Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-lactamase (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Inhibition of Escherichia coli CTX-M-15 | Antimicrob Agents Chemother 51: 3089-95 (2007) Article DOI: 10.1128/AAC.00218-07 BindingDB Entry DOI: 10.7270/Q2BG2NR1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Citrobacter gillenii) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
H�pital de Bic�tre Curated by ChEMBL | Assay Description Inhibition of Citrobacter gillenii CIP 106783 Beta-lactamase GIL1 expressed in Escherichia coli DH10B | Antimicrob Agents Chemother 51: 1365-72 (2007) Article DOI: 10.1128/AAC.01152-06 BindingDB Entry DOI: 10.7270/Q2S46SS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Salmonella enterica subsp. enterica serovar Westha...) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre National de R£f£rence des Salmonella Curated by ChEMBL | Assay Description Inhibition of Salmonella enterica serotype Westhampton beta-lactamase CTX-M-53 | Antimicrob Agents Chemother 53: 1944-51 (2009) Article DOI: 10.1128/AAC.01581-08 BindingDB Entry DOI: 10.7270/Q2445MRF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against Escherichia coli TEM-3 Beta-lactamase | J Med Chem 41: 3961-71 (1998) Article DOI: 10.1021/jm980023c BindingDB Entry DOI: 10.7270/Q2HT2NF0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Klebsiella pneumoniae) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of Klebsiella pneumoniae Beta-Lactamase SHV-55 | Antimicrob Agents Chemother 52: 1897-8 (2008) Article DOI: 10.1128/AAC.01525-07 BindingDB Entry DOI: 10.7270/Q2PV6KKC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase SHV-1 (Klebsiella pneumoniae (Enterobacteria)) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | 20.1 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against Escherichia coli HA208 Class-III SHV-1 type beta-lactamase enzyme | Citation and Details BindingDB Entry DOI: 10.7270/Q2ZW1P2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Staphylococcus aureus) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank | n/a | n/a | 25.1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibitory activity against Staphylococcus aureus CJ8 beta-lactamase enzyme | Citation and Details BindingDB Entry DOI: 10.7270/Q2ZW1P2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase SHV-1 (Klebsiella pneumoniae (Enterobacteria)) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Lek Pharmaceuticals d.d. Curated by ChEMBL | Assay Description Inhibition of Escherichia coli SHV1 | J Med Chem 50: 4113-21 (2007) Article DOI: 10.1021/jm0703237 BindingDB Entry DOI: 10.7270/Q2FF3T5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 29.5 | n/a | n/a | n/a | n/a | 7.0 | 37 |
NABRIVA THERAPEUTICS AG US Patent | Assay Description The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ... | US Patent US9120808 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Lek Pharmaceuticals d.d. Curated by ChEMBL | Assay Description Inhibition of Escherichia coli TEM1 | J Med Chem 50: 4113-21 (2007) Article DOI: 10.1021/jm0703237 BindingDB Entry DOI: 10.7270/Q2FF3T5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Klebsiella oxytoca) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | 30.1 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against Klebsiella oxytoca HC7 Class-IV K1 type beta-lactamase enzyme | Citation and Details BindingDB Entry DOI: 10.7270/Q2ZW1P2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase BRO-1 (Moraxella catarrhalis) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | 30.1 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against Branhamella catarrhalis 89001 Class-III BRO-1 type beta-lactamase enzyme | Citation and Details BindingDB Entry DOI: 10.7270/Q2ZW1P2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase SHV-1 (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 30.3 | n/a | n/a | n/a | n/a | 7.0 | 37 |
NABRIVA THERAPEUTICS AG US Patent | Assay Description The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ... | US Patent US9120808 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Pseudomonas luteola) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Pasteur Curated by ChEMBL | Assay Description Inhibition of Pseudomonas luteola LAM Beta-lactamase LUT-1 | Antimicrob Agents Chemother 54: 45-51 (2010) Article DOI: 10.1128/AAC.00427-09 BindingDB Entry DOI: 10.7270/Q2KS6VCC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for beta-lactamase inhibition activity of Escherichia coli after 15 min of preincubation with the enzyme at 37 degree C | Bioorg Med Chem Lett 7: 2217-2222 (1997) Article DOI: 10.1016/S0960-894X(97)00401-0 BindingDB Entry DOI: 10.7270/Q2M32VR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | 40.2 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against Escherichia coli HA58R Class-III TEM-1 type beta-lactamase enzyme | Citation and Details BindingDB Entry DOI: 10.7270/Q2ZW1P2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against beta-Lactamase enzyme derived from Escherichia coli WC3310 TEM-2 | Bioorg Med Chem Lett 5: 1513-1518 (1995) Article DOI: 10.1016/0960-894X(95)00249-S BindingDB Entry DOI: 10.7270/Q2ZW1MDG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Proteus mirabilis) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | 65.3 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against Proteus vulgaris HJ33C Class-I beta-lactamase enzyme | Citation and Details BindingDB Entry DOI: 10.7270/Q2ZW1P2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Pasteur Hellenique Curated by ChEMBL | Assay Description Inhibition of Escherichia coli beta-lactamase SCO1 | Antimicrob Agents Chemother 51: 2185-8 (2007) Article DOI: 10.1128/AAC.01439-06 BindingDB Entry DOI: 10.7270/Q2028SFP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
CHU Clermont-Ferrand Curated by ChEMBL | Assay Description Inhibition of Escherichia coli DH5alpha beta-lactamase TEM-1 | Antimicrob Agents Chemother 51: 4181-3 (2007) Article DOI: 10.1128/AAC.00614-07 BindingDB Entry DOI: 10.7270/Q2H131TX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Staphylococcus aureus) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against Penicillinase from Staphylococcus aureus TH-14 using piperacillin (40 uM) as a substrate | J Med Chem 30: 1469-74 (1987) BindingDB Entry DOI: 10.7270/Q28G8JQ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Class A beta-lactamase BCL-1 (Bacillus clausii) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
H�pital de Bic�tre Curated by ChEMBL | Assay Description Inhibition of Bacillus clausii NR beta-lactamase BCL1 expressed in Escherichia coli BL21 (DE3) | Antimicrob Agents Chemother 51: 4009-14 (2007) Article DOI: 10.1128/AAC.00537-07 BindingDB Entry DOI: 10.7270/Q20R9QBS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Proteus mirabilis) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 95.4 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of Proteus mirabilis C889 beta-lactamase assessed as inhibition of nitrocefin hydrolysis preincubated for 5 mins by microtiter plate assay | J Nat Prod 57: 654-7 (1994) Article DOI: 10.1021/np50107a016 BindingDB Entry DOI: 10.7270/Q2SQ935W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase SHV-1 (Klebsiella pneumoniae (Enterobacteria)) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 2.00E+3 | n/a | 100 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Case Western Reserve University | Assay Description Steady state kinetics were performed on an Agilent 8453 diode array spectrophotometer in 10 mM phosphate-buffered saline (pH 7.4). IC50, defined as t... | Biochemistry 54: 734-43 (2015) Article DOI: 10.1021/bi501197t BindingDB Entry DOI: 10.7270/Q2736PNW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Pseudomonas aeruginosa) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Hellenic Pasteur Institute Curated by ChEMBL | Assay Description Inhibition of Pseudomonas aeruginosa GES-13 beta lactamase | Antimicrob Agents Chemother 54: 1331-3 (2010) Article DOI: 10.1128/AAC.01561-09 BindingDB Entry DOI: 10.7270/Q29C6XN5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Pseudomonas aeruginosa) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
H�pital de Bic�tre Curated by ChEMBL | Assay Description Inhibition of Pseudomonas aeruginosa 531 beta-lactamase BEL-2 | Antimicrob Agents Chemother 54: 533-5 (2010) Article DOI: 10.1128/AAC.00859-09 BindingDB Entry DOI: 10.7270/Q2G163PS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Pseudomonas aeruginosa) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
H�pital de Bic�tre Curated by ChEMBL | Assay Description Inhibition of Pseudomonas aeruginosa 51170 beta-lactamase BEL-1 | Antimicrob Agents Chemother 54: 533-5 (2010) Article DOI: 10.1128/AAC.00859-09 BindingDB Entry DOI: 10.7270/Q2G163PS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 145 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of Escherichia coli JT4 beta-lactamase TEM1 assessed as inhibition of nitrocefin hydrolysis preincubated for 5 mins by microtiter plate as... | J Nat Prod 57: 654-7 (1994) Article DOI: 10.1021/np50107a016 BindingDB Entry DOI: 10.7270/Q2SQ935W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Staphylococcus aureus) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of Staphylococcus aureus Russell beta-lactamase assessed as inhibition of nitrocefin hydrolysis pre-incubated for 5 mins by microtiter pla... | J Nat Prod 57: 654-7 (1994) Article DOI: 10.1021/np50107a016 BindingDB Entry DOI: 10.7270/Q2SQ935W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Pasteur Hellenique Curated by ChEMBL | Assay Description Inhibition of Escherichia coli K12 TEM1 | Antimicrob Agents Chemother 51: 2185-8 (2007) Article DOI: 10.1128/AAC.01439-06 BindingDB Entry DOI: 10.7270/Q2028SFP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase SHV-1 (Klebsiella pneumoniae (Enterobacteria)) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Health Dr. Ricardo Jorge Av. Padre Cruz Curated by ChEMBL | Assay Description Inhibition of Klebsiella pneumoniae Beta-Lactamase SHV-1 | Antimicrob Agents Chemother 52: 1806-11 (2008) Article DOI: 10.1128/AAC.01381-07 BindingDB Entry DOI: 10.7270/Q2TM7B93 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase SHV-1 (Klebsiella pneumoniae (Enterobacteria)) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of Klebsiella pneumoniae Beta-Lactamase SHV-1 | Antimicrob Agents Chemother 52: 1897-8 (2008) Article DOI: 10.1128/AAC.01525-07 BindingDB Entry DOI: 10.7270/Q2PV6KKC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metallo-beta-lactamase type 2 (Bacteroides fragilis) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | 251 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against Bacteroides fragilis 88854 Class-I beta-lactamase enzyme | Citation and Details BindingDB Entry DOI: 10.7270/Q2ZW1P2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase OXA-1 (Escherichia coli (Enterobacteria)) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | 401 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against Escherichia coli HA209 Class-V OXA-1 type beta-lactamase enzyme | Citation and Details BindingDB Entry DOI: 10.7270/Q2ZW1P2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Pseudomonas aeruginosa (PAO1)) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd. Curated by ChEMBL | Assay Description Deacylation of 18SH Beta-lactamase of Pseudomonas aeruginosa | J Med Chem 41: 3961-71 (1998) Article DOI: 10.1021/jm980023c BindingDB Entry DOI: 10.7270/Q2HT2NF0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Klebsiella pneumoniae) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.72E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Health Dr. Ricardo Jorge Av. Padre Cruz Curated by ChEMBL | Assay Description Inhibition of Klebsiella pneumoniae Beta-Lactamase SHV-72 | Antimicrob Agents Chemother 52: 1806-11 (2008) Article DOI: 10.1128/AAC.01381-07 BindingDB Entry DOI: 10.7270/Q2TM7B93 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Class D beta-lactamase (Brachyspira pilosicoli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Pasteur Curated by ChEMBL | Assay Description Inhibition of Brachyspira pilosicoli beta-lactamase OXA-63 expressed in Escherichia coli BL21 (DE3) assessed as reduction in nitrocefin hydrolysis by... | Antimicrob Agents Chemother 52: 1264-8 (2008) Article DOI: 10.1128/AAC.00684-07 BindingDB Entry DOI: 10.7270/Q26W9B91 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase OXA-1 (Escherichia coli (Enterobacteria)) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against Beta-lactamase type OXA1 (penicillinase) from E. coli OXA1 using ampicillin (40 uM) as a substrate | J Med Chem 30: 1469-74 (1987) BindingDB Entry DOI: 10.7270/Q28G8JQ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 8.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CHU Clermont-Ferrand Curated by ChEMBL | Assay Description Inhibition of Escherichia coli DH5alpha beta-lactamase TEM-158 | Antimicrob Agents Chemother 51: 4181-3 (2007) Article DOI: 10.1128/AAC.00614-07 BindingDB Entry DOI: 10.7270/Q2H131TX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbapenem-hydrolyzing beta-lactamase KPC (Klebsiella pneumoniae) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Service de Bactériologie-Virologie, Hôpital de Bicêtre Curated by ChEMBL | Assay Description Inhibition of carbapenem-resistant Klebsiella pneumoniae carbepenem-hydrolyzing beta-lactamase KPC-1 | Antimicrob Agents Chemother 54: 328-32 (2009) Article DOI: 10.1128/AAC.00961-09 BindingDB Entry DOI: 10.7270/Q2ZW1M3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Citrobacter freundii) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against Citrobacter freundii 87470 Class-I beta-lactamase enzyme | Citation and Details BindingDB Entry DOI: 10.7270/Q2ZW1P2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Enterobacter cloacae) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against beta-Lactamase enzyme derived from Enterobacter cloacae SC 12368 E-2 | Bioorg Med Chem Lett 5: 1513-1518 (1995) Article DOI: 10.1016/0960-894X(95)00249-S BindingDB Entry DOI: 10.7270/Q2ZW1MDG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Enterobacter cloacae) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against beta-Lactamase enzyme derived from Enterobacter cloacae P99 | Bioorg Med Chem Lett 5: 1513-1518 (1995) Article DOI: 10.1016/0960-894X(95)00249-S BindingDB Entry DOI: 10.7270/Q2ZW1MDG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against Beta-lactamase type TEM2 (penicillinase) from E. coli TEM2 using penicillin G (40 uM) as a substrate | J Med Chem 30: 1469-74 (1987) BindingDB Entry DOI: 10.7270/Q28G8JQ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lek d.d. Curated by ChEMBL | Assay Description The compound was tested for its inhibitory activity towards Class A TEM-1 beta-lactamase from Escherichia coli at 0.3 umol | Bioorg Med Chem Lett 12: 971-5 (2002) BindingDB Entry DOI: 10.7270/Q2NC61S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Enterobacter cloacae) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | 3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against Enterobacter cloacae HC8 Class-I beta-lactamase enzyme type P99 | Citation and Details BindingDB Entry DOI: 10.7270/Q2ZW1P2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | <4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Inhibitory concentration which is required to cause 50% inhibition of human leukocyte elastase (HLE) enzyme | J Med Chem 33: 2513-21 (1990) BindingDB Entry DOI: 10.7270/Q2Q81C2Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Serratia fonticola) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 7.28E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Aveiro Curated by ChEMBL | Assay Description Inhibition of Serratia fonticola UTAD54 SFC1 beta lactamase expressed in Escherichia coli BL21(DE3) by SDS-PAGE | Antimicrob Agents Chemother 51: 4512-4 (2007) Article DOI: 10.1128/AAC.00491-07 BindingDB Entry DOI: 10.7270/Q2PK0FX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article | n/a | n/a | 7.53E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Concentration required for its inhibitory activity against Escherichia coli K12(PSE4) class A beta-lactamase | Citation and Details Article DOI: 10.1016/S0960-894X(01)80506-0 BindingDB Entry DOI: 10.7270/Q21V5HPM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Proteus mirabilis) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article | n/a | n/a | 9.54E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Concentration required for its inhibitory activity against Proteus mirabilis C889 class A beta-lactamase | Citation and Details Article DOI: 10.1016/S0960-894X(01)80506-0 BindingDB Entry DOI: 10.7270/Q21V5HPM | |||||||||||
More data for this Ligand-Target Pair |
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