1-3H3 | PDB
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The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l... |
ACS Med Chem Lett 11: 558-565 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00015
BindingDB Entry DOI: 10.7270/Q29S1VJ7 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM4627
(5-[(6,7-dimethoxyquinazolin-4-yl)amino]-4-fluoro-2...)Show InChI InChI=1S/C17H16FN3O3/c1-9-4-11(18)13(6-14(9)22)21-17-10-5-15(23-2)16(24-3)7-12(10)19-8-20-17/h4-8,22H,1-3H3,(H,19,20,21) | PDB
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| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ... |
Eur J Med Chem 112: 20-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.039
BindingDB Entry DOI: 10.7270/Q27W6F1V |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50575350
(CHEMBL4877264)Show SMILES CC(=O)N1CCN(CC1)[C@H]1C[C@H](C1)n1cc(-c2ccc(Cl)c(N)c2)c2c(N)ncnc12 |r,wU:11.14,9.9,(30.61,-31.29,;32.11,-30.97,;33.14,-32.11,;32.59,-29.5,;31.56,-28.36,;32.03,-26.9,;33.54,-26.58,;34.57,-27.71,;34.09,-29.18,;34.01,-25.11,;33.3,-23.74,;34.67,-23.04,;35.38,-24.41,;35.14,-21.56,;34.23,-20.32,;35.13,-19.07,;34.65,-17.62,;33.15,-17.31,;32.66,-15.85,;33.69,-14.69,;33.2,-13.23,;35.2,-15.01,;36.22,-13.86,;35.68,-16.47,;36.59,-19.54,;37.93,-18.77,;37.92,-17.23,;39.27,-19.53,;39.27,-21.08,;37.93,-21.85,;36.6,-21.08,)| | PDB
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TBA
| Assay Description
Inhibition of KIF5B-RET fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hr... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00450
BindingDB Entry DOI: 10.7270/Q23R0XP8 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50153979
(CHEMBL3774904)Show InChI InChI=1S/C16H14FN3O3/c1-22-14-6-10-12(7-15(14)23-2)18-8-19-16(10)20-13-5-9(21)3-4-11(13)17/h3-8,21H,1-2H3,(H,18,19,20) | PDB
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| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ... |
Eur J Med Chem 112: 20-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.039
BindingDB Entry DOI: 10.7270/Q27W6F1V |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50153906
(CHEMBL3775169)Show InChI InChI=1S/C16H13F2N3O3/c1-23-14-3-8-11(6-15(14)24-2)19-7-20-16(8)21-12-5-13(22)10(18)4-9(12)17/h3-7,22H,1-2H3,(H,19,20,21) | PDB
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| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ... |
Eur J Med Chem 112: 20-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.039
BindingDB Entry DOI: 10.7270/Q27W6F1V |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50538513
(CHEMBL4636800)Show SMILES COc1ccc(cc1OC)-c1cnn2c(N)c(c(NCCCN(C)C)nc12)-c1ccccc1 Show InChI InChI=1S/C25H30N6O2/c1-30(2)14-8-13-27-24-22(17-9-6-5-7-10-17)23(26)31-25(29-24)19(16-28-31)18-11-12-20(32-3)21(15-18)33-4/h5-7,9-12,15-16H,8,13-14,26H2,1-4H3,(H,27,29) | PDB
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The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l... |
ACS Med Chem Lett 11: 558-565 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00015
BindingDB Entry DOI: 10.7270/Q29S1VJ7 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50538511
(CHEMBL4642409)Show SMILES COc1ccc(cc1OC)-c1cnn2c(N)c(-c3ccccc3)c(OCCCN(C)C)nc12 Show InChI InChI=1S/C25H29N5O3/c1-29(2)13-8-14-33-25-22(17-9-6-5-7-10-17)23(26)30-24(28-25)19(16-27-30)18-11-12-20(31-3)21(15-18)32-4/h5-7,9-12,15-16H,8,13-14,26H2,1-4H3 | PDB
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The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l... |
ACS Med Chem Lett 11: 558-565 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00015
BindingDB Entry DOI: 10.7270/Q29S1VJ7 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50538510
(CHEMBL4640989)Show SMILES COc1ccc(cc1OC)-c1cnn2c(N)c(-c3ccccc3)c(OC3CCNCC3)nc12 Show InChI InChI=1S/C25H27N5O3/c1-31-20-9-8-17(14-21(20)32-2)19-15-28-30-23(26)22(16-6-4-3-5-7-16)25(29-24(19)30)33-18-10-12-27-13-11-18/h3-9,14-15,18,27H,10-13,26H2,1-2H3 | PDB
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The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l... |
ACS Med Chem Lett 11: 558-565 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00015
BindingDB Entry DOI: 10.7270/Q29S1VJ7 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50153908
(CHEMBL3774489)Show InChI InChI=1S/C16H14ClN3O3/c1-22-14-6-10-12(7-15(14)23-2)18-8-19-16(10)20-13-5-9(21)3-4-11(13)17/h3-8,21H,1-2H3,(H,18,19,20) | PDB
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University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ... |
Eur J Med Chem 112: 20-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.039
BindingDB Entry DOI: 10.7270/Q27W6F1V |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50575348
(CHEMBL4853155)Show SMILES CC(=O)N1CCN(CC1)[C@H]1C[C@H](C1)n1cc(-c2ccc(Cl)c(O)c2)c2c(N)ncnc12 |r,wU:11.14,9.9,(30.61,-31.29,;32.11,-30.97,;33.14,-32.11,;32.59,-29.5,;31.56,-28.36,;32.03,-26.9,;33.54,-26.58,;34.57,-27.71,;34.09,-29.18,;34.01,-25.11,;33.3,-23.74,;34.67,-23.04,;35.38,-24.41,;35.14,-21.56,;34.23,-20.32,;35.13,-19.07,;34.65,-17.62,;33.15,-17.31,;32.66,-15.85,;33.69,-14.69,;33.2,-13.23,;35.2,-15.01,;36.22,-13.86,;35.68,-16.47,;36.59,-19.54,;37.93,-18.77,;37.92,-17.23,;39.27,-19.53,;39.27,-21.08,;37.93,-21.85,;36.6,-21.08,)| | PDB
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TBA
| Assay Description
Inhibition of KIF5B-RET fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hr... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00450
BindingDB Entry DOI: 10.7270/Q23R0XP8 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50538509
(CHEMBL4636995)Show SMILES COc1ccc(cc1OC)-c1cnn2c(N)c(-c3nccs3)c(OC3CCN(C)CC3)nc12 Show InChI InChI=1S/C23H26N6O3S/c1-28-9-6-15(7-10-28)32-22-19(23-25-8-11-33-23)20(24)29-21(27-22)16(13-26-29)14-4-5-17(30-2)18(12-14)31-3/h4-5,8,11-13,15H,6-7,9-10,24H2,1-3H3 | PDB
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The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l... |
ACS Med Chem Lett 11: 558-565 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00015
BindingDB Entry DOI: 10.7270/Q29S1VJ7 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50153902
(CHEMBL3775557)Show InChI InChI=1S/C16H13F2N3O3/c1-23-12-5-8-10(6-13(12)24-2)19-7-20-16(8)21-15-9(17)3-4-11(22)14(15)18/h3-7,22H,1-2H3,(H,19,20,21) | PDB
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University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ... |
Eur J Med Chem 112: 20-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.039
BindingDB Entry DOI: 10.7270/Q27W6F1V |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50021574
(BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC Show InChI InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34) | PDB
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| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ... |
Eur J Med Chem 112: 20-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.039
BindingDB Entry DOI: 10.7270/Q27W6F1V |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50154001
(CHEMBL3775934)Show InChI InChI=1S/C16H14FN3O3/c1-22-14-6-12-13(7-15(14)23-2)18-8-19-16(12)20-10-3-9(17)4-11(21)5-10/h3-8,21H,1-2H3,(H,18,19,20) | PDB
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| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ... |
Eur J Med Chem 112: 20-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.039
BindingDB Entry DOI: 10.7270/Q27W6F1V |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50575344
(CHEMBL4854822)Show SMILES CC(=O)N1CCN(CC1)[C@H]1C[C@H](C1)n1cc(-c2cc(O)ccc2F)c2c(N)ncnc12 |r,wU:11.14,9.9,(5.38,-23.19,;6.89,-22.87,;7.92,-24.01,;7.36,-21.4,;6.33,-20.26,;6.8,-18.8,;8.31,-18.48,;9.35,-19.61,;8.87,-21.08,;8.78,-17.01,;8.08,-15.64,;9.45,-14.94,;10.15,-16.31,;9.91,-13.47,;9,-12.23,;9.9,-10.98,;9.42,-9.52,;10.45,-8.37,;9.97,-6.91,;11,-5.76,;8.46,-6.59,;7.43,-7.75,;7.92,-9.21,;6.9,-10.36,;11.37,-11.45,;12.7,-10.67,;12.7,-9.13,;14.04,-11.43,;14.05,-12.98,;12.71,-13.76,;11.37,-12.99,)| | PDB
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TBA
| Assay Description
Inhibition of KIF5B-RET fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hr... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00450
BindingDB Entry DOI: 10.7270/Q23R0XP8 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50153895
(CHEMBL3774953)Show InChI InChI=1S/C16H13ClFN3O3/c1-23-12-5-8-10(6-13(12)24-2)19-7-20-16(8)21-15-9(18)3-4-11(22)14(15)17/h3-7,22H,1-2H3,(H,19,20,21) | PDB
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| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ... |
Eur J Med Chem 112: 20-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.039
BindingDB Entry DOI: 10.7270/Q27W6F1V |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50153901
(CHEMBL3775511)Show InChI InChI=1S/C16H13ClFN3O3/c1-23-12-5-8-10(6-13(12)24-2)19-7-20-16(8)21-15-9(17)3-4-11(22)14(15)18/h3-7,22H,1-2H3,(H,19,20,21) | PDB
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| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ... |
Eur J Med Chem 112: 20-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.039
BindingDB Entry DOI: 10.7270/Q27W6F1V |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM4622
(3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol | An...)Show InChI InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-4-3-5-11(20)6-10/h3-9,20H,1-2H3,(H,17,18,19) | PDB
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Article
PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ... |
Eur J Med Chem 112: 20-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.039
BindingDB Entry DOI: 10.7270/Q27W6F1V |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM21
(CHEMBL24828 | N-(4-bromo-2-fluorophenyl)-6-methoxy...)Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) | PDB
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| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ... |
Eur J Med Chem 112: 20-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.039
BindingDB Entry DOI: 10.7270/Q27W6F1V |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50153907
(CHEMBL3774951)Show InChI InChI=1S/C17H17N3O3/c1-10-4-5-11(21)6-13(10)20-17-12-7-15(22-2)16(23-3)8-14(12)18-9-19-17/h4-9,21H,1-3H3,(H,18,19,20) | PDB
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| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ... |
Eur J Med Chem 112: 20-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.039
BindingDB Entry DOI: 10.7270/Q27W6F1V |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50153897
(CHEMBL3775560)Show InChI InChI=1S/C17H16ClN3O3/c1-9-4-5-11(15(18)16(9)22)21-17-10-6-13(23-2)14(24-3)7-12(10)19-8-20-17/h4-8,22H,1-3H3,(H,19,20,21) | PDB
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| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ... |
Eur J Med Chem 112: 20-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.039
BindingDB Entry DOI: 10.7270/Q27W6F1V |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50154249
(CHEMBL3775879)Show InChI InChI=1S/C16H14FN3O3/c1-22-14-6-10-12(7-15(14)23-2)18-8-19-16(10)20-9-3-4-11(17)13(21)5-9/h3-8,21H,1-2H3,(H,18,19,20) | PDB
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| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ... |
Eur J Med Chem 112: 20-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.039
BindingDB Entry DOI: 10.7270/Q27W6F1V |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM26477
(5-[(6,7-dimethoxyquinazolin-4-yl)amino]-2-methylph...)Show InChI InChI=1S/C17H17N3O3/c1-10-4-5-11(6-14(10)21)20-17-12-7-15(22-2)16(23-3)8-13(12)18-9-19-17/h4-9,21H,1-3H3,(H,18,19,20) | PDB
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| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ... |
Eur J Med Chem 112: 20-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.039
BindingDB Entry DOI: 10.7270/Q27W6F1V |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50154010
(CHEMBL3775903)Show InChI InChI=1S/C16H14FN3O3/c1-22-13-6-9-11(7-14(13)23-2)18-8-19-16(9)20-10-4-3-5-12(21)15(10)17/h3-8,21H,1-2H3,(H,18,19,20) | PDB
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| n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ... |
Eur J Med Chem 112: 20-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.039
BindingDB Entry DOI: 10.7270/Q27W6F1V |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50165897
(CHEMBL3798883)Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCCN1CCCC1C(F)(F)F Show InChI InChI=1S/C24H26F4N4O3/c1-14-18(33)7-6-16(25)22(14)31-23-15-11-19(34-2)20(12-17(15)29-13-30-23)35-10-4-9-32-8-3-5-21(32)24(26,27)28/h6-7,11-13,21,33H,3-5,8-10H2,1-2H3,(H,29,30,31) | PDB
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| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of recombinant KIF5B/RET (unknown origin) expressed in IL3 deficient BAF3 cells assessed as reduction in cell viability after 48 hrs by Ce... |
Bioorg Med Chem Lett 26: 2724-9 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.100
BindingDB Entry DOI: 10.7270/Q2WM1G93 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50538509
(CHEMBL4636995)Show SMILES COc1ccc(cc1OC)-c1cnn2c(N)c(-c3nccs3)c(OC3CCN(C)CC3)nc12 Show InChI InChI=1S/C23H26N6O3S/c1-28-9-6-15(7-10-28)32-22-19(23-25-8-11-33-23)20(24)29-21(27-22)16(13-26-29)14-4-5-17(30-2)18(12-14)31-3/h4-5,8,11-13,15H,6-7,9-10,24H2,1-3H3 | PDB
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| n/a | n/a | 610 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B-RET V804M mutant (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs b... |
ACS Med Chem Lett 11: 558-565 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00015
BindingDB Entry DOI: 10.7270/Q29S1VJ7 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50153893
(CHEMBL3775672)Show InChI InChI=1S/C16H14N2O4/c1-20-14-7-12-13(8-15(14)21-2)17-9-18-16(12)22-11-5-3-4-10(19)6-11/h3-9,19H,1-2H3 | PDB
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| n/a | n/a | 620 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ... |
Eur J Med Chem 112: 20-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.039
BindingDB Entry DOI: 10.7270/Q27W6F1V |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50575345
(CHEMBL4848347)Show SMILES CC(=O)N1CCN(CC1)[C@H]1C[C@H](C1)n1cc(-c2cccc(O)c2)c2c(N)ncnc12 |r,wU:11.14,9.9,(15.86,-22.2,;17.36,-21.88,;18.39,-23.03,;17.84,-20.42,;16.81,-19.27,;17.28,-17.81,;18.79,-17.49,;19.83,-18.62,;19.35,-20.09,;19.26,-16.03,;18.55,-14.66,;19.92,-13.95,;20.63,-15.32,;20.39,-12.48,;19.48,-11.24,;20.38,-9.99,;19.9,-8.53,;18.4,-8.22,;17.91,-6.76,;18.94,-5.61,;20.45,-5.92,;21.48,-4.77,;20.93,-7.38,;21.85,-10.46,;23.18,-9.68,;23.18,-8.14,;24.52,-10.45,;24.52,-12,;23.19,-12.77,;21.85,-12,)| | PDB
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| n/a | n/a | 770 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of KIF5B-RET fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hr... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00450
BindingDB Entry DOI: 10.7270/Q23R0XP8 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50154248
(CHEMBL235851)Show InChI InChI=1S/C16H14ClN3O3/c1-22-14-6-10-12(7-15(14)23-2)18-8-19-16(10)20-9-3-4-11(17)13(21)5-9/h3-8,21H,1-2H3,(H,18,19,20) | PDB
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| n/a | n/a | 940 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ... |
Eur J Med Chem 112: 20-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.039
BindingDB Entry DOI: 10.7270/Q27W6F1V |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50154246
(CHEMBL3774580)Show InChI InChI=1S/C16H15N3O4/c1-22-13-6-9-11(7-14(13)23-2)17-8-18-16(9)19-10-4-3-5-12(20)15(10)21/h3-8,20-21H,1-2H3,(H,17,18,19) | PDB
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| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ... |
Eur J Med Chem 112: 20-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.039
BindingDB Entry DOI: 10.7270/Q27W6F1V |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50165898
(CHEMBL3800346)Show SMILES COc1cc2c(Nc3c(C)c(O)ccc3F)ncnc2cc1OCc1cccnc1 Show InChI InChI=1S/C22H19FN4O3/c1-13-18(28)6-5-16(23)21(13)27-22-15-8-19(29-2)20(9-17(15)25-12-26-22)30-11-14-4-3-7-24-10-14/h3-10,12,28H,11H2,1-2H3,(H,25,26,27) | PDB
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| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of recombinant KIF5B/RET (unknown origin) expressed in IL3 deficient BAF3 cells assessed as reduction in cell viability after 48 hrs by Ce... |
Bioorg Med Chem Lett 26: 2724-9 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.100
BindingDB Entry DOI: 10.7270/Q2WM1G93 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50165912
(CHEMBL3797413)Show InChI InChI=1S/C19H20FN3O4/c1-11-15(24)5-4-13(20)18(11)23-19-12-8-16(26-3)17(27-7-6-25-2)9-14(12)21-10-22-19/h4-5,8-10,24H,6-7H2,1-3H3,(H,21,22,23) | PDB
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| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of recombinant KIF5B/RET (unknown origin) expressed in IL3 deficient BAF3 cells assessed as reduction in cell viability after 48 hrs by Ce... |
Bioorg Med Chem Lett 26: 2724-9 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.100
BindingDB Entry DOI: 10.7270/Q2WM1G93 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50165895
(CHEMBL3800250)Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCN1CCC(F)C1 Show InChI InChI=1S/C22H24F2N4O3/c1-13-18(29)4-3-16(24)21(13)27-22-15-9-19(30-2)20(10-17(15)25-12-26-22)31-8-7-28-6-5-14(23)11-28/h3-4,9-10,12,14,29H,5-8,11H2,1-2H3,(H,25,26,27) | PDB
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| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of recombinant KIF5B/RET (unknown origin) expressed in IL3 deficient BAF3 cells assessed as reduction in cell viability after 48 hrs by Ce... |
Bioorg Med Chem Lett 26: 2724-9 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.100
BindingDB Entry DOI: 10.7270/Q2WM1G93 |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50153905
(CHEMBL3775190)Show InChI InChI=1S/C16H13Cl2N3O3/c1-23-14-3-8-11(6-15(14)24-2)19-7-20-16(8)21-12-5-13(22)10(18)4-9(12)17/h3-7,22H,1-2H3,(H,19,20,21) | PDB
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| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ... |
Eur J Med Chem 112: 20-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.039
BindingDB Entry DOI: 10.7270/Q27W6F1V |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50154000
(CHEMBL3775086)Show InChI InChI=1S/C17H17N3O3/c1-10-4-11(6-12(21)5-10)20-17-13-7-15(22-2)16(23-3)8-14(13)18-9-19-17/h4-9,21H,1-3H3,(H,18,19,20) | PDB
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| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester
Curated by ChEMBL
| Assay Description
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ... |
Eur J Med Chem 112: 20-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.039
BindingDB Entry DOI: 10.7270/Q27W6F1V |
More data for this
Ligand-Target Pair | |
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