Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Amine oxidase [flavin-containing] B (Homo sapiens (Human)) | BDBM50246766 (CHEMBL489079 | Mofegiline | US9302986, Mofegiline) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of human recombinant MAOB expressed in Pichia pastoris by kinetic assay | J Med Chem 51: 8019-26 (2008) Article DOI: 10.1021/jm8011867 BindingDB Entry DOI: 10.7270/Q2542NGF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase [flavin-containing] B (Homo sapiens (Human)) | BDBM50246766 (CHEMBL489079 | Mofegiline | US9302986, Mofegiline) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.bmcl.2022.128942 BindingDB Entry DOI: 10.7270/Q2639TQ8 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase [flavin-containing] B (Rattus norvegicus (rat)) | BDBM50246766 (CHEMBL489079 | Mofegiline | US9302986, Mofegiline) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of rat membrane MAOB | J Med Chem 51: 8019-26 (2008) Article DOI: 10.1021/jm8011867 BindingDB Entry DOI: 10.7270/Q2542NGF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase [flavin-containing] B (Homo sapiens (Human)) | BDBM50246766 (CHEMBL489079 | Mofegiline | US9302986, Mofegiline) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.4 | 37 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH US Patent | Assay Description Recombinant human MAO-B (0.06 mg/mL; Sigma Aldrich) was used as source of MAO-B enzyme activities. The assay was performed in a similar way as for hu... | US Patent US9302986 (2016) BindingDB Entry DOI: 10.7270/Q2ZC81QZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase [flavin-containing] B (Homo sapiens (Human)) | BDBM50246766 (CHEMBL489079 | Mofegiline | US9302986, Mofegiline) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaxis Ltd. Curated by ChEMBL | Assay Description Inhibition of human recombinant MAO-B assessed as H2O2 production by Resorufin/Amplex Red assay | Bioorg Med Chem Lett 22: 3935-40 (2012) Article DOI: 10.1016/j.bmcl.2012.04.111 BindingDB Entry DOI: 10.7270/Q2SQ91D6 | |||||||||||
More data for this Ligand-Target Pair |