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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Cyclin-C' and Ligand = 'BDBM50585694'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-C


(Homo sapiens (Human))
BDBM50585694
PNG
(CHEMBL4878072)
Show SMILES CN1CCN(CC1)C(=O)c1ccc2cc(CCNc3ccnc4ccc(cc34)C#N)ccc2c1
PDB

UniProtKB/SwissProt

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MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.60n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of kinase tracer 236 binding to His tagged recombinant human CDK8/cyclin C incubated for 60 min FRET based LanthaScreen Eu-Kinase binding ...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01951
BindingDB Entry DOI: 10.7270/Q2WD44G8
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50585694
PNG
(CHEMBL4878072)
Show SMILES CN1CCN(CC1)C(=O)c1ccc2cc(CCNc3ccnc4ccc(cc34)C#N)ccc2c1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 1.40n/an/an/an/an/a


TBA

Assay Description
Binding affinity to kinase tracer 236 binding to His tagged recombinant human CDK8/cyclinC assessed as dissociation constant by TR FRET based assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01951
BindingDB Entry DOI: 10.7270/Q2WD44G8
More data for this
Ligand-Target Pair