Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Arachidonate 5-lipoxygenase-activating protein' and Ligand = 'BDBM145731'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145731 (US8952177, 85 | US9089569, 85 | US9695149, 85) Show SMILES Cn1cc(F)c(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)cc4F)c3c2)n1 |r| Show InChI InChI=1S/C27H25F5N4O4/c1-35-13-21(29)23(34-35)14-39-16-8-9-22-24(11-16)36(25(33-22)18-4-2-3-5-19(18)26(37)38)12-15-6-7-17(10-20(15)28)40-27(30,31)32/h6-11,13,18-19H,2-5,12,14H2,1H3,(H,37,38)/t18-,19+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...				US Patent US8952177 (2015) BindingDB Entry DOI: 10.7270/Q2G73CFW
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145731 (US8952177, 85 | US9089569, 85 | US9695149, 85) Show SMILES Cn1cc(F)c(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)cc4F)c3c2)n1 |r| Show InChI InChI=1S/C27H25F5N4O4/c1-35-13-21(29)23(34-35)14-39-16-8-9-22-24(11-16)36(25(33-22)18-4-2-3-5-19(18)26(37)38)12-15-6-7-17(10-20(15)28)40-27(30,31)32/h6-11,13,18-19H,2-5,12,14H2,1H3,(H,37,38)/t18-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9695149 (2017) BindingDB Entry DOI: 10.7270/Q2Q52MSC
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145731 (US8952177, 85 | US9089569, 85 | US9695149, 85) Show SMILES Cn1cc(F)c(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)cc4F)c3c2)n1 |r| Show InChI InChI=1S/C27H25F5N4O4/c1-35-13-21(29)23(34-35)14-39-16-8-9-22-24(11-16)36(25(33-22)18-4-2-3-5-19(18)26(37)38)12-15-6-7-17(10-20(15)28)40-27(30,31)32/h6-11,13,18-19H,2-5,12,14H2,1H3,(H,37,38)/t18-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9089569 (2015) BindingDB Entry DOI: 10.7270/Q23X85DB
					More data for this Ligand-Target Pair