BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'Complement factor D [24-253]' and Ligand = 'BDBM171350'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Complement factor D [24-253] (Homo sapiens (Human))	BDBM171350 (1-(2-((1R,3S,5R)-3-((6-Bromopyridin-2-yl)carbamoyl...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.5	25
Novartis Pharma AG					Assay Description Briefly, recombinant human or murine FD catalytic domain (10 nM concentration) were incubated with compound at various concentrations for 1 h at room...				Nat Chem Biol 12: 1105-1110 (2016) Article DOI: 10.1038/nchembio.2208 BindingDB Entry DOI: 10.7270/Q2KD1WR1
Novartis Pharma AG					More data for this Ligand-Target Pair				3D Structure (crystal)
Complement factor D [24-253] (Homo sapiens (Human))	BDBM171350 (1-(2-((1R,3S,5R)-3-((6-Bromopyridin-2-yl)carbamoyl...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	7.4	4
Novartis Pharma AG					Assay Description Recombinant human FD (10 nM concentration) was incubated with compound at various concentrations for 1 h at room temperature in 0.1 M PBS (pH 7.4) ...				Nat Chem Biol 12: 1105-1110 (2016) Article DOI: 10.1038/nchembio.2208 BindingDB Entry DOI: 10.7270/Q2KD1WR1
Novartis Pharma AG					More data for this Ligand-Target Pair				3D Structure (crystal)