Compile Data Set for Download or QSAR

Found 11 hits of ic50 for UniProtKB: P05121   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasminogen activator inhibitor 1/Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM264610 (US9718760, C165) Show SMILES Oc1ccc(cc1O)S(=O)(=O)N(c1ccc(cc1)-c1ccccc1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C24H19NO8S2/c26-21-12-10-19(14-23(21)28)34(30,31)25(35(32,33)20-11-13-22(27)24(29)15-20)18-8-6-17(7-9-18)16-4-2-1-3-5-16/h1-15,26-29H	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM264609 (US9718760, C163) Show SMILES Oc1ccc(cc1O)S(=O)(=O)N(c1cccc(c1)C(F)(F)F)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C19H14F3NO8S2/c20-19(21,22)11-2-1-3-12(8-11)23(32(28,29)13-4-6-15(24)17(26)9-13)33(30,31)14-5-7-16(25)18(27)10-14/h1-10,24-27H	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	611	n/a	n/a	n/a	n/a	n/a	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM264613 (US9718760, C157) Show SMILES CCCCCCCCCCN(S(=O)(=O)c1ccc(O)c(O)c1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C22H31NO8S2/c1-2-3-4-5-6-7-8-9-14-23(32(28,29)17-10-12-19(24)21(26)15-17)33(30,31)18-11-13-20(25)22(27)16-18/h10-13,15-16,24-27H,2-9,14H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	980	n/a	n/a	n/a	n/a	n/a	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM264607 (US9718760, C153) Show SMILES Oc1ccc(cc1O)S(=O)(=O)N(c1ccccc1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C18H15NO8S2/c20-15-8-6-13(10-17(15)22)28(24,25)19(12-4-2-1-3-5-12)29(26,27)14-7-9-16(21)18(23)11-14/h1-11,20-23H	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.02E+3	n/a	n/a	n/a	n/a	n/a	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM264614 (US9718760, C158) Show SMILES CCCCCCCCCCCCN(S(=O)(=O)c1ccc(O)c(O)c1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C24H35NO8S2/c1-2-3-4-5-6-7-8-9-10-11-16-25(34(30,31)19-12-14-21(26)23(28)17-19)35(32,33)20-13-15-22(27)24(29)18-20/h12-15,17-18,26-29H,2-11,16H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.44E+3	n/a	n/a	n/a	n/a	n/a	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM264597 (US9718760, C152) Show SMILES CCCCCCCCN(S(=O)(=O)c1ccc(O)c(O)c1)S(=O)(=O)c1cc(F)c(O)c(F)c1 Show InChI InChI=1S/C20H25F2NO7S2/c1-2-3-4-5-6-7-10-23(31(27,28)14-8-9-18(24)19(25)13-14)32(29,30)15-11-16(21)20(26)17(22)12-15/h8-9,11-13,24-26H,2-7,10H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.71E+3	n/a	n/a	n/a	n/a	n/a	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM264648 (US9718760, C161) Show SMILES CCCCCCCCNC(=O)c1cc(O)c(O)c(O)c1 Show InChI InChI=1S/C15H23NO4/c1-2-3-4-5-6-7-8-16-15(20)11-9-12(17)14(19)13(18)10-11/h9-10,17-19H,2-8H2,1H3,(H,16,20)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.21E+3	n/a	n/a	n/a	n/a	n/a	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM264608 (US9718760, C162) Show SMILES Oc1ccc(cc1O)S(=O)(=O)N(CCc1ccccn1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C19H18N2O8S2/c22-16-6-4-14(11-18(16)24)30(26,27)21(10-8-13-3-1-2-9-20-13)31(28,29)15-5-7-17(23)19(25)12-15/h1-7,9,11-12,22-25H,8,10H2	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.59E+3	n/a	n/a	n/a	n/a	n/a	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM264598 (US9718760, C155) Show SMILES CCCCCCCCN(S(=O)(=O)c1cc(F)c(O)c(F)c1)S(=O)(=O)c1cc(F)c(O)c(F)c1 Show InChI InChI=1S/C20H23F4NO6S2/c1-2-3-4-5-6-7-8-25(32(28,29)13-9-15(21)19(26)16(22)10-13)33(30,31)14-11-17(23)20(27)18(24)12-14/h9-12,26-27H,2-8H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.48E+4	n/a	n/a	n/a	n/a	n/a	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM264627 (US9718760, C160) Show SMILES Oc1ccc(cc1O)S(=O)(=O)NCc1ccccc1 Show InChI InChI=1S/C13H13NO4S/c15-12-7-6-11(8-13(12)16)19(17,18)14-9-10-4-2-1-3-5-10/h1-8,14-16H,9H2	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.82E+4	n/a	n/a	n/a	n/a	n/a	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM264647 (US9718760, C156) Show SMILES CC(C)(C)OC(=O)NCCCOC(=O)c1cc(O)c(O)c(O)c1 Show InChI InChI=1S/C15H21NO7/c1-15(2,3)23-14(21)16-5-4-6-22-13(20)9-7-10(17)12(19)11(18)8-9/h7-8,17-19H,4-6H2,1-3H3,(H,16,21)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.81E+5	n/a	n/a	n/a	n/a	n/a	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair