BindingDB PrimarySearch

Found 11 hits Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 6' and Ligand = 'BDBM50110183'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cyclin-dependent kinase 6 (Homo sapiens (Human))	BDBM50110183 (Abemaciclib \| LY-2835219 \| US10626107, Example LY2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai HaiHe Pharmaceutial, Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of CDK6 (unknown origin) using U-light as substrate preincubated for 1 hr followed by EDTA addition measured after 1 hr by LANCE Ultra kin...				Bioorg Med Chem Lett 27: 5332-5336 (2017) Article DOI: 10.1016/j.bmcl.2017.09.050 BindingDB Entry DOI: 10.7270/Q2H134K1
Shanghai HaiHe Pharmaceutial, Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-dependent kinase 6 (Homo sapiens (Human))	BDBM50110183 (Abemaciclib \| LY-2835219 \| US10626107, Example LY2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	3.41	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were respectively dissolved in ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2SJ1PTP
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-dependent kinase 6 (Homo sapiens (Human))	BDBM50110183 (Abemaciclib \| LY-2835219 \| US10626107, Example LY2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	3.41	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were respectively dissolved in ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2SJ1PTP
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-dependent kinase 6 (Homo sapiens (Human))	BDBM50110183 (Abemaciclib \| LY-2835219 \| US10626107, Example LY2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
The First Affiliated Hospital of Zhengzhou University Curated by ChEMBL					Assay Description Inhibition of CDK6 (unknown origin)				Eur J Med Chem 164: 615-639 (2019) Article DOI: 10.1016/j.ejmech.2019.01.003 BindingDB Entry DOI: 10.7270/Q2C53QDZ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-dependent kinase 6 (Homo sapiens (Human))	BDBM50110183 (Abemaciclib \| LY-2835219 \| US10626107, Example LY2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
University of Padova Curated by ChEMBL					Assay Description Inhibition of CDK6 (unknown origin)				Eur J Med Chem 172: 143-153 (2019) Article DOI: 10.1016/j.ejmech.2019.03.064 BindingDB Entry DOI: 10.7270/Q27M0C84
University of Padova Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-dependent kinase 6 (Homo sapiens (Human))	BDBM50110183 (Abemaciclib \| LY-2835219 \| US10626107, Example LY2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	7.80	n/a	n/a	n/a	n/a	n/a	n/a
Beijing University of Technology Curated by ChEMBL					Assay Description Inhibition of recombinant human full length CDK6 expressed in baculovirus infected Sf9 insect cells using histone H1 substrate after 90 mins by ADP-G...				Bioorg Med Chem Lett 28: 974-978 (2018) Article DOI: 10.1016/j.bmcl.2017.12.068 BindingDB Entry DOI: 10.7270/Q2BC4236
Beijing University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-dependent kinase 6 (Homo sapiens (Human))	BDBM50110183 (Abemaciclib \| LY-2835219 \| US10626107, Example LY2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist potency at cloned recombinant human adenosine A2A receptor transfected in CHO cells by cAMP assay				Citation and Details
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-dependent kinase 6 (Homo sapiens (Human))	BDBM50110183 (Abemaciclib \| LY-2835219 \| US10626107, Example LY2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Central University of Punjab Curated by ChEMBL					Assay Description Inhibition of CDK6 (unknown origin)				Eur J Med Chem 142: 424-458 (2017) Article DOI: 10.1016/j.ejmech.2017.08.071 BindingDB Entry DOI: 10.7270/Q2S1856W
Central University of Punjab Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-dependent kinase 6 (Homo sapiens (Human))	BDBM50110183 (Abemaciclib \| LY-2835219 \| US10626107, Example LY2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2020.112904 BindingDB Entry DOI: 10.7270/Q2XP791Q
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-dependent kinase 6 (Homo sapiens (Human))	BDBM50110183 (Abemaciclib \| LY-2835219 \| US10626107, Example LY2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	11.7	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. US Patent					Assay Description 1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...				US Patent US10988476 (2021) BindingDB Entry DOI: 10.7270/Q2PR8047
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-dependent kinase 6 (Homo sapiens (Human))	BDBM50110183 (Abemaciclib \| LY-2835219 \| US10626107, Example LY2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	11.7	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. US Patent					Assay Description 1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...				US Patent US10662186 (2020) BindingDB Entry DOI: 10.7270/Q2GX4FKS
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)