Found 12 hits of ki for monomerid = 50356884 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50356884
(CHEMBL1915540)Show InChI InChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.56 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamas... |
Bioorg Med Chem Lett 21: 6596-602 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.125
BindingDB Entry DOI: 10.7270/Q20C4W6C |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50356884
(CHEMBL1915540)Show InChI InChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cells |
Bioorg Med Chem Lett 21: 6596-602 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.125
BindingDB Entry DOI: 10.7270/Q20C4W6C |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50356884
(CHEMBL1915540)Show InChI InChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development, LLC
Curated by ChEMBL
| Assay Description
Binding affinity to human histamine H4 receptor |
J Med Chem 58: 7119-27 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00516
BindingDB Entry DOI: 10.7270/Q20G3MZK |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50356884
(CHEMBL1915540)Show InChI InChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 6.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development, LLC
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 58: 7119-27 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00516
BindingDB Entry DOI: 10.7270/Q20G3MZK |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Rattus norvegicus (rat)) | BDBM50356884
(CHEMBL1915540)Show InChI InChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development, LLC
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293T cells |
J Med Chem 58: 7119-27 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00516
BindingDB Entry DOI: 10.7270/Q20G3MZK |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Rattus norvegicus (rat)) | BDBM50356884
(CHEMBL1915540)Show InChI InChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 12.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-histamine from rat H4R expressed in HEK293T cells |
Bioorg Med Chem Lett 21: 6596-602 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.125
BindingDB Entry DOI: 10.7270/Q20C4W6C |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Mus musculus (mouse)) | BDBM50356884
(CHEMBL1915540)Show InChI InChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 20.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-histamine from mouse H4R expressed in HEK293T cells |
Bioorg Med Chem Lett 21: 6596-602 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.125
BindingDB Entry DOI: 10.7270/Q20C4W6C |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Mus musculus (mouse)) | BDBM50356884
(CHEMBL1915540)Show InChI InChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development, LLC
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from mouse histamine H4 receptor expressed in HEK293T cells |
J Med Chem 58: 7119-27 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00516
BindingDB Entry DOI: 10.7270/Q20G3MZK |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Rattus norvegicus (rat)) | BDBM50356884
(CHEMBL1915540)Show InChI InChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Binding affinity to rat histamine H4 receptor |
Bioorg Med Chem Lett 23: 2663-70 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.091
BindingDB Entry DOI: 10.7270/Q2K35W11 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Mus musculus (mouse)) | BDBM50356884
(CHEMBL1915540)Show InChI InChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Binding affinity to mouse histamine H4 receptor |
Bioorg Med Chem Lett 23: 2663-70 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.091
BindingDB Entry DOI: 10.7270/Q2K35W11 |
More data for this
Ligand-Target Pair | |
Histamine receptor H4
(GUINEA PIG) | BDBM50356884
(CHEMBL1915540)Show InChI InChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 123 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development, LLC
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from guinea pig histamine H4 receptor expressed in HEK293T cells |
J Med Chem 58: 7119-27 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00516
BindingDB Entry DOI: 10.7270/Q20G3MZK |
More data for this
Ligand-Target Pair | |
Histamine receptor H4
(GUINEA PIG) | BDBM50356884
(CHEMBL1915540)Show InChI InChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 123 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cells |
Bioorg Med Chem Lett 21: 6596-602 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.125
BindingDB Entry DOI: 10.7270/Q20C4W6C |
More data for this
Ligand-Target Pair | |
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