Found 11 hits Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 7' and Ligand = 'BDBM50098550' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM50098550
(3,N-Dimethyl-N-[(R)-1-methyl-3-(4-methyl-piperidin...)Show SMILES C[C@H](CCN1CCC(C)CC1)N(C)S(=O)(=O)c1cccc(C)c1 Show InChI InChI=1S/C18H30N2O2S/c1-15-8-11-20(12-9-15)13-10-17(3)19(4)23(21,22)18-7-5-6-16(2)14-18/h5-7,14-15,17H,8-13H2,1-4H3/t17-/m1/s1 | PDB
Reactome pathway
KEGG
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| PubMed
| 31.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells |
J Med Chem 44: 1337-40 (2001)
BindingDB Entry DOI: 10.7270/Q23X85WM |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50098550
(3,N-Dimethyl-N-[(R)-1-methyl-3-(4-methyl-piperidin...)Show SMILES C[C@H](CCN1CCC(C)CC1)N(C)S(=O)(=O)c1cccc(C)c1 Show InChI InChI=1S/C18H30N2O2S/c1-15-8-11-20(12-9-15)13-10-17(3)19(4)23(21,22)18-7-5-6-16(2)14-18/h5-7,14-15,17H,8-13H2,1-4H3/t17-/m1/s1 | PDB
Reactome pathway
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| Article
PubMed
| 31.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
| |
Br J Pharmacol 124: 1300-6 (1998)
Article DOI: 10.1038/sj.bjp.0701946
BindingDB Entry DOI: 10.7270/Q269724V |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50098550
(3,N-Dimethyl-N-[(R)-1-methyl-3-(4-methyl-piperidin...)Show SMILES C[C@H](CCN1CCC(C)CC1)N(C)S(=O)(=O)c1cccc(C)c1 Show InChI InChI=1S/C18H30N2O2S/c1-15-8-11-20(12-9-15)13-10-17(3)19(4)23(21,22)18-7-5-6-16(2)14-18/h5-7,14-15,17H,8-13H2,1-4H3/t17-/m1/s1 | PDB
Reactome pathway
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PubMed
| 31.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
| |
J Med Chem 41: 655-7 (1998)
Article DOI: 10.1021/jm970519e
BindingDB Entry DOI: 10.7270/Q2GX4949 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50098550
(3,N-Dimethyl-N-[(R)-1-methyl-3-(4-methyl-piperidin...)Show SMILES C[C@H](CCN1CCC(C)CC1)N(C)S(=O)(=O)c1cccc(C)c1 Show InChI InChI=1S/C18H30N2O2S/c1-15-8-11-20(12-9-15)13-10-17(3)19(4)23(21,22)18-7-5-6-16(2)14-18/h5-7,14-15,17H,8-13H2,1-4H3/t17-/m1/s1 | PDB
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| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Complutense
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells |
Bioorg Med Chem Lett 10: 1097-100 (2000)
BindingDB Entry DOI: 10.7270/Q2JS9RNJ |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50098550
(3,N-Dimethyl-N-[(R)-1-methyl-3-(4-methyl-piperidin...)Show SMILES C[C@H](CCN1CCC(C)CC1)N(C)S(=O)(=O)c1cccc(C)c1 Show InChI InChI=1S/C18H30N2O2S/c1-15-8-11-20(12-9-15)13-10-17(3)19(4)23(21,22)18-7-5-6-16(2)14-18/h5-7,14-15,17H,8-13H2,1-4H3/t17-/m1/s1 | PDB
Reactome pathway
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PubMed
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Binding affinity to 5-HT7 receptor (unknown origin) |
J Med Chem 61: 8475-8503 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01898
BindingDB Entry DOI: 10.7270/Q2V98BPM |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50098550
(3,N-Dimethyl-N-[(R)-1-methyl-3-(4-methyl-piperidin...)Show SMILES C[C@H](CCN1CCC(C)CC1)N(C)S(=O)(=O)c1cccc(C)c1 Show InChI InChI=1S/C18H30N2O2S/c1-15-8-11-20(12-9-15)13-10-17(3)19(4)23(21,22)18-7-5-6-16(2)14-18/h5-7,14-15,17H,8-13H2,1-4H3/t17-/m1/s1 | PDB
Reactome pathway
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| Article
PubMed
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Normandie Univ
Curated by ChEMBL
| Assay Description
Antagonist activity at 5-HT7 receptor (unknown origin) |
Eur J Med Chem 183: (2019)
Article DOI: 10.1016/j.ejmech.2019.111705
BindingDB Entry DOI: 10.7270/Q2377D11 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50098550
(3,N-Dimethyl-N-[(R)-1-methyl-3-(4-methyl-piperidin...)Show SMILES C[C@H](CCN1CCC(C)CC1)N(C)S(=O)(=O)c1cccc(C)c1 Show InChI InChI=1S/C18H30N2O2S/c1-15-8-11-20(12-9-15)13-10-17(3)19(4)23(21,22)18-7-5-6-16(2)14-18/h5-7,14-15,17H,8-13H2,1-4H3/t17-/m1/s1 | PDB
Reactome pathway
KEGG
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| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSD |
Bioorg Med Chem Lett 12: 2451-4 (2002)
BindingDB Entry DOI: 10.7270/Q25T3JTZ |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50098550
(3,N-Dimethyl-N-[(R)-1-methyl-3-(4-methyl-piperidin...)Show SMILES C[C@H](CCN1CCC(C)CC1)N(C)S(=O)(=O)c1cccc(C)c1 Show InChI InChI=1S/C18H30N2O2S/c1-15-8-11-20(12-9-15)13-10-17(3)19(4)23(21,22)18-7-5-6-16(2)14-18/h5-7,14-15,17H,8-13H2,1-4H3/t17-/m1/s1 | PDB
Reactome pathway
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| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Science and Technology
Curated by ChEMBL
| Assay Description
Binding affinity to 5HT7 receptor (unknown origin) |
Bioorg Med Chem 21: 2568-76 (2013)
Article DOI: 10.1016/j.bmc.2013.02.038
BindingDB Entry DOI: 10.7270/Q2QZ2CGC |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50098550
(3,N-Dimethyl-N-[(R)-1-methyl-3-(4-methyl-piperidin...)Show SMILES C[C@H](CCN1CCC(C)CC1)N(C)S(=O)(=O)c1cccc(C)c1 Show InChI InChI=1S/C18H30N2O2S/c1-15-8-11-20(12-9-15)13-10-17(3)19(4)23(21,22)18-7-5-6-16(2)14-18/h5-7,14-15,17H,8-13H2,1-4H3/t17-/m1/s1 | PDB
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| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University
Curated by ChEMBL
| Assay Description
Binding affinity towards human 5-hydroxytryptamine 7 receptor |
J Med Chem 46: 2795-812 (2003)
Article DOI: 10.1021/jm030030n
BindingDB Entry DOI: 10.7270/Q2M0465F |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50098550
(3,N-Dimethyl-N-[(R)-1-methyl-3-(4-methyl-piperidin...)Show SMILES C[C@H](CCN1CCC(C)CC1)N(C)S(=O)(=O)c1cccc(C)c1 Show InChI InChI=1S/C18H30N2O2S/c1-15-8-11-20(12-9-15)13-10-17(3)19(4)23(21,22)18-7-5-6-16(2)14-18/h5-7,14-15,17H,8-13H2,1-4H3/t17-/m1/s1 | PDB
Reactome pathway
KEGG
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CHEMBL
MCE
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PC sid
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| Article
PubMed
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Complutense
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand |
J Med Chem 46: 5638-50 (2003)
Article DOI: 10.1021/jm030841r
BindingDB Entry DOI: 10.7270/Q29W0J74 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM50098550
(3,N-Dimethyl-N-[(R)-1-methyl-3-(4-methyl-piperidin...)Show SMILES C[C@H](CCN1CCC(C)CC1)N(C)S(=O)(=O)c1cccc(C)c1 Show InChI InChI=1S/C18H30N2O2S/c1-15-8-11-20(12-9-15)13-10-17(3)19(4)23(21,22)18-7-5-6-16(2)14-18/h5-7,14-15,17H,8-13H2,1-4H3/t17-/m1/s1 | PDB
Reactome pathway
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CHEMBL
MCE
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| Article
PubMed
| 79 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Complutense
Curated by ChEMBL
| Assay Description
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand. |
J Med Chem 46: 5638-50 (2003)
Article DOI: 10.1021/jm030841r
BindingDB Entry DOI: 10.7270/Q29W0J74 |
More data for this
Ligand-Target Pair | |
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