Compile Data Set for Download or QSAR

Found 6 hits Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM107481'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM107481 (US8575157, 189 | US8592410, Comparator 1 | US85981...) Show SMILES OCC[C@@]1(CCN(C(=O)O1)c1cccc(c1)-c1ccc(F)cc1F)c1ccccc1 |r| Show InChI InChI=1S/C24H21F2NO3/c25-19-9-10-21(22(26)16-19)17-5-4-8-20(15-17)27-13-11-24(12-14-28,30-23(27)29)18-6-2-1-3-7-18/h1-10,15-16,28H,11-14H2/t24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.770	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...				US Patent US8592410 (2013) BindingDB Entry DOI: 10.7270/Q2CF9NRN
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM107481 (US8575157, 189 | US8592410, Comparator 1 | US85981...) Show SMILES OCC[C@@]1(CCN(C(=O)O1)c1cccc(c1)-c1ccc(F)cc1F)c1ccccc1 |r| Show InChI InChI=1S/C24H21F2NO3/c25-19-9-10-21(22(26)16-19)17-5-4-8-20(15-17)27-13-11-24(12-14-28,30-23(27)29)18-6-2-1-3-7-18/h1-10,15-16,28H,11-14H2/t24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.770	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH US Patent					Assay Description The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...				US Patent US8575157 (2013) BindingDB Entry DOI: 10.7270/Q2416VPS
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM107481 (US8575157, 189 | US8592410, Comparator 1 | US85981...) Show SMILES OCC[C@@]1(CCN(C(=O)O1)c1cccc(c1)-c1ccc(F)cc1F)c1ccccc1 |r| Show InChI InChI=1S/C24H21F2NO3/c25-19-9-10-21(22(26)16-19)17-5-4-8-20(15-17)27-13-11-24(12-14-28,30-23(27)29)18-6-2-1-3-7-18/h1-10,15-16,28H,11-14H2/t24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.770	n/a	n/a	n/a	n/a	7.4	n/a
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...				US Patent US8598163 (2013) BindingDB Entry DOI: 10.7270/Q29K48WR
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM107481 (US8575157, 189 | US8592410, Comparator 1 | US85981...) Show SMILES OCC[C@@]1(CCN(C(=O)O1)c1cccc(c1)-c1ccc(F)cc1F)c1ccccc1 |r| Show InChI InChI=1S/C24H21F2NO3/c25-19-9-10-21(22(26)16-19)17-5-4-8-20(15-17)27-13-11-24(12-14-28,30-23(27)29)18-6-2-1-3-7-18/h1-10,15-16,28H,11-14H2/t24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12.0	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH US Patent					Assay Description Inhibition assay using 11β-HSD1 in the presence of 50% human plasma.				US Patent US8575157 (2013) BindingDB Entry DOI: 10.7270/Q2416VPS
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM107481 (US8575157, 189 | US8592410, Comparator 1 | US85981...) Show SMILES OCC[C@@]1(CCN(C(=O)O1)c1cccc(c1)-c1ccc(F)cc1F)c1ccccc1 |r| Show InChI InChI=1S/C24H21F2NO3/c25-19-9-10-21(22(26)16-19)17-5-4-8-20(15-17)27-13-11-24(12-14-28,30-23(27)29)18-6-2-1-3-7-18/h1-10,15-16,28H,11-14H2/t24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12.0	n/a	n/a	n/a	n/a	7.4	n/a
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...				US Patent US8598163 (2013) BindingDB Entry DOI: 10.7270/Q29K48WR
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM107481 (US8575157, 189 | US8592410, Comparator 1 | US85981...) Show SMILES OCC[C@@]1(CCN(C(=O)O1)c1cccc(c1)-c1ccc(F)cc1F)c1ccccc1 |r| Show InChI InChI=1S/C24H21F2NO3/c25-19-9-10-21(22(26)16-19)17-5-4-8-20(15-17)27-13-11-24(12-14-28,30-23(27)29)18-6-2-1-3-7-18/h1-10,15-16,28H,11-14H2/t24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12.0	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition assay using 11β-HSD1.				US Patent US8592410 (2013) BindingDB Entry DOI: 10.7270/Q2CF9NRN
					More data for this Ligand-Target Pair