Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Arachidonate 5-lipoxygenase-activating protein' and Ligand = 'BDBM145672'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145672 (US8952177, 26 | US9089569, 26 | US9695149, 26) Show SMILES Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)cc4F)c3c2)nc1 |r| Show InChI InChI=1S/C29H27F4N3O4/c1-17-6-8-19(34-14-17)16-39-20-10-11-25-26(13-20)36(27(35-25)22-4-2-3-5-23(22)28(37)38)15-18-7-9-21(12-24(18)30)40-29(31,32)33/h6-14,22-23H,2-5,15-16H2,1H3,(H,37,38)/t22-,23+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	4.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...				US Patent US8952177 (2015) BindingDB Entry DOI: 10.7270/Q2G73CFW
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145672 (US8952177, 26 | US9089569, 26 | US9695149, 26) Show SMILES Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)cc4F)c3c2)nc1 |r| Show InChI InChI=1S/C29H27F4N3O4/c1-17-6-8-19(34-14-17)16-39-20-10-11-25-26(13-20)36(27(35-25)22-4-2-3-5-23(22)28(37)38)15-18-7-9-21(12-24(18)30)40-29(31,32)33/h6-14,22-23H,2-5,15-16H2,1H3,(H,37,38)/t22-,23+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	4.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9695149 (2017) BindingDB Entry DOI: 10.7270/Q2Q52MSC
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145672 (US8952177, 26 | US9089569, 26 | US9695149, 26) Show SMILES Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)cc4F)c3c2)nc1 |r| Show InChI InChI=1S/C29H27F4N3O4/c1-17-6-8-19(34-14-17)16-39-20-10-11-25-26(13-20)36(27(35-25)22-4-2-3-5-23(22)28(37)38)15-18-7-9-21(12-24(18)30)40-29(31,32)33/h6-14,22-23H,2-5,15-16H2,1H3,(H,37,38)/t22-,23+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	4.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9089569 (2015) BindingDB Entry DOI: 10.7270/Q23X85DB
					More data for this Ligand-Target Pair