Found 78 hits Enz. Inhib. hit(s) with Target = 'Aminopeptidase N' and Ligand = 'BDBM23971' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Haute Alsace
Curated by ChEMBL
| Assay Description Competitive inhibition of pig APN using L-leucine-p-nitroanilide as substrate by Dixon-plot analysis |
Bioorg Med Chem 20: 4942-53 (2012)
Article DOI: 10.1016/j.bmc.2012.06.041 BindingDB Entry DOI: 10.7270/Q2RB75Q1 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de La Habana
Curated by ChEMBL
| Assay Description Inhibition of human cytomegalovirus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 d... |
Bioorg Med Chem 25: 4628-4636 (2017)
Article DOI: 10.1016/j.bmc.2017.06.047 BindingDB Entry DOI: 10.7270/Q2MS3W75 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Homo sapiens (Human)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| 2.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University
Curated by ChEMBL
| Assay Description Inhibition of soluble human APN ectodomain stably expressed in HEK293 GnTI(-) cells using H-Leu-NHMec as substrate preincubated for 10 mins followed ... |
J Med Chem 62: 7185-7209 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00757 BindingDB Entry DOI: 10.7270/Q2KK9G8J |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Mus musculus) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | Reactome pathway KEGG
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| 3.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of mouse APN |
ACS Med Chem Lett 3: 959-964 (2012)
Article DOI: 10.1021/ml3000758 BindingDB Entry DOI: 10.7270/Q2QJ7JFR |
More data for this Ligand-Target Pair | |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Haute Alsace
Curated by ChEMBL
| Assay Description Inhibition of porcine kidney APN using L-leucine para-notroanilide as substrate assessed as release of para-nitroaniline by Dixon plot analysis |
Bioorg Med Chem 21: 6447-55 (2013)
Article DOI: 10.1016/j.bmc.2013.08.044 BindingDB Entry DOI: 10.7270/Q2PR7XF2 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| 3.73E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of porcine kidney microsome aminopeptidase using L-Leu-p-nitroanilide as substrate by Dixon method |
Bioorg Med Chem Lett 22: 5863-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.086 BindingDB Entry DOI: 10.7270/Q2VD70KS |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin
Curated by ChEMBL
| Assay Description Inhibitory activity against Aminopeptidase M |
J Med Chem 31: 2193-9 (1988)
BindingDB Entry DOI: 10.7270/Q2Z038RM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against rabbit kidney aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate |
J Med Chem 28: 1158-69 (1985)
BindingDB Entry DOI: 10.7270/Q20C4WB5 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Homo sapiens (Human)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota
Curated by ChEMBL
| Assay Description Inhibition of recombinant human C-terminal His10-tagged APN (Lys69 to Lys967 residues) using Ala-AMC as substrate measured for 30 mins by fluorescenc... |
Eur J Med Chem 139: 325-336 (2017)
Article DOI: 10.1016/j.ejmech.2017.07.048 BindingDB Entry DOI: 10.7270/Q2FT8PJD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description Inhibition of pig kidney microsome aminopeptidase-N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured... |
Bioorg Med Chem 21: 2663-70 (2013)
Article DOI: 10.1016/j.bmc.2012.06.024 BindingDB Entry DOI: 10.7270/Q2J67J8H |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 1.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description Inhibition of pig kidney microsomal APN using L-Leu-p-nitroanilide as substrate preincubated for 5 mins before substrate addition measured after 30 m... |
Bioorg Med Chem 22: 3055-64 (2014)
Article DOI: 10.1016/j.bmc.2013.12.025 BindingDB Entry DOI: 10.7270/Q29888JP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wroclaw University of Technology
Curated by ChEMBL
| Assay Description Inhibition of pig kidney aminopeptidase N using Leu-AMC as substrate |
Bioorg Med Chem 18: 2930-6 (2010)
Article DOI: 10.1016/j.bmc.2010.02.056 BindingDB Entry DOI: 10.7270/Q2FN16C0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wroc£?aw University of Technology
Curated by ChEMBL
| Assay Description Inhibition of pig kidney aminopeptidase N |
Bioorg Med Chem Lett 18: 3734-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.050 BindingDB Entry DOI: 10.7270/Q2H41R6T |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description Inhibition of pig kidney microsomal aminopeptidase assessed as liberation of p-nitroanilide |
Bioorg Med Chem Lett 17: 2935-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.095 BindingDB Entry DOI: 10.7270/Q2HT2P11 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description Inhibition of pig kidney microsomes aminopeptidase N preincubated for 30 mins |
Eur J Med Chem 44: 4819-25 (2009)
Article DOI: 10.1016/j.ejmech.2009.07.022 BindingDB Entry DOI: 10.7270/Q2251J73 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Homo sapiens (Human)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description Inhibition of aminopeptidase N |
Eur J Med Chem 45: 1618-26 (2010)
Article DOI: 10.1016/j.ejmech.2009.12.071 BindingDB Entry DOI: 10.7270/Q20C4VXC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 2.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description Inhibition of porcine kidney CD13 using L-leucine-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition measured after 3... |
Eur J Med Chem 143: 334-347 (2018)
Article DOI: 10.1016/j.ejmech.2017.11.074 BindingDB Entry DOI: 10.7270/Q23R0WD8 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Homo sapiens (Human)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description Inhibition of aminopeptidase N (unknown origin) |
Bioorg Med Chem Lett 23: 4948-52 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.058 BindingDB Entry DOI: 10.7270/Q2377B4J |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | 7.2 | n/a |
Shandong University
| Assay Description Briefly, the assay was performed in 96-well plates in 50 mm PBS, pH 7.2 as the assay buffer, at 37 °C. The APN solution was mixed with compounds at v... |
Chem Biol Drug Des 88: 542-55 (2016)
Article DOI: 10.1111/cbdd.12778 BindingDB Entry DOI: 10.7270/Q2HX1BHT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 2.55E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Shan Dong University
| Assay Description IC50 values against APN from Porcine Kidney were determined by using L-Leu-p-nitroanilide as a substrate. All the solutions of the inhibitors were pr... |
J Enzyme Inhib Med Chem 28: 545-51 (2013)
Article DOI: 10.3109/14756366.2012.656622 BindingDB Entry DOI: 10.7270/Q24J0D1S |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Homo sapiens (Human)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | 2.62E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description Inhibitory activity against aminopeptidase N assayed by the L-Ala-MCA method. |
J Med Chem 41: 263-5 (1998)
Article DOI: 10.1021/jm970624o BindingDB Entry DOI: 10.7270/Q24X5BJC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Lille 2
Curated by ChEMBL
| Assay Description Inhibition of microsomal neural aminopeptidase in pig kidney |
Bioorg Med Chem 15: 63-76 (2006)
Article DOI: 10.1016/j.bmc.2006.10.010 BindingDB Entry DOI: 10.7270/Q23F4P9V |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Homo sapiens (Human)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lille 2
Curated by ChEMBL
| Assay Description Inhibitory activity against mammalian Aminopeptidase N (APN) |
Bioorg Med Chem Lett 13: 2659-62 (2003)
BindingDB Entry DOI: 10.7270/Q20G3KPK |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description Inhibition of pig kidney microsomal Aminopeptidase N |
Bioorg Med Chem 17: 3810-7 (2009)
Article DOI: 10.1016/j.bmc.2009.04.038 BindingDB Entry DOI: 10.7270/Q2VT1S0J |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description Inhibition of pig kidney microsome aminopeptidase N by UV-visible spectrophotometer |
Bioorg Med Chem 16: 9984-90 (2008)
Article DOI: 10.1016/j.bmc.2008.10.025 BindingDB Entry DOI: 10.7270/Q2JQ10VD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description Inhibition of pig kidney microsomal APN |
Bioorg Med Chem 17: 2775-84 (2009)
Article DOI: 10.1016/j.bmc.2009.02.034 BindingDB Entry DOI: 10.7270/Q29G5MQ0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description Inhibition of pig microsomal aminopeptidase N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after... |
Bioorg Med Chem 21: 1621-7 (2013)
Article DOI: 10.1016/j.bmc.2013.01.068 BindingDB Entry DOI: 10.7270/Q2W95BJ0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Inhibition of APN in porcine kidney microsomes preincubated for 5 mins before L-leu-p-nitroanilide substrate addition for 30 mins by plate reader ana... |
Eur J Med Chem 108: 21-7 (2016)
Article DOI: 10.1016/j.ejmech.2015.11.021 BindingDB Entry DOI: 10.7270/Q2ZC84RN |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ENSCMu
| Assay Description Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t... |
Bioorg Med Chem 14: 7241-57 (2006)
Article DOI: 10.1016/j.bmc.2006.06.050 BindingDB Entry DOI: 10.7270/Q2N29V73 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Homo sapiens (Human)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoire de Chimie Organique et Bioorganique, FRE3252, ENSCMu, F-68093 Mulhouse Cedex, France.
Curated by ChEMBL
| Assay Description Inhibition of human aminopeptidase N by Dixon plot analysis |
Bioorg Med Chem 19: 1434-49 (2011)
Article DOI: 10.1016/j.bmc.2011.01.008 BindingDB Entry DOI: 10.7270/Q2G44QJQ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description Inhibition of porcine kidney microsome APN assessed as L-Leu-p-nitroanilide hydrolysis |
Bioorg Med Chem 17: 7398-404 (2009)
Article DOI: 10.1016/j.bmc.2009.07.014 BindingDB Entry DOI: 10.7270/Q2QV3MMD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 3.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of APN in pig kidney microsomes assessed as reduction in p-nitroanilide release using L-leu-p-nitroanilide as substrate incubated for 30 m... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00504 BindingDB Entry DOI: 10.7270/Q20005WB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description Inhibition of pig kidney microsomal APN assessed as hydrolysis of L-Leu-p-nitroanilide after 1 hr by spectrophotometry |
Bioorg Med Chem 19: 5190-8 (2011)
Article DOI: 10.1016/j.bmc.2011.07.008 BindingDB Entry DOI: 10.7270/Q2HX1D2T |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of porcine kidney microsomal CD13 using L-leucine-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition and m... |
Citation and Details
Article DOI: 10.1016/j.bmc.2016.09.033 BindingDB Entry DOI: 10.7270/Q2JD51FV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description Inhibition of aminopeptidase N in pig kidney microsome by spectrophotometry |
Bioorg Med Chem 17: 4666-73 (2009)
Article DOI: 10.1016/j.bmc.2009.04.056 BindingDB Entry DOI: 10.7270/Q2D21XN3 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description Inhibition of APN from pig kidney microsomes by spectrophotometry |
Bioorg Med Chem 18: 887-95 (2010)
Article DOI: 10.1016/j.bmc.2009.11.036 BindingDB Entry DOI: 10.7270/Q2J67H1Z |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Homo sapiens (Human)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sejong University
Curated by ChEMBL
| Assay Description Inhibitory concentration against aminopeptidase N |
Bioorg Med Chem Lett 15: 181-3 (2004)
Article DOI: 10.1016/j.bmcl.2004.10.010 BindingDB Entry DOI: 10.7270/Q2BG2PRF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| PDB Article PubMed
| n/a | n/a | 4.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description Inhibition of pig kidney microsome aminopeptidase N after 30 mins by UV-vis spectrophotometric analysis |
Bioorg Med Chem 18: 5981-7 (2010)
Article DOI: 10.1016/j.bmc.2010.06.078 BindingDB Entry DOI: 10.7270/Q20R9PKH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 5.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of porcine kidney microsomal CD13 using L-leucine-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition and m... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2016.05.068 BindingDB Entry DOI: 10.7270/Q2TX3K2F |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 5.55E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shan Dong University
Curated by ChEMBL
| Assay Description Inhibition of pig kidney microsome aminopeptidase N using L-Leu-p-nitroanilide substrate |
Bioorg Med Chem 19: 6015-25 (2011)
Article DOI: 10.1016/j.bmc.2011.08.041 BindingDB Entry DOI: 10.7270/Q2251JKK |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 5.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description Inhibition of pig microsomal aminopeptidase N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after... |
Bioorg Med Chem Lett 23: 4948-52 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.058 BindingDB Entry DOI: 10.7270/Q2377B4J |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 5.87E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Shandong University
Curated by ChEMBL
| Assay Description Inhibition of porcine kidney microsomal APN after 10 mins at room temperature by spectrophotometry |
Bioorg Med Chem 19: 900-6 (2011)
Article DOI: 10.1016/j.bmc.2010.11.066 BindingDB Entry DOI: 10.7270/Q2KK9C15 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 6.25E+3 | n/a | n/a | n/a | n/a | 7.2 | n/a |
Shandong University
| Assay Description IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P... |
J Enzyme Inhib Med Chem 28: 717-26 (2013)
Article DOI: 10.3109/14756366.2012.680062 BindingDB Entry DOI: 10.7270/Q2930S39 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| PDB Article PubMed
| n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description Inhibition of porcine kidney microsomal APN using L-Leu-para-nitroanilide as substrate incubated for 2 hrs prior to substrate addition measured after... |
Bioorg Med Chem 23: 6632-40 (2015)
Article DOI: 10.1016/j.bmc.2015.09.013 BindingDB Entry DOI: 10.7270/Q29025M9 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shan Dong University
| Assay Description The samples and positive controls were serial diluted to various concentrations: 1280 μg/mL, 320 μg/mL, 80 μg/mL, and 20 μg/mL, 5... |
J Enzyme Inhib Med Chem 27: 302-10 (2012)
Article DOI: 10.3109/14756361003698147 BindingDB Entry DOI: 10.7270/Q2R21083 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| PDB Article PubMed
| n/a | n/a | 8.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI... |
Bioorg Med Chem 20: 3807-15 (2012)
Article DOI: 10.1016/j.bmc.2012.04.035 BindingDB Entry DOI: 10.7270/Q2B56KS2 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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Similars
| PDB Article PubMed
| n/a | n/a | 8.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV-Vi... |
Bioorg Med Chem Lett 23: 2512-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.021 BindingDB Entry DOI: 10.7270/Q21G0NN4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| PDB Article PubMed
| n/a | n/a | 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ShanDong University
Curated by ChEMBL
| Assay Description Inhibition of pig kidney microsomes aminopeptidase N |
Bioorg Med Chem 16: 6663-8 (2008)
Article DOI: 10.1016/j.bmc.2008.05.081 BindingDB Entry DOI: 10.7270/Q2RB74DK |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| PDB Article PubMed
| n/a | n/a | 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of porcine kidney microsome aminopeptidase using L-Leu-p-nitroanilide as substrate after 30 mins |
Bioorg Med Chem Lett 22: 5863-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.086 BindingDB Entry DOI: 10.7270/Q2VD70KS |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aminopeptidase N
(Sus scrofa (Pig)) | BDBM23971
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1 | PDB
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| n/a | n/a | 9.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of APN in porcine kidney microsome assessed as inhibition of L-Leu-p-nitroanilide substrate hydrolysis incubated for 5 mins before substra... |
ACS Med Chem Lett 3: 959-964 (2012)
Article DOI: 10.1021/ml3000758 BindingDB Entry DOI: 10.7270/Q2QJ7JFR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |