Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Bcl-2-like protein 1' and Ligand = 'BDBM209176'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bcl-2-like protein 1 (Homo sapiens (Human))	BDBM209176 (US9266877, 122) Show SMILES OC(=O)c1nc(ccc1-c1cn(Cc2ccccc2)nn1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1 Show InChI InChI=1S/C32H25N7O3S/c40-30(35-32-33-25-11-4-5-12-27(25)43-32)22-10-6-9-21-15-16-38(18-24(21)22)28-14-13-23(29(34-28)31(41)42)26-19-39(37-36-26)17-20-7-2-1-3-8-20/h1-14,19H,15-18H2,(H,41,42)(H,33,35,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of F-Bak (GQVGRQLAIIGDK(6-FAM)INR-amide probe binding to BCL-xl (unknown origin) incubated for 1 hr by TR-FRET assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00568 BindingDB Entry DOI: 10.7270/Q2542S8D
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 (Homo sapiens (Human))	BDBM209176 (US9266877, 122) Show SMILES OC(=O)c1nc(ccc1-c1cn(Cc2ccccc2)nn1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1 Show InChI InChI=1S/C32H25N7O3S/c40-30(35-32-33-25-11-4-5-12-27(25)43-32)22-10-6-9-21-15-16-38(18-24(21)22)28-14-13-23(29(34-28)31(41)42)26-19-39(37-36-26)17-20-7-2-1-3-8-20/h1-14,19H,15-18H2,(H,41,42)(H,33,35,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	117	-39.6	n/a	n/a	n/a	n/a	n/a	n/a	25
ABBVIE INC. US Patent					Assay Description The measurement of competition of compounds of Formula (I) with F-Bak for a Bcl-2 family protein (Bcl-xL) binding site using a Time Resolved Fluoresc...				US Patent US9266877 (2016) BindingDB Entry DOI: 10.7270/Q2H41Q7V
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 (Mus musculus (Mouse))	BDBM209176 (US9266877, 122) Show SMILES OC(=O)c1nc(ccc1-c1cn(Cc2ccccc2)nn1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1 Show InChI InChI=1S/C32H25N7O3S/c40-30(35-32-33-25-11-4-5-12-27(25)43-32)22-10-6-9-21-15-16-38(18-24(21)22)28-14-13-23(29(34-28)31(41)42)26-19-39(37-36-26)17-20-7-2-1-3-8-20/h1-14,19H,15-18H2,(H,41,42)(H,33,35,40)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The efficacy of the compounds of Formula (I) can also be determined in cell-based killing assays using a variety of cell lines and mouse tumor models...				US Patent US9266877 (2016) BindingDB Entry DOI: 10.7270/Q2H41Q7V
					More data for this Ligand-Target Pair