| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2A |
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| Ligand | BDBM50081701 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2567 (CHEMBL617114) |
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| EC50 | 2300±n/a nM |
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| Citation |  Chambers, JJ; Parrish, JC; Jensen, NH; Kurrasch-Orbaugh, DM; Marona-Lewicka, D; Nichols, DE Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands. J Med Chem46:3526-35 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 2A |
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| Name: | 5-hydroxytryptamine receptor 2A |
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| Synonyms: | 5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 52852.05 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Rat cortex membranes 5-HT2A receptors. |
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| Residue: | 471 |
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| Sequence: | MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYK
SSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
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| BDBM50081701 |
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| n/a |
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| Name | BDBM50081701 |
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| Synonyms: | 3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydroxy-N,N-dimethyltryptamine | CHEMBL65547 | N,N-dimethyl-4-hydroxytryptamine | Psilocin | US11427604, Compound (I-45) | US11453689, Compound Psilocin | US11591353, Compound I-45 | US11597738, Example 3 | US11642336, Compound Psilocin | US20240051978, Compound Psilocin |
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| Type | Small organic molecule |
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| Emp. Form. | C12H16N2O |
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| Mol. Mass. | 204.2682 |
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| SMILES | CN(C)CCc1c[nH]c2cccc(O)c12 |
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| Structure | 
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