BindingDB PrimarySearch

Found 11 hits Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 2A' and Ligand = 'BDBM50052337'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50052337 (2-(8-bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...) Show SMILES CC(N)Cc1c2CCOc2c(Br)c2CCOc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Agonistic activity at cloned human 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand				J Med Chem 39: 2953-61 (1996) Article DOI: 10.1021/jm960199j BindingDB Entry DOI: 10.7270/Q28914ZS
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50052337 (2-(8-bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...) Show SMILES CC(N)Cc1c2CCOc2c(Br)c2CCOc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Binding activity against cloned human 5-hydroxytryptamine 2A receptor using [125I]-DOI as the radioligand.				J Med Chem 41: 5148-9 (1999) Article DOI: 10.1021/jm9803525 BindingDB Entry DOI: 10.7270/Q2862FKX
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50052337 (2-(8-bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...) Show SMILES CC(N)Cc1c2CCOc2c(Br)c2CCOc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-La Crosse Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from rat 5HT2A receptor expressed in mouse NIH3T3 cells				Bioorg Med Chem 16: 6242-51 (2008) Article DOI: 10.1016/j.bmc.2008.04.030 BindingDB Entry DOI: 10.7270/Q2QZ29R4
University of Wisconsin-La Crosse Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50052337 (2-(8-bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...) Show SMILES CC(N)Cc1c2CCOc2c(Br)c2CCOc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Antagonistic activity at cloned human 5-hydroxytryptamine 2A receptor using [3H]-ketanserin as radioligand				J Med Chem 39: 2953-61 (1996) Article DOI: 10.1021/jm960199j BindingDB Entry DOI: 10.7270/Q28914ZS
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50052337 (2-(8-bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...) Show SMILES CC(N)Cc1c2CCOc2c(Br)c2CCOc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	14.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Antagonistic activity measured for 5-hydroxytryptamine 2A receptor using [3H]-MDL- 100,907 as radioligand in rat cortical homogenates.				J Med Chem 41: 5148-9 (1999) Article DOI: 10.1021/jm9803525 BindingDB Entry DOI: 10.7270/Q2862FKX
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50052337 (2-(8-bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...) Show SMILES CC(N)Cc1c2CCOc2c(Br)c2CCOc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	14.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Displacement of [3H]MDL100907 from 5HT2A receptor in Sprague-Dawley rat brain by liquid scintillation spectroscopy				Bioorg Med Chem 16: 4661-9 (2008) Article DOI: 10.1016/j.bmc.2008.02.033 BindingDB Entry DOI: 10.7270/Q25D8RNZ
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50052337 (2-(8-bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...) Show SMILES CC(N)Cc1c2CCOc2c(Br)c2CCOc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Binding affinity of the compound towards rat cortical 5-hydroxytryptamine 2A receptor using [3H]-ketanserin as radioligand				J Med Chem 39: 2953-61 (1996) Article DOI: 10.1021/jm960199j BindingDB Entry DOI: 10.7270/Q28914ZS
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50052337 (2-(8-bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...) Show SMILES CC(N)Cc1c2CCOc2c(Br)c2CCOc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from 5HT2A receptor in Sprague-Dawley rat brain by liquid scintillation spectroscopy				Bioorg Med Chem 16: 4661-9 (2008) Article DOI: 10.1016/j.bmc.2008.02.033 BindingDB Entry DOI: 10.7270/Q25D8RNZ
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50052337 (2-(8-bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...) Show SMILES CC(N)Cc1c2CCOc2c(Br)c2CCOc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Research, Ltd Curated by ChEMBL					Assay Description Displacement of [125I]DOI from 5HT2A receptor in rat cerebral cortex				Bioorg Med Chem Lett 17: 2998-3002 (2007) Article DOI: 10.1016/j.bmcl.2007.03.073 BindingDB Entry DOI: 10.7270/Q2KS6R7B
Alcon Research, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50052337 (2-(8-bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...) Show SMILES CC(N)Cc1c2CCOc2c(Br)c2CCOc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
University of Wisconsin-La Crosse Curated by ChEMBL					Assay Description Agonist activity at rat 5HT2A receptor expressed in mouse NIH3T3 cells assessed as stimulation of inositol phosphate accumulation				Bioorg Med Chem 16: 6242-51 (2008) Article DOI: 10.1016/j.bmc.2008.04.030 BindingDB Entry DOI: 10.7270/Q2QZ29R4
University of Wisconsin-La Crosse Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50052337 (2-(8-bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...) Show SMILES CC(N)Cc1c2CCOc2c(Br)c2CCOc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
Alcon Research, Ltd Curated by ChEMBL					Assay Description Agonist activity at 5HT2A receptor in rat A7r5 cells assessed as intracellular calcium mobilization relative to 5HT				Bioorg Med Chem Lett 17: 2998-3002 (2007) Article DOI: 10.1016/j.bmcl.2007.03.073 BindingDB Entry DOI: 10.7270/Q2KS6R7B
Alcon Research, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair