| Reaction Details |
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 | Report a problem with these data |
| Target | Complement factor D [24-253] |
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| Ligand | BDBM171350 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Complement FD Thioesterolysis Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 6± 2 nM |
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| Comments | extracted |
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| Citation |  Maibaum, J; Liao, SM; Vulpetti, A; Ostermann, N; Randl, S; Rüdisser, S; Lorthiois, E; Erbel, P; Kinzel, B; Kolb, FA; Barbieri, S; Wagner, J; Durand, C; Fettis, K; Dussauge, S; Hughes, N; Delgado, O; Hommel, U; Gould, T; Mac Sweeney, A; Gerhartz, B; Cumin, F; Flohr, S; Schubart, A; Jaffee, B; Harrison, R; Risitano, AM; Eder, J; Anderson, K Small-molecule factor D inhibitors targeting the alternative complement pathway. Nat Chem Biol12:1105-1110 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Complement factor D [24-253] |
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| Name: | Complement factor D [24-253] |
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| Synonyms: | CFAD_HUMAN | CFD | Complement factor D (FD) catalytic domain (Human fD) | DF | PFD |
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| Type: | Protein |
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| Mol. Mass.: | 24622.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00746 (24-253 aa) |
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| Residue: | 230 |
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| Sequence: | GRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAH
SLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVA
PGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDS
CKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
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| BDBM171350 |
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| n/a |
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| Name | BDBM171350 |
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| Synonyms: | 1-(2-((1R,3S,5R)-3-((6-Bromopyridin-2-yl)carbamoyl)-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)-1H-indazole-3-carboxamide (7) | US9085555, 727 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19BrN6O3 |
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| Mol. Mass. | 483.318 |
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| SMILES | NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2cccc(Br)n2)c2ccccc12 |
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| Structure | 
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