Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM28369 (N-{4-[(1-cyanocyclopropyl)methyl]cyclohexyl}-N-cyc...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Amgen | Assay Description Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e... | Bioorg Med Chem Lett 19: 1797-801 (2009) Article DOI: 10.1016/j.bmcl.2009.01.058 BindingDB Entry DOI: 10.7270/Q2FB5180 | |||||||||||
More data for this Ligand-Target Pair |