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Target11-beta-hydroxysteroid dehydrogenase 1
LigandBDBM50400167
Substrate/Competitorn/a
Meas. Tech.ChEMBL_878466 (CHEMBL2187380)
IC50 15±n/a nM
Citation Goldberg, FW; Leach, AG; Scott, JS; Snelson, WL; Groombridge, SD; Donald, CS; Bennett, SN; Bodin, C; Gutierrez, PM; Gyte, AC Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors. J Med Chem55:10652-61 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
11-beta-hydroxysteroid dehydrogenase 1
Name:11-beta-hydroxysteroid dehydrogenase 1
Synonyms:11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:Enzyme
Mol. Mass.:32409.16
Organism:Homo sapiens (Human)
Description:P28845
Residue:292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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  Blast E-value cutoff:
BDBM50400167
n/a
NameBDBM50400167
Synonyms:CHEMBL2179026
TypeSmall organic molecule
Emp. Form.C23H34N4O3
Mol. Mass.414.5411
SMILESCOCCNc1ncc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)c(n1)C1CCCC1 |r,wU:12.11,wD:19.20,TLB:20:19:12:16.15.14,11:12:22.18.19:16.15.14,11:12:14:22.19.21,THB:20:19:12.17.16:14,21:19:12:16.15.14,21:15:12:22.18.19,18:17:14:22.19.21,18:19:12.17.16:14,(21.41,-20.78,;21.41,-22.32,;22.74,-23.09,;22.74,-24.63,;24.07,-25.4,;25.41,-24.63,;25.41,-23.09,;26.74,-22.31,;28.07,-23.08,;29.4,-22.3,;29.4,-20.76,;30.74,-23.07,;32.07,-22.29,;32.06,-20.55,;31.03,-19.47,;31.68,-18.2,;31.7,-19.64,;32.87,-20.97,;34.28,-20.4,;34.14,-18.78,;35.67,-18.79,;33.1,-17.66,;33.36,-19.99,;28.08,-24.63,;26.74,-25.4,;29.41,-25.4,;29.58,-26.92,;31.08,-27.24,;31.85,-25.91,;30.82,-24.76,)|
Structure
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