Found 2 hits Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM50400167' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50400167
(CHEMBL2179026)Show SMILES COCCNc1ncc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)c(n1)C1CCCC1 |r,wU:12.11,wD:19.20,TLB:20:19:12:16.15.14,11:12:22.18.19:16.15.14,11:12:14:22.19.21,THB:20:19:12.17.16:14,21:19:12:16.15.14,21:15:12:22.18.19,18:17:14:22.19.21,18:19:12.17.16:14,(21.41,-20.78,;21.41,-22.32,;22.74,-23.09,;22.74,-24.63,;24.07,-25.4,;25.41,-24.63,;25.41,-23.09,;26.74,-22.31,;28.07,-23.08,;29.4,-22.3,;29.4,-20.76,;30.74,-23.07,;32.07,-22.29,;32.06,-20.55,;31.03,-19.47,;31.68,-18.2,;31.7,-19.64,;32.87,-20.97,;34.28,-20.4,;34.14,-18.78,;35.67,-18.79,;33.1,-17.66,;33.36,-19.99,;28.08,-24.63,;26.74,-25.4,;29.41,-25.4,;29.58,-26.92,;31.08,-27.24,;31.85,-25.91,;30.82,-24.76,)| Show InChI InChI=1S/C23H34N4O3/c1-30-7-6-24-22-25-13-18(20(27-22)15-4-2-3-5-15)21(28)26-19-16-8-14-9-17(19)12-23(29,10-14)11-16/h13-17,19,29H,2-12H2,1H3,(H,26,28)(H,24,25,27)/t14?,16?,17?,19-,23- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human 11beta-HSD1 by HTRF assay |
J Med Chem 55: 10652-61 (2012)
Article DOI: 10.1021/jm3013163 BindingDB Entry DOI: 10.7270/Q2BG2Q4S |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse)) | BDBM50400167
(CHEMBL2179026)Show SMILES COCCNc1ncc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)c(n1)C1CCCC1 |r,wU:12.11,wD:19.20,TLB:20:19:12:16.15.14,11:12:22.18.19:16.15.14,11:12:14:22.19.21,THB:20:19:12.17.16:14,21:19:12:16.15.14,21:15:12:22.18.19,18:17:14:22.19.21,18:19:12.17.16:14,(21.41,-20.78,;21.41,-22.32,;22.74,-23.09,;22.74,-24.63,;24.07,-25.4,;25.41,-24.63,;25.41,-23.09,;26.74,-22.31,;28.07,-23.08,;29.4,-22.3,;29.4,-20.76,;30.74,-23.07,;32.07,-22.29,;32.06,-20.55,;31.03,-19.47,;31.68,-18.2,;31.7,-19.64,;32.87,-20.97,;34.28,-20.4,;34.14,-18.78,;35.67,-18.79,;33.1,-17.66,;33.36,-19.99,;28.08,-24.63,;26.74,-25.4,;29.41,-25.4,;29.58,-26.92,;31.08,-27.24,;31.85,-25.91,;30.82,-24.76,)| Show InChI InChI=1S/C23H34N4O3/c1-30-7-6-24-22-25-13-18(20(27-22)15-4-2-3-5-15)21(28)26-19-16-8-14-9-17(19)12-23(29,10-14)11-16/h13-17,19,29H,2-12H2,1H3,(H,26,28)(H,24,25,27)/t14?,16?,17?,19-,23- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of mouse 11beta-HSD1 by HTRF assay |
J Med Chem 55: 10652-61 (2012)
Article DOI: 10.1021/jm3013163 BindingDB Entry DOI: 10.7270/Q2BG2Q4S |
More data for this Ligand-Target Pair | |