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Found 1 hit Enz. Inhib. hit(s) with Target = 'ATP-dependent translocase ABCB1' and Ligand = 'BDBM50032263'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
ATP-dependent translocase ABCB1


(Homo sapiens (Human))		BDBM50032263
PNG
(CHEMBL3352973)
Show SMILES COc1ccc(cc1)-c1ccc2OCC(CC(=O)N3CCc4cc(OC)c(OC)cc4C3)=Cc2c1 |c:34|
Show InChI InChI=1S/C29H29NO5/c1-32-25-7-4-20(5-8-25)21-6-9-26-23(14-21)12-19(18-35-26)13-29(31)30-11-10-22-15-27(33-2)28(34-3)16-24(22)17-30/h4-9,12,14-16H,10-11,13,17-18H2,1-3H3
PDB

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 5.80E+3n/an/an/an/a



Universit£ degli Studi di Bari"A. Moro"

Curated by ChEMBL


Assay Description
Inhibition of MDR1 (unknown origin) over-expressed in MDCK cells assessed as calcein accumulation incubated for 30 mins prior to Calcein-AM addition ...

J Med Chem 57: 9983-94 (2014)


Article DOI: 10.1021/jm501640e
BindingDB Entry DOI: 10.7270/Q2K9394N
More data for this
Ligand-Target Pair