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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Voltage-dependent L-type calcium channel subunit beta-1/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1 (Rattus norvegicus-Rattus norvegicus (Rat)) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet  | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Calgary Curated by ChEMBL | Assay Description Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce... | Bioorg Med Chem Lett 19: 6467-72 (2009) Article DOI: 10.1016/j.bmcl.2009.09.008 BindingDB Entry DOI: 10.7270/Q2PV6P57 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 228 | n/a | n/a | n/a | n/a | n/a | n/a |
Suntory Biomedical Research Limited Curated by ChEMBL | Assay Description Concentration required for 50% inhibitory effect on Dopamine receptor D2 determined in competition experiments with [3H]raclopride | J Med Chem 43: 3372-6 (2000) BindingDB Entry DOI: 10.7270/Q27945CD | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 228 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Biomedical Research Curated by ChEMBL | Assay Description Inhibition of [3H]raclopride binding to Dopamine receptor D2 of rat striatum membranes | Bioorg Med Chem Lett 9: 2999-3002 (1999) BindingDB Entry DOI: 10.7270/Q2D21Z3B | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Sodium channel protein type 1/2/3 subunit alpha (Rattus norvegicus) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Biomedical Research Curated by ChEMBL | Assay Description Inhibition of veratridine-induced depolarization in rat cerebrocortical synaptosomes using the voltage sensitive fluorescent dye Rhodamine 6G | Bioorg Med Chem Lett 9: 2999-3002 (1999) BindingDB Entry DOI: 10.7270/Q2D21Z3B | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Sodium channel protein type 2 subunit alpha (Rattus norvegicus) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel t... | J Med Chem 37: 268-74 (1994) BindingDB Entry DOI: 10.7270/Q2CJ8F39 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Sodium channel protein type 2 subunit alpha (Rattus norvegicus) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibitory activity against type IIA sodium channel in CNaIIA-1 cell line expressed in CHO cells | J Med Chem 39: 1514-20 (1996) Article DOI: 10.1021/jm950467y BindingDB Entry DOI: 10.7270/Q2JS9PJC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Sodium channel protein type 1/2/3 subunit alpha (Homo sapiens (Human)) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea... | J Med Chem 28: 381-8 (1985) BindingDB Entry DOI: 10.7270/Q2Z321T8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cytochrome P450 2J2 (Homo sapiens (Human)) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 760 | n/a | n/a | n/a | n/a | n/a | n/a |
Tongji University Curated by ChEMBL | Assay Description Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation after 30 mins by LC-MS/MS method in presence of 1 mM NADPH | Drug Metab Dispos 41: 60-71 (2012) Article DOI: 10.1124/dmd.112.048264 BindingDB Entry DOI: 10.7270/Q2K0761G | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cytochrome P450 2J2 (Homo sapiens (Human)) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 940 | n/a | n/a | n/a | n/a | n/a | n/a |
Tongji University Curated by ChEMBL | Assay Description Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS method | Drug Metab Dispos 41: 60-71 (2012) Article DOI: 10.1124/dmd.112.048264 BindingDB Entry DOI: 10.7270/Q2K0761G | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cytochrome P450 2J2 (Homo sapiens (Human)) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 950 | n/a | n/a | n/a | n/a | n/a | n/a |
Tongji University Curated by ChEMBL | Assay Description Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation reduction in astemizole O-demethylation after 30 mins by L... | Drug Metab Dispos 41: 60-71 (2012) Article DOI: 10.1124/dmd.112.048264 BindingDB Entry DOI: 10.7270/Q2K0761G | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Voltage-dependent N-type calcium channel subunit alpha-1B (Homo sapiens (Human)) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.67E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ionix Pharmaceuticals Ltd Curated by ChEMBL | Assay Description Inhibition of calcium channel Cav2.2 in IMR32 cells | Bioorg Med Chem Lett 17: 662-7 (2007) Article DOI: 10.1016/j.bmcl.2006.10.098 BindingDB Entry DOI: 10.7270/Q26W99Q0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mu-type opioid receptor (Homo sapiens (Human)) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 2.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
F-59000 Lille Curated by ChEMBL | Assay Description Binding affinity against mu opioid receptor using [3H]DAMGO | J Med Chem 44: 3391-401 (2001) BindingDB Entry DOI: 10.7270/Q2057GN9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Potassium two pore domain channel subfamily K member 2 (Bos taurus) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | PDB Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Clermont Auvergne Curated by ChEMBL | Assay Description Activation of bovine TREK1 expressed in AZT cells assessed as reduction in channel currents | J Med Chem 59: 5149-57 (2016) Article DOI: 10.1021/acs.jmedchem.5b00671 BindingDB Entry DOI: 10.7270/Q2319XSS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Delta-type opioid receptor (Homo sapiens (Human)) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 3.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
F-59000 Lille Curated by ChEMBL | Assay Description Binding affinity against delta opiate receptor using [3H]DPDPE | J Med Chem 44: 3391-401 (2001) BindingDB Entry DOI: 10.7270/Q2057GN9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Arachidonate 15-lipoxygenase (Pseudomonas aeruginosa) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
University of California, Santa Cruz | Assay Description Briefly, 3 uL of enzyme (approximately 20 nM LoxA, final concentration) or buffer (no-enzyme control) was dispensed into 1536-well Greiner black clea... | Biochemistry 55: 3329-40 (2016) Article DOI: 10.1021/acs.biochem.6b00338 BindingDB Entry DOI: 10.7270/Q21N7ZXT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.89E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tongji University Curated by ChEMBL | Assay Description Inhibition of CYP2D6 in human liver microsomes using bufuralol substrate by LC-MS/MS method | Drug Metab Dispos 41: 60-71 (2012) Article DOI: 10.1124/dmd.112.048264 BindingDB Entry DOI: 10.7270/Q2K0761G | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 9.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
F-59000 Lille Curated by ChEMBL | Assay Description Binding affinity against opioid receptor kappa 1 by using [3H]U-69593 as radioligand | J Med Chem 44: 3391-401 (2001) BindingDB Entry DOI: 10.7270/Q2057GN9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bile salt export pump (Homo sapiens (Human)) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-... | Drug Metab Dispos 40: 2332-41 (2012) Article DOI: 10.1124/dmd.112.047068 BindingDB Entry DOI: 10.7270/Q2ZP488M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cytochrome P450 2C9 (Homo sapiens (Human)) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tongji University Curated by ChEMBL | Assay Description Inhibition of CYP2C9 in human liver microsomes using tolbutamide substrate by LC-MS/MS method | Drug Metab Dispos 41: 60-71 (2012) Article DOI: 10.1124/dmd.112.048264 BindingDB Entry DOI: 10.7270/Q2K0761G | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tongji University Curated by ChEMBL | Assay Description Inhibition of CYP3A4 in human liver microsomes using testosterone substrate by LC-MS/MS method | Drug Metab Dispos 41: 60-71 (2012) Article DOI: 10.1124/dmd.112.048264 BindingDB Entry DOI: 10.7270/Q2K0761G | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cytochrome P450 1A2 (Homo sapiens (Human)) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tongji University Curated by ChEMBL | Assay Description Inhibition of CYP1A2 in human liver microsomes using phenacetin substrate by LC-MS/MS method | Drug Metab Dispos 41: 60-71 (2012) Article DOI: 10.1124/dmd.112.048264 BindingDB Entry DOI: 10.7270/Q2K0761G | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cytochrome P450 2C19 (Homo sapiens (Human)) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tongji University Curated by ChEMBL | Assay Description Inhibition of CYP2C19 in human liver microsomes using omeprazole substrate by LC-MS/MS method | Drug Metab Dispos 41: 60-71 (2012) Article DOI: 10.1124/dmd.112.048264 BindingDB Entry DOI: 10.7270/Q2K0761G | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
