BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'C5a anaphylatoxin chemotactic receptor 1' and Ligand = 'BDBM50266072'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
C5a anaphylatoxin chemotactic receptor 1 (Homo sapiens (Human))	BDBM50266072 ((+/-)-ethyl 2-(N-(1,4-dioxaspiro[4.5]decan-8-yl)-1...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assay				Bioorg Med Chem Lett 18: 5605-8 (2008) Article DOI: 10.1016/j.bmcl.2008.08.101 BindingDB Entry DOI: 10.7270/Q2M61K31
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor 1 (Homo sapiens (Human))	BDBM50266072 ((+/-)-ethyl 2-(N-(1,4-dioxaspiro[4.5]decan-8-yl)-1...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Antagonist activity at C5a receptor assessed as inhibition of C5a-induced elastase release in human neutrophils during degranulation preincubated 5 m...				Bioorg Med Chem Lett 18: 5605-8 (2008) Article DOI: 10.1016/j.bmcl.2008.08.101 BindingDB Entry DOI: 10.7270/Q2M61K31
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair