Compile Data Set for Download or QSAR

Found 4 hits of ec50 for UniProtKB: P56817   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 1/2 (Homo sapiens (Human))	BDBM50171340 (5-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureido]-2-di...) Show SMILES CN(C)c1ccc(NC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1C(=O)NCCCN1CCOCC1 Show InChI InChI=1S/C25H29F6N5O3/c1-35(2)21-5-4-18(15-20(21)22(37)32-6-3-7-36-8-10-39-11-9-36)33-23(38)34-19-13-16(24(26,27)28)12-17(14-19)25(29,30)31/h4-5,12-15H,3,6-11H2,1-2H3,(H,32,37)(H2,33,34,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.5	n/a	n/a	n/a	n/a
University of Zürich Curated by ChEMBL					Assay Description Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion protein				J Med Chem 48: 5108-11 (2005) Article DOI: 10.1021/jm050499d BindingDB Entry DOI: 10.7270/Q228074P
					More data for this Ligand-Target Pair
Beta-secretase 1/2 (Homo sapiens (Human))	BDBM50171339 (1-(3-Acetyl-phenyl)-3-(3-ethylsulfanyl-[1,2,4]thia...) Show SMILES CCSc1nsc(NC(=O)Nc2cccc(c2)C(C)=O)n1 Show InChI InChI=1S/C13H14N4O2S2/c1-3-20-13-16-12(21-17-13)15-11(19)14-10-6-4-5-9(7-10)8(2)18/h4-7H,3H2,1-2H3,(H2,14,15,16,17,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
University of Zürich Curated by ChEMBL					Assay Description Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion protein				J Med Chem 48: 5108-11 (2005) Article DOI: 10.1021/jm050499d BindingDB Entry DOI: 10.7270/Q228074P
					More data for this Ligand-Target Pair
Beta-secretase 1/2 (Homo sapiens (Human))	BDBM50171337 (5-[3-(3-Chloro-phenyl)-ureido]-2-dimethylamino-N-(...) Show SMILES CCOCCCNC(=O)c1cc(NC(=O)Nc2cccc(Cl)c2)ccc1N(C)C Show InChI InChI=1S/C21H27ClN4O3/c1-4-29-12-6-11-23-20(27)18-14-17(9-10-19(18)26(2)3)25-21(28)24-16-8-5-7-15(22)13-16/h5,7-10,13-14H,4,6,11-12H2,1-3H3,(H,23,27)(H2,24,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	23	n/a	n/a	n/a	n/a
University of Zürich Curated by ChEMBL					Assay Description Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion protein				J Med Chem 48: 5108-11 (2005) Article DOI: 10.1021/jm050499d BindingDB Entry DOI: 10.7270/Q228074P
					More data for this Ligand-Target Pair
Beta-secretase 1/2 (Homo sapiens (Human))	BDBM50171338 (5-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureido]-2-di...) Show SMILES COCCCNC(=O)c1cc(NC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)ccc1N(C)C Show InChI InChI=1S/C22H24F6N4O3/c1-32(2)18-6-5-15(12-17(18)19(33)29-7-4-8-35-3)30-20(34)31-16-10-13(21(23,24)25)9-14(11-16)22(26,27)28/h5-6,9-12H,4,7-8H2,1-3H3,(H,29,33)(H2,30,31,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.70E+4	n/a	n/a	n/a	n/a
University of Zürich Curated by ChEMBL					Assay Description Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion protein				J Med Chem 48: 5108-11 (2005) Article DOI: 10.1021/jm050499d BindingDB Entry DOI: 10.7270/Q228074P
					More data for this Ligand-Target Pair