Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Corticotropin-releasing factor receptor 1' and Ligand = 'BDBM131872'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM131872 (US8835444, 4.2) Show SMILES Cc1cc(nn1C[C@H]1CC[C@@H](CC1)NC(=O)c1cc(ccc1Cl)C(F)(F)F)-c1ccc2OCOc2c1 |r,wU:7.7,wD:10.14,(4.91,4.22,;4.91,2.68,;6.16,1.77,;5.68,.31,;4.14,.31,;3.67,1.77,;2.33,2.54,;1,1.77,;1,.23,;-.34,-.54,;-1.67,.23,;-1.67,1.77,;-.34,2.54,;-3,-.54,;-4.34,.23,;-4.34,1.77,;-5.67,-.54,;-7,.23,;-8.34,-.54,;-8.34,-2.08,;-7,-2.85,;-5.67,-2.08,;-4.34,-2.85,;-9.67,.23,;-11,-.54,;-9.67,1.77,;-11,1,;6.45,-1.02,;5.98,-2.49,;7.01,-3.63,;8.51,-3.31,;9.76,-4.22,;11,-3.31,;10.53,-1.85,;8.99,-1.85,;7.96,-.7,)| Show InChI InChI=1S/C26H25ClF3N3O3/c1-15-10-22(17-4-9-23-24(11-17)36-14-35-23)32-33(15)13-16-2-6-19(7-3-16)31-25(34)20-12-18(26(28,29)30)5-8-21(20)27/h4-5,8-12,16,19H,2-3,6-7,13-14H2,1H3,(H,31,34)/t16-,19-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing either the human or rat recombinant CRF-1 or human CRF-2alpha (Chen et al, Proc Natl Acad Sci USA 90, 89...				US Patent US8835444 (2014) BindingDB Entry DOI: 10.7270/Q28K77ST
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