BindingDB PrimarySearch

Found 8 hits Enz. Inhib. hit(s) with Target = 'C-C chemokine receptor type 5' and Ligand = 'BDBM50506124'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
C-C chemokine receptor type 5 (Homo sapiens (Human))	BDBM50506124 (CHEMBL4544504) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	112	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Antagonist activity at human TEV cleavage site-linked CCR5 expressed in human U2OS cells harboring beta-lactamase reporter gene assessed as inhibitio...				J Med Chem 62: 11035-11053 (2019) Article DOI: 10.1021/acs.jmedchem.9b00742 BindingDB Entry DOI: 10.7270/Q2QR51DD
Leiden University Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 5 (Homo sapiens (Human))	BDBM50506124 (CHEMBL4544504) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	112	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Antagonist activity at human TEV cleavage site-linked CCR5 expressed in human U2OS cells harboring beta-lactamase reporter gene assessed as inhibitio...				J Med Chem 62: 11035-11053 (2019) Article DOI: 10.1021/acs.jmedchem.9b00742 BindingDB Entry DOI: 10.7270/Q2QR51DD
Leiden University Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 5 (Homo sapiens (Human))	BDBM50506124 (CHEMBL4544504) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GT...				J Med Chem 62: 11035-11053 (2019) Article DOI: 10.1021/acs.jmedchem.9b00742 BindingDB Entry DOI: 10.7270/Q2QR51DD
Leiden University Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 5 (Homo sapiens (Human))	BDBM50506124 (CHEMBL4544504) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTP...				J Med Chem 62: 11035-11053 (2019) Article DOI: 10.1021/acs.jmedchem.9b00742 BindingDB Entry DOI: 10.7270/Q2QR51DD
Leiden University Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 5 (Homo sapiens (Human))	BDBM50506124 (CHEMBL4544504) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	8.90	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GT...				J Med Chem 62: 11035-11053 (2019) Article DOI: 10.1021/acs.jmedchem.9b00742 BindingDB Entry DOI: 10.7270/Q2QR51DD
Leiden University Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 5 (Homo sapiens (Human))	BDBM50506124 (CHEMBL4544504) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTP...				J Med Chem 62: 11035-11053 (2019) Article DOI: 10.1021/acs.jmedchem.9b00742 BindingDB Entry DOI: 10.7270/Q2QR51DD
Leiden University Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 5 (Homo sapiens (Human))	BDBM50506124 (CHEMBL4544504) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	6.20	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GT...				J Med Chem 62: 11035-11053 (2019) Article DOI: 10.1021/acs.jmedchem.9b00742 BindingDB Entry DOI: 10.7270/Q2QR51DD
Leiden University Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 5 (Homo sapiens (Human))	BDBM50506124 (CHEMBL4544504) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTP...				J Med Chem 62: 11035-11053 (2019) Article DOI: 10.1021/acs.jmedchem.9b00742 BindingDB Entry DOI: 10.7270/Q2QR51DD
Leiden University Curated by ChEMBL					More data for this Ligand-Target Pair