BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'Amyloid-beta precursor protein' and Ligand = 'BDBM50163996'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50163996 (4-(4-Chloro-benzenesulfonyl)-4-(2-methoxy-phenyl)-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.03E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibition of amyloid precursor protein 695 activity in CHO cells expressing human APP				Bioorg Med Chem Lett 15: 1891-4 (2005) Article DOI: 10.1016/j.bmcl.2005.02.006 BindingDB Entry DOI: 10.7270/Q2N879B4
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50163996 (4-(4-Chloro-benzenesulfonyl)-4-(2-methoxy-phenyl)-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	530	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro reduction of Swedish NL mutant amyloid precursor protein activity expressed in CHO cells				Bioorg Med Chem Lett 15: 1891-4 (2005) Article DOI: 10.1016/j.bmcl.2005.02.006 BindingDB Entry DOI: 10.7270/Q2N879B4
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50163996 (4-(4-Chloro-benzenesulfonyl)-4-(2-methoxy-phenyl)-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	640	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro elevation of beta C-terminal fragment (Ct-99) in CHO cells expressing mutant Swedish NL human APP				Bioorg Med Chem Lett 15: 1891-4 (2005) Article DOI: 10.1016/j.bmcl.2005.02.006 BindingDB Entry DOI: 10.7270/Q2N879B4
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50163996 (4-(4-Chloro-benzenesulfonyl)-4-(2-methoxy-phenyl)-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro effective concentration against beta amyloid protein 40 in ELISA				Bioorg Med Chem Lett 15: 1891-4 (2005) Article DOI: 10.1016/j.bmcl.2005.02.006 BindingDB Entry DOI: 10.7270/Q2N879B4
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50163996 (4-(4-Chloro-benzenesulfonyl)-4-(2-methoxy-phenyl)-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro effective concentration against beta amyloid protein 42 in ELISA				Bioorg Med Chem Lett 15: 1891-4 (2005) Article DOI: 10.1016/j.bmcl.2005.02.006 BindingDB Entry DOI: 10.7270/Q2N879B4
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair