Found 2 hits Enz. Inhib. hit(s) with Target = 'Corticotropin-releasing factor receptor 1' and Ligand = 'BDBM50417502' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50417502
(CHEMBL1287905)Show SMILES CC[C@@H](Nc1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1C)c1nc(C)no1 |r,wU:2.2,(12.72,-33.43,;14.06,-34.18,;14.08,-35.71,;15.43,-36.46,;15.45,-38.01,;14.11,-38.8,;14.13,-40.34,;12.81,-41.13,;15.48,-41.08,;16.8,-40.3,;18.27,-40.76,;19.16,-39.51,;20.7,-39.48,;18.24,-38.27,;16.79,-38.76,;19.05,-42.09,;18.28,-43.43,;19.04,-44.74,;20.58,-44.75,;21.35,-46.08,;22.9,-46.08,;21.35,-43.42,;20.58,-42.08,;21.35,-40.75,;12.85,-36.64,;11.38,-36.18,;10.5,-37.42,;8.96,-37.45,;11.41,-38.66,;12.88,-38.18,)| Show InChI InChI=1S/C22H26N6O2/c1-7-18(22-24-15(5)27-30-22)25-19-11-13(3)23-21-20(14(4)26-28(19)21)17-9-8-16(29-6)10-12(17)2/h8-11,18,25H,7H2,1-6H3/t18-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant CRF1 receptor |
Bioorg Med Chem Lett 20: 7259-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.095 BindingDB Entry DOI: 10.7270/Q2736S5V |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50417502
(CHEMBL1287905)Show SMILES CC[C@@H](Nc1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1C)c1nc(C)no1 |r,wU:2.2,(12.72,-33.43,;14.06,-34.18,;14.08,-35.71,;15.43,-36.46,;15.45,-38.01,;14.11,-38.8,;14.13,-40.34,;12.81,-41.13,;15.48,-41.08,;16.8,-40.3,;18.27,-40.76,;19.16,-39.51,;20.7,-39.48,;18.24,-38.27,;16.79,-38.76,;19.05,-42.09,;18.28,-43.43,;19.04,-44.74,;20.58,-44.75,;21.35,-46.08,;22.9,-46.08,;21.35,-43.42,;20.58,-42.08,;21.35,-40.75,;12.85,-36.64,;11.38,-36.18,;10.5,-37.42,;8.96,-37.45,;11.41,-38.66,;12.88,-38.18,)| Show InChI InChI=1S/C22H26N6O2/c1-7-18(22-24-15(5)27-30-22)25-19-11-13(3)23-21-20(14(4)26-28(19)21)17-9-8-16(29-6)10-12(17)2/h8-11,18,25H,7H2,1-6H3/t18-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant CRF1 receptor |
Bioorg Med Chem Lett 20: 7259-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.095 BindingDB Entry DOI: 10.7270/Q2736S5V |
More data for this Ligand-Target Pair | |