Compile Data Set for Download or QSAR

Found 4 hits of ic50 for monomerid = 18235   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydrofolate reductase (Mycobacterium avium)	BDBM18235 (5-{2-[(2,4-diaminopteridin-6-yl)methyl]-2-azatricy...) Show SMILES Nc1nc(N)c2nc(CN3c4ccccc4C=Cc4cc(ccc34)C#CCCC(O)=O)cnc2n1 |c:17| Show InChI InChI=1S/C26H21N7O2/c27-24-23-25(32-26(28)31-24)29-14-19(30-23)15-33-20-7-3-2-6-17(20)10-11-18-13-16(9-12-21(18)33)5-1-4-8-22(34)35/h2-3,6-7,9-14H,4,8,15H2,(H,34,35)(H4,27,28,29,31,32)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School					Assay Description Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...				J Med Chem 48: 4420-31 (2005) Article DOI: 10.1021/jm0581718 BindingDB Entry DOI: 10.7270/Q2W0946F
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18235 (5-{2-[(2,4-diaminopteridin-6-yl)methyl]-2-azatricy...) Show SMILES Nc1nc(N)c2nc(CN3c4ccccc4C=Cc4cc(ccc34)C#CCCC(O)=O)cnc2n1 |c:17| Show InChI InChI=1S/C26H21N7O2/c27-24-23-25(32-26(28)31-24)29-14-19(30-23)15-33-20-7-3-2-6-17(20)10-11-18-13-16(9-12-21(18)33)5-1-4-8-22(34)35/h2-3,6-7,9-14H,4,8,15H2,(H,34,35)(H4,27,28,29,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School					Assay Description Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...				J Med Chem 48: 4420-31 (2005) Article DOI: 10.1021/jm0581718 BindingDB Entry DOI: 10.7270/Q2W0946F
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM18235 (5-{2-[(2,4-diaminopteridin-6-yl)methyl]-2-azatricy...) Show SMILES Nc1nc(N)c2nc(CN3c4ccccc4C=Cc4cc(ccc34)C#CCCC(O)=O)cnc2n1 |c:17| Show InChI InChI=1S/C26H21N7O2/c27-24-23-25(32-26(28)31-24)29-14-19(30-23)15-33-20-7-3-2-6-17(20)10-11-18-13-16(9-12-21(18)33)5-1-4-8-22(34)35/h2-3,6-7,9-14H,4,8,15H2,(H,34,35)(H4,27,28,29,31,32)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	7.4	37
Harvard Medical School					Assay Description Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...				J Med Chem 48: 4420-31 (2005) Article DOI: 10.1021/jm0581718 BindingDB Entry DOI: 10.7270/Q2W0946F
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM18235 (5-{2-[(2,4-diaminopteridin-6-yl)methyl]-2-azatricy...) Show SMILES Nc1nc(N)c2nc(CN3c4ccccc4C=Cc4cc(ccc34)C#CCCC(O)=O)cnc2n1 |c:17| Show InChI InChI=1S/C26H21N7O2/c27-24-23-25(32-26(28)31-24)29-14-19(30-23)15-33-20-7-3-2-6-17(20)10-11-18-13-16(9-12-21(18)33)5-1-4-8-22(34)35/h2-3,6-7,9-14H,4,8,15H2,(H,34,35)(H4,27,28,29,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School					Assay Description Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...				J Med Chem 48: 4420-31 (2005) Article DOI: 10.1021/jm0581718 BindingDB Entry DOI: 10.7270/Q2W0946F
					More data for this Ligand-Target Pair