BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM50044949'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM50044949
PNG
(CHEMBL3309307)
Show SMILES FC(F)(F)S(=O)(=O)c1cc(ccc1N[C@H](CCN1CCOCC1)CSc1ccccc1)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(Cc2ccncc2-c2ccc(Cl)cc2)CC1 |r|
Show InChI InChI=1S/C44H46ClF3N6O6S3/c45-35-10-6-32(7-11-35)40-29-49-18-16-34(40)30-53-20-22-54(23-21-53)37-12-8-33(9-13-37)43(55)51-63(58,59)39-14-15-41(42(28-39)62(56,57)44(46,47)48)50-36(17-19-52-24-26-60-27-25-52)31-61-38-4-2-1-3-5-38/h1-16,18,28-29,36,50H,17,19-27,30-31H2,(H,51,55)/t36-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a<10n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of c-terminal 6xHis-tagged Bcl-2 (amino acids 1 to 204) (unknown origin) preincubated for 1 hr prior to substrate addition measured after ...

Bioorg Med Chem Lett 24: 3026-33 (2014)


Article DOI: 10.1016/j.bmcl.2014.05.036
BindingDB Entry DOI: 10.7270/Q27M09JW
More data for this
Ligand-Target Pair