Found 27 hits Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 2A' and Ligand = 'BDBM50081701' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB
Reactome pathway KEGG
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| PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University
Curated by PDSP Ki Database
| |
J Neurosci 9: 3482-90 (1989)
BindingDB Entry DOI: 10.7270/Q2FX77Z2 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB
Reactome pathway KEGG
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| Article PubMed
| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description In vitro binding to 5-hydroxytryptamine 2A receptor using [125 I]-DOI |
J Med Chem 46: 3526-35 (2003)
Article DOI: 10.1021/jm030064v BindingDB Entry DOI: 10.7270/Q20P0ZC1 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB
Reactome pathway KEGG
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| Article PubMed
| 323 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description Displacement of [3H]MDL100907 from 5HT2A receptor in Sprague-Dawley rat brain by liquid scintillation spectroscopy |
Bioorg Med Chem 16: 4661-9 (2008)
Article DOI: 10.1016/j.bmc.2008.02.033 BindingDB Entry DOI: 10.7270/Q25D8RNZ |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
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| | 340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2S46WX8 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB
Reactome pathway KEGG
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| 390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity using [3H]-MDL-100,907 at 5-hydroxytryptamine 2A receptor sites in rat cortical homogenate. |
J Med Chem 42: 4257-63 (1999)
BindingDB Entry DOI: 10.7270/Q2FX78PW |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Modulation of human 5HT2A expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq f... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00578 BindingDB Entry DOI: 10.7270/Q2BR8X3V |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB MMDB
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| US Patent
| n/a | n/a | 112 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description 1. Culture the cells in cell culture medium (DMEM containing 10% FBS 1× penicillin-streptomycin 300 μg/ml G418 and 100 μg/ml hygromycin B) ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2CC14MX |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
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| US Patent
| n/a | n/a | 352 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description 1. Culture the cells in cell culture medium (DMEM containing 10% FBS 1× penicillin-streptomycin 300 μg/ml G418 and 100 μg/ml hygromycin B) ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2CC14MX |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
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| US Patent
| n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Table 2: i. Prepare the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2 4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followe... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2CJ8HQ6 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB MMDB
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| US Patent
| n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description i. Prepare the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2 4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followed by 0.2 ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077JM |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB MMDB
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| US Patent
| n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Table 2: i. Prepare the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2 4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followe... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2CJ8HQ6 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB MMDB
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| US Patent
| n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2G44V7B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB MMDB
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| US Patent
| n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2G44V7B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB MMDB
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| | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB MMDB
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| Article PubMed
| n/a | n/a | n/a | n/a | 75 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H]-ketanserin from human 5-HT2A receptor incubated for 90 mins by scintillation counting analysis |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00467 BindingDB Entry DOI: 10.7270/Q2TT4VR2 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB MMDB
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| Article PubMed
| n/a | n/a | n/a | n/a | 75 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H]-ketanserin from human 5-HT2A receptor incubated for 90 mins by scintillation counting analysis |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00467 BindingDB Entry DOI: 10.7270/Q2TT4VR2 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB MMDB
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| US Patent
| n/a | n/a | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a |
TBA
| Assay Description i. Prepare the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2 4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followed by 0.2 ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077JM |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB MMDB
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| Article PubMed
| n/a | n/a | n/a | n/a | 6.5 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00577 BindingDB Entry DOI: 10.7270/Q2Z89H7T |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Mus musculus (Mouse)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB
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| Article PubMed
| n/a | n/a | n/a | n/a | 9.80 | n/a | n/a | n/a | n/a |
Usona Institute
Curated by ChEMBL
| Assay Description Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by... |
J Nat Prod 83: 461-467 (2020)
Article DOI: 10.1021/acs.jnatprod.9b01061 BindingDB Entry DOI: 10.7270/Q2RX9GM1 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Mus musculus (Mouse)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB
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| Article PubMed
| n/a | n/a | n/a | n/a | 9.90 | n/a | n/a | n/a | n/a |
Usona Institute
Curated by ChEMBL
| Assay Description Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by... |
J Nat Prod 83: 461-467 (2020)
Article DOI: 10.1021/acs.jnatprod.9b01061 BindingDB Entry DOI: 10.7270/Q2RX9GM1 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB MMDB
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| Article PubMed
| n/a | n/a | n/a | n/a | 6.5 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00129 BindingDB Entry DOI: 10.7270/Q23T9N3F |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB MMDB
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| Article PubMed
| n/a | n/a | n/a | n/a | 4.30 | n/a | n/a | n/a | n/a |
Usona Institute
Curated by ChEMBL
| Assay Description Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by... |
J Nat Prod 83: 461-467 (2020)
Article DOI: 10.1021/acs.jnatprod.9b01061 BindingDB Entry DOI: 10.7270/Q2RX9GM1 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB MMDB
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| Article PubMed
| n/a | n/a | n/a | n/a | 24 | n/a | n/a | n/a | n/a |
Organix Inc.
Curated by ChEMBL
| Assay Description Effective concentration required for accumulation of [3H]-inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determi... |
Bioorg Med Chem Lett 15: 4555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.104 BindingDB Entry DOI: 10.7270/Q2PZ58B5 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB MMDB
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| Article PubMed
| n/a | n/a | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00128 BindingDB Entry DOI: 10.7270/Q2KD22Z5 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB
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| Article PubMed
| n/a | n/a | n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description Tested for its ability to activate phospholipase C by quantification of IP3 at cloned rat 5-hydroxytryptamine 2A receptor |
J Med Chem 46: 3526-35 (2003)
Article DOI: 10.1021/jm030064v BindingDB Entry DOI: 10.7270/Q20P0ZC1 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00352 BindingDB Entry DOI: 10.7270/Q2CC14Q8 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50081701
(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)Show InChI InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 4.30 | n/a | n/a | n/a | n/a |
Usona Institute
Curated by ChEMBL
| Assay Description Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by... |
J Nat Prod 83: 461-467 (2020)
Article DOI: 10.1021/acs.jnatprod.9b01061 BindingDB Entry DOI: 10.7270/Q2RX9GM1 |
More data for this Ligand-Target Pair | |