Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lysophosphatidic acid receptor 2 (Homo sapiens (Human)) | BDBM50148348 ((R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
The University of Tennessee Health Science Center Curated by ChEMBL | Assay Description Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay | J Med Chem 57: 7136-40 (2014) Article DOI: 10.1021/jm5007116 BindingDB Entry DOI: 10.7270/Q22V2HS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysophosphatidic acid receptor 2 (Homo sapiens (Human)) | BDBM50148348 ((R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.80 | n/a | n/a | n/a | n/a |
Oxford University Curated by ChEMBL | Assay Description Agonistic activity against lysophosphatidic acid receptor 2 using [35S]-GTP-gammaS as radioligand tested in vitro | Bioorg Med Chem Lett 14: 3473-6 (2004) Article DOI: 10.1016/j.bmcl.2004.04.061 BindingDB Entry DOI: 10.7270/Q2D50MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysophosphatidic acid receptor 4 (Homo sapiens (Human)) | BDBM50148348 ((R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 8.10 | n/a | n/a | n/a | n/a |
The University of Utah Curated by ChEMBL | Assay Description Agonist activity at human LPA4 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425 | Bioorg Med Chem Lett 23: 1865-9 (2013) Article DOI: 10.1016/j.bmcl.2013.01.002 BindingDB Entry DOI: 10.7270/Q2SN0B9G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysophosphatidic acid receptor 5 (Homo sapiens (Human)) | BDBM50148348 ((R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
University of Tennessee Health Science Center Curated by ChEMBL | Assay Description Agonist activity at LPA5 expressed in human chem1 cells assessed as intracellular calcium mobilization by FLIPR assay | Bioorg Med Chem 18: 477-95 (2010) Article DOI: 10.1016/j.bmc.2009.12.020 BindingDB Entry DOI: 10.7270/Q2W66KWQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysophosphatidic acid receptor 1 (Homo sapiens (Human)) | BDBM50148348 ((R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 17 | n/a | n/a | n/a | n/a |
Oxford University Curated by ChEMBL | Assay Description Agonistic activity against lysophosphatidic acid receptor 1 using [35S]-GTP-gammaS as radioligand tested in vitro | Bioorg Med Chem Lett 14: 3473-6 (2004) Article DOI: 10.1016/j.bmcl.2004.04.061 BindingDB Entry DOI: 10.7270/Q2D50MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysophosphatidic acid receptor 1 (Homo sapiens (Human)) | BDBM50148348 ((R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 18 | n/a | n/a | n/a | n/a |
The University of Utah Curated by ChEMBL | Assay Description Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay | Bioorg Med Chem Lett 23: 1865-9 (2013) Article DOI: 10.1016/j.bmcl.2013.01.002 BindingDB Entry DOI: 10.7270/Q2SN0B9G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysophosphatidic acid receptor 2 (Homo sapiens (Human)) | BDBM50148348 ((R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 29 | n/a | n/a | n/a | n/a |
The University of Utah Curated by ChEMBL | Assay Description Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay | Bioorg Med Chem Lett 23: 1865-9 (2013) Article DOI: 10.1016/j.bmcl.2013.01.002 BindingDB Entry DOI: 10.7270/Q2SN0B9G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysophosphatidic acid receptor 1 (Homo sapiens (Human)) | BDBM50148348 ((R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 31 | n/a | n/a | n/a | n/a |
University of Tennessee Health Science Center Curated by ChEMBL | Assay Description Agonist activity at LPA1 expressed in human chem1 cells assessed as intracellular calcium mobilization by FLIPR assay | Bioorg Med Chem 18: 477-95 (2010) Article DOI: 10.1016/j.bmc.2009.12.020 BindingDB Entry DOI: 10.7270/Q2W66KWQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysophosphatidic acid receptor 5 (Homo sapiens (Human)) | BDBM50148348 ((R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a |
The University of Utah Curated by ChEMBL | Assay Description Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425 | Bioorg Med Chem Lett 23: 1865-9 (2013) Article DOI: 10.1016/j.bmcl.2013.01.002 BindingDB Entry DOI: 10.7270/Q2SN0B9G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysophosphatidic acid receptor 3 (Homo sapiens (Human)) | BDBM50148348 ((R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 77 | n/a | n/a | n/a | n/a |
The University of Utah Curated by ChEMBL | Assay Description Agonist activity at human LPA3 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay | Bioorg Med Chem Lett 23: 1865-9 (2013) Article DOI: 10.1016/j.bmcl.2013.01.002 BindingDB Entry DOI: 10.7270/Q2SN0B9G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysophosphatidic acid receptor 3 (Homo sapiens (Human)) | BDBM50148348 ((R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
University of Tennessee Health Science Center Curated by ChEMBL | Assay Description Agonist activity at LPA3 expressed in human chem1 cells assessed as intracellular calcium mobilization by FLIPR assay | Bioorg Med Chem 18: 477-95 (2010) Article DOI: 10.1016/j.bmc.2009.12.020 BindingDB Entry DOI: 10.7270/Q2W66KWQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysophosphatidic acid receptor 4 (Mus musculus) | BDBM50148348 ((R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 260 | n/a | n/a | n/a | n/a |
The University of Tennessee Health Science Center Curated by ChEMBL | Assay Description Agonist activity at mouse LPA4 expressed in CHO cells by Fura-2AM dye based Ca2+ mobilization assay | J Med Chem 57: 7136-40 (2014) Article DOI: 10.1021/jm5007116 BindingDB Entry DOI: 10.7270/Q22V2HS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysophosphatidic acid receptor 3 (Homo sapiens (Human)) | BDBM50148348 ((R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 263 | n/a | n/a | n/a | n/a |
Oxford University Curated by ChEMBL | Assay Description Agonistic activity against lysophosphatidic acid receptor 3 using [35S]-GTP-gammaS as radioligand tested in vitro | Bioorg Med Chem Lett 14: 3473-6 (2004) Article DOI: 10.1016/j.bmcl.2004.04.061 BindingDB Entry DOI: 10.7270/Q2D50MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysophosphatidic acid receptor 1 (Homo sapiens (Human)) | BDBM50148348 ((R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 350 | n/a | n/a | n/a | n/a |
The University of Tennessee Health Science Center Curated by ChEMBL | Assay Description Agonist activity at human LPA1 expressed in LPA1xLPA2 double knockout mouse MEF cells up to 10 uM by Fura-2AM dye based Ca2+ mobilization assay | J Med Chem 57: 7136-40 (2014) Article DOI: 10.1021/jm5007116 BindingDB Entry DOI: 10.7270/Q22V2HS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysophosphatidic acid receptor 5 (Homo sapiens (Human)) | BDBM50148348 ((R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 510 | n/a | n/a | n/a | n/a |
The University of Tennessee Health Science Center Curated by ChEMBL | Assay Description Agonist activity at FLAG-tagged human LPA5 expressed in rat B103 cells by Fura-2AM dye based Ca2+ mobilization assay | J Med Chem 57: 7136-40 (2014) Article DOI: 10.1021/jm5007116 BindingDB Entry DOI: 10.7270/Q22V2HS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysophosphatidic acid receptor 1 (Homo sapiens (Human)) | BDBM50148348 ((R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 830 | n/a | n/a | n/a | n/a |
Universidad Complutense de Madrid Curated by ChEMBL | Assay Description Agonist activity at LPA1 receptor (unknown origin) stably expressed in rat RH7777 cells assessed as increase in intracellular calcium level by Fluo-4... | J Med Chem 63: 2372-2390 (2020) Article DOI: 10.1021/acs.jmedchem.9b01287 BindingDB Entry DOI: 10.7270/Q2DF6VSR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysophosphatidic acid receptor 3 (Homo sapiens (Human)) | BDBM50148348 ((R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 830 | n/a | n/a | n/a | n/a |
The University of Tennessee Health Science Center Curated by ChEMBL | Assay Description Agonist activity at human LPA3 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay | J Med Chem 57: 7136-40 (2014) Article DOI: 10.1021/jm5007116 BindingDB Entry DOI: 10.7270/Q22V2HS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysophosphatidic acid receptor 6 (Homo sapiens (Human)) | BDBM50148348 ((R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 970 | n/a | n/a | n/a | n/a |
The University of Utah Curated by ChEMBL | Assay Description Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425 | Bioorg Med Chem Lett 23: 1865-9 (2013) Article DOI: 10.1016/j.bmcl.2013.01.002 BindingDB Entry DOI: 10.7270/Q2SN0B9G | |||||||||||
More data for this Ligand-Target Pair |